LOCUS       NM_001387048            3808 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens sulfatase 2 (SULF2), transcript variant 4, mRNA.
ACCESSION   NM_001387048 XM_005260458
VERSION     NM_001387048.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3808)
  AUTHORS   Panigrahi,A., Benicky,J., Aljuhani,R., Mukherjee,P., Novakova,Z.,
            Barinka,C. and Goldman,R.
  TITLE     Galectin-3-Binding Protein Inhibits Extracellular Heparan
            6-O-Endosulfatase Sulf-2
  JOURNAL   Mol Cell Proteomics 23 (7), 100793 (2024)
   PUBMED   38825040
  REMARK    GeneRIF: Galectin-3-Binding Protein Inhibits Extracellular Heparan
            6-O-Endosulfatase Sulf-2.
REFERENCE   2  (bases 1 to 3808)
  AUTHORS   Siegel,R.J., Singh,A.K., Panipinto,P.M., Shaikh,F.S., Vinh,J.,
            Han,S.U., Kenney,H.M., Schwarz,E.M., Crowson,C.S., Khuder,S.A.,
            Khuder,B.S., Fox,D.A. and Ahmed,S.
  TITLE     Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis
            and mediates the TNF-alpha-induced inflammatory activation of
            synovial fibroblasts
  JOURNAL   Cell Mol Immunol 19 (10), 1185-1195 (2022)
   PUBMED   36068294
  REMARK    GeneRIF: Extracellular sulfatase-2 is overexpressed in rheumatoid
            arthritis and mediates the TNF-alpha-induced inflammatory
            activation of synovial fibroblasts.
REFERENCE   3  (bases 1 to 3808)
  AUTHORS   He,R., Shi,J., Xu,D., Yang,J., Shen,Y., Jiang,Y.S., Tao,L.,
            Yang,M., Fu,X., Yang,J.Y., Liu,D., Huo,Y., Shen,X., Lu,P., Niu,N.,
            Sun,Y.W., Xue,J. and Liu,W.
  TITLE     SULF2 enhances GDF15-SMAD axis to facilitate the initiation and
            progression of pancreatic cancer
  JOURNAL   Cancer Lett 538, 215693 (2022)
   PUBMED   35472437
  REMARK    GeneRIF: SULF2 enhances GDF15-SMAD axis to facilitate the
            initiation and progression of pancreatic cancer.
REFERENCE   4  (bases 1 to 3808)
  AUTHORS   El Masri,R., Seffouh,A., Roelants,C., Seffouh,I., Gout,E.,
            Perard,J., Dalonneau,F., Nishitsuji,K., Noborn,F., Nikpour,M.,
            Larson,G., Cretinon,Y., Friedel-Arboleas,M., Uchimura,K.,
            Daniel,R., Lortat-Jacob,H., Filhol,O. and Vives,R.R.
  TITLE     Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan
            sulfate chain that modulates its enzyme activity
  JOURNAL   Cell Rep 38 (11), 110516 (2022)
   PUBMED   35294879
REFERENCE   5  (bases 1 to 3808)
  AUTHORS   Yang,Y.W., Jablons,D.M. and Lemjabbar-Alaoui,H.
  TITLE     Extracellular sulfatases as potential blood-based biomarkers for
            early detection of lung cancer
  JOURNAL   Exp Lung Res 47 (6), 261-279 (2021)
   PUBMED   33908819
  REMARK    GeneRIF: Extracellular sulfatases as potential blood-based
            biomarkers for early detection of lung cancer.
REFERENCE   6  (bases 1 to 3808)
  AUTHORS   Dai,Y., Yang,Y., MacLeod,V., Yue,X., Rapraeger,A.C., Shriver,Z.,
            Venkataraman,G., Sasisekharan,R. and Sanderson,R.D.
  TITLE     HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth
            in vivo
  JOURNAL   J Biol Chem 280 (48), 40066-40073 (2005)
   PUBMED   16192265
  REMARK    GeneRIF: HSulf-1 and HSulf-2 have roles in inhibiting myeloma tumor
            growth
            GeneRIF: HSulf-1 (SULF1) and HSulf-2 (SULF2) are potent inhibitors
            of myeloma tumor growth in vivo.
