LOCUS       NM_001017390            1356 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens sulfotransferase family 1A member 4 (SULT1A4), mRNA.
ACCESSION   NM_001017390
VERSION     NM_001017390.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Idris,M., Mitchell,D.J., Gordon,R., Sidharthan,N.P., Butcher,N.J.
            and Minchin,R.F.
  TITLE     Interaction of the Brain-Selective Sulfotransferase SULT4A1 with
            Other Cytosolic Sulfotransferases: Effects on Protein Expression
            and Function
  JOURNAL   Drug Metab Dispos 48 (5), 337-344 (2020)
   PUBMED   32152050
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Bairam,A.F., Rasool,M.I., Alherz,F.A., Abunnaja,M.S., El
            Daibani,A.A., Gohal,S.A., Alatwi,E.S., Kurogi,K. and Liu,M.C.
  TITLE     Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of
            phenylephrine and salbutamol by human SULT1A3 allozymes
  JOURNAL   Pharmacogenet Genomics 29 (5), 99-105 (2019)
   PUBMED   31145702
  REMARK    GeneRIF: The results obtained showed clearly the differential
            enzymatic characteristics of SULT1A3 allozymes in mediating the
            sulfation of phenylephrine and salbutamol. This information may
            contribute toward a better understanding of the pharmacokinetics of
            these two drugs in individuals with distinct SULT1A3 and/or SULT1A4
            genotypes.
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Bairam,A.F., Rasool,M.I., Alherz,F.A., Abunnaja,M.S., El
            Daibani,A.A., Kurogi,K. and Liu,M.C.
  TITLE     Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the
            sulfation of acetaminophen and opioid drugs by the cytosolic
            sulfotransferase SULT1A3
  JOURNAL   Arch Biochem Biophys 648, 44-52 (2018)
   PUBMED   29705271
  REMARK    GeneRIF: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on
            the sulfation of acetaminophen and opioid drugs by the cytosolic
            sulfotransferase SULT1A3
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Sidharthan,N.P., Minchin,R.F. and Butcher,N.J.
  TITLE     Cytosolic sulfotransferase 1A3 is induced by dopamine and protects
            neuronal cells from dopamine toxicity: role of D1
            receptor-N-methyl-D-aspartate receptor coupling
  JOURNAL   J Biol Chem 288 (48), 34364-34374 (2013)
   PUBMED   24136195
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Kurogi,K., Davidson,G., Mohammed,Y.I., Williams,F.E., Liu,M.Y.,
            Sakakibara,Y., Suiko,M. and Liu,M.C.
  TITLE     Ethanol sulfation by the human cytosolic sulfotransferases: a
            systematic analysis
  JOURNAL   Biol Pharm Bull 35 (12), 2180-2185 (2012)
   PUBMED   23207770
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Hildebrandt,M.A., Salavaggione,O.E., Martin,Y.N., Flynn,H.C.,
            Jalal,S., Wieben,E.D. and Weinshilboum,R.M.
  TITLE     Human SULT1A3 pharmacogenetics: gene duplication and functional
            genomic studies
  JOURNAL   Biochem Biophys Res Commun 321 (4), 870-878 (2004)
   PUBMED   15358107
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Bernier,F., Leblanc,G., Labrie,F. and Luu-The,V.
  TITLE     Structure of human estrogen and aryl sulfotransferase gene. Two
            mRNA species issued from a single gene
  JOURNAL   J Biol Chem 269 (45), 28200-28205 (1994)
   PUBMED   7961757
REFERENCE   8  (bases 1 to 1356)
  AUTHORS   Veronese,M.E., Burgess,W., Zhu,X. and McManus,M.E.
  TITLE     Functional characterization of two human sulphotransferase cDNAs
            that encode monoamine- and phenol-sulphating forms of phenol
            sulphotransferase: substrate kinetics, thermal-stability and
            inhibitor-sensitivity studies
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 497-502 (1994)
   PUBMED   8093002
REFERENCE   9  (bases 1 to 1356)
  AUTHORS   Wood,T.C., Aksoy,I.A., Aksoy,S. and Weinshilboum,R.M.
  TITLE     Human liver thermolabile phenol sulfotransferase: cDNA cloning,
            expression and characterization
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1119-1127 (1994)
   PUBMED   8117269
REFERENCE   10 (bases 1 to 1356)
  AUTHORS   Zhu,X., Veronese,M.E., Bernard,C.C., Sansom,L.N. and McManus,M.E.
  TITLE     Identification of two human brain aryl sulfotransferase cDNAs
  JOURNAL   Biochem Biophys Res Commun 195 (1), 120-127 (1993)
   PUBMED   8363592
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133555.3.
