LOCUS       NM_006588               2850 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1C member 4 (SULT1C4),
            transcript variant 1, mRNA.
ACCESSION   NM_006588
VERSION     NM_006588.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Jiang,L., Xu,F., Li,C., Liu,T., Zhao,Q., Liu,Y., Zhao,Y., Li,Y.,
            Zhang,Z., Tang,X. and Zhang,J.
  TITLE     Sulfotransferase 1C2 promotes hepatocellular carcinoma progression
            by enhancing glycolysis and fatty acid metabolism
  JOURNAL   Cancer Med 12 (9), 10738-10754 (2023)
   PUBMED   36880364
  REMARK    GeneRIF: Sulfotransferase 1C2 promotes hepatocellular carcinoma
            progression by enhancing glycolysis and fatty acid metabolism.
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Mei,X., Gohal,S.A., Zhou,C.Y. and Liu,M.C.
  TITLE     Sulfation of hyperoside by the human cytosolic sulfotransferases
            (SULTs): impact of genetic polymorphisms on hyperoside-sulfating
            activity of SULT1C4 allozymes
  JOURNAL   J Asian Nat Prod Res 25 (1), 75-84 (2023)
   PUBMED   35249434
  REMARK    GeneRIF: Sulfation of hyperoside by the human cytosolic
            sulfotransferases (SULTs): impact of genetic polymorphisms on
            hyperoside-sulfating activity of SULT1C4 allozymes.
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Dubaisi,S., Fang,H., Caruso,J.A., Gaedigk,R., Vyhlidal,C.A.,
            Kocarek,T.A. and Runge-Morris,M.
  TITLE     Developmental Expression of SULT1C4 Transcript Variants in Human
            Liver: Implications for Discordance Between SULT1C4 mRNA and
            Protein Levels
  JOURNAL   Drug Metab Dispos 48 (6), 515-520 (2020)
   PUBMED   32303576
  REMARK    GeneRIF: Developmental Expression of SULT1C4 Transcript Variants in
            Human Liver: Implications for Discordance Between SULT1C4 mRNA and
            Protein Levels.
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Guidry,A.L., Tibbs,Z.E., Runge-Morris,M. and Falany,C.N.
  TITLE     Expression, purification and characterization of human cytosolic
            sulfotransferase (SULT) 1C4
  JOURNAL   Horm Mol Biol Clin Investig 29 (1), 27-36 (2017)
   PUBMED   28222028
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Luo,L., Zhou,C., Hui,Y., Kurogi,K., Sakakibara,Y., Suiko,M. and
            Liu,M.C.
  TITLE     Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of
            doxorubicin and epirubicin
  JOURNAL   Drug Metab Pharmacokinet 31 (2), 163-166 (2016)
   PUBMED   26948952
  REMARK    GeneRIF: The current study aimed to identify the human cytosolic
            sulfotransferase(s) that is(are) capable of sulfating doxorubicin
            and its analog epirubicin, and to verify whether sulfation of
            doxorubicin and epirubicin may occur under metabolic conditions.
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Glatt,H.
  TITLE     Sulfotransferases in the bioactivation of xenobiotics
  JOURNAL   Chem Biol Interact 129 (1-2), 141-170 (2000)
   PUBMED   11154739
  REMARK    Review article
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Freimuth,R.R., Raftogianis,R.B., Wood,T.C., Moon,E., Kim,U.J.,
            Xu,J., Siciliano,M.J. and Weinshilboum,R.M.
  TITLE     Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization,
            gene cloning, and chromosomal localization
  JOURNAL   Genomics 65 (2), 157-165 (2000)
   PUBMED   10783263
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Glatt,H., Engelke,C.E., Pabel,U., Teubner,W., Jones,A.L.,
            Coughtrie,M.W., Andrae,U., Falany,C.N. and Meinl,W.
  TITLE     Sulfotransferases: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 341-348 (2000)
   PUBMED   10720750
  REMARK    Review article
REFERENCE   9  (bases 1 to 2850)
  AUTHORS   Sakakibara,Y., Yanagisawa,K., Katafuchi,J., Ringer,D.P., Takami,Y.,
            Nakayama,T., Suiko,M. and Liu,M.C.
