LOCUS       NM_001320878            1244 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1C member 3 (SULT1C3),
            transcript variant 1, coding, mRNA.
ACCESSION   NM_001320878 XM_011511209
VERSION     NM_001320878.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Kurogi,K., Shimohira,T., Kouriki-Nagatomo,H., Zhang,G.,
            Miller,E.R., Sakakibara,Y., Suiko,M. and Liu,M.C.
  TITLE     Human Cytosolic Sulphotransferase SULT1C3: genomic analysis and
            functional characterization of splice variant SULT1C3a and SULT1C3d
  JOURNAL   J Biochem 162 (6), 403-414 (2017)
   PUBMED   28992322
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Dubaisi,S., Fang,H., Kocarek,T.A. and Runge-Morris,M.
  TITLE     Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3
            by Peroxisome Proliferator-Activated Receptor gamma in LS180 Human
            Colorectal Adenocarcinoma Cells
  JOURNAL   Mol Pharmacol 90 (5), 562-569 (2016)
   PUBMED   27565680
  REMARK    GeneRIF: PPARgamma regulatory network includes SULT1C3 and imply
            that this enzyme contributes to the control of such
            PPARgamma-regulated intestinal processes as growth,
            differentiation, and metabolism.
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Simino,J., Shi,G., Bis,J.C., Chasman,D.I., Ehret,G.B., Gu,X.,
            Guo,X., Hwang,S.J., Sijbrands,E., Smith,A.V., Verwoert,G.C.,
            Bragg-Gresham,J.L., Cadby,G., Chen,P., Cheng,C.Y., Corre,T., de
            Boer,R.A., Goel,A., Johnson,T., Khor,C.C., Lluis-Ganella,C.,
            Luan,J., Lyytikainen,L.P., Nolte,I.M., Sim,X., Sober,S., van der
            Most,P.J., Verweij,N., Zhao,J.H., Amin,N., Boerwinkle,E.,
            Bouchard,C., Dehghan,A., Eiriksdottir,G., Elosua,R., Franco,O.H.,
            Gieger,C., Harris,T.B., Hercberg,S., Hofman,A., James,A.L.,
            Johnson,A.D., Kahonen,M., Khaw,K.T., Kutalik,Z., Larson,M.G.,
            Launer,L.J., Li,G., Liu,J., Liu,K., Morrison,A.C., Navis,G.,
            Ong,R.T., Papanicolau,G.J., Penninx,B.W., Psaty,B.M., Raffel,L.J.,
            Raitakari,O.T., Rice,K., Rivadeneira,F., Rose,L.M., Sanna,S.,
            Scott,R.A., Siscovick,D.S., Stolk,R.P., Uitterlinden,A.G.,
            Vaidya,D., van der Klauw,M.M., Vasan,R.S., Vithana,E.N., Volker,U.,
            Volzke,H., Watkins,H., Young,T.L., Aung,T., Bochud,M., Farrall,M.,
            Hartman,C.A., Laan,M., Lakatta,E.G., Lehtimaki,T., Loos,R.J.,
            Lucas,G., Meneton,P., Palmer,L.J., Rettig,R., Snieder,H., Tai,E.S.,
            Teo,Y.Y., van der Harst,P., Wareham,N.J., Wijmenga,C., Wong,T.Y.,
            Fornage,M., Gudnason,V., Levy,D., Palmas,W., Ridker,P.M.,
            Rotter,J.I., van Duijn,C.M., Witteman,J.C., Chakravarti,A. and
            Rao,D.C.
  CONSRTM   LifeLines Cohort Study
  TITLE     Gene-age interactions in blood pressure regulation: a large-scale
            investigation with the CHARGE, Global BPgen, and ICBP Consortia
  JOURNAL   Am J Hum Genet 95 (1), 24-38 (2014)
   PUBMED   24954895
REFERENCE   5  (bases 1 to 1244)
  AUTHORS   Rondini,E.A., Fang,H., Runge-Morris,M. and Kocarek,T.A.
  TITLE     Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by
            nuclear signaling pathways in LS180 colorectal adenocarcinoma cells
  JOURNAL   Drug Metab Dispos 42 (3), 361-368 (2014)
   PUBMED   24335393
  REMARK    GeneRIF: Our findings are the first to characterize the regulation
            of human SULT1C2 and SULT1C3 expression by several transcription
            factor activators.
REFERENCE   6  (bases 1 to 1244)
  AUTHORS   Duniec-Dmuchowski,Z., Rondini,E.A., Tibbs,Z.E., Falany,C.N.,
            Runge-Morris,M. and Kocarek,T.A.
  TITLE     Expression of the orphan cytosolic sulfotransferase SULT1C3 in
            human intestine: characterization of the transcript variant and
            implications for function
  JOURNAL   Drug Metab Dispos 42 (3), 352-360 (2014)
   PUBMED   24335392
  REMARK    GeneRIF: These data indicate that SULT1C3 is expressed in human
            intestine.
            Erratum:[Drug Metab Dispos. 2014 May;42(5):853]
REFERENCE   7  (bases 1 to 1244)
  AUTHORS   Runge-Morris,M. and Kocarek,T.A.
  TITLE     Expression of the sulfotransferase 1C family: implications for
            xenobiotic toxicity
  JOURNAL   Drug Metab Rev 45 (4), 450-459 (2013)
   PUBMED   24028175
  REMARK    Review article
REFERENCE   8  (bases 1 to 1244)
  AUTHORS   Meinl,W., Donath,C., Schneider,H., Sommer,Y. and Glatt,H.
