LOCUS       NM_001002255            1017 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.
ACCESSION   NM_001002255
VERSION     NM_001002255.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Li,H., Ning,M., Li,Q., Wang,T., Li,W., Xiao,J., Wang,L., Wang,K.,
            Zou,R., Hao,F., Yu,M., Shi,Y., Lei,C., Wang,Z., Yang,Z., Xu,H. and
            Gong,B.
  TITLE     The association of five polymorphisms with diabetic retinopathy in
            a Chinese population
  JOURNAL   Ophthalmic Genet 44 (4), 346-351 (2023)
   PUBMED   37066695
  REMARK    GeneRIF: The association of five polymorphisms with diabetic
            retinopathy in a Chinese population.
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Osmanovic,A., Forster,A., Widjaja,M., Auber,B., Das,A.M.,
            Christians,A., Brand,F., Petri,S. and Weber,R.G.
  TITLE     A SUMO4 initiator codon variant in amyotrophic lateral sclerosis
            reduces SUMO4 expression and alters stress granule dynamics
  JOURNAL   J Neurol 269 (9), 4863-4871 (2022)
   PUBMED   35503374
  REMARK    GeneRIF: A SUMO4 initiator codon variant in amyotrophic lateral
            sclerosis reduces SUMO4 expression and alters stress granule
            dynamics.
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Kucukali,C.I., Salman,B., Yuceer,H., Ulusoy,C., Abaci,N.,
            Ekmekci,S.S., Tuzun,E., Bilgic,B. and Hanagasi,H.A.
  TITLE     Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene
            polymorphisms in Parkinson's disease
  JOURNAL   Neurol Res 42 (6), 451-457 (2020)
   PUBMED   32237992
  REMARK    GeneRIF: Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene
            polymorphisms in Parkinson's disease.
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Zhang,T., Liu,Y., Zeng,R., Ling,Q., Wen,P., Fan,J. and Peng,Z.
  TITLE     Association of donor small ubiquitin-like modifier 4 rs237025
            genetic variant with tacrolimus elimination in the early period
            after liver transplantation
  JOURNAL   Liver Int 38 (4), 724-732 (2018)
   PUBMED   28941036
  REMARK    GeneRIF: Donor SUMO4 rs237025 genetic variant was associated with
            higher tacrolimus C/D ratios in the early period after liver
            transplantation, which might be related to the down-regulation of
            CYP3A5 enzyme through the NF-kB signalling pathway.
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Zhang,T., Liu,Y., Hu,Y., Zhang,X., Zhong,L., Fan,J. and Peng,Z.
  TITLE     Association of donor and recipient SUMO4 rs237025 genetic variant
            with new-onset diabetes mellitus after liver transplantation in a
            Chinese population
  JOURNAL   Gene 627, 428-433 (2017)
   PUBMED   28689037
  REMARK    GeneRIF: Both donor and recipient SUMO4 rs237025 polymorphisms
            contribute to the development of new-onset diabetes mellitus after
            liver transplantation.
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Bohren,K.M., Nadkarni,V., Song,J.H., Gabbay,K.H. and Owerbach,D.
  TITLE     A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially
            activates heat shock transcription factors and is associated with
            susceptibility to type I diabetes mellitus
  JOURNAL   J Biol Chem 279 (26), 27233-27238 (2004)
   PUBMED   15123604
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Zhoucun,A., Zhang,S. and Xiao,C.
  TITLE     Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and
            IDDM8 with IDDM in Chengdu population
  JOURNAL   Chin Med Sci J 16 (2), 120-122 (2001)
   PUBMED   12901503
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Luo,D.F., Buzzetti,R., Rotter,J.I., Maclaren,N.K., Raffel,L.J.,
            Nistico,L., Giovannini,C., Pozzilli,P., Thomson,G. and She,J.X.
  TITLE     Confirmation of three susceptibility genes to insulin-dependent
            diabetes mellitus: IDDM4, IDDM5 and IDDM8
  JOURNAL   Hum Mol Genet 5 (5), 693-698 (1996)
   PUBMED   8733139
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Davies,J.L., Kawaguchi,Y., Bennett,S.T., Copeman,J.B.,
            Cordell,H.J., Pritchard,L.E., Reed,P.W., Gough,S.C., Jenkins,S.C.,
            Palmer,S.M. et al.
