LOCUS       NM_001367671            3912 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 1 (SUN1), transcript
            variant 34, mRNA.
ACCESSION   NM_001367671
VERSION     NM_001367671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3912)
  AUTHORS   Fan,T., Zhu,J., Liu,W., Qu,R., Khan,A.U., Shi,Y., Liu,J., Zhou,Z.,
            Xu,C., Dai,J. and Ouyang,J.
  TITLE     SUN1 inhibits osteogenesis and promotes adipogenesis of human
            adipose-derived stem cells by regulating alpha-tubulin and CD36
            expression
  JOURNAL   J Cell Mol Med 28 (19), e70143 (2024)
   PUBMED   39383106
  REMARK    GeneRIF: SUN1 inhibits osteogenesis and promotes adipogenesis of
            human adipose-derived stem cells by regulating alpha-tubulin and
            CD36 expression.
REFERENCE   2  (bases 1 to 3912)
  AUTHORS   Gurusaran,M., Erlandsen,B.S. and Davies,O.R.
  TITLE     The crystal structure of SUN1-KASH6 reveals an asymmetric LINC
            complex architecture compatible with nuclear membrane insertion
  JOURNAL   Commun Biol 7 (1), 138 (2024)
   PUBMED   38291267
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3912)
  AUTHORS   Baskerville,V., Rapuri,S., Mehlhop,E. and Coyne,A.N.
  TITLE     SUN1 facilitates CHMP7 nuclear influx and injury cascades in
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Brain 147 (1), 109-121 (2024)
   PUBMED   37639327
  REMARK    GeneRIF: SUN1 facilitates CHMP7 nuclear influx and injury cascades
            in sporadic amyotrophic lateral sclerosis.
REFERENCE   4  (bases 1 to 3912)
  AUTHORS   Meng,Q., Shao,B., Zhao,D., Fu,X., Wang,J., Li,H., Zhou,Q. and
            Gao,T.
  TITLE     Loss of SUN1 function in spermatocytes disrupts the attachment of
            telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans
  JOURNAL   Hum Genet 142 (4), 531-541 (2023)
   PUBMED   36933034
  REMARK    GeneRIF: Loss of SUN1 function in spermatocytes disrupts the
            attachment of telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans.
REFERENCE   5  (bases 1 to 3912)
  AUTHORS   Wu,H., Zhang,X., Hua,R., Li,Y., Cheng,L., Li,K., Liu,Y., Gao,Y.,
            Shen,Q., Wang,G., Lv,M., Xu,Y., He,X., Cao,Y. and Liu,M.
  TITLE     Homozygous missense mutation in CCDC155 disrupts the transmembrane
            distribution of CCDC155 and SUN1, resulting in non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Hum Genet 141 (11), 1795-1809 (2022)
   PUBMED   35587281
  REMARK    GeneRIF: Homozygous missense mutation in CCDC155 disrupts the
            transmembrane distribution of CCDC155 and SUN1, resulting in
            non-obstructive azoospermia and premature ovarian insufficiency in
            humans.
REFERENCE   6  (bases 1 to 3912)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
REFERENCE   7  (bases 1 to 3912)
  AUTHORS   Padmakumar,V.C., Libotte,T., Lu,W., Zaim,H., Abraham,S.,
            Noegel,A.A., Gotzmann,J., Foisner,R. and Karakesisoglou,I.
  TITLE     The inner nuclear membrane protein Sun1 mediates the anchorage of
            Nesprin-2 to the nuclear envelope
  JOURNAL   J Cell Sci 118 (Pt 15), 3419-3430 (2005)
   PUBMED   16079285
  REMARK    GeneRIF: The Sun1 itself does not require functional A-type lamins
            for its localisation at the inner nuclear membrane in mammalian
            cells.
REFERENCE   8  (bases 1 to 3912)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
  REMARK    GeneRIF: Isolation of a cDNA encoding a mouse homolog of the human
            SUN1 (UNC84A) gene.
REFERENCE   9  (bases 1 to 3912)
  AUTHORS   Dreger,M., Bengtsson,L., Schoneberg,T., Otto,H. and Hucho,F.
  TITLE     Nuclear envelope proteomics: novel integral membrane proteins of
            the inner nuclear membrane
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11943-11948 (2001)
   PUBMED   11593002
  REMARK    GeneRIF: KIAA0810 is a novel 100-kDa transmembrane protein with
            similarity to Caenorhabditis elegans Unc-84A and resides in the
            inner nuclear membrane. It is likely to interact with the nuclear
            lamina.
REFERENCE   10 (bases 1 to 3912)
  AUTHORS   Malone,C.J., Fixsen,W.D., Horvitz,H.R. and Han,M.
  TITLE     UNC-84 localizes to the nuclear envelope and is required for
            nuclear migration and anchoring during C. elegans development
  JOURNAL   Development 126 (14), 3171-3181 (1999)
   PUBMED   10375507
  REMARK    GeneRIF: Describes cloning and function of C. elegans unc-84 and
            cloning of human orthologs.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099731.5.
