LOCUS       NM_006937               3166 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens small ubiquitin like modifier 2 (SUMO2), transcript
            variant 1, mRNA.
ACCESSION   NM_006937
VERSION     NM_006937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3166)
  AUTHORS   Kaur,A., Singh,H., Kumar,D., Gahlay,G.K. and Mithu,V.S.
  TITLE     Characterizing the Conformational Dynamics of Human SUMO2: Insights
            into its Interaction with Metal Ions and SIMs
  JOURNAL   Chembiochem 25 (11), e202400045 (2024)
   PUBMED   38593270
  REMARK    GeneRIF: Characterizing the Conformational Dynamics of Human SUMO2:
            Insights into its Interaction with Metal Ions and SIMs.
REFERENCE   2  (bases 1 to 3166)
  AUTHORS   Feng,D., He,J., Yuan,M., Chen,Q., Zeng,X., Zhou,Q., Wu,J. and
            Han,B.
  TITLE     SUMO2/3 promotes the progression and oxaliplatin resistance of
            colorectal cancer through facilitating the SUMOylation at Ku80-K307
  JOURNAL   Biofactors 49 (6), 1158-1173 (2023)
   PUBMED   37338025
  REMARK    GeneRIF: SUMO2/3 promotes the progression and oxaliplatin
            resistance of colorectal cancer through facilitating the
            SUMOylation at Ku80-K307.
REFERENCE   3  (bases 1 to 3166)
  AUTHORS   Hu,Y., Chen,C., Tong,X., Chen,S., Hu,X., Pan,B., Sun,X., Chen,Z.,
            Shi,X., Hu,Y., Shen,X., Xue,X. and Lu,M.
  TITLE     NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and
            regulates mRNA m5C methylation
  JOURNAL   Cell Death Dis 12 (9), 842 (2021)
   PUBMED   34504059
  REMARK    GeneRIF: NSUN2 modified by SUMO-2/3 promotes gastric cancer
            progression and regulates mRNA m5C methylation.
            Erratum:[Cell Death Dis. 2024 Jul 11;15(7):495. doi:
            10.1038/s41419-024-06859-4.. PMID: 38991998]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3166)
  AUTHORS   Bouchard,D., Wang,W., Yang,W.C., He,S., Garcia,A. and Matunis,M.J.
  TITLE     SUMO paralogue-specific functions revealed through systematic
            analysis of human knockout cell lines and gene expression data
  JOURNAL   Mol Biol Cell 32 (19), 1849-1866 (2021)
   PUBMED   34232706
  REMARK    GeneRIF: SUMO paralogue-specific functions revealed through
            systematic analysis of human knockout cell lines and gene
            expression data.
REFERENCE   5  (bases 1 to 3166)
  AUTHORS   Mo,Y., Wang,Y., Zhang,S., Xiong,F., Yan,Q., Jiang,X., Deng,X.,
            Wang,Y., Fan,C., Tang,L., Zhang,S., Gong,Z., Wang,F., Liao,Q.,
            Guo,C., Li,Y., Li,X., Li,G., Zeng,Z. and Xiong,W.
  TITLE     Circular RNA circRNF13 inhibits proliferation and metastasis of
            nasopharyngeal carcinoma via SUMO2
  JOURNAL   Mol Cancer 20 (1), 112 (2021)
   PUBMED   34465340
  REMARK    GeneRIF: Circular RNA circRNF13 inhibits proliferation and
            metastasis of nasopharyngeal carcinoma via SUMO2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3166)
  AUTHORS   Saitoh,H. and Hinchey,J.
  TITLE     Functional heterogeneity of small ubiquitin-related protein
            modifiers SUMO-1 versus SUMO-2/3
  JOURNAL   J Biol Chem 275 (9), 6252-6258 (2000)
   PUBMED   10692421
REFERENCE   7  (bases 1 to 3166)
  AUTHORS   Kamitani,T., Kito,K., Nguyen,H.P., Fukuda-Kamitani,T. and Yeh,E.T.
  TITLE     Characterization of a second member of the sentrin family of
            ubiquitin-like proteins
  JOURNAL   J Biol Chem 273 (18), 11349-11353 (1998)
   PUBMED   9556629
REFERENCE   8  (bases 1 to 3166)
  AUTHORS   Kamitani,T., Nguyen,H.P., Kito,K., Fukuda-Kamitani,T. and Yeh,E.T.
