LOCUS       NM_014351               2478 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sulfotransferase family 4A member 1 (SULT4A1), mRNA.
ACCESSION   NM_014351
VERSION     NM_014351.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Idris,M., Mitchell,D.J., Gordon,R., Sidharthan,N.P., Butcher,N.J.
            and Minchin,R.F.
  TITLE     Interaction of the Brain-Selective Sulfotransferase SULT4A1 with
            Other Cytosolic Sulfotransferases: Effects on Protein Expression
            and Function
  JOURNAL   Drug Metab Dispos 48 (5), 337-344 (2020)
   PUBMED   32152050
  REMARK    GeneRIF: Interaction of the Brain-Selective Sulfotransferase
            SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein
            Expression and Function.
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Hossain,M.I., Marcus,J.M., Lee,J.H., Garcia,P.L., Gagne,J.P.,
            Poirier,G.G., Falany,C.N. and Andrabi,S.A.
  TITLE     SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial
            Dysfunction in Neuronal Cells
  JOURNAL   Drug Metab Dispos 47 (9), 949-953 (2019)
   PUBMED   31266751
  REMARK    GeneRIF: Study in SULT4A1 knockout mice demonstrates that depletion
            of SULT4A1 induces oxidative stress in neurons and expression of
            SULT4A1 in human SH-SY5Y cells protects against
            oxidative-stress-induced mitochondrial dysfunction and cell death.
            Results suggest that SULT4A1 may have a crucial protective function
            against mitochondrial dysfunction and oxidative stress.
REFERENCE   6  (bases 1 to 2478)
  AUTHORS   Glatt,H.
  TITLE     Sulfotransferases in the bioactivation of xenobiotics
  JOURNAL   Chem Biol Interact 129 (1-2), 141-170 (2000)
   PUBMED   11154739
  REMARK    Review article
REFERENCE   7  (bases 1 to 2478)
  AUTHORS   Glatt,H., Engelke,C.E., Pabel,U., Teubner,W., Jones,A.L.,
            Coughtrie,M.W., Andrae,U., Falany,C.N. and Meinl,W.
  TITLE     Sulfotransferases: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 341-348 (2000)
   PUBMED   10720750
  REMARK    Review article
REFERENCE   8  (bases 1 to 2478)
  AUTHORS   Falany,C.N., Xie,X., Wang,J., Ferrer,J. and Falany,J.L.
  TITLE     Molecular cloning and expression of novel sulphotransferase-like
            cDNAs from human and rat brain
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 857-864 (2000)
   PUBMED   10698717
REFERENCE   9  (bases 1 to 2478)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2478)
  AUTHORS   Weinshilboum,R.M., Otterness,D.M., Aksoy,I.A., Wood,T.C., Her,C.
            and Raftogianis,R.B.
  TITLE     Sulfation and sulfotransferases 1: Sulfotransferase molecular
            biology: cDNAs and genes
  JOURNAL   FASEB J 11 (1), 3-14 (1997)
   PUBMED   9034160
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z97055.1 and AF251263.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014351.3.
            
            Summary: This gene encodes a member of the sulfotransferase family.
            The encoded protein is a brain-specific sulfotransferase believed
            to be involved in the metabolism of neurotransmitters.
            Polymorphisms in this gene may be associated with susceptibility to
            schizophrenia. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188698.1, SRR3476690.392545.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330884.9/ ENSP00000332565.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                Z97055.1           116188-116202       c
            16-102              Z97055.1           116101-116187       c
            103-1374            AF251263.1         1-1272
            1375-2478           Z97055.1           78198-79301         c
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..2478
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /note="sulfotransferase family 4A member 1"
                     /db_xref="GeneID:25830"
                     /db_xref="HGNC:HGNC:14903"
                     /db_xref="MIM:608359"
     exon            1..300
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..986
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /EC_number="2.8.2.-"
                     /note="sulfotransferase-related protein; nervous system
                     cytosolic sulfotransferase; ST4A1; hBR-STL; nervous system
                     sulfotransferase; brain sulfotransferase-like protein"
                     /codon_start=1
                     /product="sulfotransferase 4A1"
