LOCUS       NM_177536               1395 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens sulfotransferase family 1A member 1 (SULT1A1),
            transcript variant 5, mRNA.
ACCESSION   NM_177536
VERSION     NM_177536.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Toth,D., Dudas,B., Miteva,M.A. and Balog,E.
  TITLE     Role of Conformational Dynamics of Sulfotransferases SULT1A1 and
            SULT1A3 in Substrate Specificity
  JOURNAL   Int J Mol Sci 24 (23), 16900 (2023)
   PUBMED   38069221
  REMARK    GeneRIF: Role of Conformational Dynamics of Sulfotransferases
            SULT1A1 and SULT1A3 in Substrate Specificity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Dudas,B., Toth,D., Perahia,D., Nicot,A.B., Balog,E. and Miteva,M.A.
  TITLE     Insights into the substrate binding mechanism of SULT1A1 through
            molecular dynamics with excited normal modes simulations
  JOURNAL   Sci Rep 11 (1), 13129 (2021)
   PUBMED   34162941
  REMARK    GeneRIF: Insights into the substrate binding mechanism of SULT1A1
            through molecular dynamics with excited normal modes simulations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Ma,G., Geng,L., Lu,Y., Wei,X. and Yu,H.
  TITLE     Investigating the molecular mechanism of hydroxylated bromdiphenyl
            ethers to inhibit the thyroid hormone sulfotransferase SULT1A1
  JOURNAL   Chemosphere 263, 128353 (2021)
   PUBMED   33297275
  REMARK    GeneRIF: Investigating the molecular mechanism of hydroxylated
            bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase
            SULT1A1.
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Beckmann,J.D., Chodavarapu,S. and Doyle,B.
  TITLE     Evaluation of a conserved tryptophanyl residue in donor substrate
            binding and catalysis by a phenol sulfotransferase (SULT1A1)
  JOURNAL   Arch Biochem Biophys 695, 108621 (2020)
   PUBMED   33049293
  REMARK    GeneRIF: Evaluation of a conserved tryptophanyl residue in donor
            substrate binding and catalysis by a phenol sulfotransferase
            (SULT1A1).
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Jones,A.L., Hagen,M., Coughtrie,M.W., Roberts,R.C. and Glatt,H.
  TITLE     Human platelet phenolsulfotransferases: cDNA cloning, stable
            expression in V79 cells and identification of a novel allelic
            variant of the phenol-sulfating form
  JOURNAL   Biochem Biophys Res Commun 208 (2), 855-862 (1995)
   PUBMED   7695643
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Hwang,S.R., Kohn,A.B. and Hook,V.Y.
  TITLE     Molecular cloning of an isoform of phenol sulfotransferase from
            human brain hippocampus
  JOURNAL   Biochem Biophys Res Commun 207 (2), 701-707 (1995)
   PUBMED   7864863
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Ozawa,S., Nagata,K., Shimada,M., Ueda,M., Tsuzuki,T., Yamazoe,Y.
            and Kato,R.
  TITLE     Primary structures and properties of two related forms of aryl
            sulfotransferases in human liver
  JOURNAL   Pharmacogenetics 5 Spec No, S135-S140 (1995)
   PUBMED   7581483
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Falany,C.N., Zhuang,W. and Falany,J.L.
  TITLE     Characterization of expressed human phenol-sulfating phenol
            sulfotransferase: effect of mutating cys70 on activity and
            thermostability
  JOURNAL   Chem Biol Interact 92 (1-3), 57-66 (1994)
   PUBMED   8033270
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Yamazoe,Y., Nagata,K., Ozawa,S. and Kato,R.
  TITLE     Structural similarity and diversity of sulfotransferases
  JOURNAL   Chem Biol Interact 92 (1-3), 107-117 (1994)
   PUBMED   8033246
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020765.8.
