LOCUS       NM_177973               1196 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sulfotransferase family 2B member 1 (SULT2B1),
            transcript variant 2, mRNA.
ACCESSION   NM_177973
VERSION     NM_177973.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Gao,H., Xia,M. and Ruan,H.
  TITLE     Knockdown of sulfotransferase 2B1 suppresses cell migration,
            invasion and promotes apoptosis in ovarian carcinoma cells via
            targeting annexin A9
  JOURNAL   J Obstet Gynaecol Res 50 (8), 1334-1344 (2024)
   PUBMED   38777329
  REMARK    GeneRIF: Knockdown of sulfotransferase 2B1 suppresses cell
            migration, invasion and promotes apoptosis in ovarian carcinoma
            cells via targeting annexin A9.
REFERENCE   2  (bases 1 to 1196)
  AUTHORS   Pan,H., Wu,T., Huang,K., Guo,Z., Liang,H., Lyu,P., Huang,H.,
            Feng,X., Wang,Q., Hu,J., He,Y., Guo,Z., Yin,M. and Zhang,Y.
  TITLE     Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with
            SMAD4 to inhibit the macrophage inflammatory response and delay
            atherosclerosis progression
  JOURNAL   Transl Res 268, 13-27 (2024)
   PUBMED   38286358
  REMARK    GeneRIF: Reducing SULT2B1 promotes the interaction of
            LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory
            response and delay atherosclerosis progression.
REFERENCE   3  (bases 1 to 1196)
  AUTHORS   Che,G., Wang,W., Wang,J., He,C., Yin,J., Chen,Z., He,C., Wang,X.,
            Yang,Y. and Liu,J.
  TITLE     Sulfotransferase SULT2B1 facilitates colon cancer metastasis by
            promoting SCD1-mediated lipid metabolism
  JOURNAL   Clin Transl Med 14 (2), e1587 (2024)
   PUBMED   38372484
  REMARK    GeneRIF: Sulfotransferase SULT2B1 facilitates colon cancer
            metastasis by promoting SCD1-mediated lipid metabolism.
REFERENCE   4  (bases 1 to 1196)
  AUTHORS   Wang,Y., Liu,Y., Wang,Y., Wu,Y., Chen,Z., Wang,F., Wan,X., Wang,F.
            and Sun,X.
  TITLE     Macrophage Sult2b1 promotes pathological neovascularization in
            age-related macular degeneration
  JOURNAL   Life Sci Alliance 6 (11), e202302020 (2023)
   PUBMED   37550000
  REMARK    GeneRIF: Macrophage Sult2b1 promotes pathological
            neovascularization in age-related macular degeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1196)
  AUTHORS   Li,Z., Li,M.Y., Wang,L.L., Li,L., Chen,Q.Y., Zhu,Y.H., Li,Y.,
            Qin,Y.R. and Guan,X.Y.
  TITLE     The promoter hypermethylation of SULT2B1 accelerates esophagus
            tumorigenesis via downregulated PER1
  JOURNAL   Thorac Cancer 12 (24), 3370-3379 (2021)
   PUBMED   34730281
  REMARK    GeneRIF: The promoter hypermethylation of SULT2B1 accelerates
            esophagus tumorigenesis via downregulated PER1.
            Erratum:[Thorac Cancer. 2022 Sep;13(18):2664-2665. doi:
            10.1111/1759-7714.14639.. PMID: 36106348]
REFERENCE   6  (bases 1 to 1196)
  AUTHORS   Glatt,H.
  TITLE     Sulfotransferases in the bioactivation of xenobiotics
  JOURNAL   Chem Biol Interact 129 (1-2), 141-170 (2000)
   PUBMED   11154739
  REMARK    Review article
REFERENCE   7  (bases 1 to 1196)
  AUTHORS   Glatt,H., Engelke,C.E., Pabel,U., Teubner,W., Jones,A.L.,
            Coughtrie,M.W., Andrae,U., Falany,C.N. and Meinl,W.
  TITLE     Sulfotransferases: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 341-348 (2000)
   PUBMED   10720750
  REMARK    Review article
REFERENCE   8  (bases 1 to 1196)
  AUTHORS   Her,C., Wood,T.C., Eichler,E.E., Mohrenweiser,H.W., Ramagli,L.S.,
            Siciliano,M.J. and Weinshilboum,R.M.
  TITLE     Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded
            by a single chromosome 19 gene
  JOURNAL   Genomics 53 (3), 284-295 (1998)
   PUBMED   9799594
REFERENCE   9  (bases 1 to 1196)
  AUTHORS   Weinshilboum,R.M., Otterness,D.M., Aksoy,I.A., Wood,T.C., Her,C.
            and Raftogianis,R.B.
