LOCUS       NM_014465               7018 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1B member 1 (SULT1B1), mRNA.
ACCESSION   NM_014465
VERSION     NM_014465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7018)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 7018)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7018)
  AUTHORS   Tibbs,Z.E., Guidry,A.L., Falany,J.L., Kadlubar,S.A. and Falany,C.N.
  TITLE     A high frequency missense SULT1B1 allelic variant (L145V)
            selectively expressed in African descendants exhibits altered
            kinetic properties
  JOURNAL   Xenobiotica 48 (1), 79-88 (2018)
   PUBMED   28084139
  REMARK    GeneRIF: (L145V) selectively expressed in African descendants
            exhibits altered kinetic properties
REFERENCE   4  (bases 1 to 7018)
  AUTHORS   Tibbs,Z.E. and Falany,C.N.
  TITLE     An engineered heterodimeric model to investigate SULT1B1 dependence
            on intersubunit communication
  JOURNAL   Biochem Pharmacol 115, 123-133 (2016)
   PUBMED   27338799
  REMARK    GeneRIF: the intersubunit interactions of SULT1B1 as it relates to
            enzyme activity
REFERENCE   5  (bases 1 to 7018)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 7018)
  AUTHORS   Glatt,H.
  TITLE     Sulfotransferases in the bioactivation of xenobiotics
  JOURNAL   Chem Biol Interact 129 (1-2), 141-170 (2000)
   PUBMED   11154739
  REMARK    Review article
REFERENCE   7  (bases 1 to 7018)
  AUTHORS   Glatt,H., Engelke,C.E., Pabel,U., Teubner,W., Jones,A.L.,
            Coughtrie,M.W., Andrae,U., Falany,C.N. and Meinl,W.
  TITLE     Sulfotransferases: genetics and role in toxicology
  JOURNAL   Toxicol Lett 112-113, 341-348 (2000)
   PUBMED   10720750
  REMARK    Review article
REFERENCE   8  (bases 1 to 7018)
  AUTHORS   Wang,J., Falany,J.L. and Falany,C.N.
  TITLE     Expression and characterization of a novel thyroid
            hormone-sulfating form of cytosolic sulfotransferase from human
            liver
  JOURNAL   Mol Pharmacol 53 (2), 274-282 (1998)
   PUBMED   9463486
REFERENCE   9  (bases 1 to 7018)
  AUTHORS   Fujita,K., Nagata,K., Ozawa,S., Sasano,H. and Yamazoe,Y.
  TITLE     Molecular cloning and characterization of rat ST1B1 and human ST1B2
            cDNAs, encoding thyroid hormone sulfotransferases
  JOURNAL   J Biochem 122 (5), 1052-1061 (1997)
   PUBMED   9443824
REFERENCE   10 (bases 1 to 7018)
  AUTHORS   Weinshilboum,R.M., Otterness,D.M., Aksoy,I.A., Wood,T.C., Her,C.
            and Raftogianis,R.B.
  TITLE     Sulfation and sulfotransferases 1: Sulfotransferase molecular
            biology: cDNAs and genes
  JOURNAL   FASEB J 11 (1), 3-14 (1997)
   PUBMED   9034160
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010895.1, AC125239.4,
            U95726.1 and BG461453.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014465.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members.