                     /protein_id="NP_055166.1"
                     /db_xref="CCDS:CCDS14051.1"
                     /db_xref="GeneID:25830"
                     /db_xref="HGNC:HGNC:14903"
                     /db_xref="MIM:608359"
                     /translation="MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVR
                     PSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKEL
                     TSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQE
                     FCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSC
                     DKAQLEALTEHCHQLVDQCCNAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKC
                     DLTFDFYL"
     exon            301..431
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..512
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..639
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..734
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..873
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            874..2478
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /note="hexamer: AATAAA"
     polyA_site      2478
                     /gene="SULT4A1"
                     /gene_synonym="BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1;
                     NST; SULTX3"
                     /note="major polyA site"
ORIGIN      
        1 gtcacgcctg cggagctgcc gccgcgcgcc ggtggggcgc gagcgtgtgc ggggcgcggg
       61 cgcgggcgcg ggcgcgggcg cgtgcgggct gcgagccggg aggcggcggc ggcgacggcg
      121 acggcggcgg catggcggag agcgaggccg agacccccag caccccgggg gagttcgaga
      181 gcaagtactt cgagttccat ggcgtgcggc tgccgccctt ctgccgcggg aagatggagg
      241 agatcgccaa cttcccggtg cggcccagcg acgtgtggat cgtcacctac cccaagtccg
      301 gcaccagctt gctgcaggag gtggtctact tggtgagcca gggcgctgac cccgatgaga
      361 tcggcttgat gaacatcgac gagcagctcc cggtcctgga gtacccacag ccgggcctgg
      421 acatcatcaa ggaactgacc tctccccgcc tcatcaagag ccacctgccc taccgctttc
      481 tgccctctga cctccacaat ggagactcca aggtcatcta tatggctcgc aaccccaagg
      541 atctggtggt gtcttattat cagttccacc gctctctgcg gaccatgagc taccgaggca
      601 cctttcaaga attctgccgg aggtttatga atgataagct gggctacggc tcctggtttg
      661 agcacgtgca ggagttctgg gagcaccgca tggactcgaa cgtgcttttt ctcaagtatg
      721 aagacatgca tcgggacctg gtgacgatgg tggagcagct ggccagattc ctgggggtgt
      781 cctgtgacaa ggcccagctg gaagccctga cggagcactg ccaccagctg gtggaccagt
      841 gctgcaacgc tgaggccctg cccgtgggcc ggggaagagt tgggctgtgg aaggacatct
      901 tcaccgtctc catgaatgag aagtttgact tggtgtataa acagaagatg ggaaagtgtg
      961 acctcacgtt tgacttttat ttataataac agaaacaaca acctgcatgc tcacaatacc
     1021 cagacagtct actagccaaa agtcctgtat gcattcattt attccttgct ggacaaactc
     1081 tggaagcagc gtgtgaaaca gcgggggaag ggaagagcgg cgtgagcgga gggagtgtga
     1141 tgattcccaa ccgaaagcag ctgtctcgcc tttagaacgt gcagcctctc catgtctgat
     1201 tacaaacagt ctccacattg cagttccaat ggcctggacc gtaaggataa agcctgtaat
     1261 atatgcaact agaatgtctg ccttttcaac cccgtattat tgtattttat agagcttttc
     1321 actggaaatc tacataaatg tcagtaaacc aaataaaagt tcatttccaa ggggaatcag
     1381 gagcgagcca cacccgaatg gtagaaagat ctcagggtta actctttatt tttgtagttt
     1441 tattatctaa ggcacagcca ttctgttctc acttggttct gagatagtgg tgagaacaga
     1501 ggatgagttg ggtctgttgg ggggaatctg gacacttgtt tattctgacg gagttcactt
     1561 cttcagaacc ttcctgaaat gagcagaaat tgttcactag gtcttcagaa tggacgtcct
     1621 tctgccagag acttccagcg ggcggctcca aaggcccaat gcagaggagc ccgcggagca
     1681 tgtgctgagg gaagtctgcc tggtgaggct ggcaggtggg agtctaatgc agtcaggagc
     1741 atttgcatgc agtgggtgga gagtcggcca ccaaaggacc gagttgcgct cggaatttga
     1801 gctgaattcc acagccttac tttgtttcct gaagtgatag cctactaatg ctggcaagca
     1861 gatgcttaat agtaaatttc taaaatcccc gggtctttat cattcagttt gttctgtgca
     1921 cctgaggcgc tcagccgtgg gaggaccatt ttgcgagtgt agccctgttt cactcggatc
     1981 aggttggcac ggccgcctgc gtgtctgtcc acctcatccc tccgtgtatc tgagggagta
     2041 aaggtgaggt ctttattgct tcactgccta attttctcac ccacattcgc tgaagcgatg
     2101 gagagtcggg ggccagtagc cagccaaccc cgtggggacc ggggttgtct gtcatttatg
     2161 tggctggaaa gcacccaaag tggtggtcag gagggtcgct gctgtggaag gggtctccgt
     2221 tcttggtgct gtatttgaaa cgggtgtaga gagaagcttg tgtttttgtt tgtaatgggg
     2281 agaagcgtgg ccaggcaggt ggcacgtggc atcgcatggt gggctcggca gcaccttgcc
     2341 tgtgtttctg tgagggaggc tgctttctgt gaaatttcat ttatattttt ctatttttag
     2401 tactgtatgg atgttactga gcactacaca tgatccttct gtgcttgctt gcatctttaa
     2461 taaagacatg ttcccggc
//
