LOCUS       NM_003167               1904 bp    mRNA    linear   PRI 16-AUG-2024
DEFINITION  Homo sapiens sulfotransferase family 2A member 1 (SULT2A1), mRNA.
ACCESSION   NM_003167
VERSION     NM_003167.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Peng,H., Feng,K., Jia,W., Li,Y., Lv,Q. and Zhang,Y.
  TITLE     An integrated investigation of sulfotransferases (SULTs) in
            hepatocellular carcinoma and identification of the role of SULT2A1
            on stemness
  JOURNAL   Apoptosis 29 (5-6), 898-919 (2024)
   PUBMED   38411862
  REMARK    GeneRIF: An integrated investigation of sulfotransferases (SULTs)
            in hepatocellular carcinoma and identification of the role of
            SULT2A1 on stemness.
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Yoshimura,Y., Togashi,M., Ogawa,S. and Higashi,T.
  TITLE     3-Epi-25-hydroxyvitamin D3 is a poor substrate for SULT2A1:
            Analysis of its 3-sulfate in cord plasma and recombinant human
            SULT2A1 incubate
  JOURNAL   Steroids 162, 108695 (2020)
   PUBMED   32649998
  REMARK    GeneRIF: 3-Epi-25-hydroxyvitamin D3 is a poor substrate for
            SULT2A1: Analysis of its 3-sulfate in cord plasma and recombinant
            human SULT2A1 incubate.
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Abunnaja,M.S., Alherz,F.A., El Daibani,A.A., Bairam,A.F.,
            Rasool,M.I., Gohal,S.A., Kurogi,K., Suiko,M., Sakakibara,Y. and
            Liu,M.C.
  TITLE     Effects of genetic polymorphisms on the sulfation of
            dehydroepiandrosterone and pregnenolone by human cytosolic
            sulfotransferase SULT2A1
  JOURNAL   Biochem Cell Biol 96 (5), 655-662 (2018)
   PUBMED   29671343
  REMARK    GeneRIF: Kinetic analyses showed further differential catalytic
            efficiency and substrate affinity of the SULT2A1 allozymes, in
            comparison with wild-type SULT2A1. These findings provided useful
            information concerning the effects of genetic polymorphisms on the
            sulfating activity of SULT2A1 allozymes.
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Mueller,J.W., Idkowiak,J., Gesteira,T.F., Vallet,C., Hardman,R.,
            van den Boom,J., Dhir,V., Knauer,S.K., Rosta,E. and Arlt,W.
  TITLE     Human DHEA sulfation requires direct interaction between PAPS
            synthase 2 and DHEA sulfotransferase SULT2A1
  JOURNAL   J Biol Chem 293 (25), 9724-9735 (2018)
   PUBMED   29743239
  REMARK    GeneRIF: Energy-dependent scoring of docking solutions identified
            the interaction as specific for the PAPSS2 and SULT2A1 isoforms
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Forbes,K.J., Hagen,M., Glatt,H., Hume,R. and Coughtrie,M.W.
  TITLE     Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning,
            stable expression in V79 cells and functional characterisation of
            the expressed enzyme
  JOURNAL   Mol Cell Endocrinol 112 (1), 53-60 (1995)
   PUBMED   7589785
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Kong,A.N., Yang,L., Ma,M., Tao,D. and Bjornsson,T.D.
  TITLE     Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of
            sulfotransferase from human liver
  JOURNAL   Biochem Biophys Res Commun 187 (1), 448-454 (1992)
   PUBMED   1520333
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Otterness,D.M., Wieben,E.D., Wood,T.C., Watson,W.G., Madden,B.J.,
            McCormick,D.J. and Weinshilboum,R.M.
  TITLE     Human liver dehydroepiandrosterone sulfotransferase: molecular
            cloning and expression of cDNA
  JOURNAL   Mol Pharmacol 41 (5), 865-872 (1992)
   PUBMED   1588921
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Comer,K.A. and Falany,C.N.
  TITLE     Immunological characterization of dehydroepiandrosterone
            sulfotransferase from human liver and adrenal
  JOURNAL   Mol Pharmacol 41 (4), 645-651 (1992)
   PUBMED   1569919
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Radominska,A., Comer,K.A., Zimniak,P., Falany,J., Iscan,M. and
            Falany,C.N.
  TITLE     Human liver steroid sulphotransferase sulphates bile acids
  JOURNAL   Biochem J 272 (3), 597-604 (1990)
   PUBMED   2268288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX509490.1, BC020755.1 and
            AC024582.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003167.3.
            
            Summary: This gene encodes a member of the sulfotransferase family.