            However, the total genomic length of this gene is greater than that
            of other SULT1 genes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010895.1, DRR138517.338471.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310613.8/ ENSP00000308770.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BC010895.1         96-133
            39-39               AC125239.4         101019-101019       c
            40-753              BC010895.1         134-847
            754-1098            U95726.1           563-907
            1099-1165           BG461453.1         113-179
            1166-1204           BC010895.1         1260-1298
            1205-1217           BG461453.1         219-231
            1218-7018           AC125239.4         61604-67404         c
FEATURES             Location/Qualifiers
     source          1..7018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..7018
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /note="sulfotransferase family 1B member 1"
                     /db_xref="GeneID:27284"
                     /db_xref="HGNC:HGNC:17845"
                     /db_xref="MIM:608436"
     exon            1..162
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..354
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1097
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /EC_number="2.8.2.1"
                     /note="thyroid hormone sulfotransferase; sulfotransferase
                     1B2; sulfotransferase family, cytosolic, 1B, member 1"
                     /codon_start=1
                     /product="sulfotransferase 1B1"
                     /protein_id="NP_055280.2"
                     /db_xref="CCDS:CCDS3530.1"
                     /db_xref="GeneID:27284"
                     /db_xref="HGNC:HGNC:17845"
                     /db_xref="MIM:608436"
                     /translation="MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIA
                     TYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPS
                     PRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYL
                     EKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLND
                     EILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEK
                     FDAIYETEMSKTALQFRTEI"
     exon            355..483
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..581
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..708
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..803
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..984
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..7018
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
                     /note="hexamer: ATTACA"
     polyA_site      2065
                     /gene="SULT1B1"
                     /gene_synonym="ST1B1; ST1B2; SULT1B2"
ORIGIN      
        1 gattgctacg ttcagatcaa accttgaact tttttttttc tggtgccagg agccttcctg
       61 tgctccccat tgcctgccag aaccaccacc gtttcccatg gttactctac agcagcttca
      121 ctgcctgaaa atgaaaactg aacaaaggga ttaaattgtg agaacaactg tcaatctatt
      181 atatatttgt acaatctggt attaaaatgc tttccccaaa agatattctg cgaaaagatc
      241 tgaagttggt ccatggttat cccatgacct gtgcttttgc aagcaactgg gaaaaaattg
      301 aacagttcca tagcagacca gatgacattg tgatagccac ttatcctaaa tcaggtacta
      361 cttgggttag tgaaattata gacatgattc taaatgatgg agatattgaa aaatgtaagc
      421 gaggttttat tactgaaaaa gttccaatgt tggaaatgac tctccctgga ttaagaacat
      481 caggtataga acaattggag aagaatccat caccccggat tgtgaaaaca catctaccga
      541 ctgatcttct tcctaaatct ttctgggaaa acaattgcaa gatgatttat ctggctcgta
      601 atgccaagga tgtttcagtc tcatattacc attttgactt aatgaataat ttacagcctt
      661 ttcctggtac ctgggaagaa tatctggaga aattcttaac tggaaaagtg gcctatggtt
      721 cctggtttac tcatgttaaa aactggtgga agaaaaagga agaacaccca atactttttt
      781 tgtactatga agatatgaaa gagaatccaa aggaggaaat caagaagatc attagatttc