            
            On Nov 26, 2019 this sequence version replaced NM_001017390.2.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes a phenol sulfotransferase with thermolabile enzyme
            activity. Four sulfotransferase genes are located on the p arm of
            chromosome 16, this gene and SULT1A3 arose from a segmental
            duplication. Read-through transcription exists between this gene
            and the upstream SLX1B (SLX1 structure-specific endonuclease
            subunit homolog B) gene that encodes a protein containing GIY-YIG
            domains. [provided by RefSeq, Nov 2010].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132920.1, SRR14038192.3645752.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360423.12/ ENSP00000353600.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC133555.3         70717-70789         c
            74-225              AC133555.3         69169-69320         c
            226-351             AC133555.3         68939-69064         c
            352-449             AC133555.3         68752-68849         c
            450-576             AC133555.3         67231-67357         c
            577-671             AC133555.3         67041-67135         c
            672-852             AC133555.3         66362-66542         c
            853-1356            AC133555.3         65736-66239         c
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1356
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /note="sulfotransferase family 1A member 4"
                     /db_xref="GeneID:445329"
                     /db_xref="HGNC:HGNC:30004"
                     /db_xref="MIM:615819"
     exon            1..73
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            74..225
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..965
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /EC_number="2.8.2.1"
                     /note="sulfokinase; aryl sulfotransferase 1A3/1A4;
                     placental estrogen sulfotransferase; thermolabile phenol
                     sulfotransferase; sulfotransferase, monoamine-preferring;
                     monoamine-sulfating phenol sulfotransferase;
                     catecholamine-sulfating phenol sulfotransferase;
                     SLX1B-SULT1A4; sulfotransferase family, cytosolic, 1A,
                     phenol-preferring, member 4; Sulfotransferase 1A3"
                     /codon_start=1
                     /product="sulfotransferase 1A4"
                     /protein_id="NP_001017390.1"
                     /db_xref="CCDS:CCDS32427.1"
                     /db_xref="GeneID:445329"
                     /db_xref="HGNC:HGNC:30004"
                     /db_xref="MIM:615819"
                     /translation="MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLIN
                     TYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPP
                     RLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLE
                     KFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEE
                     TMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERF
                     DADYAEKMAGCSLSFRSEL"
     exon            226..351
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            352..449
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            450..576
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            577..671
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            672..852
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1356
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /note="hexamer: AATAAA"
     polyA_site      1356
                     /gene="SULT1A4"
                     /gene_synonym="HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A4;
                     STM; TL-PST"
                     /note="major polyA site"
ORIGIN      
        1 acactcccta caccacaccc atactcagcc cctgcaggca aggagagaac aggtcaggtt
       61 cccgagagct caggaacatg gagctgatcc aggacacctc ccgcccgcca ctggagtacg
      121 tgaagggggt cccgctcatc aagtactttg cagaggcact ggggcccctg cagagcttcc
      181 aagcccgacc tgatgacctg ctcatcaaca cctaccccaa gtctggcacc acctgggtga
      241 gccagatact ggacatgatc taccagggcg gcgacctaga gaagtgtaac cgggctccca
      301 tctacgtacg ggtgcccttc cttgaggtca atgatccagg ggaaccctca gggctggaga
      361 ctctgaaaga cacaccgccc ccacggctca tcaagtcaca cctgcccctg gctctgctcc
      421 ctcagactct gttggatcag aaggtcaagg tggtctatgt tgcccgaaac ccaaaggacg
      481 tggcggtctc ctactaccat ttccaccgta tggaaaaggc gcaccctgag cctgggacct
      541 gggacagctt cctggaaaag ttcatggctg gagaagtgtc ctacgggtcc tggtaccagc
      601 acgtgcagga gtggtgggag ctgagccgca cccaccctgt tctctacctc ttctatgaag
      661 acatgaagga gaaccccaaa agggagattc aaaagatcct ggagtttgtg gggcgctccc
      721 tgccagagga gaccatggac ttcatggttc agcacacgtc gttcaaggag atgaagaaga
      781 accctatgac caactacacc accgtccccc aggagctcat ggaccacagc atctccccct
      841 tcatgaggaa aggcatggct ggggactgga agaccacctt caccgtggcg cagaatgagc
      901 gcttcgatgc ggactatgcg gagaagatgg caggctgcag cctcagcttc cgctctgagc
      961 tgtgagaggg gctcctggag tcactgcaga gggagtgtgc gaatctaccc tgaccaatgg
     1021 gctcaagaat aaagtatgat ttttgagtca ggcacagtgg ctcatgtctg caatcccagc
     1081 gatttgggag gttgagctgg taggatcaca ataggccacg aatttgagac cagcctggta
     1141 aaatagtgag acctcatctc tacaaagatg taaaaaaatt agccacatgt gctggcactt
     1201 acctgtagtc ccagctactt gggaagcaga ggctggagga tcatttcagc ccaggaggtt
     1261 gtggatacag tgagttatga catgcccatt cactacagcc tggatgacaa gcaagaccct
     1321 ccctccaaag aaaataaagc tcaaaataaa atatga
//
