LOCUS       NM_001055               1569 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens sulfotransferase family 1A member 1 (SULT1A1),
            transcript variant 1, mRNA.
ACCESSION   NM_001055
VERSION     NM_001055.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Toth,D., Dudas,B., Miteva,M.A. and Balog,E.
  TITLE     Role of Conformational Dynamics of Sulfotransferases SULT1A1 and
            SULT1A3 in Substrate Specificity
  JOURNAL   Int J Mol Sci 24 (23), 16900 (2023)
   PUBMED   38069221
  REMARK    GeneRIF: Role of Conformational Dynamics of Sulfotransferases
            SULT1A1 and SULT1A3 in Substrate Specificity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Dudas,B., Toth,D., Perahia,D., Nicot,A.B., Balog,E. and Miteva,M.A.
  TITLE     Insights into the substrate binding mechanism of SULT1A1 through
            molecular dynamics with excited normal modes simulations
  JOURNAL   Sci Rep 11 (1), 13129 (2021)
   PUBMED   34162941
  REMARK    GeneRIF: Insights into the substrate binding mechanism of SULT1A1
            through molecular dynamics with excited normal modes simulations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Ma,G., Geng,L., Lu,Y., Wei,X. and Yu,H.
  TITLE     Investigating the molecular mechanism of hydroxylated bromdiphenyl
            ethers to inhibit the thyroid hormone sulfotransferase SULT1A1
  JOURNAL   Chemosphere 263, 128353 (2021)
   PUBMED   33297275
  REMARK    GeneRIF: Investigating the molecular mechanism of hydroxylated
            bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase
            SULT1A1.
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Beckmann,J.D., Chodavarapu,S. and Doyle,B.
  TITLE     Evaluation of a conserved tryptophanyl residue in donor substrate
            binding and catalysis by a phenol sulfotransferase (SULT1A1)
  JOURNAL   Arch Biochem Biophys 695, 108621 (2020)
   PUBMED   33049293
  REMARK    GeneRIF: Evaluation of a conserved tryptophanyl residue in donor
            substrate binding and catalysis by a phenol sulfotransferase
            (SULT1A1).
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Jones,A.L., Hagen,M., Coughtrie,M.W., Roberts,R.C. and Glatt,H.
  TITLE     Human platelet phenolsulfotransferases: cDNA cloning, stable
            expression in V79 cells and identification of a novel allelic
            variant of the phenol-sulfating form
  JOURNAL   Biochem Biophys Res Commun 208 (2), 855-862 (1995)
   PUBMED   7695643
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Hwang,S.R., Kohn,A.B. and Hook,V.Y.
  TITLE     Molecular cloning of an isoform of phenol sulfotransferase from
            human brain hippocampus
  JOURNAL   Biochem Biophys Res Commun 207 (2), 701-707 (1995)
   PUBMED   7864863
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Ozawa,S., Nagata,K., Shimada,M., Ueda,M., Tsuzuki,T., Yamazoe,Y.
            and Kato,R.
  TITLE     Primary structures and properties of two related forms of aryl
            sulfotransferases in human liver
  JOURNAL   Pharmacogenetics 5 Spec No, S135-S140 (1995)
   PUBMED   7581483
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Falany,C.N., Zhuang,W. and Falany,J.L.
  TITLE     Characterization of expressed human phenol-sulfating phenol
            sulfotransferase: effect of mutating cys70 on activity and
            thermostability
  JOURNAL   Chem Biol Interact 92 (1-3), 57-66 (1994)
   PUBMED   8033270
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Yamazoe,Y., Nagata,K., Ozawa,S. and Kato,R.
  TITLE     Structural similarity and diversity of sulfotransferases
  JOURNAL   Chem Biol Interact 92 (1-3), 107-117 (1994)
   PUBMED   8033246
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020765.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2021 this sequence version replaced NM_001055.3.