      841 tagagaagaa cctgaatgat gagatcttgg ataggatcat ccatcacacc tcatttgaag
      901 tgatgaagga caatcctttg gtaaattata cacatctacc aactacagtg atggatcata
      961 gcaaatcccc ttttatgcgt aaagggacgg ctggtgactg gaagaattac ttcaccgtgg
     1021 cccaaaatga gaaatttgat gctatttatg agacagaaat gtccaaaact gcacttcaat
     1081 tccgcacaga gatttaaagt gtctaaatca cacatctgaa gaaataagag attgtctgta
     1141 gttgattgaa acgagggcag ttatgaattg atttgggcaa tcaaatgaat ttataaagga
     1201 gaataatatg cttttaatat gttgattctt ttcaatgtta ttaatcagat cccagttttg
     1261 ttcctttgat tctgagtttc caaattctct aaggctaaag ttcattgtta actttttgta
     1321 acaaaggaac aatgtaacca caggctcttc ctgccttttt ctacactagt actgataaga
     1381 aagaagggat ttattttact taatctccca tatattatga tttagaatta agttcccctc
     1441 cctagtacca tggtccaaga aatgctgttt tcataatgag actatatttc ctaactctgc
     1501 cccaatttcc ctttgccgaa aatttgaccc aggacactgt gttccactgc tgtctaccga
     1561 gtttcaagtt gttctctgag tcatagctca tcttcctgca gtgcctctat ttggataaca
     1621 aagttcatgt ccccgatcat gtagttcaga ttttggaaat cttttttcta tatcatacct
     1681 aatgtctaag tctccgaaag gcaaacgcct acaatagtct ctgtaggatt ggttacctgg
     1741 gaactggagc tctgttctga aaagcagccc tgagggctgt gacctacttc ttatggggag
     1801 tcctcttttt cccaacagac ccgtttgaac ttcagagaaa tcacctactg ctgtgttctg
     1861 gtcaccattt gggaacttca gttacttaat cttatatttg gatagatttg gataccttaa
     1921 tagcaccttt aatatcctag acatgatcat aacctctgca aaatatttcc caatctggtg
     1981 cccaaggaag actctctagg ctgaatctcc actctgccct cttgacccaa tgttccttct
     2041 acttattatt acatgcttat atctatttgt gtggtctctg atctatgttt tcttggaaca
     2101 tttatatata tatatatata tatatatata tatatatata tatatatata tgtacatttt
     2161 attattatac tttaagttcc aggttacatg tgcacaatgt gcaggtttgt tatatatgca
     2221 tacatgtgcc atgttggtgt gctgcatcca ttaactcgtc atttacatta ggtatacctc
     2281 ctaatgctat ccttcccccc tccctccacc ccacaacagg ccccagtgtg tgatgttacc
     2341 tttcctgtgt ccaagtgttc tcatcgttca attcccacca atgactaaga acatgaggtg
     2401 tttggttttt ttgttcttgc aatagtttgc tgaaaagtat ggtttccagc tttatccatg
     2461 tccctacaaa ggacatgaac tcatcatttt ttatggctgc acagtattct atggtgtata
     2521 tgtgccacat tttcttaatc cagtctatca ttgatggaca tttgggttgg ttccaagtct
     2581 ttgctattgt gaatagtgcc gcaataaata tacgtgtgca tgtgtcttta tagcagcatg
     2641 atttataatc ctttgggtat atacccagta atgggatggc tgggtcaaat ggtatttcta
     2701 gttctagatc tctgaggaat tgccacactg tcttccacaa tggttgaact agtttacact
     2761 cccaccaaaa gtgtaaaagt gttcctattt ctccacatcc tttccagcac ctgttgtttc
     2821 ctgacttttt aatgattgcc attctaactg gtgtgagatg gtatctcatt gtggttttga
     2881 tttgcatttc cctgatggcc agtgatgatg agcatttttt catgtgtctg ttggctgcat
     2941 aaatgtcttc ttttgagaag tatctgttca tattctttgc acacttgttg atggggttgt
     3001 tttttttttc ttgtaaattt gtttgagttc tttgtagatt ctggatatta gccctttgtc
     3061 agatgagtag attgcaaaaa ttttctccca ttctgtaggt tgcctgttca cgctgatggt
     3121 agtttctttt gctgtgcaga agctctttag tttaattaga tcccatttgt caattttggc
     3181 ttttgttgcc attgcttttg gtgttttaga catgaagtcc ttgcccatgc ctatgtcctg
     3241 aatgatattg cctaggtttt cttctagggt ttttatggtt ttaggtctta catttaagtc
     3301 tttaatccat cttgaattaa tttttgtata aggtgtaagg aagggatcca ggttctgctt
     3361 tctacatatg gctagccagt tttcccagca ccatttatta aatagggaat cctttcccca
     3421 ttgcttgttt tcgtcaggtt tgtcaaagat cagataattg tagatgtgta gtattatttc
     3481 tgagggctct gttctgttcc attggtctat atctctgttt tggtccagta ccatgctgtt
     3541 ttggttactg tagccttgta gtatagtttg aagtcaggta gtatgatgct tccagctttg
     3601 ctcttttggc ttaggattga cttggcaatg cgggctcttt tttggtttct tatgaacttt
     3661 aaagtagttt tttccaattc tgtgaagaaa gtcattggta gcttaatggg gatggcattg
     3721 aatctataaa tgaccttggg cagtatggcc attttcatga tattgattct tcctatccat
     3781 gagcatggaa tgttcttcta tttgtttgta tcctctttta tttcattgag cagtggtttg
     3841 tagttctcct tgaagtgatc cttcacatcc cttgtaagtt ggattcctag gtattttatt
