LOCUS       NM_001054               1031 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sulfotransferase family 1A member 2 (SULT1A2),
            transcript variant 1, mRNA.
ACCESSION   NM_001054
VERSION     NM_001054.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Lv,H.Y., Shi,G., Li,C., Ye,Y.F., Chen,Y.H., Chen,L.H., Tung,T.H.
            and Zhang,M.
  TITLE     Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in
            southern Chinese adults
  JOURNAL   Sci Rep 13 (1), 7256 (2023)
   PUBMED   37142702
  REMARK    GeneRIF: Association of SULT1A2 rs1059491 with obesity and
            dyslipidaemia in southern Chinese adults.
            Erratum:[Sci Rep. 2023 May 31;13(1):8829. doi:
            10.1038/s41598-023-35762-9.. PMID: 37258596]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Monien,B.H., Sachse,B., Meinl,W., Abraham,K., Lampen,A. and
            Glatt,H.
  TITLE     Hemoglobin adducts of furfuryl alcohol in genetically modified
            mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and
            transgenic human sulfotransferases 1A1/1A2
  JOURNAL   Toxicol Lett 295, 173-178 (2018)
   PUBMED   29908303
  REMARK    GeneRIF: Suggest SULT1A1/1A2 play a central role in furfuryl
            alcohol bioactivation and the formation of hemoglobin adducts.
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Shah,I.A., Bhat,G.A., Mehta,P., Lone,M.M. and Dar,N.A.
  TITLE     Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell
            carcinoma of esophagus: outcome of a case-control study from
            Kashmir, India
  JOURNAL   Dis Esophagus 29 (8), 937-943 (2016)
   PUBMED   26455829
  REMARK    GeneRIF: The polymorphism of SULT1A2*2 is not associated with
            esophageal squamous cell carcinoma risk.
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Hui,Y., Luo,L., Zhang,L., Kurogi,K., Zhou,C., Sakakibara,Y.,
            Suiko,M. and Liu,M.C.
  TITLE     Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by
            the human cytosolic sulfotransferases (SULTs): A systematic
            analysis
  JOURNAL   J Pharmacol Sci 128 (3), 144-149 (2015)
   PUBMED   26169578
  REMARK    GeneRIF: It metabolizes breast cancer drugs like afimoxifene and
            endoxifen by sulfation.
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Her,C., Raftogianis,R. and Weinshilboum,R.M.
  TITLE     Human phenol sulfotransferase STP2 gene: molecular cloning,
            structural characterization, and chromosomal localization
  JOURNAL   Genomics 33 (3), 409-420 (1996)
   PUBMED   8661000
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Zhu,X., Veronese,M.E., Iocco,P. and McManus,M.E.
  TITLE     cDNA cloning and expression of a new form of human aryl
            sulfotransferase
  JOURNAL   Int J Biochem Cell Biol 28 (5), 565-571 (1996)
   PUBMED   8697101
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Ozawa,S., Nagata,K., Shimada,M., Ueda,M., Tsuzuki,T., Yamazoe,Y.
            and Kato,R.
  TITLE     Primary structures and properties of two related forms of aryl
            sulfotransferases in human liver
  JOURNAL   Pharmacogenetics 5 Spec No, S135-S140 (1995)
   PUBMED   7581483
REFERENCE   9  (bases 1 to 1031)
  AUTHORS   Yamazoe,Y., Ozawa,S., Nagata,K., Gong,D.W. and Kato,R.
  TITLE     Characterization and expression of hepatic sulfotransferase
            involved in the metabolism of N-substituted aryl compounds
  JOURNAL   Environ Health Perspect 102 Suppl 6 (Suppl 6), 99-103 (1994)
   PUBMED   7889867
REFERENCE   10 (bases 1 to 1031)
  AUTHORS   Yamazoe,Y., Nagata,K., Ozawa,S. and Kato,R.
