LOCUS       NM_005420               1773 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1E member 1 (SULT1E1), mRNA.
ACCESSION   NM_005420
VERSION     NM_005420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Wang,R., Li,X., Li,Y., Zhao,M., Mi,L., Chen,W. and Song,J.
  TITLE     Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated
            Factors in Malignant Tumours
  JOURNAL   Protein Pept Lett 30 (10), 821-829 (2023)
   PUBMED   37724676
  REMARK    GeneRIF: Estrogen Sulfotransferase SULT1E1 Expression Levels and
            Regulated Factors in Malignant Tumours.
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Sato,A., Watanabe,H., Yamazaki,M., Sakurai,E. and Ebina,K.
  TITLE     Estrogen Sulfotransferase is Highly Expressed in Vascular
            Endothelial Cells Overlying Atherosclerotic Plaques
  JOURNAL   Protein J 41 (1), 179-188 (2022)
   PUBMED   35059953
  REMARK    GeneRIF: Estrogen Sulfotransferase is Highly Expressed in Vascular
            Endothelial Cells Overlying Atherosclerotic Plaques.
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Sato,A., Watanabe,H., Yamazaki,M., Sakurai,E. and Ebina,K.
  TITLE     Interaction of Native- and Oxidized-Low-Density Lipoprotein with
            Human Estrogen Sulfotransferase
  JOURNAL   Protein J 40 (2), 192-204 (2021)
   PUBMED   33665770
  REMARK    GeneRIF: Interaction of Native- and Oxidized-Low-Density
            Lipoprotein with Human Estrogen Sulfotransferase.
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   El Daibani,A.A., Alherz,F.A., Abunnaja,M.S., Bairam,A.F.,
            Rasool,M.I., Kurogi,K. and Liu,M.C.
  TITLE     Impact of Human SULT1E1 Polymorphisms on the Sulfation of
            17beta-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by
            SULT1E1 Allozymes
  JOURNAL   Eur J Drug Metab Pharmacokinet 46 (1), 105-118 (2021)
   PUBMED   33064293
  REMARK    GeneRIF: Impact of Human SULT1E1 Polymorphisms on the Sulfation of
            17beta-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by
            SULT1E1 Allozymes.
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Falany,J.L. and Falany,C.N.
  TITLE     Expression of cytosolic sulfotransferases in normal mammary
            epithelial cells and breast cancer cell lines
  JOURNAL   Cancer Res 56 (7), 1551-1555 (1996)
   PUBMED   8603401
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Her,C., Aksoy,I.A., Kimura,S., Brandriff,B.F., Wasmuth,J.J. and
            Weinshilboum,R.M.
  TITLE     Human estrogen sulfotransferase gene (STE): cloning, structure, and
            chromosomal localization
  JOURNAL   Genomics 29 (1), 16-23 (1995)
   PUBMED   8530066
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Falany,C.N., Krasnykh,V. and Falany,J.L.
  TITLE     Bacterial expression and characterization of a cDNA for human liver
            estrogen sulfotransferase
  JOURNAL   J Steroid Biochem Mol Biol 52 (6), 529-539 (1995)
   PUBMED   7779757
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Bernier,F., Leblanc,G., Labrie,F. and Luu-The,V.
  TITLE     Structure of human estrogen and aryl sulfotransferase gene. Two
            mRNA species issued from a single gene
  JOURNAL   J Biol Chem 269 (45), 28200-28205 (1994)
   PUBMED   7961757
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Aksoy,I.A., Wood,T.C. and Weinshilboum,R.
  TITLE     Human liver estrogen sulfotransferase: identification by cDNA
            cloning and expression
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1621-1629 (1994)
   PUBMED   8185618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108941.4.
