LOCUS       NM_177552               1355 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.
ACCESSION   NM_177552
VERSION     NM_177552.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Toth,D., Dudas,B., Miteva,M.A. and Balog,E.
  TITLE     Role of Conformational Dynamics of Sulfotransferases SULT1A1 and
            SULT1A3 in Substrate Specificity
  JOURNAL   Int J Mol Sci 24 (23), 16900 (2023)
   PUBMED   38069221
  REMARK    GeneRIF: Role of Conformational Dynamics of Sulfotransferases
            SULT1A1 and SULT1A3 in Substrate Specificity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Dou,Y., Pei,S., Li,Y., Wang,M., Liu,Z., Li,J., Cao,J., Qin,J.,
            Zhang,M., Hou,L. and Sun,H.
  TITLE     Farnesoid X receptor represses human sulfotransferase 1A3
            expression through direct binding to the promoter
  JOURNAL   Chem Biol Drug Des 102 (5), 1014-1023 (2023)
   PUBMED   37487659
  REMARK    GeneRIF: Farnesoid X receptor represses human sulfotransferase 1A3
            expression through direct binding to the promoter.
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Idris,M., Mitchell,D.J., Gordon,R., Sidharthan,N.P., Butcher,N.J.
            and Minchin,R.F.
  TITLE     Interaction of the Brain-Selective Sulfotransferase SULT4A1 with
            Other Cytosolic Sulfotransferases: Effects on Protein Expression
            and Function
  JOURNAL   Drug Metab Dispos 48 (5), 337-344 (2020)
   PUBMED   32152050
  REMARK    GeneRIF: Interaction of the Brain-Selective Sulfotransferase
            SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein
            Expression and Function.
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Bairam,A.F., Rasool,M.I., Alherz,F.A., Abunnaja,M.S., El
            Daibani,A.A., Gohal,S.A., Alatwi,E.S., Kurogi,K. and Liu,M.C.
  TITLE     Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of
            phenylephrine and salbutamol by human SULT1A3 allozymes
  JOURNAL   Pharmacogenet Genomics 29 (5), 99-105 (2019)
   PUBMED   31145702
  REMARK    GeneRIF: The results obtained showed clearly the differential
            enzymatic characteristics of SULT1A3 allozymes in mediating the
            sulfation of phenylephrine and salbutamol. This information may
            contribute toward a better understanding of the pharmacokinetics of
            these two drugs in individuals with distinct SULT1A3 and/or SULT1A4
            genotypes.
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Bairam,A.F., Rasool,M.I., Alherz,F.A., Abunnaja,M.S., El
            Daibani,A.A., Kurogi,K. and Liu,M.C.
  TITLE     Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the
            sulfation of acetaminophen and opioid drugs by the cytosolic
            sulfotransferase SULT1A3
  JOURNAL   Arch Biochem Biophys 648, 44-52 (2018)
   PUBMED   29705271
  REMARK    GeneRIF: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on
            the sulfation of acetaminophen and opioid drugs by the cytosolic
            sulfotransferase SULT1A3
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Hildebrandt,M.A., Salavaggione,O.E., Martin,Y.N., Flynn,H.C.,
            Jalal,S., Wieben,E.D. and Weinshilboum,R.M.
  TITLE     Human SULT1A3 pharmacogenetics: gene duplication and functional
            genomic studies
  JOURNAL   Biochem Biophys Res Commun 321 (4), 870-878 (2004)
   PUBMED   15358107
  REMARK    GeneRIF: 2 SULT1A3 genes were present on chromosome 16 in all DNA
            samples studied.
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Jones,A.L., Hagen,M., Coughtrie,M.W., Roberts,R.C. and Glatt,H.
  TITLE     Human platelet phenolsulfotransferases: cDNA cloning, stable
            expression in V79 cells and identification of a novel allelic
            variant of the phenol-sulfating form
  JOURNAL   Biochem Biophys Res Commun 208 (2), 855-862 (1995)
   PUBMED   7695643
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Aksoy,I.A. and Weinshilboum,R.M.
  TITLE     Human thermolabile phenol sulfotransferase gene (STM): molecular
            cloning and structural characterization
  JOURNAL   Biochem Biophys Res Commun 208 (2), 786-795 (1995)
   PUBMED   7695637
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Dooley,T.P., Probst,P., Munroe,P.B., Mole,S.E., Liu,Z. and
            Doggett,N.A.
  TITLE     Genomic organization and DNA sequence of the human
            catecholamine-sulfating phenol sulfotransferase gene (STM)
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1325-1332 (1994)
   PUBMED   7802665
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   Aksoy,I.A., Callen,D.F., Apostolou,S., Her,C. and Weinshilboum,R.M.
  TITLE     Thermolabile phenol sulfotransferase gene (STM): localization to
            human chromosome 16p11.2
  JOURNAL   Genomics 23 (1), 275-277 (1994)
   PUBMED   7829089
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC144355.1 and BC078144.1.