     3901 ctctttgaag caattgtgaa tgggagttca ctcctgattt ggctctctgt ctgttattgg
     3961 tgtataagaa tgcttgtgat ttttgtacat tgattttgta tcctgagact ttgctgaagt
     4021 tgcttatcag cttaaggaga ttttgggctg agacaatggg gttttctaca tatacaatca
     4081 tgtcatctgc aaacagggac aatttgactt cctcttctcc taattgaata ccctttattt
     4141 ctttctcctg cctgattgcc ctggccagaa cttccaacac tatgttgaat aggagtggtg
     4201 agagacggca tccctgtctt gtgccagttt tcaaagggaa tgcttccagg ttttgcccat
     4261 gcagtatgat attggctggt ggtttgtcat agagggctct ccttattttg agatacattc
     4321 catcaatacc taatttattg agagttttta gcatgaaggc tgttgaattt tgtcaaaggc
     4381 cttttctgca tctattgaga taatcatgtg gtttttgtct ttggttctgt ttatatgctg
     4441 gattacattt attgatttgc atatgttgaa ccagccttga atcccaggga tgaagcccac
     4501 ttgatcatgg tggataagct ttttgatgtg ctgctggatt cggtttgcca gtattttatt
     4561 gaggattttt gcatcaatgt tcatcagggt tattggtcta aaattctctt tttttgttgt
     4621 gtctctgcca ggctttggta tcaggatgat gctggcctca taaaatgagt tagggaggat
     4681 tccctccttt tctgttcatt ggaatagttt cagaaggaat ggtaccagct cctccttgga
     4741 cctctggtag aattcagctg tgaatctatc tggtcctgga cttcttttgg ttggtaagct
     4801 attaattatt gcctctattt cagagcatgt tatttttcta ttcagagatt caacttcttc
     4861 ctggtttatt cttgggaggg tgtatgtgtc gaggaattta tccatttctt ctagattttc
     4921 tagtttattt gcgtagaggt gtttttagta ttctctgacg gtagtttgta tttctgtggg
     4981 atcatcggtg gtgatatccc ctttatcttt ttttattgca tctatttgat tcttctctct
     5041 tttcttcttt attagtcttg ctggtggtct atcaattttg ttgatctttt cgaaaaacca
     5101 gctcctgaat tcactgattt tttgaagggg tttttgtgtc tttgtctcct tcagttatgc
     5161 tctgatctta actccagctt ggcattagaa gtagttgttt atatccccat gtgcagcaaa
     5221 gtctttttcc tgagatcata tcacatgtgc caagttatat gccaagccat ggttctcaag
     5281 ctgaaggtac agtaccctgg gcccttactt gttctgaaag gggtgggggt ggtggttttg
     5341 gacatactgt tagactttct gagccacaac tgaggtagct atggcttatc gtattttgac
     5401 ttcacaggtg aatctccgct gtcagccagg aatagccagg aatagctaaa atagctcctt
     5461 aagctgtaac atttctcttt tccaacccca gcaaaggatt ggtctagtgg taacaacaaa
     5521 cctcatagaa gtagtacacc tattattctg gagatacttg cttctataga tttattacaa
     5581 tatgttttat aaagtatttt agagtatata atttgtgttt atgttccaca gaaacatatt
     5641 ttataggagt taatcttgac tatctaaagg tattgtgaac tagttccagc tttctccaat
     5701 acccttgtcc acgagaagta aactaaatca tgtatctatt tcctctatta tctttattaa
     5761 ataataagtt aatgtggcct gaatatatac ggatttctga tactatggtc tattactgag
     5821 ggaaaaaaca ccactaaact atcctctaat ctgtgtaata gattagctac actttcttca
     5881 ctagcaagat aaaataattt ccacattttc tagttttact ttgtagaaat aactctctgt
     5941 aattggactg tattcaacga aaacttagta agttgtaatt atgcctcagg tatgtttcta
     6001 tgcactgagt gaagagtgga gataaaaata gaatttagat tttcctttac tttttaaata
     6061 ggttgttgcc tcttatatat ttattctatg atgcaaatgt cactatccta attcctcagt
     6121 ttatgtttaa cagcacacag tggcacttct atgattcaaa tacatttgat accctttgaa
     6181 atcaatcaga atactgcaaa attaattttt ctaaaacaat gcttttatcg ttatttctcc
     6241 tgttgaatca tcagtacaat ttccaaatga aaacacttaa aataatctca tattacaatc
     6301 tttctctaac agaaccatga tgtaaggaca gtgataacaa atatctgaca atgatatgat
     6361 tatttcctca tccatggaaa ttttccttaa taaactaaag ggctattttc taaaaagcca
     6421 aagcattgct tacaagaact tttcatcatg acatggatag acactcagat tcatacattc
     6481 aaagggaagt gtcatgtatt ccctttcaat ccaccctatt ctattgtgtt atcttcctaa
     6541 attattttct atctacattc ttcattctct ttcccattga ccctatgttc tgtgtgataa
     6601 aaattgcgtc attggaggct tttgaaggtt aagtattatg ccccatttca ccattaatca
     6661 acatacaacc cttctccata ttttgtaatt cctttcatat acagaaaaaa agatactata
     6721 atttcttcaa aatgcttgat attaatgata tatgggaaaa caattatttt gtgcagcaat
     6781 cttcagataa ctgggaaagg ccggggaaaa agagagatac tggtggttat caatgaccca
     6841 tgtataaatt gtttttatta tgtaagctgt cttcacaaat gtcttcttat gtatgatcat
     6901 tagaactgtt ttatatatat atgtaaaatt tccacattat cgagacatta ctttcagcag
     6961 tgaagtaatc cttttttaac tgccacttaa tgaattcaat aaaatataat ttattgta
//