REFERENCE   7  (bases 1 to 3808)
  AUTHORS   Morimoto-Tomita,M., Uchimura,K., Bistrup,A., Lum,D.H., Egeblad,M.,
            Boudreau,N., Werb,Z. and Rosen,S.D.
  TITLE     Sulf-2, a proangiogenic heparan sulfate endosulfatase, is
            upregulated in breast cancer
  JOURNAL   Neoplasia 7 (11), 1001-1010 (2005)
   PUBMED   16331886
  REMARK    GeneRIF: Purified recombinant Sulf-2 promoted angiogenesis in the
            chick chorioallantoic membrane assay.
REFERENCE   8  (bases 1 to 3808)
  AUTHORS   Morimoto-Tomita,M., Uchimura,K., Werb,Z., Hemmerich,S. and
            Rosen,S.D.
  TITLE     Cloning and characterization of two extracellular heparin-degrading
            endosulfatases in mice and humans
  JOURNAL   J Biol Chem 277 (51), 49175-49185 (2002)
   PUBMED   12368295
  REMARK    GeneRIF: Sulfs are extracellular endosulfatases with strong
            potential for modulating the interactions of heparan sulfate
            proteoglycans in the extracellular microenvironment
REFERENCE   9  (bases 1 to 3808)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3808)
  AUTHORS   Fossey,S.C., Mychaleckyj,J.C., Pendleton,J.K., Snyder,J.R.,
            Bensen,J.T., Hirakawa,S., Rich,S.S., Freedman,B.I. and Bowden,D.W.
  TITLE     A high-resolution 6.0-megabase transcript map of the type 2
            diabetes susceptibility region on human chromosome 20
  JOURNAL   Genomics 76 (1-3), 45-57 (2001)
   PUBMED   11549316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121777.39, AL354813.31 and AL034418.5.
            
            On Sep 21, 2020 this sequence version replaced XM_005260458.3.
            
            Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors
            for numerous heparin-binding growth factors and cytokines and are
            involved in cell signaling. Heparan sulfate 6-O-endosulfatases,
            such as SULF2, selectively remove 6-O-sulfate groups from heparan
            sulfate. This activity modulates the effects of heparan sulfate by
            altering binding sites for signaling molecules (Dai et al., 2005
            [PubMed 16192265]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2433978.1,
                                           SRR14038195.799779.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688720.1/ ENSP00000508753.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL121777.39        21896-22034         c
            140-414             AL354813.31        86798-87072         c
            415-654             AL354813.31        66312-66551         c
            655-806             AL354813.31        32128-32279         c
            807-976             AL354813.31        19735-19904         c
            977-1127            AL354813.31        14040-14190         c
            1128-1303           AL354813.31        12603-12778         c
            1304-1432           AL354813.31        8285-8413           c
            1433-1489           AL354813.31        6687-6743           c
            1490-1619           AL354813.31        6103-6232           c
            1620-1815           AL354813.31        1807-2002           c
            1816-2044           AL034418.5         82222-82450         c
            2045-2141           AL034418.5         81819-81915         c
            2142-2236           AL034418.5         81161-81255         c
            2237-2296           AL034418.5         80092-80151         c
            2297-2466           AL034418.5         79415-79584         c
            2467-2609           AL034418.5         79032-79174         c
            2610-2733           AL034418.5         77735-77858         c
            2734-2767           AL034418.5         75659-75692         c
            2768-2821           AL034418.5         75361-75414         c
            2822-3808           AL034418.5         73368-74354         c
FEATURES             Location/Qualifiers
     source          1..3808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3808
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /note="sulfatase 2"
                     /db_xref="GeneID:55959"
                     /db_xref="HGNC:HGNC:20392"
