LOCUS       NM_001130965            4010 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens Sad1 and UNC84 domain containing 1 (SUN1), transcript
            variant 1, mRNA.
ACCESSION   NM_001130965
VERSION     NM_001130965.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4010)
  AUTHORS   Fan,T., Zhu,J., Liu,W., Qu,R., Khan,A.U., Shi,Y., Liu,J., Zhou,Z.,
            Xu,C., Dai,J. and Ouyang,J.
  TITLE     SUN1 inhibits osteogenesis and promotes adipogenesis of human
            adipose-derived stem cells by regulating alpha-tubulin and CD36
            expression
  JOURNAL   J Cell Mol Med 28 (19), e70143 (2024)
   PUBMED   39383106
  REMARK    GeneRIF: SUN1 inhibits osteogenesis and promotes adipogenesis of
            human adipose-derived stem cells by regulating alpha-tubulin and
            CD36 expression.
REFERENCE   2  (bases 1 to 4010)
  AUTHORS   Gurusaran,M., Erlandsen,B.S. and Davies,O.R.
  TITLE     The crystal structure of SUN1-KASH6 reveals an asymmetric LINC
            complex architecture compatible with nuclear membrane insertion
  JOURNAL   Commun Biol 7 (1), 138 (2024)
   PUBMED   38291267
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4010)
  AUTHORS   Baskerville,V., Rapuri,S., Mehlhop,E. and Coyne,A.N.
  TITLE     SUN1 facilitates CHMP7 nuclear influx and injury cascades in
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Brain 147 (1), 109-121 (2024)
   PUBMED   37639327
  REMARK    GeneRIF: SUN1 facilitates CHMP7 nuclear influx and injury cascades
            in sporadic amyotrophic lateral sclerosis.
REFERENCE   4  (bases 1 to 4010)
  AUTHORS   Meng,Q., Shao,B., Zhao,D., Fu,X., Wang,J., Li,H., Zhou,Q. and
            Gao,T.
  TITLE     Loss of SUN1 function in spermatocytes disrupts the attachment of
            telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans
  JOURNAL   Hum Genet 142 (4), 531-541 (2023)
   PUBMED   36933034
  REMARK    GeneRIF: Loss of SUN1 function in spermatocytes disrupts the
            attachment of telomeres to the nuclear envelope and contributes to
            non-obstructive azoospermia in humans.
REFERENCE   5  (bases 1 to 4010)
  AUTHORS   Wu,H., Zhang,X., Hua,R., Li,Y., Cheng,L., Li,K., Liu,Y., Gao,Y.,
            Shen,Q., Wang,G., Lv,M., Xu,Y., He,X., Cao,Y. and Liu,M.
  TITLE     Homozygous missense mutation in CCDC155 disrupts the transmembrane
            distribution of CCDC155 and SUN1, resulting in non-obstructive
            azoospermia and premature ovarian insufficiency in humans
  JOURNAL   Hum Genet 141 (11), 1795-1809 (2022)
   PUBMED   35587281
  REMARK    GeneRIF: Homozygous missense mutation in CCDC155 disrupts the
            transmembrane distribution of CCDC155 and SUN1, resulting in
            non-obstructive azoospermia and premature ovarian insufficiency in
            humans.
REFERENCE   6  (bases 1 to 4010)
  AUTHORS   Crisp,M., Liu,Q., Roux,K., Rattner,J.B., Shanahan,C., Burke,B.,
            Stahl,P.D. and Hodzic,D.
  TITLE     Coupling of the nucleus and cytoplasm: role of the LINC complex
  JOURNAL   J Cell Biol 172 (1), 41-53 (2006)
   PUBMED   16380439
REFERENCE   7  (bases 1 to 4010)
  AUTHORS   Padmakumar,V.C., Libotte,T., Lu,W., Zaim,H., Abraham,S.,
            Noegel,A.A., Gotzmann,J., Foisner,R. and Karakesisoglou,I.