            
            On Nov 26, 2019 this sequence version replaced NM_177552.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes a phenol sulfotransferase with thermolabile enzyme
            activity. Four sulfotransferase genes are located on the p arm of
            chromosome 16; this gene and SULT1A4 arose from a segmental
            duplication. This gene is the most centromeric of the four
            sulfotransferase genes. Read-through transcription exists between
            this gene and the upstream SLX1A (SLX1 structure-specific
            endonuclease subunit homolog A) gene that encodes a protein
            containing GIY-YIG domains. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3063776.1, L25275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338971.10/ ENSP00000343645.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1084              BC144355.1         25-1108
            1085-1355           BC078144.1         1056-1326
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1355
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /note="sulfotransferase family 1A member 3"
                     /db_xref="GeneID:6818"
                     /db_xref="HGNC:HGNC:11455"
                     /db_xref="MIM:600641"
     exon            1..73
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            74..225
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..965
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /EC_number="2.8.2.1"
                     /note="catecholamine-sulfating phenol sulfotransferase;
                     thermolabile (monoamine, M form) phenol sulfotransferase;
                     monoamine-sulfating phenosulfotransferase; placental
                     estrogen sulfotransferase; phenol sulfotransferase 1A5;
                     sulfokinase; dopamine-specific sulfotransferase; aryl
                     sulfotransferase 1A3/1A4; sulfotransferase family,
                     cytosolic, 1A, phenol-preferring, member 3;
                     Sulfotransferase 1A4"
                     /codon_start=1
                     /product="sulfotransferase 1A3"
                     /protein_id="NP_808220.1"
                     /db_xref="CCDS:CCDS10674.1"
                     /db_xref="GeneID:6818"
                     /db_xref="HGNC:HGNC:11455"
                     /db_xref="MIM:600641"
                     /translation="MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLIN
                     TYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPP
                     RLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLE
                     KFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEE
                     TMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERF
                     DADYAEKMAGCSLSFRSEL"
     exon            226..351
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            352..449
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            450..576
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            577..671
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            672..852
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1355
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /note="hexamer: AATAAA"
     polyA_site      1355
                     /gene="SULT1A3"
                     /gene_synonym="HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4;
                     ST1A4; ST1A5; STM; TL-PST"
                     /note="major polyA site"
ORIGIN      
        1 acactcccta caccacaccc atactcagcc cctgcaggca aggagagaac aggtcaggtt
       61 cccgagagct caggaacatg gagctgatcc aggacacctc ccgcccgcca ctggagtacg
      121 tgaagggggt cccgctcatc aagtactttg cagaggcact ggggcccctg cagagcttcc
      181 aagcccgacc tgatgacctg ctcatcaaca cctaccccaa gtctggcacc acctgggtga
      241 gccagatact ggacatgatc taccagggcg gcgacctaga gaagtgtaac cgggctccca
      301 tctacgtacg ggtgcccttc cttgaggtca atgatccagg ggaaccctca gggctggaga
      361 ctctgaaaga cacaccgccc ccacggctca tcaagtcaca cctgcccctg gctctgctcc
      421 ctcagactct gttggatcag aaggtcaagg tggtctatgt tgcccgaaac ccaaaggacg
      481 tggcggtctc ctactaccat ttccaccgta tggaaaaggc gcaccctgag cctgggacct
      541 gggacagctt cctggaaaag ttcatggctg gagaagtgtc ctacgggtcc tggtaccagc
      601 acgtgcagga gtggtgggag ctgagccgca cccaccctgt tctctacctc ttctatgaag
      661 acatgaagga gaaccccaaa agggagattc aaaagatcct ggagtttgtg gggcgctccc
      721 tgccagagga gaccatggac ttcatggttc agcacacgtc gttcaaggag atgaagaaga
      781 accctatgac caactacacc accgtccccc aggagctcat ggaccacagc atctccccct
      841 tcatgaggaa aggcatggct ggggactgga agaccacctt caccgtggcg cagaatgagc
      901 gcttcgatgc ggactatgcg gagaagatgg caggctgcag cctcagcttc cgctctgagc
      961 tgtgagaggg gctcctggag tcactgcaga gggagtgtgc gaatctaccc tgaccaatgg
     1021 gctcaagaat aaagtatgat ttttgagtca ggcacagtgg ctcatgtctg caatcccagc
     1081 gatttgggag gttgagctgg taggatcaca ataggccacg aatttgagac cagcctggta
     1141 aaatagtgag acctcatctc tacaaagatg taaaaaaatt agccacatgt gctggcactt
     1201 acctgtagtc ccagctactt gggaagcaga ggctggagga tcatttcagc ccaggaggtt
     1261 gtggatacag tgagttatga catgcccatt cactacagcc tggatgacaa gcaagaccct
     1321 ccctccaaag aaaataaagc tcaattaaaa taaaa
//