  TITLE     Structural similarity and diversity of sulfotransferases
  JOURNAL   Chem Biol Interact 92 (1-3), 107-117 (1994)
   PUBMED   8033246
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020765.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001054.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes one of two phenol sulfotransferases with thermostable
            enzyme activity. Two alternatively spliced variants that encode the
            same protein have been described. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U28170.1, U28169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335715.9/ ENSP00000338742.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC020765.8         135464-135517       c
            55-206              AC020765.8         134250-134401       c
            207-332             AC020765.8         134017-134142       c
            333-430             AC020765.8         133834-133931       c
            431-557             AC020765.8         131909-132035       c
            558-652             AC020765.8         131719-131813       c
            653-833             AC020765.8         130730-130910       c
            834-1031            AC020765.8         130410-130607       c
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1031
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /note="sulfotransferase family 1A member 2"
                     /db_xref="GeneID:6799"
                     /db_xref="HGNC:HGNC:11454"
                     /db_xref="MIM:601292"
     exon            1..54
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..206
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..946
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /EC_number="2.8.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phenolic-metabolizing (P) form of PST; arylamine
                     sulfotransferase; phenol-preferring phenol
                     sulfotransferase2; phenol-sulfating phenol
                     sulfotransferase 2; thermostable phenol sulfotransferase;
                     sulfotransferase 1A2; aryl sulfotransferase 2;
                     sulfotransferase family, cytosolic, 1A, phenol-preferring,
                     member 2"
                     /codon_start=1
                     /product="sulfotransferase 1A2 isoform 1"
                     /protein_id="NP_001045.2"
                     /db_xref="CCDS:CCDS10636.1"
                     /db_xref="GeneID:6799"
                     /db_xref="HGNC:HGNC:11454"
                     /db_xref="MIM:601292"
                     /translation="MELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLIS
                     TYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAP
                     RLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLE
                     KFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEE
                     TVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERF
                     DADYAKKMAGCSLSFRSEL"
     exon            207..332
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..430
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..557
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..652
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..833
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1031
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="SULT1A2"
                     /gene_synonym="HAST4; P-PST; P-PST 2; ST1A2; STP2; TSPST2"
                     /note="major polyA site"
ORIGIN      
        1 acactcagcc actgcgggcg aggagggcac aaggccaggt tcccaagagc tcaggaacat
       61 ggagctgatc caggacatct ctcgcccgcc actggagtac gtgaaggggg tcccgctcat
      121 caagtacttt gcagaggcac tggggcccct gcagagcttc caggcccggc ctgatgacct
      181 gctcatcagc acctacccca agtccggcac cacctgggtg agccagattc tggacatgat
      241 ctaccagggc ggtgacctgg aaaagtgtca ccgagctccc atcttcatgc gggtgccctt
      301 ccttgagttc aaagtcccag ggattccctc agggatggag actctgaaaa acacaccagc
      361 cccacgactc ctgaagacac acctgcccct ggctctgctc ccccagactc tgttggatca
      421 gaaggtcaag gtggtctatg ttgcccgcaa cgcaaaggat gtggcggttt cctactacca
      481 cttctaccac atggccaaag tgtaccctca ccctgggacc tgggaaagct tcctggagaa
      541 gttcatggct ggagaagtgt cctatgggtc ctggtaccag cacgtgcaag agtggtggga
      601 gctgagccgc acccaccctg ttctctacct cttctatgaa gacatgaagg agaaccccaa
      661 aagggagatt caaaagatcc tggagtttgt ggggcgctcc ctgccagagg agactgtgga
      721 cctcatggtt gagcacacgt cgttcaagga gatgaagaag aaccctatga ccaactacac
      781 caccgtccgc cgggagttca tggaccacag catctccccc ttcatgagga aaggcatggc
      841 tggggactgg aagaccacct tcaccgtggc gcagaatgag cgcttcgatg cggactatgc
      901 gaagaagatg gcaggctgca gcctcagctt ccgctctgag ctgtgagagg ggttcctgga
      961 gtcactgcag agggagtgtg cgaatcaagc ctgaccaaga ggctccagaa taaagtatga
     1021 tttgtgttca a
//