  TITLE     The inner nuclear membrane protein Sun1 mediates the anchorage of
            Nesprin-2 to the nuclear envelope
  JOURNAL   J Cell Sci 118 (Pt 15), 3419-3430 (2005)
   PUBMED   16079285
  REMARK    GeneRIF: The Sun1 itself does not require functional A-type lamins
            for its localisation at the inner nuclear membrane in mammalian
            cells.
REFERENCE   8  (bases 1 to 4010)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
  REMARK    GeneRIF: Isolation of a cDNA encoding a mouse homolog of the human
            SUN1 (UNC84A) gene.
REFERENCE   9  (bases 1 to 4010)
  AUTHORS   Dreger,M., Bengtsson,L., Schoneberg,T., Otto,H. and Hucho,F.
  TITLE     Nuclear envelope proteomics: novel integral membrane proteins of
            the inner nuclear membrane
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11943-11948 (2001)
   PUBMED   11593002
  REMARK    GeneRIF: KIAA0810 is a novel 100-kDa transmembrane protein with
            similarity to Caenorhabditis elegans Unc-84A and resides in the
            inner nuclear membrane. It is likely to interact with the nuclear
            lamina.
REFERENCE   10 (bases 1 to 4010)
  AUTHORS   Malone,C.J., Fixsen,W.D., Horvitz,H.R. and Han,M.
  TITLE     UNC-84 localizes to the nuclear envelope and is required for
            nuclear migration and anchoring during C. elegans development
  JOURNAL   Development 126 (14), 3171-3181 (1999)
   PUBMED   10375507
  REMARK    GeneRIF: Describes cloning and function of C. elegans unc-84 and
            cloning of human orthologs.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099731.5, AB018353.1,
            AK022816.1 and BM689998.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001130965.2.
            
            Summary: This gene is a member of the unc-84 homolog family and
            encodes a nuclear envelope protein with an Unc84 (SUN) domain. The
            protein is involved in nuclear anchorage and migration.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jan 2019].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            72, and 73 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142707.1, SRR1660809.107361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401592.6/ ENSP00000384015.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC099731.5         167787-167815
            30-400              AB018353.1         18-388
            401-570             AK022816.1         326-495
            571-707             AB018353.1         559-695
            708-3978            AB018353.1         777-4047
            3979-3996           BM689998.1         450-467
            3997-4010           AC099731.5         210232-210245
FEATURES             Location/Qualifiers
     source          1..4010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4010
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="Sad1 and UNC84 domain containing 1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
     exon            1..126
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2407
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="isoform a is encoded by transcript variant 1; Sad1
                     unc-84 domain protein 1; protein unc-84 homolog A; SUN
                     domain-containing protein 1; sad1/unc-84 protein-like 1"
                     /codon_start=1
                     /product="SUN domain-containing protein 1 isoform a"
                     /protein_id="NP_001124437.1"
                     /db_xref="CCDS:CCDS47525.1"
                     /db_xref="GeneID:23353"
                     /db_xref="HGNC:HGNC:18587"
                     /db_xref="MIM:607723"
                     /translation="MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDP
