LOCUS       NM_001367551            1057 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 6B member 1 (SULT6B1),
            transcript variant 1, mRNA.
ACCESSION   NM_001367551
VERSION     NM_001367551.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1057)
  AUTHORS   Fang,J.L., Wu,Y., Gamboa da Costa,G., Chen,S., Chitranshi,P. and
            Beland,F.A.
  TITLE     Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan
  JOURNAL   Toxicol Sci 150 (1), 27-39 (2016)
   PUBMED   26660633
REFERENCE   2  (bases 1 to 1057)
  AUTHORS   Ikeda,M., Aleksic,B., Kinoshita,Y., Okochi,T., Kawashima,K.,
            Kushima,I., Ito,Y., Nakamura,Y., Kishi,T., Okumura,T., Fukuo,Y.,
            Williams,H.J., Hamshere,M.L., Ivanov,D., Inada,T., Suzuki,M.,
            Hashimoto,R., Ujike,H., Takeda,M., Craddock,N., Kaibuchi,K.,
            Owen,M.J., Ozaki,N., O'Donovan,M.C. and Iwata,N.
  TITLE     Genome-wide association study of schizophrenia in a Japanese
            population
  JOURNAL   Biol Psychiatry 69 (5), 472-478 (2011)
   PUBMED   20832056
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 1057)
  AUTHORS   Allali-Hassani,A., Pan,P.W., Dombrovski,L., Najmanovich,R.,
            Tempel,W., Dong,A., Loppnau,P., Martin,F., Thornton,J.,
            Edwards,A.M., Bochkarev,A., Plotnikov,A.N., Vedadi,M. and
            Arrowsmith,C.H.
  TITLE     Structural and chemical profiling of the human cytosolic
            sulfotransferases
  JOURNAL   PLoS Biol 5 (5), e97 (2007)
   PUBMED   17425406
  REMARK    Erratum:[PLoS Biol. 2007 Jun;5(6):e165. Thonton, Janet [corrected
            to Thornton, Janet]]
REFERENCE   4  (bases 1 to 1057)
  AUTHORS   Freimuth,R.R., Wiepert,M., Chute,C.G., Wieben,E.D. and
            Weinshilboum,R.M.
  TITLE     Human cytosolic sulfotransferase database mining: identification of
            seven novel genes and pseudogenes
  JOURNAL   Pharmacogenomics J 4 (1), 54-65 (2004)
   PUBMED   14676822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007899.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535679.6/ ENSP00000444081.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC007899.3         2535-2763
            230-342             AC007899.3         3738-3850
            343-432             AC007899.3         7691-7780
            433-559             AC007899.3         11621-11747
            560-654             AC007899.3         15979-16073
            655-811             AC007899.3         19615-19771
            812-1057            AC007899.3         23140-23385
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..1057
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /note="sulfotransferase family 6B member 1"
                     /db_xref="GeneID:391365"
                     /db_xref="HGNC:HGNC:33433"
                     /db_xref="MIM:617152"
     exon            1..229
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..942
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /EC_number="2.8.2.n2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfotransferase 6B1; sulfotransferase SULT6B1; thyroxine
                     sulfotransferase; sulfotransferase family, cytosolic, 6B,
                     member 1"
                     /codon_start=1
                     /product="sulfotransferase 6B1 isoform 1"
                     /protein_id="NP_001354480.1"
                     /db_xref="CCDS:CCDS92738.1"
                     /db_xref="GeneID:391365"
                     /db_xref="HGNC:HGNC:33433"
                     /db_xref="MIM:617152"
                     /translation="MADKSKFIEYIDEALEKSKETALSHLFFTYQGIPYPITMCTSET
                     FQALDTFEARHDDIVLASYPKCGSNWILHIVSELIYAVSKKKYKYPEFPVLECGDSEK
                     YQRMKGFPSPRILATHLHYDKLPGSIFENKAKILVIFRNPKDTAVSFLHFHNDVPDIP
                     SYGSWDEFFRQFMKGQVSWGRYFDFAINWNKHLDGDNVKFILYEDLKENLAAGIKQIA
                     EFLGFFLTGEQIQTISVQSTFQAMRAKSQDTHGAVGPFLFRKGEVGDWKNLFSEIQNQ
                     EMDEKFKECLAGTSLGAKLKYESYCQG"
     exon            230..342
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..432
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..559
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..654
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..811
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1057
                     /gene="SULT6B1"
                     /gene_synonym="ST6B1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagcagg ttcttttaca gggagccacc atggctgata aatccaaatt tattgaatac
       61 attgacgaag ctttagaaaa atcaaaagaa actgcactct ctcatttatt tttcacctat
      121 caggggattc cttaccccat caccatgtgc acctcagaaa ctttccaagc gctggacacc
      181 ttcgaagcca gacatgatga catcgtgcta gcatcttatc caaagtgcgg ttcaaactgg
      241 attctccaca ttgtcagtga attaatatat gctgtttcta aaaaaaagta taaatatcca
      301 gaattcccag ttcttgaatg tggggattca gaaaaatatc agagaatgaa aggctttcca
      361 tcaccaagga ttttggcaac tcacctccac tatgacaaat tacctgggtc tatcttcgag
      421 aataaagcca agatattggt gatatttcga aaccctaaag atacagcagt atcttttttg
      481 catttccaca acgatgtccc cgatattcca agctatggct cttgggatga attcttcaga
      541 cagttcatga aaggacaagt ttcttgggga aggtattttg attttgcaat caattggaac
      601 aaacatcttg atggcgacaa tgttaagttc atattatatg aagacctgaa agagaatctg
      661 gctgctggaa taaaacagat tgctgagttc ttgggattct ttctaactgg ggagcaaatt
      721 caaactatct cagtccagag caccttccaa gccatgcgtg cgaagtctca ggacacacac
      781 ggtgctgtcg gcccattcct tttccgcaaa ggtgaagttg gtgattggaa aaatttgttc
      841 agtgaaattc agaaccagga aatggatgaa aaattcaaag agtgcttagc aggcacctcc
      901 ctcggagcaa agttgaagta tgaatcatat tgccagggtt gattccagtc aattcagcag
      961 gcctagattt attttcctta ataataatta agtgtaaata attaaatgat aattcaatca
     1021 aataatcaaa taataattaa acaatattga aatctaa
//