            
            On Apr 21, 2021 this sequence version replaced NM_177536.4.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes one of two phenol sulfotransferases with thermostable
            enzyme activity.  Multiple alternatively spliced variants that
            encode two isoforms have been identified for this gene. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL580215.2, SRR1660805.205110.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC020765.8         161598-161842       c
            246-316             AC020765.8         158530-158600       c
            317-443             AC020765.8         145418-145544       c
            444-538             AC020765.8         145228-145322       c
            539-719             AC020765.8         144523-144703       c
            720-1395            AC020765.8         143725-144400       c
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1395
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="sulfotransferase family 1A member 1"
                     /db_xref="GeneID:6817"
                     /db_xref="HGNC:HGNC:11453"
                     /db_xref="MIM:171150"
     exon            1..245
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..316
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..832
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /EC_number="2.8.2.1"
                     /note="isoform c is encoded by transcript variant 5;
                     thermostable phenol sulfotransferase1; sulfotransferase
                     1A1; aryl sulfotransferase 1; phenol-sulfating phenol
                     sulfotransferase 1; sulfotransferase family, cytosolic,
                     1A, phenol-preferring, member 1"
                     /codon_start=1
                     /product="sulfotransferase 1A1 isoform c"
                     /protein_id="NP_803880.2"
                     /db_xref="GeneID:6817"
                     /db_xref="HGNC:HGNC:11453"
                     /db_xref="MIM:171150"
                     /translation="MSILQGKDDIFLDLKQKFWNTYMVVYVARNAKDVAVSYYHFYHM
                     AKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKRE
                     IQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMA
                     GDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL"
     exon            317..443
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..538
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..719
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1395
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     regulatory      1041..1046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     polyA_site      1051
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="major polyA site"
     regulatory      1065..1070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     polyA_site      1066
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
     polyA_site      1090
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATACA"
     polyA_site      1395
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
ORIGIN      
        1 gtgccgtagc tcgctcgtct ccgccgggga cgtgctgcag caacggctgc agggccgcta
       61 ggccgactgg cgccagacgc ggcgcgtggc cacgttggtg gtgaccttcc acgccaactt
      121 caactacgtg tggctgggcc tgctggagcg cgcgctcccg ggccgagcgc cgcgcgccat
      181 gctggccaag ttgctgtgcg accaggtggt cggtgcgccc atcgcggtct cggccttcta
      241 cgccggtatg agcattctcc agggaaagga tgacatattt ttggacctga aacagaaatt
      301 ctggaacacc tatatggtgg tctatgttgc ccgcaacgca aaggatgtgg cagtttccta
      361 ctaccacttc taccacatgg ccaaggtgca ccctgagcct gggacctggg acagcttcct
      421 ggagaagttc atggtcggag aagtgtccta cggatcctgg taccagcacg tgcaggagtg
      481 gtgggagctg agccgcaccc accctgttct ctacctcttc tatgaagaca tgaaggagaa
      541 cccgaaaagg gagattcaaa agatcctgga gtttgtgggg cgctccctgc cagaggagac
      601 cgtggacttc gtggttcagc acacgtcgtt caaggagatg aagaagaacc ctatgaccaa
      661 ctacaccacc gtcccccagg agttcatgga ccacagcatc tcccccttca tgaggaaagg
      721 catggctggg gactggaaga ccaccttcac cgtggcgcag aatgagcgct tcgatgcgga
      781 ctatgcggag aagatggcag gctgcagcct cagcttccgc tctgagctgt gagaggggct
      841 cctggagtca ctgcagaggg agtgtgcgaa tcaaacctga ccaagcggct caagaataaa
      901 atatgaattg agggcccggg acggtaggtc atgtctgtaa tcccagcaat ttggaggctg
      961 aggtgggagg atcatttgag cccaggagtt cgagaccaac ctgggcaaca tagtgagatt
     1021 ctgttaaaaa aataaaataa aataaaacca atttttaaaa agagaataaa atatgattgt
     1081 gggccaggca gagtggctca tgcctgtaat cccagcaatt tgagaagttg aggctagagg
     1141 atcactggag gacaggagtt tgggaccagc ctgttcaaca ttacaagaca tcatccctac
     1201 aaaaatttga gaaaattatc tgtacgtgat ggtgggcacc tgtagtccca gctacttgac
     1261 aagtgaaggc aggaggatcg cctgagccag ggaggttatg gctgcagtgg gctgactggg
     1321 ctaatccact caagcctgag ggacagagca aatcttgctt gagaaataaa taaaatacaa
     1381 tttacttaac ataaa
//