                     /db_xref="MIM:610013"
     exon            1..139
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..414
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2852
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /EC_number="3.1.6.1"
                     /EC_number="3.1.6.14"
                     /note="isoform a precursor is encoded by transcript
                     variant 4; extracellular sulfatase SULF-2; arylsulfatase;
                     N-acetylglucosamine-6-sulfatase"
                     /codon_start=1
                     /product="extracellular sulfatase Sulf-2 isoform a
                     precursor"
                     /protein_id="NP_001373977.1"
                     /db_xref="CCDS:CCDS13408.1"
                     /db_xref="GeneID:55959"
                     /db_xref="HGNC:HGNC:20392"
                     /db_xref="MIM:610013"
                     /translation="MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRP
                     NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH
                     NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEW
                     VGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLM
                     VISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFT
                     NMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMP
                     YEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDT
                     ERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAE
                     YQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLGGSRALSNLVPKYYGQGSEACTCDS
                     GDYKLSLAGRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAAQPRNLTKRH
                     WPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAW
                     KDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHRGSSL
                     HPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPF
                     WTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTL
                     DRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRP
                     SSKSLGQLWEGWEG"
     exon            415..654
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..806
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..976
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1127
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1303
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1432
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1489
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1619
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1815
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2044
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2141
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2236
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2296
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2466
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2609
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2733
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2767
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2821
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..3808
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /note="hexamer: AATAAA"
     polyA_site      3546
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
                     /note="major polyA site"
     polyA_site      3808
                     /gene="SULF2"
                     /gene_synonym="HSULF-2"
ORIGIN      
        1 agcagcggca gcggcggcgg cggcggcggc agcggcagcg gcggcgcgga gtcccctgcg
       61 cccagcggcc cggccgggct gcggcagagg cggcggcggc gccccgctcc gggtgaggtt
      121 gccggggccg tgcgcgctga tctgcgagtg aagagggacg agggaaaaga aacaaagcca
      181 cagacgcaac ttgagactcc cgcatcccaa aagaagcacc agatcagcaa aaaaagaaga
      241 tgggcccccc gagcctcgtg ctgtgcttgc tgtccgcaac tgtgttctcc ctgctgggtg
      301 gaagctcggc cttcctgtcg caccaccgcc tgaaaggcag gtttcagagg gaccgcagga
      361 acatccgccc caacatcatc ctggtgctga cggacgacca ggatgtggag ctgggttcca
      421 tgcaggtgat gaacaagacc cggcgcatca tggagcaggg cggggcgcac ttcatcaacg