  TITLE     A genome-wide search for human type 1 diabetes susceptibility genes
  JOURNAL   Nature 371 (6493), 130-136 (1994)
   PUBMED   8072542
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031133.1 and AY340238.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001002255.1.
            
            Summary: This gene is a member of the SUMO gene family. This family
            of genes encode small ubiquitin-related modifiers that are attached
            to proteins and control the target proteins' subcellular
            localization, stability, or activity. The protein described in this
            record is located in the cytoplasm and specifically modifies IKBA,
            leading to negative regulation of NF-kappa-B-dependent
            transcription of the IL12B gene. A specific polymorphism in this
            SUMO gene, which leads to the M55V substitution, has been
            associated with type I diabetes. The RefSeq contains this
            polymorphism. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.1902974.1,
                                        SRR7346977.815715.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326669.6/ ENSP00000318635.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL031133.1         94427-94523         c
            98-785              AY340238.1         1-688
            786-1017            AL031133.1         93507-93738         c
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1017
                     /gene="SUMO4"
                     /gene_synonym="dJ281H8.4; IDDM5; SMT3H4; SUMO-4"
                     /note="small ubiquitin like modifier 4"
                     /db_xref="GeneID:387082"
                     /db_xref="HGNC:HGNC:21181"
                     /db_xref="MIM:608829"
     exon            1..1017
                     /gene="SUMO4"
                     /gene_synonym="dJ281H8.4; IDDM5; SMT3H4; SUMO-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..418
                     /gene="SUMO4"
                     /gene_synonym="dJ281H8.4; IDDM5; SMT3H4; SUMO-4"
                     /note="small ubiquitin-like modifier 4 protein; SMT3
                     suppressor of mif two 3 homolog 2; SMT3 suppressor of mif
                     two 3 homolog 4; insulin-dependent diabetes mellitus 5"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 4"
                     /protein_id="NP_001002255.1"
                     /db_xref="CCDS:CCDS34549.1"
                     /db_xref="GeneID:387082"
                     /db_xref="HGNC:HGNC:21181"
                     /db_xref="MIM:608829"
                     /translation="MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLM
                     KAYCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY"
ORIGIN      
        1 tgtgcacgca ccctctccct catccaccgc tgtcacctcc tgctgctctt cctgctgctc
       61 gtgtactcgt taggtgcgga cccgccacct cttttgtgaa gcagcagctg aggagactcc
      121 ggtgttcacc atggccaacg aaaagcccac agaagaagtc aagactgaga acaacaatca
      181 tattaatttg aaggtggcgg gacaggatgg ttctgtggtg cagtttaaga ttaagaggca
      241 gacaccactt agtaaactaa tgaaagccta ttgtgaacca cggggattgt cagtgaagca
      301 gatcagattc cgatttggtg ggcaaccaat cagtggaaca gacaaacctg cacagttgga
      361 aatggaagat gaagatacaa ttgatgtgtt tcaacagcct acgggaggtg tctactgaaa
      421 agggaacctg cttctttact ccagaacgct gttctttaaa gaccaagatt actgcattct
      481 caattagaaa actgcaattt ggttccacca cattctgact actacagtat agttttctct
      541 attcttttgt ttcccccttc cacattcttt tattatacat gaagtaactg gtatgtgtac
      601 acaagcatat tgcttttttc ttcaaaccaa acagccaatg gtatgttttg attgacatca
      661 agtggagaca ggatgggaaa aaatactgat tctgtgaaaa tacccccttt atccattagt
      721 ggcatgttca ttcaggtctt atctttatat tctagtaagt tattttgctc tcactgtttt
      781 aacaacaaca aaaaaaaatt ctcacatacc ttgttcaatt ggaggatttt catgtttttc
      841 atttatcatt gtaaaaccaa ggacaatttt ataacttttg tgtacatagc tgttacatgt
      901 agggcaatct gtctttaagt agggataaat tactctaaaa aaaaaagaaa gaatcctaga
      961 aagtttttcc ttcaagtcag gcttcttatt taaataaact ttttgtttaa aatgaaa
//