  TITLE     Molecular cloning, expression, and characterization of novel human
            SULT1C sulfotransferases that catalyze the sulfonation of
            N-hydroxy-2-acetylaminofluorene
  JOURNAL   J Biol Chem 273 (51), 33929-33935 (1998)
   PUBMED   9852044
REFERENCE   10 (bases 1 to 2850)
  AUTHORS   Weinshilboum,R.M., Otterness,D.M., Aksoy,I.A., Wood,T.C., Her,C.
            and Raftogianis,R.B.
  TITLE     Sulfation and sulfotransferases 1: Sulfotransferase molecular
            biology: cDNAs and genes
  JOURNAL   FASEB J 11 (1), 3-14 (1997)
   PUBMED   9034160
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068941.7 and BC125043.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006588.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes a protein that belongs to the SULT1 subfamily,
            responsible for transferring a sulfo moiety from PAPS to
            phenol-containing compounds. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments, including
            RNA-seq data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.264815.1,
                                           SRR1803616.413212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272452.7/ ENSP00000272452.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC068941.7         17756-17986
            232-679             BC125043.1         1-448
            680-777             AC068941.7         22187-22284
            778-904             AC068941.7         22895-23021
            905-1501            BC125043.1         449-1045
            1502-2850           AC068941.7         27443-28791
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.3"
     gene            1..2850
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /note="sulfotransferase family 1C member 4"
                     /db_xref="GeneID:27233"
                     /db_xref="HGNC:HGNC:11457"
                     /db_xref="MIM:608357"
     exon            1..553
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1293
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /EC_number="2.8.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfotransferase family, cytosolic, 1C, member C2;
                     sulfotransferase family, cytosolic, 1C, member 2;
                     sulfotransferase 1C4; sulfotransferase 1C2; ST1C4;
                     SULT1C#2; sulfotransferase family, cytosolic, 1C, member
                     4"
                     /codon_start=1
                     /product="sulfotransferase 1C4 isoform 1"
                     /protein_id="NP_006579.2"
                     /db_xref="CCDS:CCDS2077.1"
                     /db_xref="GeneID:27233"
                     /db_xref="HGNC:HGNC:11457"
                     /db_xref="MIM:608357"
                     /translation="MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAK
                     PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQ
                     AHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPG
                     TWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFI
                     GKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFT
                     VAQNERFDEDYKKKMTDTRLTFHFQF"
     exon            554..679
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..777
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..904
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..999
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1180
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..2850
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /note="hexamer: ATTAAA"
     polyA_site      2850
                     /gene="SULT1C4"