            Sulfotransferases aid in the metabolism of drugs and endogenous
            compounds by converting these substances into more hydrophilic
            water-soluble sulfate conjugates that can be easily excreted. This
            protein catalyzes the sulfation of steroids and bile acids in the
            liver and adrenal glands, and may have a role in the inherited
            adrenal androgen excess in women with polycystic ovary syndrome.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020755.1, SRR5189664.117161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222002.4/ ENSP00000222002.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BX509490.1         84-110
            28-1044             BC020755.1         27-1043
            1045-1904           AC024582.7         30599-31458         c
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1904
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="sulfotransferase family 2A member 1"
                     /db_xref="GeneID:6822"
                     /db_xref="HGNC:HGNC:11458"
                     /db_xref="MIM:125263"
     exon            1..194
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..916
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /EC_number="2.8.2.2"
                     /EC_number="2.8.2.14"
                     /note="alcohol/hydroxysteroid sulfotransferase; bile-salt
                     sulfotranasferase 2A1; sulfotransferase family, cytosolic,
                     2A, dehydroepiandrosterone (DHEA)-preferring, member 1"
                     /codon_start=1
                     /product="sulfotransferase 2A1"
                     /protein_id="NP_003158.2"
                     /db_xref="CCDS:CCDS12707.1"
                     /db_xref="GeneID:6822"
                     /db_xref="HGNC:HGNC:11458"
                     /db_xref="MIM:125263"
                     /translation="MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPK
                     SGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPI
                     QLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLY
                     GSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNS
                     SFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMAD
                     LPRELFPWE"
     exon            195..403
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..530
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..625
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..803
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1904
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1045
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="major polyA site"
     polyA_site      1052
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
     regulatory      1745..1750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="hexamer: AAGAAA"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="hexamer: AATAAA"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="hexamer: ATTACA"
     polyA_site      1763
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
     polyA_site      1767
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
     polyA_site      1791
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
                     /note="hexamer: AATAAA"
     polyA_site      1904
                     /gene="SULT2A1"
                     /gene_synonym="DHEA-ST; DHEA-ST8; DHEAS; HST; hSTa; ST2;
                     ST2A1; ST2A3; STD; SULT2A3"
ORIGIN      
        1 agcctccagc ggtggctaca gttgaaaccc tcacaccacg caggaagagg tcatcatcat
       61 gtcggacgat ttcttatggt ttgaaggcat agctttccct actatgggtt tcagatccga
      121 aaccttaaga aaagtacgtg atgagttcgt gataagggat gaagatgtaa taatattgac
      181 ttaccccaaa tcaggaacaa actggttggc tgagattctc tgcctgatgc actccaaggg
      241 ggatgccaag tggatccaat ctgtgcccat ctgggagcga tcaccctggg tagagagtga
      301 gattgggtat acagcactca gtgaaacgga gagtccacgt ttattctcct cccacctccc
      361 catccagtta ttccccaagt ctttcttcag ttccaaggcc aaggtgattt atctcatgag
      421 aaatcccaga gatgttttgg tgtctggtta ttttttctgg aaaaacatga agtttattaa
      481 gaaaccaaag tcatgggaag aatattttga atggttttgt caaggaactg tgctatatgg
      541 gtcatggttt gaccacattc atggctggat gcccatgaga gaggagaaaa acttcctgtt
      601 actgagttat gaggagctga aacaggacac aggaagaacc atagagaaga tctgtcaatt
      661 cctgggaaag acgttagaac ccgaagaact gaacttaatt ctcaagaaca gctcctttca
      721 gagcatgaaa gaaaacaaga tgtccaatta ttccctcctg agtgttgatt atgtagtgga
      781 caaagcacaa cttctgagaa aaggtgtatc tggggactgg aaaaatcact tcacagtggc
      841 ccaagctgaa gactttgata aattgttcca agagaagatg gcagatcttc ctcgagagct
      901 gttcccatgg gaataacgtc caaaacactc tggatcttat atggagaatg acattgattc
      961 tcctgtcctt gtacatgtac ctgactgggg tcattgtgta agacttatta ttttatcctg
     1021 aaaccttaaa tatcaaacct ctgcatctct gatcccttcc ttgttaaaag ttaccagggt
     1081 tggccaggca cggtggttca tgcctgtaat cccagcacta tgggaggccg agacgggcgg
     1141 atcacgaggt caggagactg agaccatcct ggctaacacg gtgaaacccc atctctacta
     1201 aaaatacaaa aaccaaaaaa aattagccag gcgcattggc tcatgtctgt aatcccagca
     1261 ctttgggagg tcgggggggt gggggaggat cacggggtca ggagatcgag accatcctgg
     1321 ccaacatgat gaaaccctat ctctactaaa aatacaaaaa ttagccgggc atggtggtgc
     1381 acgcctatag tcccagctac tcgggaggct gaggtaggag aatcgtttga actcaggagg
     1441 cagaggttgc aatgagccaa gatcgcgcca ctgcactcca gcctgggtga cagagcgaga
     1501 ccgtctcaaa aagaaagaag tgactagggt tcagagaacc agggttcaaa gcccagggat
     1561 gcaaaggttg cagtgagttg agtcatggga tcccagactt ttttaaatgt ttgcaatgtt
     1621 tcccgtttac agaatgctac aagaataatg tacgtactac ctaaaaggat gtctaaatgt
     1681 ttgttaataa aaataagaaa tagctacagt gacagatttt agagcaaaaa ttagtaataa
     1741 aaataagaaa taaaattaca ggagcaatta aggttccatt tcttttcatc acatgtatct
     1801 ccacaattta ttattgctct gatcttaagg agtgtaattt gcaatctaat tttatcctct
     1861 tactctgtgt tgttaaacca tatacaataa acggtgttta tgga
//