            
            Summary: Sulfotransferase enzymes catalyze the sulfate conjugation
            of many hormones, neurotransmitters, drugs, and xenobiotic
            compounds. These cytosolic enzymes are different in their tissue
            distributions and substrate specificities. The gene structure
            (number and length of exons) is similar among family members. This
            gene encodes one of two phenol sulfotransferases with thermostable
            enzyme activity.  Multiple alternatively spliced variants that
            encode two isoforms have been identified for this gene. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3445629.1, BC000923.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314752.12/ ENSP00000321988.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC020765.8         148398-148511       c
            115-266             AC020765.8         147175-147326       c
            267-392             AC020765.8         146945-147070       c
            393-490             AC020765.8         146758-146855       c
            491-617             AC020765.8         145418-145544       c
            618-712             AC020765.8         145228-145322       c
            713-893             AC020765.8         144523-144703       c
            894-1569            AC020765.8         143725-144400       c
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1569
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="sulfotransferase family 1A member 1"
                     /db_xref="GeneID:6817"
                     /db_xref="HGNC:HGNC:11453"
                     /db_xref="MIM:171150"
     exon            1..114
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..266
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1006
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /EC_number="2.8.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     thermostable phenol sulfotransferase1; sulfotransferase
                     1A1; aryl sulfotransferase 1; phenol-sulfating phenol
                     sulfotransferase 1; sulfotransferase family, cytosolic,
                     1A, phenol-preferring, member 1"
                     /codon_start=1
                     /product="sulfotransferase 1A1 isoform a"
                     /protein_id="NP_001046.2"
                     /db_xref="CCDS:CCDS32420.1"
                     /db_xref="GeneID:6817"
                     /db_xref="HGNC:HGNC:11453"
                     /db_xref="MIM:171150"
                     /translation="MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLIS
                     TYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAP
                     RLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLE
                     KFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEE
                     TVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERF
                     DADYAEKMAGCSLSFRSEL"
     exon            267..392
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..490
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..617
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..712
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..893
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1569
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     polyA_site      1225
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="major polyA site"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATAAA"
     polyA_site      1240
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
     polyA_site      1264
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
                     /note="hexamer: AATACA"
     polyA_site      1569
                     /gene="SULT1A1"
                     /gene_synonym="HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1;
                     ST1A3; STP; STP1; ts-PST; TSPST1"
ORIGIN      
        1 acagtggacc taggaaaccc tcagctcaga gaacaaccct gcattcccca cacaacaccc
       61 acaatcagcc actgcgggcg aggagggcac gaggccaggt tcccaagagc tcaggaacat
      121 ggagctgatc caggacacct cccgcccgcc actggagtac gtgaaggggg tcccgctcat
      181 caagtacttt gcagaggcac tggggcccct gcagagcttc caggcccggc ctgatgacct
      241 gctcatcagc acctacccca agtccggcac tacctgggta agccagattc tggacatgat
      301 ctaccagggt ggtgacctgg agaagtgtca ccgagctccc atcttcatgc gggtgccctt
      361 ccttgagttc aaagccccag ggattccctc agggatggag actctgaaag acacaccggc
      421 cccacgactc ctgaagacac acctgcccct ggctctgctc ccccagactc tgttggatca
      481 gaaggtcaag gtggtctatg ttgcccgcaa cgcaaaggat gtggcagttt cctactacca
      541 cttctaccac atggccaagg tgcaccctga gcctgggacc tgggacagct tcctggagaa
      601 gttcatggtc ggagaagtgt cctacggatc ctggtaccag cacgtgcagg agtggtggga
      661 gctgagccgc acccaccctg ttctctacct cttctatgaa gacatgaagg agaacccgaa
      721 aagggagatt caaaagatcc tggagtttgt ggggcgctcc ctgccagagg agaccgtgga
      781 cttcgtggtt cagcacacgt cgttcaagga gatgaagaag aaccctatga ccaactacac
      841 caccgtcccc caggagttca tggaccacag catctccccc ttcatgagga aaggcatggc
      901 tggggactgg aagaccacct tcaccgtggc gcagaatgag cgcttcgatg cggactatgc
      961 ggagaagatg gcaggctgca gcctcagctt ccgctctgag ctgtgagagg ggctcctgga
     1021 gtcactgcag agggagtgtg cgaatcaaac ctgaccaagc ggctcaagaa taaaatatga
     1081 attgagggcc cgggacggta ggtcatgtct gtaatcccag caatttggag gctgaggtgg
     1141 gaggatcatt tgagcccagg agttcgagac caacctgggc aacatagtga gattctgtta
     1201 aaaaaataaa ataaaataaa accaattttt aaaaagagaa taaaatatga ttgtgggcca
     1261 ggcagagtgg ctcatgcctg taatcccagc aatttgagaa gttgaggcta gaggatcact
     1321 ggaggacagg agtttgggac cagcctgttc aacattacaa gacatcatcc ctacaaaaat
     1381 ttgagaaaat tatctgtacg tgatggtggg cacctgtagt cccagctact tgacaagtga
     1441 aggcaggagg atcgcctgag ccagggaggt tatggctgca gtgggctgac tgggctaatc
     1501 cactcaagcc tgagggacag agcaaatctt gcttgagaaa taaataaaat acaatttact
     1561 taacataaa
//
