LOCUS       NM_001056               2539 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1C member 2 (SULT1C2),
            transcript variant 1, mRNA.
ACCESSION   NM_001056
VERSION     NM_001056.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Johnson,C., Mullen,D.J., Selamat,S.A., Campan,M., Offringa,I.A. and
            Marconett,C.N.
  TITLE     The Sulfotransferase SULT1C2 Is Epigenetically Activated and
            Transcriptionally Induced by Tobacco Exposure and Is Associated
            with Patient Outcome in Lung Adenocarcinoma
  JOURNAL   Int J Environ Res Public Health 19 (1), 416 (2021)
   PUBMED   35010676
  REMARK    GeneRIF: The Sulfotransferase SULT1C2 Is Epigenetically Activated
            and Transcriptionally Induced by Tobacco Exposure and Is Associated
            with Patient Outcome in Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Barrett,K.G., Fang,H., Kocarek,T.A. and Runge-Morris,M.
  TITLE     Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by
            Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
  JOURNAL   Drug Metab Dispos 44 (8), 1431-1434 (2016)
   PUBMED   27130351
  REMARK    GeneRIF: Vitamin D receptor can interact directly with the SULT1C2
            VDRE sequence to transcriptionally regulation SULT1C2 expression in
            colorectal tumor cells.
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Rondini,E.A., Fang,H., Runge-Morris,M. and Kocarek,T.A.
  TITLE     Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by
            nuclear signaling pathways in LS180 colorectal adenocarcinoma cells
  JOURNAL   Drug Metab Dispos 42 (3), 361-368 (2014)
   PUBMED   24335393
  REMARK    GeneRIF: Our findings are the first to characterize the regulation
            of human SULT1C2 and SULT1C3 expression by several transcription
            factor activators.
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Runge-Morris,M. and Kocarek,T.A.
  TITLE     Expression of the sulfotransferase 1C family: implications for
            xenobiotic toxicity
  JOURNAL   Drug Metab Rev 45 (4), 450-459 (2013)
   PUBMED   24028175
  REMARK    Review article
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Sakakibara,Y., Yanagisawa,K., Katafuchi,J., Ringer,D.P., Takami,Y.,
            Nakayama,T., Suiko,M. and Liu,M.C.
  TITLE     Molecular cloning, expression, and characterization of novel human
            SULT1C sulfotransferases that catalyze the sulfonation of
            N-hydroxy-2-acetylaminofluorene
  JOURNAL   J Biol Chem 273 (51), 33929-33935 (1998)
   PUBMED   9852044
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Yoshinari,K., Nagata,K., Shimada,M. and Yamazoe,Y.
  TITLE     Molecular characterization of ST1C1-related human sulfotransferase
  JOURNAL   Carcinogenesis 19 (5), 951-953 (1998)
   PUBMED   9635888
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Her,C., Kaur,G.P., Athwal,R.S. and Weinshilboum,R.M.
  TITLE     Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific
            expression, and chromosomal localization
  JOURNAL   Genomics 41 (3), 467-470 (1997)
   PUBMED   9169148
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   Weinshilboum,R.M., Otterness,D.M., Aksoy,I.A., Wood,T.C., Her,C.
            and Raftogianis,R.B.
  TITLE     Sulfation and sulfotransferases 1: Sulfotransferase molecular
            biology: cDNAs and genes
  JOURNAL   FASEB J 11 (1), 3-14 (1997)
   PUBMED   9034160
  REMARK    Review article
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Kiehlbauch,C.C., Lam,Y.F. and Ringer,D.P.
  TITLE     Homodimeric and heterodimeric aryl sulfotransferases catalyze the
            sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene
  JOURNAL   J Biol Chem 270 (32), 18941-18947 (1995)
   PUBMED   7642552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF186252.1, AC019100.4 and
            AA856596.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001056.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes a protein that belongs to the SULT1 subfamily,
            responsible for transferring a sulfo moiety from PAPS to
            phenol-containing compounds. Two alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and it encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008164.1, AF186251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251481.11/ ENSP00000251481.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1337              AF186252.1         257-1593
            1338-2077           AC019100.4         159991-160730
            2078-2539           AA856596.1         5-466               c
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.3"
     gene            1..2539
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /note="sulfotransferase family 1C member 2"
                     /db_xref="GeneID:6819"
                     /db_xref="HGNC:HGNC:11456"
                     /db_xref="MIM:602385"
     exon            1..176
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..348