  TITLE     SULT1C3, an orphan sequence of the human genome, encodes an enzyme
            activating various promutagens
  JOURNAL   Food Chem Toxicol 46 (4), 1249-1256 (2008)
   PUBMED   17936463
REFERENCE   9  (bases 1 to 1244)
  AUTHORS   Allali-Hassani,A., Pan,P.W., Dombrovski,L., Najmanovich,R.,
            Tempel,W., Dong,A., Loppnau,P., Martin,F., Thornton,J.,
            Edwards,A.M., Bochkarev,A., Plotnikov,A.N., Vedadi,M. and
            Arrowsmith,C.H.
  TITLE     Structural and chemical profiling of the human cytosolic
            sulfotransferases
  JOURNAL   PLoS Biol 5 (5), e97 (2007)
   PUBMED   17425406
  REMARK    Erratum:[PLoS Biol. 2007 Jun;5(6):e165. Thonton, Janet [corrected
            to Thornton, Janet]]
REFERENCE   10 (bases 1 to 1244)
  AUTHORS   Freimuth,R.R., Wiepert,M., Chute,C.G., Wieben,E.D. and
            Weinshilboum,R.M.
  TITLE     Human cytosolic sulfotransferase database mining: identification of
            seven novel genes and pseudogenes
  JOURNAL   Pharmacogenomics J 4 (1), 54-65 (2004)
   PUBMED   14676822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019100.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001320878.1.
            
            Transcript Variant: This variant (1, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.17155.1,
                                           ERR279840.1850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681802.2/ ENSP00000505748.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC019100.4         91245-91360
            117-295             AC019100.4         98465-98643
            296-424             AC019100.4         103642-103770
            425-522             AC019100.4         104622-104719
            523-649             AC019100.4         106849-106975
            650-744             AC019100.4         110011-110105
            745-925             AC019100.4         110243-110423
            926-1244            AC019100.4         111845-112163
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.3"
     gene            1..1244
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /note="sulfotransferase family 1C member 3"
                     /db_xref="GeneID:442038"
                     /db_xref="HGNC:HGNC:33543"
                     /db_xref="MIM:617151"
     exon            1..116
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            117..295
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1038
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /EC_number="2.8.2.1"
                     /EC_number="2.8.2.2"
                     /note="isoform 1 is encoded by transcript variant 1,
                     coding; sulfotransferase 1C3; sulfotransferase family,
                     cytosolic, 1C, member 3"
                     /codon_start=1
                     /product="sulfotransferase 1C3 isoform 1"
                     /protein_id="NP_001307807.1"
                     /db_xref="CCDS:CCDS92828.1"
                     /db_xref="GeneID:442038"
                     /db_xref="HGNC:HGNC:33543"
                     /db_xref="MIM:617151"
                     /translation="MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQA
                     KPDDLILATYPKSGTTWMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDL
                     EFVLEMSSPQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPD
                     PQNLEEFYEKFMSGKVVGGSWFDHVKGWWAAKDMHRILYLFYEDIKKNPKHEIHKVLE
                     FLEKTWSGDVINKIVHHTSFDVMKDNPMANHTAVPAHIFNHSISKFMRKGMPGDWKNH
                     FTVALNENFDKHYEKKMAGSTLNFCLEI"
     exon            296..424
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..522
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..649
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..744
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..925
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1244
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /note="hexamer: AATAAA"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /note="hexamer: AATAAG"
     polyA_site      1239
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
     polyA_site      1244
                     /gene="SULT1C3"
                     /gene_synonym="ST1C3"
                     /note="major polyA site"
ORIGIN      
        1 ctcacctgct gtgctcttgc ttgcacagtg tcctggagct ggacctggct ctgggtttcc
       61 aggaagcagt ttgactaaag gcagcaagct gcttcctctg ctgcctgaga taccagattc
      121 ccaatggcga agattgagaa aaacgctccc acgatggaaa aaaagccaga actgtttaac
      181 atcatggaag tagatggagt ccctacgttg atattatcaa aagaatggtg ggaaaaagta
      241 tgtaatttcc aagccaagcc tgatgatctt attctggcaa cttacccaaa gtcaggtaca
      301 acatggatgc atgaaatttt agacatgatt ctaaatgatg gtgatgtgga gaaatgcaaa
      361 agagcccaga ctctagatag acacgctttc cttgaactga aatttcccca taaagaaaaa
      421 ccagatttgg agttcgttct tgaaatgtcc tcaccacaac tgataaaaac acatctccct
      481 tcacatctga ttccaccatc tatctggaaa gaaaactgca agattgtcta tgtggccaga
      541 aatcccaagg attgcctggt gtcctactac cactttcaca ggatggcttc ctttatgcct
      601 gatcctcaga acttagagga attttatgag aaattcatgt ccggaaaagt tgttggcggg
      661 tcctggtttg accatgtgaa aggatggtgg gctgcaaaag acatgcaccg gatcctctac
      721 ctcttctacg aggatattaa aaaaaatcca aaacatgaga tccacaaggt gttggaattc
      781 ttggagaaaa cttggtcagg tgatgttata aacaagattg tccaccatac ctcatttgat
      841 gtaatgaagg ataatcccat ggccaaccat actgcggtac ctgctcacat attcaatcac
      901 tccatctcaa aatttatgag gaaagggatg cctggagact ggaagaacca ctttactgtg
      961 gctttgaatg agaactttga taagcattat gaaaagaaga tggcagggtc cacactgaac
     1021 ttctgcctgg agatctgaga ggaacaacaa caaactaggt gacagagact atgccaacta
     1081 tttcgccttt tattctgttg agcaaggaac tgtgactgaa tgtggagctt atgagcttca
     1141 gtccatctcc tatagtgtgg ctagtttgct ataatattaa aacatgattt aaaatatcaa
     1201 caaaccagtt actccagtaa ataaaataag agaattagag agca
//