  TITLE     Covalent modification of PML by the sentrin family of
            ubiquitin-like proteins
  JOURNAL   J Biol Chem 273 (6), 3117-3120 (1998)
   PUBMED   9452416
REFERENCE   9  (bases 1 to 3166)
  AUTHORS   Lapenta,V., Chiurazzi,P., van der Spek,P., Pizzuti,A., Hanaoka,F.
            and Brahe,C.
  TITLE     SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to
            chromosome 21qter and defines a novel gene family
  JOURNAL   Genomics 40 (2), 362-366 (1997)
   PUBMED   9119407
REFERENCE   10 (bases 1 to 3166)
  AUTHORS   Mannen,H., Tseng,H.M., Cho,C.L. and Li,S.S.
  TITLE     Cloning and expression of human homolog HSMT3 to yeast SMT3
            suppressor of MIF2 mutations in a centromere protein gene
  JOURNAL   Biochem Biophys Res Commun 222 (1), 178-180 (1996)
   PUBMED   8630065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008450.1, AK024823.1 and
            AC022211.5.
            
            On Nov 22, 2018 this sequence version replaced NM_006937.3.
            
            Summary: This gene encodes a protein that is a member of the SUMO
            (small ubiquitin-like modifier) protein family. It functions in a
            manner similar to ubiquitin in that it is bound to target proteins
            as part of a post-translational modification system. However,
            unlike ubiquitin which targets proteins for degradation, this
            protein is involved in a variety of cellular processes, such as
            nuclear transport, transcriptional regulation, apoptosis, and
            protein stability. It is not active until the last two amino acids
            of the carboxy-terminus have been cleaved off. Numerous pseudogenes
            have been reported for this gene. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.564202.1,
                                           SRR1660803.197095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420826.7/ ENSP00000405965.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               BC008450.1         12-180
            170-173             AK024823.1         115-118
            174-1022            BC008450.1         185-1033
            1023-3166           AC022211.5         55247-57390         c
FEATURES             Location/Qualifiers
     source          1..3166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3166
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="small ubiquitin like modifier 2"
                     /db_xref="GeneID:6613"
                     /db_xref="HGNC:HGNC:11125"
                     /db_xref="MIM:603042"
     exon            1..146
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..413
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; sentrin 2; SMT3 suppressor of mif two 3 homolog
                     2; SMT3 homolog 2; ubiquitin-like protein SMT3B;
                     ubiquitin-like protein SMT3A"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 2 isoform a
                     precursor"
                     /protein_id="NP_008868.3"
                     /db_xref="CCDS:CCDS45774.1"
                     /db_xref="GeneID:6613"
                     /db_xref="HGNC:HGNC:11125"
                     /db_xref="MIM:603042"
                     /translation="MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLM
                     KAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY"
     exon            147..278
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..350
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..3166
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      570..575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="hexamer: CATAAA"
     polyA_site      596
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="hexamer: AATAAA"
     polyA_site      1022
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="major polyA site"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="hexamer: AATAAA"
     polyA_site      1442
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
     regulatory      3145..3150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
                     /note="hexamer: AATATA"