            
            On Nov 26, 2018 this sequence version replaced NM_005420.2.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes a protein that transfers a sulfo moiety to and from
            estrone, which may control levels of estrogen receptors. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027956.1, S77383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226444.4/ ENSP00000226444.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC108941.4         79458-79554         c
            98-251              AC108941.4         76909-77062         c
            252-377             AC108941.4         74710-74835         c
            378-475             AC108941.4         73626-73723         c
            476-602             AC108941.4         68846-68972         c
            603-697             AC108941.4         67107-67201         c
            698-878             AC108941.4         63570-63750         c
            879-1773            AC108941.4         60621-61515         c
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1773
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /note="sulfotransferase family 1E member 1"
                     /db_xref="GeneID:6783"
                     /db_xref="HGNC:HGNC:11377"
                     /db_xref="MIM:600043"
     exon            1..97
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            98..251
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..991
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /EC_number="2.8.2.4"
                     /note="sulfotransferase, estrogen-preferring; estrogen
                     sulfotransferase; estrone sulfotransferase;
                     sulfotransferase family 1E, estrogen-preferring, member 1"
                     /codon_start=1
                     /product="sulfotransferase 1E1"
                     /protein_id="NP_005411.1"
                     /db_xref="CCDS:CCDS3531.1"
                     /db_xref="GeneID:6783"
                     /db_xref="HGNC:HGNC:11377"
                     /db_xref="MIM:600043"
                     /translation="MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIAT
                     YPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPR
                     IVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEK
                     FMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEEL
                     VDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFD
                     KHYEQQMKESTLKFRTEI"
     exon            252..377
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            378..475
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            476..602
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            603..697
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            698..878
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1773
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /note="hexamer: AATAAA"
     polyA_site      1773
                     /gene="SULT1E1"
                     /gene_synonym="EST; EST-1; ST1E1; STE"
                     /note="major polyA site"
ORIGIN      
        1 agaagtggtt ctcatctttt tttgcagctt aagatctgcc ttggtatttg aagagatata
       61 aactagatca atttctttca caggatcaac taaacagtgt accacaatga attctgaact
      121 tgactattat gaaaagtttg aagaagtcca tgggattcta atgtataaag attttgtcaa
      181 atattgggat aatgtggaag cgttccaggc aagaccagat gatcttgtca ttgccaccta
      241 ccctaaatct ggtacaacct gggttagtga aattgtgtat atgatctata aagagggtga
      301 tgtggaaaag tgcaaagaag atgtaatttt taatcgaata cctttcctgg aatgcagaaa
      361 agaaaacctc atgaatggag taaaacaatt agatgagatg aattctccta gaattgtgaa
      421 gactcatttg ccacctgaac ttcttcctgc ctcattttgg gaaaaggatt gtaagataat
      481 ctatctttgc cggaatgcaa aggatgtggc tgtttccttt tattatttct ttctaatggt
      541 ggctggtcat ccaaatcctg gatcctttcc agagtttgtg gagaaattca tgcaaggaca
      601 ggttccttat ggttcctggt ataaacatgt aaaatcttgg tgggaaaagg gaaagagtcc
      661 acgtgtacta tttcttttct acgaagacct gaaagaggat atcagaaaag aggtgataaa
      721 attgatacat ttcctggaaa ggaagccatc agaggagctt gtggacagga ttatacatca
      781 tacttcgttc caagagatga agaacaatcc atccacaaat tacacaacac tgccagacga
      841 aattatgaac cagaaattgt cgcccttcat gagaaaggga attacaggag actggaaaaa
      901 tcactttaca gtagccctga atgaaaaatt tgataaacat tatgagcagc aaatgaagga
      961 atctacactg aagtttcgaa ctgagatcta agaaggtctt tctttactta acatatctga
     1021 tattaaagat ttcttttcat tattctccac tttttcttat tttagattgc tagaaaagac
     1081 ataatcatgg attatgttga cattttcttt ttaaattttt gtttaacttt tttttttttt
     1141 ttttgagaca gagtctcact ctgttgccta ggctggagga cagtggcaca atcatggctg
     1201 attgcagcct tgacctcctt gactcaattg atcctcccat ctcagcctcc caagtagcta
     1261 ggactacaga catgtgcaac catgtttggc taattttttt aatgtttttt tgtagagatg
     1321 aggtcttatt atattgtcca ggctggtctt gaattcctgg gctcaagctt cccaagtagc
     1381 tgcaacaaca ggcacacacc accatgctca actaatttta tttctatttt ttgtatagac
     1441 aggggcttgc tatagtgtcc aggctggtct gaaacccttg agctcaagtg atcttcccac
     1501 accagcctcc caaaatactg ggattacagg cttgagcctc catgcctggc ccaggtaaca
     1561 tgtttattga gctgtacatg catatgagaa ataagaaact tttttttcct actatcatct
     1621 cttaaatttt gttttctttt tcttttgctt cctcttcttc ttttctattt tttataaata
     1681 tcatgcacaa ctataaccta tgggaatgat gtagtaacac agattattca tcttgttaga
     1741 gttgtattaa aaataaacaa gcatttcaaa tta
//