            
            Summary: This gene is a member of the unc-84 homolog family and
            encodes a nuclear envelope protein with an Unc84 (SUN) domain. The
            protein is involved in nuclear anchorage and migration.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jan 2019].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.94631.1,
                                           SRR1660805.72650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC099731.5         151954-151984
            32-220              AC099731.5         174109-174297
            221-405             AC099731.5         177257-177441
            406-432             AC099731.5         178517-178543
            433-612             AC099731.5         178652-178831
            613-711             AC099731.5         186695-186793
            712-805             AC099731.5         187261-187354
            806-864             AC099731.5         187920-187978
            865-1004            AC099731.5         188124-188263
            1005-1214           AC099731.5         188720-188929
            1215-1301           AC099731.5         190231-190317
            1302-1345           AC099731.5         191669-191712
            1346-1475           AC099731.5         193139-193268
            1476-1730           AC099731.5         195439-195693
            1731-1815           AC099731.5         196691-196775
            1816-1931           AC099731.5         201263-201378
            1932-2099           AC099731.5         204660-204827
            2100-2192           AC099731.5         207781-207873
            2193-3912           AC099731.5         208526-210245
FEATURES             Location/Qualifiers
     source          1..3912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..3912
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="Sad1 and UNC84 domain containing 1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
     exon            1..31
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            32..220
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2309
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="isoform hh is encoded by transcript variant 34;
                     Sad1 unc-84 domain protein 1; protein unc-84 homolog A;
                     SUN domain-containing protein 1; sad1/unc-84 protein-like
                     1"
                     /codon_start=1
                     /product="SUN domain-containing protein 1 isoform hh"
                     /protein_id="NP_001354600.1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
                     /translation="MSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQR
                     RSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGL
                     DDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSR
                     VYSRDRNQKCYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWY
                     QFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLGLSLRGQGNFFSFLPVLNWASMH
                     RTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRE
                     LTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILG
                     KLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCET
                     VDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQIL
                     RNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFA
                     LESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQ
                     GYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFT
                     YDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK"
     exon            221..405
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            406..432
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            433..612
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            613..711
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            712..805
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            806..864
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1004
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1214
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1301
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1345
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1475
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1730
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1815
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1931
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2099
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2192
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..3912
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3854..3859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: AATAAA"
     polyA_site      3880
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="major polyA site"
     regulatory      3888..3893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: TATAAA"