     polyA_site      3166
                     /gene="SUMO2"
                     /gene_synonym="HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3"
ORIGIN      
        1 ctctcccctc gtccaccgct gccgcctcct tcttctgccg ctcctggtgc tgcttgtgtg
       61 ctcgtttggt gcggacctgg tacctctttt gtgaagcggc agctgaggag actccggcgc
      121 tcgccatggc cgacgaaaag cccaaggaag gagtcaagac tgagaacaac gatcatatta
      181 atttgaaggt ggcggggcag gatggttctg tggtgcagtt taagattaag aggcatacac
      241 cacttagtaa actaatgaaa gcctattgtg aacgacaggg attgtcaatg aggcagatca
      301 gattccgatt tgacgggcaa ccaatcaatg aaacagacac acctgcacag ttggaaatgg
      361 aggatgaaga tacaattgat gtgttccaac agcagacggg aggtgtctac tgaaaaggga
      421 acctgcttct ttactccaga actctgttct ttaaagacca agattacatt ctcaattaga
      481 aaactgcaat ttggttccac cacatcctga ctactaccgt atagttttct ctattctttc
      541 atttccccct tccccattcc tttattgtac ataaagtaac tggtatatgt gcacaagcat
      601 attgcatttt tttttttttt aactaaacag ccaatggtat gttttgattg acatcaagtg
      661 gagacgggat ggggaaaaat actgattctg tgaaaatacc ccctttctcc attagtggca
      721 tgctcattca gctcttatct ttatattcca gtaagttatt ttgctctcac tgttttaaca
      781 aaaaaaaaaa acaacaacat aaaaatcctt gcataccttg ttcaattgga gaattttaat
      841 gtttttcatt tatcattgta aaaccaagga caattttata acttttttgt acgtagctgt
      901 tacatgtagg gcaatctgtc tttaagtagg gataaattac tctaaaacaa aaaagaatcc
      961 tagatagttt tcccttcaag tcaagcgtct tgttgtttaa ataaacttct tgtttaaaat
     1021 gagctgtttt ctttattctg agaaatatta aatagaaaat tgaggcttag aaaaaacata
     1081 aataggcctg cttagaagta acatttcaag aaggaaataa agctacttgg tgtttctgac
     1141 agactgatac tgatgccaaa caaagaataa cagttttata aatatcacct tgttccaaaa
     1201 gtttctctag gtcccatgtt aatatgcaag tatactagca gaaaaattgg gccatagtat
     1261 cgtggatttc caggtatttt ctgtatatta agtgaggcac ggagcatagg gtatagggta
     1321 gcacatgtgg caaggaaaaa gttctgattt tgcctttgtt gctgataaaa cactgaacca
     1381 ttctagcctg cacttatcat aagtaaatac tccctaacct aaaataaagt tttcgttcct
     1441 tattcaagga tttttttttt gagacggagt tttcctcttg ttgcccaggc tggagtgtag
     1501 tggtgcaatt tcagctcact gcaacctcag cctcctgagt agctgggggg tcataggtgc
     1561 atgccaccac gcccagctaa ttttttttct atttttagtc gagacagggt tttatcacgt
     1621 atgccaggct ggtctcgaac tcctgacctt aggtgatcca cccgcctcag cctcccaaag
     1681 tgcagggatt acggcatgag ccaccacgcc tggcctattc aagaatattg agggacagaa
     1741 aatatctata tatatccatc ctcagaacct taaatataca ggtcactaca gtctttatta
     1801 ttttaatttt tgtttcttag ggtttctttt ggtggtggtt ttttgagatg gagcatcatt
     1861 ccgtctccca ggctgtagtg cagtggcaca atcttggctc actgcaagct ccgcctcccg
     1921 ggttcacgcc attctcctgc ctcagcctcc cgtcttaggt ctttttgaaa gaggttatgc
     1981 ctctgttgcc tagtctggag tggtgcaatg gtgtgatctt ggctcactgc aacctccacc
     2041 tccaggtctt aagagatcct ccctgctcag cctcgtgagt agctagaacc gcaggtgcat
     2101 gccaccacag ctaattcttg tattttttat agagagtgtt tcgccatatt gtccaggccg
     2161 ggctcaaacc cctgatctta agtgatctat ctgccttagc ctcccaatgt gctgggttta
     2221 caggcgtgag ccactatgcc cagccccttt ttaatttttt aaaaatgttt atttttgaga
     2281 tggagtttcg ctcttgttgc cccaactgga gaccaatgac atgatctcag ctcactgcaa
     2341 cctccgcctc ccgggttcaa ctgattctcc tccctcagcc tccggaaaag ctgggattac
     2401 aagcatctac catcatacct ggctaattct gtatttttag tagagaaggg gtttctctat
     2461 gttggtcagg ctggtctcca cctcccgacc tcaggtgatc tgcctgcctt ggcctcccaa
     2521 agtgctgaga ttacaggctt gagccactgt gcccggccaa atttttatta tttttaaatt
     2581 agaggtgggg tctcaccatg ttgaccagtt tggtctcgaa cttctggcct cagtcccttg
     2641 tcttggcctc ccaaagtgtt ggggtttcag gtgttagacc ccatgcccaa ccactacagt
     2701 ttttgttttt gtttttgttt ttttttcaga cggagtcttg ctctgtcgcc caggctggag
     2761 tgcagtggcg caatcttggc tcacggcaag ctccacctcc cgggttcacg ccattctcct
     2821 gcctcagcct ccccagtagc tgggactaaa ggtgcccgcc accatgcccg gctaattttt
     2881 ttgtattttt agtagagaca gggcttcacc atgttagcca ggctggtctc aaactcctga
     2941 cctcagttca tccacccgcc ttggccttcc aaagtgctgg gattacaggc atgatccact
     3001 gcgcccggcc tcactgccat tttatagatg agaaagccaa gttccagaaa agttgtgaaa
     3061 tagacggtga ctataaaact gggactagag atagtatcct aatgcttgtt gattgttttt
     3121 gtccatactg attgtcaacc taccaatata atctaccatc aagtca
//