                     VFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAF
                     SINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKG
                     GNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQ
                     KCYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISW
                     LNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDD
                     PQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQK
                     LQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSE
                     AIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQER
                     VDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHV
                     SVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGS
                     ILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRL
                     SMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGES
                     LQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK"
     exon            127..315
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            316..500
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            501..527
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            528..707
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            708..806
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            807..900
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            901..959
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1102
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1312
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1399
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1443
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1573
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1828
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1913
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2029
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2197
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2290
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..4010
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: AATAAA"
     polyA_site      3978
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="major polyA site"
     regulatory      3986..3991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
                     /note="hexamer: TATAAA"
     polyA_site      4010
                     /gene="SUN1"
                     /gene_synonym="UNC84A"
ORIGIN      
        1 actctgcatt tctttcccgc cctctgcagt atggtttgaa gtggtgaaca tggatttttc
       61 tcggcttcac atgtacagtc ctccccagtg tgtgccggag aacacgggct acacgtatgc
      121 gctcagttcc agctattctt cagatgctct ggattttgag acggagcaca aattggaccc
      181 tgtatttgat tctccacgga tgtcccgccg tagtttgcgc ctggccacga cagcatgcac
      241 cctgggggat ggtgaggctg tgggtgccga cagcggcacc agcagcgctg tctccctgaa
      301 gaaccgagcg gccagaacaa caaaacagcg cagaagcaca aacaaatcag cttttagtat
      361 caaccacgtg tcaaggcagg tcacgtcctc tggcgtcagc cacggcggca ctgtcagcct
      421 gcaggatgct gtgactcgac ggcctcctgt attggacgag tcttggattc gtgaacagac
      481 cacagtggac cacttctggg gtcttgatga tgatggtgat cttaaaggtg gaaataaagc
      541 tgccattcag ggaaacgggg atgtgggagc cgccgccgcc accgcgcaca acggcttctc
      601 ctgcagcaac tgcagcatgc tgtccgagcg caaggacgtg ctcacggcgc accccgcggc
      661 ccccgggccc gtgtcgagag tttattctag ggacaggaat caaaaatgtt acttcttgct
      721 gcagattctg cgcaggatcg gagctgtggg ccaggctgtg tccaggacgg cgtggtcggc
      781 cctttggctg gccgtggttg ctccagggaa ggcagcctct ggagtgttct ggtggctggg
      841 gattggatgg taccagtttg ttactttgat ttcttggctg aatgtgtttc ttcttaccag
      901 gtgccttcga aacatctgca agtttttagt cttgctcatc ccactcttcc ttttactagc
      961 aggtctctcc ttacggggcc agggcaattt cttttcgttc ttgcccgtgt tgaactgggc