     polyA_site      3912
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
ORIGIN      
        1 agacgaggcc tgaggcggcg gcgcgaggca gttccagcta ttcttcagat gctctggatt
       61 ttgagacgga gcacaaattg gaccctgtat ttgattctcc acggatgtcc cgccgtagtt
      121 tgcgcctggc cacgacagca tgcaccctgg gggatggtga ggctgtgggt gccgacagcg
      181 gcaccagcag cgctgtctcc ctgaagaacc gagcggccag aacaacaaaa cagcgcagaa
      241 gcacaaacaa atcagctttt agtatcaacc acgtgtcaag gcaggtcacg tcctctggcg
      301 tcagccacgg cggcactgtc agcctgcagg atgctgtgac tcgacggcct cctgtattgg
      361 acgagtcttg gattcgtgaa cagaccacag tggaccactt ctggggtctt gatgatgatg
      421 gtgatcttaa aggtggaaat aaagctgcca ttcagggaaa cggggatgtg ggagccgccg
      481 ccgccaccgc gcacaacggc ttctcctgca gcaactgcag catgctgtcc gagcgcaagg
      541 acgtgctcac ggcgcacccc gcggcccccg ggcccgtgtc gagagtttat tctagggaca
      601 ggaatcaaaa atgttacttc ttgctgcaga ttctgcgcag gatcggagct gtgggccagg
      661 ctgtgtccag gacggcgtgg tcggcccttt ggctggccgt ggttgctcca gggaaggcag
      721 cctctggagt gttctggtgg ctggggattg gatggtacca gtttgttact ttgatttctt
      781 ggctgaatgt gtttcttctt accaggtgcc ttcgaaacat ctgcaagttt ttagtcttgc
      841 tcatcccact cttcctttta ctaggtctct ccttacgggg ccagggcaat ttcttttcgt
      901 tcttgcccgt gttgaactgg gcaagcatgc atagaacaca gcgggtggat gacccccagg
      961 acgtgtttaa acccacgact tctcgcctga agcagcctct gcagggtgac agtgaggctt
     1021 ttccgtggca ttggatgagt ggcgtggagc agcaggtggc ctctctgtct ggacagtgcc
     1081 accaccatgg tgagaatctc cgagagctga ccactttgct acagaagctg caggctcggg
     1141 tggaccagat ggaaggcggc gctgccgggc cgtcagcttc ggtcagagac gctgtgggac
     1201 agcccccgag ggagactgac tttatggcct ttcaccaaga acatgaagtg cgtatgtcac
     1261 acttggaaga tattctggga aaactgagag aaaaatctga ggccatccag aaggaactag
     1321 aacagaccaa gcaaaaaaca atcagtgcgg ttggtgagca gctcctgccc acagtcgagc
     1381 acctccagct ggagctggat cagctaaagt cagagctgtc cagctggcga cacgtgaaga
     1441 ccggctgtga gacagtggat gccgtacaag aaagagtgga cgtgcaagtc agagaaatgg
     1501 tgaaactcct gttttccgaa gatcagcaag gcggttctct ggaacagctg ctgcagaggt
     1561 tctcatcaca gtttgtgagc aaaggcgact tgcagacgat gctgcgagac ctgcagctgc
     1621 agatcctgcg gaacgtcacc caccacgttt ccgtgaccaa gcagctccca acctcagaag
     1681 ccgtggtgtc tgctgtgagc gaggcggggg cgtctggaat aacagaggcg caagcacgtg
     1741 ccatcgtgaa cagcgccttg aagctgtatt cccaagataa gaccgggatg gtggactttg
     1801 ctctggaatc tggtggtggc agcatcttga gtactcgctg ttctgaaact tacgaaacca
     1861 aaacggcgct gatgagtctg tttgggatcc cgctgtggta cttctcgcag tccccgcgcg
     1921 tggtcatcca gcctgacatt taccccggta actgctgggc atttaaaggc tcccaggggt
     1981 acctggtggt gaggctctcc atgatgatcc acccagccgc cttcactctg gagcacatcc
     2041 ctaagacgct gtcgccaaca ggcaacatca gcagcgcccc caaggacttc gccgtctatg
     2101 gattagaaaa tgagtatcag gaagaagggc agcttctggg acagttcacg tatgatcagg
     2161 atggggagtc gctccagatg ttccaggccc tgaaaagacc cgacgacaca gctttccaaa
     2221 tagtggaact tcggattttt tctaactggg gccatcctga gtatacctgt ctgtatcggt
     2281 tcagagttca tggcgaacct gtcaagtgaa gacactactc attatttttg tacatttttg
     2341 tatatactgg gacagcgtga aacactggaa tccttcatgg acgagggcat atacaatgat
     2401 gggacagtgc cacactcctt caataaacgt ggctgctggc cagaggacgt gagcgtgtga
     2461 cgggcgcctt ggcgccacct gttgggtgct cactgcctct gcaggtgcag aggggtcagc
     2521 agcaggagaa gcgtgttgaa cacgtggctc tcagacactc cttgttttta acgggaagct
     2581 ctttgcattt gcatttcctc aacaaaggag caaagcagag gaagctgaga gtctggcgtg
     2641 ttcttgacgc tttggtcttc agccttgcac tggctcttct aaaggacttt tggagggcag
     2701 ataatttcat ctgttaaatc caacacacat ttctttcagg gaaaaacaat gtcaccaaat
     2761 tttcagagtt ctaaactcct ttccttcaag ccggaatttt ccttttttca gcaccagtag
     2821 gtactaagtc tccagatggg gaaataacta aaatgtgttt ttctgctttg ttcgctctta
     2881 cttctgagga aggtttccag tcaggactcg ctgtaccaat atccatggag gaatatggga
     2941 gcgtttcgct ctccttgtag gctgaagtca gtctgacttg aaggggcctg gtttggatct
     3001 aagcaaacac ccagatgggg ttctctggtc tcagcaaggc ttttcctgtt gggagtcaca
     3061 gtaaacagaa acccaaaaat ctcatcttgg gtgttttcag ggcttgtttt gagttttgct
     3121 gaatagggag cgcaagacgc cctgagcctc cctctcactg gtggtgataa gaggagccgt
     3181 ctggtgtgtc agggtcacga acccgttaca tttcaggacg atcctttttc cttcagcagc
     3241 atttcttact ggctgtggct ggaatctgcc ttttatcaca gctgtcacca ttctcacgtg
     3301 attcttgtga gactcttttt ggttataatt actatttaat atttagacta ttttactgag
     3361 cagactttat aaatgagata tctacaaggc acttaaagtg ttacagatgt tttaccttaa
     3421 gaattattta agttgtgttg ggttaagaca gttttcagtg taccgtaaat gttgtgtttt
     3481 cagaaaaaga caaaacgatg gtgctgactg gttttctgta tattgcacaa cagtcctcaa
     3541 atacactgat gtatgaaact attcatacat caagcagcat ttttttcact ctccttagaa
     3601 ttggaactat gcagttaagg cagataaaat gtacagatgt ttcatatatt acaggttaca
     3661 tatataaatc aaaatttcct atataaaact gatttgggat ttggggtgga aatattttga
     3721 atattaattt atttttaaag atgcaagata ggactttgtg caatgtattt ttgtaaatgc
     3781 ttttcaaaat atctgtcttt ggtagtgctt ctgctgctgc caccaaattg ataagatgct
     3841 attaagaggt ttaaataaag agttttaatt tttaaaaggg catgggatat aaacagtcta
     3901 tttcttttct ca
//
