LOCUS       NM_003352               1523 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens small ubiquitin like modifier 1 (SUMO1), transcript
            variant 1, mRNA.
ACCESSION   NM_003352
VERSION     NM_003352.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Chen,W., Xu,Z., Jiang,J., Chen,L., Chen,Y., Yu,T., Chen,H. and
            Shi,R.
  TITLE     LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding
            to SENP1 to promote intestinal fibrosis in Crohn's disease
  JOURNAL   Int J Biol Macromol 262 (Pt 1), 129921 (2024)
   PUBMED   38309408
REFERENCE   2  (bases 1 to 1523)
  AUTHORS   Xu,X., Mao,Y., Feng,Z., Dai,F., Gu,T. and Zheng,J.
  TITLE     SENP1 inhibits ferroptosis and promotes head and neck squamous cell
            carcinoma by regulating ACSL4 protein stability via SUMO1
  JOURNAL   Oncol Rep 51 (2) (2024)
   PUBMED   38186303
  REMARK    GeneRIF: SENP1 inhibits ferroptosis and promotes head and neck
            squamous cell carcinoma by regulating ACSL4 protein stability via
            SUMO1.
REFERENCE   3  (bases 1 to 1523)
  AUTHORS   Jiang,C., Zhang,C., Dai,M., Wang,F., Xu,S., Han,D., Wang,Y.,
            Cao,Y., Liang,Y., Zhang,Z., Yan,L., Shen,Y., He,K., Shen,Y. and
            Liu,J.
  TITLE     Interplay between SUMO1-related SUMOylation and phosphorylation of
            p65 promotes hepatocellular carcinoma progression
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119595 (2024)
   PUBMED   37730133
  REMARK    GeneRIF: Interplay between SUMO1-related SUMOylation and
            phosphorylation of p65 promotes hepatocellular carcinoma
            progression.
REFERENCE   4  (bases 1 to 1523)
  AUTHORS   Wang,Y., Wang,J.M., Xiao,Y., Hu,X.B., Zheng,S.Y., Fu,J.L.,
            Zhang,L., Gan,Y.W., Liang,X.M. and Li,D.W.
  TITLE     SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells
  JOURNAL   Aging (Albany NY) 15 (17), 8812-8832 (2023)
   PUBMED   37683133
  REMARK    GeneRIF: SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells.
REFERENCE   5  (bases 1 to 1523)
  AUTHORS   Li Puma,D.D., Colussi,C., Bandiera,B., Puliatti,G., Rinaudo,M.,
            Cocco,S., Paciello,F., Re,A., Ripoli,C., De Chiara,G., Bertozzi,A.,
            Palamara,A.T., Piacentini,R. and Grassi,C.
  TITLE     Interleukin 1beta triggers synaptic and memory deficits in Herpes
            simplex virus type-1-infected mice by downregulating the expression
            of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4
            complex
  JOURNAL   Cell Mol Life Sci 80 (6), 172 (2023)
   PUBMED   37261502
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1523)
  AUTHORS   Matunis,M.J., Coutavas,E. and Blobel,G.
  TITLE     A novel ubiquitin-like modification modulates the partitioning of
            the Ran-GTPase-activating protein RanGAP1 between the cytosol and
            the nuclear pore complex
  JOURNAL   J Cell Biol 135 (6 Pt 1), 1457-1470 (1996)
   PUBMED   8978815
REFERENCE   7  (bases 1 to 1523)
  AUTHORS   Okura,T., Gong,L., Kamitani,T., Wada,T., Okura,I., Wei,C.F.,
            Chang,H.M. and Yeh,E.T.
  TITLE     Protection against Fas/APO-1- and tumor necrosis factor-mediated
            cell death by a novel protein, sentrin
  JOURNAL   J Immunol 157 (10), 4277-4281 (1996)
   PUBMED   8906799
REFERENCE   8  (bases 1 to 1523)
  AUTHORS   Shen,Z., Pardington-Purtymun,P.E., Comeaux,J.C., Moyzis,R.K. and
            Chen,D.J.
  TITLE     Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in
            a yeast two-hybrid system
  JOURNAL   Genomics 37 (2), 183-186 (1996)
   PUBMED   8921390
REFERENCE   9  (bases 1 to 1523)
  AUTHORS   Boddy,M.N., Howe,K., Etkin,L.D., Solomon,E. and Freemont,P.S.
  TITLE     PIC 1, a novel ubiquitin-like protein which interacts with the PML
            component of a multiprotein complex that is disrupted in acute
            promyelocytic leukaemia
  JOURNAL   Oncogene 13 (5), 971-982 (1996)
   PUBMED   8806687
REFERENCE   10 (bases 1 to 1523)
  AUTHORS   Shen,Z., Pardington-Purtymun,P.E., Comeaux,J.C., Moyzis,R.K. and
            Chen,D.J.
  TITLE     UBL1, a human ubiquitin-like protein associating with human
            RAD51/RAD52 proteins
  JOURNAL   Genomics 36 (2), 271-279 (1996)
   PUBMED   8812453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079354.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 3, 2020 this sequence version replaced NM_003352.7.