      481 ccttcgtgac cacacccatg tgctgcccct cacgctcctc catcctcact ggcaagtacg
      541 tccacaacca caacacctac accaacaatg agaactgctc ctcgccctcc tggcaggcac
      601 agcacgagag ccgcaccttt gccgtgtacc tcaatagcac tggctaccgg acagctttct
      661 tcgggaagta tcttaatgaa tacaacggct cctacgtgcc acccggctgg aaggagtggg
      721 tcggactcct taaaaactcc cgcttttata actacacgct gtgtcggaac ggggtgaaag
      781 agaagcacgg ctccgactac tccaaggatt acctcacaga cctcatcacc aatgacagcg
      841 tgagcttctt ccgcacgtcc aagaagatgt acccgcacag gccagtcctc atggtcatca
      901 gccatgcagc cccccacggc cctgaggatt cagccccaca atattcacgc ctcttcccaa
      961 acgcatctca gcacatcacg ccgagctaca actacgcgcc caacccggac aaacactgga
     1021 tcatgcgcta cacggggccc atgaagccca tccacatgga attcaccaac atgctccagc
     1081 ggaagcgctt gcagaccctc atgtcggtgg acgactccat ggagacgatt tacaacatgc
     1141 tggttgagac gggcgagctg gacaacacgt acatcgtata caccgccgac cacggttacc
     1201 acatcggcca gtttggcctg gtgaaaggga aatccatgcc atatgagttt gacatcaggg
     1261 tcccgttcta cgtgaggggc cccaacgtgg aagccggctg tctgaatccc cacatcgtcc
     1321 tcaacattga cctggccccc accatcctgg acattgcagg cctggacata cctgcggata
     1381 tggacgggaa atccatcctc aagctgctgg acacggagcg gccggtgaat cggtttcact
     1441 tgaaaaagaa gatgagggtc tggcgggact ccttcttggt ggagagaggc aagctgctac
     1501 acaagagaga caatgacaag gtggacgccc aggaggagaa ctttctgccc aagtaccagc
     1561 gtgtgaagga cctgtgtcag cgtgctgagt accagacggc gtgtgagcag ctgggacaga
     1621 agtggcagtg tgtggaggac gccacgggga agctgaagct gcataagtgc aagggcccca
     1681 tgcggctggg cggcagcaga gccctctcca acctcgtgcc caagtactac gggcagggca
     1741 gcgaggcctg cacctgtgac agcggggact acaagctcag cctggccgga cgccggaaaa
     1801 aactcttcaa gaagaagtac aaggccagct atgtccgcag tcgctccatc cgctcagtgg
     1861 ccatcgaggt ggacggcagg gtgtaccacg taggcctggg tgatgccgcc cagccccgaa
     1921 acctcaccaa gcggcactgg ccaggggccc ctgaggacca agatgacaag gatggtgggg
     1981 acttcagtgg cactggaggc cttcccgact actcagccgc caaccccatt aaagtgacac
     2041 atcggtgcta catcctagag aacgacacag tccagtgtga cctggacctg tacaagtccc
     2101 tgcaggcctg gaaagaccac aagctgcaca tcgaccacga gattgaaacc ctgcagaaca
     2161 aaattaagaa cctgagggaa gtccgaggtc acctgaagaa aaagcggcca gaagaatgtg
     2221 actgtcacaa aatcagctac cacacccagc acaaaggccg cctcaagcac agaggctcca
     2281 gtctgcatcc tttcaggaag ggcctgcaag agaaggacaa ggtgtggctg ttgcgggagc
     2341 agaagcgcaa gaagaaactc cgcaagctgc tcaagcgcct gcagaacaac gacacgtgca
     2401 gcatgccagg cctcacgtgc ttcacccacg acaaccagca ctggcagacg gcgcctttct
     2461 ggacactggg gcctttctgt gcctgcacca gcgccaacaa taacacgtac tggtgcatga
     2521 ggaccatcaa tgagactcac aatttcctct tctgtgaatt tgcaactggc ttcctagagt
     2581 actttgatct caacacagac ccctaccagc tgatgaatgc agtgaacaca ctggacaggg
     2641 atgtcctcaa ccagctacac gtacagctca tggagctgag gagctgcaag ggttacaagc
     2701 agtgtaaccc ccggactcga aacatggacc tgggacttaa agatggagga agctatgagc
     2761 aatacaggca gtttcagcgt cgaaagtggc cagaaatgaa gagaccttct tccaaatcac
     2821 tgggacaact gtgggaaggc tgggaaggtt aagaaacaac agaggtggac ctccaaaaac
     2881 atagaggcat cacctgactg cacaggcaat gaaaaaccat gtgggtgatt tccagcagac
     2941 ctgtggtatt ggccaggagg cctgagaaag caagcacgca ctctcagtca acatgacaga
     3001 ttctggagga taaccagcag gagcagagat aacttcagga agtccatttt tgcccctgct
     3061 tttgctttgg attatacctc accagctgca caaaatgcat tttttcgtat caaaaagtca
     3121 ccactaaccc tcccccagaa gctcacaaag gaaaacggag agagcgagcg agagagattt
     3181 ccttggaaat ttctcccaag ggcgaaagtc attggaattt ttaaatcata ggggaaaagc
     3241 agtcctgttc taaatcctct tattcttttg gtttgtcaca aagaaggaac taagaagcag
     3301 gacagaggca acgtggagag gctgaaaaca gtgcagagac gtttgacaat gagtcagtag
     3361 cacaaaagag atgacattta cctagcacta taaaccctgg ttgcctctga agaaactgcc
     3421 ttcattgtat atatgtgact atttacatgt aatcaacatg ggaactttta ggggaaccta
     3481 ataagaaatc ccaattttca ggagtggtgg tgtcaataaa cgctctgtgg ccagtgtaaa
     3541 agaaaatccc tcgcagttgt ggacatttct gttcctgtcc agataccatt tctcctagta
     3601 tttctttgtt atgtcccaga actgatgttt tttttttaag gtactgaaaa gaaatgaagt
     3661 tgatgtatgt cccaagtttt gatgaaactg tatttgtaaa aaaaattttg tagtttaagt
     3721 attgtcatac agtgttcaaa accccagcca atgaccagca gttggtatga agaacctttg
     3781 acattttgta aaaggccatt tcttggga
//