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1088
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /EC_number="2.8.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     sulfotransferase family, cytosolic, 1C, member 1;
                     sulfotransferase 1C2; sulfotransferase 1C1; SULT1C#1;
                     sulfotransferase family, cytosolic, 1C, member 2"
                     /codon_start=1
                     /product="sulfotransferase 1C2 isoform a"
                     /protein_id="NP_001047.1"
                     /db_xref="CCDS:CCDS2075.1"
                     /db_xref="GeneID:6819"
                     /db_xref="HGNC:HGNC:11456"
                     /db_xref="MIM:602385"
                     /translation="MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLI
                     CTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPS
                     PRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYF
                     ETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDE
                     TVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNER
                     FDEIYRRKMEGTSINFCMEL"
     exon            349..474
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..572
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..699
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..794
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..975
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..2539
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /note="major polyA site"
     regulatory      2517..2522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /note="hexamer: AATAAA"
     polyA_site      2539
                     /gene="SULT1C2"
                     /gene_synonym="humSULTC2; ST1C1; ST1C2; SULT1C1"
                     /note="major polyA site"
ORIGIN      
        1 acactgaagc tgagagcctc ccaaagtgct ggctacctgc tgagcgcccc cgtaactctg
       61 acacagtagt aatttgagcc tctgcaattg ccgtctgctt cctgtgaaag tcctttccgt
      121 gcccactgac ccttgagtgg gcctttgagc tgctgacttt cagctggaac ttgaagggac
      181 cccaaccctg agacactatg gccctgacct cagacctggg gaaacagata aaactgaaag
      241 aggtggaggg gaccctcctg cagcctgcaa ctgtggacaa ctggagccag atccagagct
      301 tcgaggccaa accagatgat ctcctcatct gcacctaccc taaagcaggg acaacgtgga
      361 ttcaggaaat tgtggatatg attgaacaga atggggacgt ggagaagtgc cagcgagcca
      421 tcatccaaca ccgccatcct ttcattgagt gggctcggcc accccaacct tctggtgtgg
      481 aaaaagccaa agcaatgccc tctccacgga tactaaagac tcacctttcc actcagctgc
      541 tgccaccgtc tttctgggaa aacaactgca agttccttta tgtagctcga aatgccaaag
      601 actgtatggt ttcctactac catttccaaa ggatgaacca catgcttcct gaccctggta
      661 cctgggaaga gtattttgaa accttcatca atggaaaagt ggtttggggt tcctggtttg
      721 accacgtgaa aggatggtgg gagatgaaag acagacacca gattctcttc ctcttctatg
      781 aggacataaa gagggaccca aagcatgaaa ttcggaaggt gatgcagttc atgggaaaga
      841 aggtggatga aacagtgcta gataaaattg tccaggagac gtcatttgag aaaatgaaag
      901 aaaatcccat gacaaatcgt tctacagttt ccaaatctat cttggaccag tcaatttcct
      961 ccttcatgag aaaaggaact gtgggggatt ggaaaaacca cttcactgtt gcccagaatg
     1021 agaggtttga tgaaatctat agaagaaaga tggaaggaac ctccataaac ttctgcatgg
     1081 aactctgagc aagatgtaaa taaaattaaa aggtggatgg caagagtgca aatactatct
     1141 tcaatccttc agtcccagcc agaagaatct ctgaaagcat attgtgaatg tatacaatgt
     1201 agtacaaaca atctctgtga tgattaacag tatgtcacca cttcattttt taaaaaggat
     1261 cacgtctaat gcccattttc ccaactattc tttccaaagt aagatataag gtagcttaat
     1321 aaactaagta aaacgtatga cttgagtaca aaaggattgt tttaatcccc attattctgg
     1381 aaagtgcatc ctagtctccc agtctataac atcataatac cttgagtata agtccaaata
     1441 ttaggttata tctatattaa aaacaaaatt tctgtcatct gtcctggcca ttcaggcaac
     1501 tccagcctgg gctcaatcct ggagttctgt ctggtcacta tcagaaggaa cactttgagg
     1561 gaaaccctgg tgcagccagc cctgaggaaa catggcctga gtgccctcac tggtgggtgg
     1621 gaataaaatg gaagtgcaca gaggagatgt cagaagacca aaacttggtg aatagtccca
     1681 gtgctaggtc atataggaaa cagaaagcat gacagtggcc ttttgggaac ccaagttacg
     1741 tcctggtgaa agcagaaagg aggagacagg atggctgtca acaacgtcag catgggcatg
     1801 gctcccaggc atggaggtaa ttgggtcttg gcttcaatgc cacccttttg ggaagcccta
     1861 aaccaagtga ggtgttcttt tcccttgctt cccatatttg tcccagttgc agccctgttg
     1921 ttatgtattt actcttcaat ttcttattta tacctctcac tcaattgtta attctttggg
     1981 ttcagtctca tgccatattt actcctagta cctaatgcag tgcctggcac acagcaagtg
     2041 cccttgagaa cttgtagagg gagtaaaaaa gtgcatggat aaatgactgc agcaaatcac
     2101 aaattttgaa ctttgaccct tttcttttag tcccaaatag tggcattcca tagctgaggg
     2161 tagtaggagc agttcaccct gggagcagac aataagagga agaatgaagc caactaaaat
     2221 tctgaatgct ttttgttgga tttcgtaggg tatttttttt aaaatagggt cttgctatgt
     2281 tgcccaggct ggtcttaact gactgctttt tattattacc atgcactggc aattccaaac
     2341 aatgtcagtg ttaaaatgct tctccctgaa aaagagaaaa aaaaaaggaa aaaaagaaaa
     2401 gaaaagtgaa aagaaaaact cttattggcc taagttctaa ataatagcta ggttaccact
     2461 gagttttaac tatatgtata tgagcttcaa ataagcacct ttttattatg taaataaata
     2521 aaagttatct gtatcccca
//