  TITLE     Sulfation and sulfotransferases 1: Sulfotransferase molecular
            biology: cDNAs and genes
  JOURNAL   FASEB J 11 (1), 3-14 (1997)
   PUBMED   9034160
  REMARK    Review article
REFERENCE   10 (bases 1 to 1196)
  AUTHORS   Richard,G.
  TITLE     Autosomal Recessive Congenital Ichthyosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008403.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_177973.1.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a
            typical substrate for the phenol and estrogen sulfotransferase
            subfamilies. Two alternatively spliced variants that encode
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) is also known as SULT2B1b. It
            is the predominant transcript and it encodes the longer protein
            (isoform b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92315.1, BC034694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000201586.7/ ENSP00000201586.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC008403.8         135686-135837
            153-295             AC008403.8         159455-159597
            296-504             AC008403.8         170743-170951
            505-631             AC008403.8         175123-175249
            632-726             AC008403.8         176236-176330
            727-907             AC008403.8         180253-180433
            908-1196            AC008403.8         182649-182937
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1196
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /note="sulfotransferase family 2B member 1"
                     /db_xref="GeneID:6820"
                     /db_xref="HGNC:HGNC:11459"
                     /db_xref="MIM:604125"
     exon            1..152
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1179
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /EC_number="2.8.2.2"
                     /note="isoform b is encoded by transcript variant 2;
                     ST2B1; sulfotransferase 2B1; alcohol sulfotransferase;
                     hydroxysteroid sulfotransferase 2; sulfotransferase
                     family, cytosolic, 2B, member 1; hydroxysteroid
                     sulfotransferase SULT2B1a"
                     /codon_start=1
                     /product="sulfotransferase 2B1 isoform b"
                     /protein_id="NP_814444.1"
                     /db_xref="CCDS:CCDS12723.1"
                     /db_xref="GeneID:6820"
                     /db_xref="HGNC:HGNC:11459"
                     /db_xref="MIM:604125"
                     /translation="MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLY
                     SLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAP
                     WCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYS
                     KIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQ
                     GSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKG
                     VCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLE
                     PNTSLEREPRPNSSPSPSPGQASETPHPRPS"
     exon            153..295
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..504
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..631
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..726
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..907
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1196
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /note="hexamer: AATAAA"
     polyA_site      1196
                     /gene="SULT2B1"
                     /gene_synonym="ARCI14; HSST2"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgtc gctgcgcaca cctggcctct gtgccgcctg ctccctgctc gtcctcccct
       61 ccccaccctc acccacctgc catggacggg cccgccgagc cccagatccc gggcttgtgg
      121 gacacctatg aagatgacat ctcggaaatc agccagaagt tgccaggtga atacttccgg
      181 tacaagggcg tccccttccc cgtcggcctg tactcgctcg agagcatcag cttggcggag
      241 aacacccaag atgtgcggga cgacgacatc tttatcatca cctaccccaa gtcaggcacg
      301 acctggatga tcgagatcat ctgcttaatc ctgaaggaag gggatccatc ctggatccgc
      361 tccgtgccca tctgggagcg ggcaccctgg tgtgagacca ttgtgggtgc cttcagcctc
      421 ccggaccagt acagcccccg cctcatgagc tcccatcttc ccatccagat cttcaccaag
      481 gccttcttca gctccaaggc caaggtgatc tacatgggcc gcaacccccg ggacgttgtg
      541 gtctccctct atcattactc caagatcgcc gggcagttaa aggacccggg cacacccgac
      601 cagttcctga gggacttcct caaaggcgaa gtgcagtttg gctcctggtt cgaccacatt
      661 aagggctggc ttcggatgaa gggcaaagac aacttcctat ttatcaccta cgaggagctg
      721 cagcaggact tacagggctc cgtggagcgc atctgtgggt tcctgggccg tccgctgggc
      781 aaggaggcac tgggctccgt cgtggcacac tcaaccttca gcgccatgaa ggccaacacc
      841 atgtccaact acacgctgct gcctcccagc ctgctggacc accgtcgcgg ggccttcctc
      901 cggaaagggg tctgcggcga ctggaagaac cacttcacgg tggcccagag cgaagccttc
      961 gatcgtgcct accgcaagca gatgcggggg atgccgacct tcccctggga tgaagacccg
     1021 gaggaggacg gcagcccaga tcctgagccc agccctgagc ctgagcccaa gcccagcctt
     1081 gagcccaaca ccagcctgga gcgtgagccc agacccaact ccagccccag ccccagcccc
     1141 ggccaggcct ctgagacccc gcacccacga ccctcataat aaacacgtcg attctg
//