     1021 aagcatgcat agaacacagc gggtggatga cccccaggac gtgtttaaac ccacgacttc
     1081 tcgcctgaag cagcctctgc agggtgacag tgaggctttt ccgtggcatt ggatgagtgg
     1141 cgtggagcag caggtggcct ctctgtctgg acagtgccac caccatggtg agaatctccg
     1201 agagctgacc actttgctac agaagctgca ggctcgggtg gaccagatgg aaggcggcgc
     1261 tgccgggccg tcagcttcgg tcagagacgc tgtgggacag cccccgaggg agactgactt
     1321 tatggccttt caccaagaac atgaagtgcg tatgtcacac ttggaagata ttctgggaaa
     1381 actgagagaa aaatctgagg ccatccagaa ggaactagaa cagaccaagc aaaaaacaat
     1441 cagtgcggtt ggtgagcagc tcctgcccac agtcgagcac ctccagctgg agctggatca
     1501 gctaaagtca gagctgtcca gctggcgaca cgtgaagacc ggctgtgaga cagtggatgc
     1561 cgtacaagaa agagtggacg tgcaagtcag agaaatggtg aaactcctgt tttccgaaga
     1621 tcagcaaggc ggttctctgg aacagctgct gcagaggttc tcatcacagt ttgtgagcaa
     1681 aggcgacttg cagacgatgc tgcgagacct gcagctgcag atcctgcgga acgtcaccca
     1741 ccacgtttcc gtgaccaagc agctcccaac ctcagaagcc gtggtgtctg ctgtgagcga
     1801 ggcgggggcg tctggaataa cagaggcgca agcacgtgcc atcgtgaaca gcgccttgaa
     1861 gctgtattcc caagataaga ccgggatggt ggactttgct ctggaatctg gtggtggcag
     1921 catcttgagt actcgctgtt ctgaaactta cgaaaccaaa acggcgctga tgagtctgtt
     1981 tgggatcccg ctgtggtact tctcgcagtc cccgcgcgtg gtcatccagc ctgacattta
     2041 ccccggtaac tgctgggcat ttaaaggctc ccaggggtac ctggtggtga ggctctccat
     2101 gatgatccac ccagccgcct tcactctgga gcacatccct aagacgctgt cgccaacagg
     2161 caacatcagc agcgccccca aggacttcgc cgtctatgga ttagaaaatg agtatcagga
     2221 agaagggcag cttctgggac agttcacgta tgatcaggat ggggagtcgc tccagatgtt
     2281 ccaggccctg aaaagacccg acgacacagc tttccaaata gtggaacttc ggattttttc
     2341 taactggggc catcctgagt atacctgtct gtatcggttc agagttcatg gcgaacctgt
     2401 caagtgaaga cactactcat tatttttgta catttttgta tatactggga cagcgtgaaa
     2461 cactggaatc cttcatggac gagggcatat acaatgatgg gacagtgcca cactccttca
     2521 ataaacgtgg ctgctggcca gaggacgtga gcgtgtgacg ggcgccttgg cgccacctgt
     2581 tgggtgctca ctgcctctgc aggtgcagag gggtcagcag caggagaagc gtgttgaaca
     2641 cgtggctctc agacactcct tgtttttaac gggaagctct ttgcatttgc atttcctcaa
     2701 caaaggagca aagcagagga agctgagagt ctggcgtgtt cttgacgctt tggtcttcag
     2761 ccttgcactg gctcttctaa aggacttttg gagggcagat aatttcatct gttaaatcca
     2821 acacacattt ctttcaggga aaaacaatgt caccaaattt tcagagttct aaactccttt
     2881 ccttcaagcc ggaattttcc ttttttcagc accagtaggt actaagtctc cagatgggga
     2941 aataactaaa atgtgttttt ctgctttgtt cgctcttact tctgaggaag gtttccagtc
     3001 aggactcgct gtaccaatat ccatggagga atatgggagc gtttcgctct ccttgtaggc
     3061 tgaagtcagt ctgacttgaa ggggcctggt ttggatctaa gcaaacaccc agatggggtt
     3121 ctctggtctc agcaaggctt ttcctgttgg gagtcacagt aaacagaaac ccaaaaatct
     3181 catcttgggt gttttcaggg cttgttttga gttttgctga atagggagcg caagacgccc
     3241 tgagcctccc tctcactggt ggtgataaga ggagccgtct ggtgtgtcag ggtcacgaac
     3301 ccgttacatt tcaggacgat cctttttcct tcagcagcat ttcttactgg ctgtggctgg
     3361 aatctgcctt ttatcacagc tgtcaccatt ctcacgtgat tcttgtgaga ctctttttgg
     3421 ttataattac tatttaatat ttagactatt ttactgagca gactttataa atgagatatc
     3481 tacaaggcac ttaaagtgtt acagatgttt taccttaaga attatttaag ttgtgttggg
     3541 ttaagacagt tttcagtgta ccgtaaatgt tgtgttttca gaaaaagaca aaacgatggt
     3601 gctgactggt tttctgtata ttgcacaaca gtcctcaaat acactgatgt atgaaactat
     3661 tcatacatca agcagcattt ttttcactct ccttagaatt ggaactatgc agttaaggca
     3721 gataaaatgt acagatgttt catatattac aggttacata tataaatcaa aatttcctat
     3781 ataaaactga tttgggattt ggggtggaaa tattttgaat attaatttat ttttaaagat
     3841 gcaagatagg actttgtgca atgtattttt gtaaatgctt ttcaaaatat ctgtctttgg
     3901 tagtgcttct gctgctgcca ccaaattgat aagatgctat taagaggttt aaataaagag
     3961 ttttaatttt taaaagggca tgggatataa acagtctatt tcttttctca
//