            
            Summary: This gene encodes a protein that is a member of the SUMO
            (small ubiquitin-like modifier) protein family. It functions in a
            manner similar to ubiquitin in that it is bound to target proteins
            as part of a post-translational modification system. However,
            unlike ubiquitin which targets proteins for degradation, this
            protein is involved in a variety of cellular processes, such as
            nuclear transport, transcriptional regulation, apoptosis, and
            protein stability. It is not active until the last four amino acids
            of the carboxy-terminus have been cleaved off. Several pseudogenes
            have been reported for this gene. Alternate transcriptional splice
            variants encoding different isoforms have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1962506.1,
                                           SRR14038195.1379444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392246.7/ ENSP00000376077.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC079354.4         137728-137885       c
            159-233             AC079354.4         119320-119394       c
            234-311             AC079354.4         113645-113722       c
            312-383             AC079354.4         110023-110094       c
            384-1523            AC079354.4         105470-106609       c
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..1523
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /note="small ubiquitin like modifier 1"
                     /db_xref="GeneID:7341"
                     /db_xref="HGNC:HGNC:12502"
                     /db_xref="MIM:601912"
     exon            1..158
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..452
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; GAP modifying protein 1; sentrin; SMT3
                     suppressor of mif two 3 homolog 1; SMT3 homolog 3;
                     ubiquitin-like protein UBL1; ubiquitin-like protein SMT3C;
                     ubiquitin-homology domain protein PIC1"
                     /codon_start=1
                     /product="small ubiquitin-related modifier 1 isoform a
                     precursor"
                     /protein_id="NP_003343.1"
                     /db_xref="CCDS:CCDS2352.1"
                     /db_xref="GeneID:7341"
                     /db_xref="HGNC:HGNC:12502"
                     /db_xref="MIM:601912"
                     /translation="MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHL
                     KKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV"
     exon            159..233
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..311
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..383
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..1523
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /note="hexamer: AATAAA"
     polyA_site      1523
                     /gene="SUMO1"
                     /gene_synonym="DAP1; GMP1; OFC10; PIC1; SENP2; SMT3;
                     SMT3C; SMT3H3; UBL1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgacg cgaggcgtag cggaagttac tgcagccgcg gtgttgtgct gtggggaagg
       61 gagaaggatt tgtaaacccc ggagcgaggt tctgcttacc cgaggccgct gctgtgcgga
      121 gacccccggg tgaagccacc gtcatcatgt ctgaccagga ggcaaaacct tcaactgagg
      181 acttggggga taagaaggaa ggtgaatata ttaaactcaa agtcattgga caggatagca
      241 gtgagattca cttcaaagtg aaaatgacaa cacatctcaa gaaactcaaa gaatcatact
      301 gtcaaagaca gggtgttcca atgaattcac tcaggtttct ctttgagggt cagagaattg
      361 ctgataatca tactccaaaa gaactgggaa tggaggaaga agatgtgatt gaagtttatc
      421 aggaacaaac ggggggtcat tcaacagttt agatattctt tttatttttt ttcttttccc
      481 tcaatccttt tttattttta aaaatagttc ttttgtaatg tggtgttcaa aacggaattg
      541 aaaactggca ccccatctct ttgaaacatc tggtaatttg aattctagtg ctcattattc
      601 attattgttt gttttcattg tgctgatttt tggtgatcaa gcctcagtcc ccttcatatt
      661 accctctcct ttttaaaaat tacgtgtgca cagagaggtc acctttttca ggacattgca
      721 ttttcaggct tgtggtgata aataagatcg accaatgcaa gtgttcataa tgactttcca
      781 attggccctg atgttctagc atgtgattac ttcactcctg gactgtgact ttcagtggga
      841 gatggaagtt tttcagagaa ctgaactgtg gaaaaatgac ctttccttaa cttgaagcta
      901 cttttaaaat ttgagggtct ggaccaaaag aagaggaata tcaggttgaa gtcaagatga
      961 cagataaggt gagagtaatg actaactcca aagatggctt cactgaagaa aaggcatttt
     1021 aagatttttt aaaaatcttg tcagaagatc ccagaaaagt tctaattttc attagcaatt
     1081 aataaagcta tacatgcaga aatgaataca acagaacact gctctttttg attttatttg
     1141 tactttttgg cctgggatat gggttttaaa tggacattgt ctgtaccagc ttcattaaaa
     1201 taaacaatat ttgtaaaaat catactaatg cttattttat tttaattgta tagaaagaaa
     1261 aaaatgccta aaataaggtt ttcttgcata aatactggaa attgcacatg gtacaaattt
     1321 tttcttcatt actgtacagt gatgatgtta atgactttga agcactgaaa gttactgaag
     1381 tgccttctga atcaaggatt taattaaggc cacaatacct ttttaatact cagtgttctg
     1441 tttttttaaa aacttgatat tcctgtatgg tgcatatatg atacagttac ctaatcatgt
     1501 tgaataaatg ggcatgccaa aaa
//