                     /gene_synonym="SULT1C; SULT1C2"
                     /note="major polyA site"
ORIGIN      
        1 gccagtggac aaattcataa acaagagctc cagttccctg gaacctgagt cgggagacct
       61 gcagctcact ttctccctgt ttgctggcca gcagggtttg tggccgcctc tgctgtgacg
      121 ccacagcctg gtgaggaggg ggctgcagtt cctcaggaaa ctgccagtgg acaaagtcat
      181 aaacaagagt tccagttccc tggaacctga gtcgggaggc ctgcaactca ctttctccct
      241 gtttgctggc ccagacaggc ctgtgctaga gggctggata gtgtggtagt gtggtggata
      301 gagtgctgcc tctatccaca acgcagccat atgctgactg aagataactt tgtgtctgga
      361 agagccctct gatttcttac actaatggcc ttacacgaca tggaggattt tacatttgat
      421 ggaacaaagc gcttaagtgt caactacgtg aagggaattc ttcaaccgac agacacctgt
      481 gacatctggg ataagatctg gaacttccaa gccaagcctg atgacctgct tatttctacc
      541 tatcctaaag caggaacaac atggactcag gagatagtgg aattaataca aaatgaaggt
      601 gatgtggaga aaagtaaacg ggcaccgact catcaacgat ttcctttcct cgaaatgaaa
      661 atcccatcct taggatctgg tttggaacaa gctcatgcaa tgccctcacc acggatcctg
      721 aaaacacatc ttccctttca cttgctgcca ccatccttgc tagagaaaaa ctgtaagata
      781 atctatgtag caagaaatcc caaggacaac atggtgtcct attaccattt ccaaagaatg
      841 aataaagctc ttcctgctcc aggaacatgg gaagagtatt ttgagacttt tctggctggg
      901 aaagtgtgct ggggctcctg gcatgaacat gtgaaaggat ggtgggaagc caaagacaaa
      961 caccgtattc tctatctctt ctatgaggac atgaagaaga acccaaagca tgaaattcag
     1021 aagctggcag aatttattgg gaagaaatta gatgacaaag ttctagataa aattgtccat
     1081 tacacttcgt ttgatgtcat gaaacagaat ccaatggcaa actattcatc gattcctgct
     1141 gaaatcatgg accactccat ttctccattc atgagaaaag gggcagtggg agactggaag
     1201 aaacacttca ccgtggctca gaatgagaga tttgatgaag attacaagaa gaaaatgact
     1261 gataccagac taactttcca cttccagttc tagtaaggaa gaaaaactga aaatgtttta
     1321 gtttattacc cagtatattt gggtaataat gaaagtttaa ttctcataac aaatgatatc
     1381 agattccagt tatcagaata gtttactgtg tttgctctta ttcactctac taaaaaatta
     1441 ttttaaaagg ctggaggcaa ggtggtgaca ggcagcaggg tggcgacatg gagagaggga
     1501 agctcaataa atcactaggt acaatcctgg tatcattgcc aattatcatc atatttacat
     1561 tttctacaat catgtgctta ttaacatatt ggaaatgctt cagtcctcac atgataatac
     1621 actaacattt tcagattaag ttttggttca agttaatttt tttttttttt tttttgagac
     1681 ggagtctcgc tctgtcgccc aggctggagt gcagtggcac gatctcggct cactgcaagc
     1741 tctgcttcct gggttcacgc tattcccctg cctcagcctc ccgagtagct gggactatgg
     1801 gcgcccacca ccactcccgg ctaatttttt tttttgtatt cttagtagag acgaggtttc
     1861 accgtgttag ccaggatgtt ctcgatctcc tgaccccatg atccacccgc ttcggcctcc
     1921 caaagtgctg agattacagg cgtgagccac tgcgcccagc cggttcaagt taatttttaa
     1981 atgcatcact aacgtgtaaa tagtgactgt ttgttccagc aattttttgg tggtgaagta
     2041 accatcaagt gattcaggtt cctcttggaa ccctccaaga aaaacttcag ggtcctagtg
     2101 taatacatct gtccccatct ctcactggcg tatatattta actggactca ctctcccacc
     2161 ctcagctaat gctacaatcc tggagtcacc tcttgactca tctttcccat tgccaccaca
     2221 atccattcta atatgtcaga aaatctgtca gttttaatct acgaaatctc ttaaaatatt
     2281 tccgtctaac cattccttgt tttccttcta tttctatagc cacccttctg gttcacaaac
     2341 cttttacttc ttgcctcaac tagtgtaata gcttcctaac ccatttctct ctatttcaga
     2401 cagatggcaa ggttattttc cttaaaaaga ctcttattat gttgttcctt agctcaaaat
     2461 ccttcaatgg ctgaactttc actgcctgaa agataaatcc caagatttta gccatgcatt
     2521 caagagcagc tataaccata atgactccag ccttcacact tccagcttca ccttccaaac
     2581 cacctccata ttccagcaaa ttagcctact tactgggtcc tagtcacatc ttaccacttc
     2641 ctaccctccc agttttattt ataccaagcc tcctcctgaa atttctcttc ctttctttct
     2701 acctacccaa gacataccac gtgcttcaat aaccagtccc ttcctcctac aaacactaca
     2761 acctggaaag cactcttgct tttctgaagt cctctatact tagtgtaact cttctgtgat
     2821 gaagattaaa gtgtattatg gcaactctca
//
