LOCUS       NM_001320831           14289 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens SGT1 homolog, MIS12 kinetochore complex assembly
            cochaperone (SUGT1), transcript variant 3, mRNA.
ACCESSION   NM_001320831 XM_011534892
VERSION     NM_001320831.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14289)
  AUTHORS   Bohush,A., Goral,A., Sierant,M., Nawrot,B., Lesniak,W. and
            Filipek,A.
  TITLE     Sgt1 Regulates alpha-Synuclein Subcellular Localization and
            Expression of Parkinson's Disease Related Genes, PINK1 and PARK9
  JOURNAL   Biomolecules 11 (11), 1675 (2021)
   PUBMED   34827672
  REMARK    GeneRIF: Sgt1 Regulates alpha-Synuclein Subcellular Localization
            and Expression of Parkinson's Disease Related Genes, PINK1 and
            PARK9.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14289)
  AUTHORS   Allouch,A., Di Primio,C., Paoletti,A., Le-Bury,G., Subra,F.,
            Quercioli,V., Nardacci,R., David,A., Saidi,H., Cereseto,A.,
            Ojcius,D.M., Montagnac,G., Niedergang,F., Pancino,G.,
            Saez-Cirion,A., Piacentini,M., Gougeon,M.L., Kroemer,G. and
            Perfettini,J.L.
  TITLE     SUGT1 controls susceptibility to HIV-1 infection by stabilizing
            microtubule plus-ends
  JOURNAL   Cell Death Differ 27 (12), 3243-3257 (2020)
   PUBMED   32514048
  REMARK    GeneRIF: SUGT1 controls susceptibility to HIV-1 infection by
            stabilizing microtubule plus-ends.
REFERENCE   3  (bases 1 to 14289)
  AUTHORS   Filipek,A. and Lesniak,W.
  TITLE     Current view on cellular function of S100A6 and its ligands,
            CacyBP/SIP and Sgt1
  JOURNAL   Postepy Biochem 64 (3), 242-252 (2018)
   PUBMED   30656909
  REMARK    GeneRIF: REVIEW: cellular function of S100A6 and its ligands,
            CacyBP/SIP and Sgt1
            Review article
REFERENCE   4  (bases 1 to 14289)
  AUTHORS   Niikura,Y., Kitagawa,R., Ogi,H. and Kitagawa,K.
  TITLE     SGT1-HSP90 complex is required for CENP-A deposition at centromeres
  JOURNAL   Cell Cycle 16 (18), 1683-1694 (2017)
   PUBMED   28816574
  REMARK    GeneRIF: the SGT1-HSP90 complex contributes to the E3 ligase
            activity of the CUL4A complex that is necessary for CENP-A
            ubiquitylation and CENP-A deposition at the centromere.
REFERENCE   5  (bases 1 to 14289)
  AUTHORS   Steensgaard,P., Garre,M., Muradore,I., Transidico,P., Nigg,E.A.,
            Kitagawa,K., Earnshaw,W.C., Faretta,M. and Musacchio,A.
  TITLE     Sgt1 is required for human kinetochore assembly
  JOURNAL   EMBO Rep 5 (6), 626-631 (2004)
   PUBMED   15133482
REFERENCE   6  (bases 1 to 14289)
  AUTHORS   Lee,Y.T., Jacob,J., Michowski,W., Nowotny,M., Kuznicki,J. and
            Chazin,W.J.
  TITLE     Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the
            tetratricopeptide repeat domain
  JOURNAL   J Biol Chem 279 (16), 16511-16517 (2004)
   PUBMED   14761955
REFERENCE   7  (bases 1 to 14289)
  AUTHORS   Zou,X., Ji,C., Wang,L., Wu,M., Zheng,H., Xu,J., Jin,F., Gu,S.,
            Ying,K., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of SGT1.2, a novel splice
            variant of Homo sapiens SGT1
  JOURNAL   DNA Seq 15 (2), 140-143 (2004)
   PUBMED   15346769
  REMARK    GeneRIF: SGt1.2 is a splicing variant of SGT1 and widely expressed
            in human adult tissue.
REFERENCE   8  (bases 1 to 14289)
  AUTHORS   Niikura,Y. and Kitagawa,K.
  TITLE     Identification of a novel splice variant: human SGT1B (SUGT1B)
  JOURNAL   DNA Seq 14 (6), 436-441 (2003)
   PUBMED   15018354
REFERENCE   9  (bases 1 to 14289)
  AUTHORS   Nowotny,M., Spiechowicz,M., Jastrzebska,B., Filipek,A., Kitagawa,K.
            and Kuznicki,J.
  TITLE     Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and
            other S100 proteins
  JOURNAL   J Biol Chem 278 (29), 26923-26928 (2003)
   PUBMED   12746458
  REMARK    GeneRIF: Sgt1 binds to S100A6 in a calcium-regulated manner
REFERENCE   10 (bases 1 to 14289)
  AUTHORS   Kitagawa,K., Skowyra,D., Elledge,S.J., Harper,J.W. and Hieter,P.
  TITLE     SGT1 encodes an essential component of the yeast kinetochore
            assembly pathway and a novel subunit of the SCF ubiquitin ligase
            complex
  JOURNAL   Mol Cell 4 (1), 21-33 (1999)
   PUBMED   10445024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139089.13.
            
            On Jun 2, 2019 this sequence version replaced NM_001320831.1.
            
            Summary: This gene encodes a highly conserved nuclear protein
            involved in kinetochore function and required for the G1/S and G2/M
            transitions. This protein interacts with heat shock protein 90.
            Alternative splicing results in multiple transcript variants.
            Pseudogenes for this gene have been defined on several different
            chromosomes. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (3) lacks an alternate exon and
            contains an alternate exon in the 5' region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (C) has a distinct N-terminus and is shorter than
            isoform B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.481669.1, AK302363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL139089.13        8419-8541
            124-181             AL139089.13        8629-8686
            182-272             AL139089.13        13115-13205
            273-400             AL139089.13        13682-13809
            401-470             AL139089.13        13982-14051
            471-541             AL139089.13        14762-14832
            542-595             AL139089.13        18232-18285
            596-612             AL139089.13        18679-18695
            613-635             AL139089.13        19618-19640
            636-732             AL139089.13        21220-21316
            733-840             AL139089.13        22395-22502
            841-931             AL139089.13        31813-31903
            932-1113            AL139089.13        35557-35738
            1114-14289          AL139089.13        43317-56492
FEATURES             Location/Qualifiers
     source          1..14289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..14289
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="SGT1 homolog, MIS12 kinetochore complex assembly
                     cochaperone"
                     /db_xref="GeneID:10910"
                     /db_xref="HGNC:HGNC:16987"
                     /db_xref="MIM:604098"
     exon            1..123
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..181
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..272
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..400
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1215
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="isoform C is encoded by transcript variant 3;
                     suppressor of G2 allele of SKP1, S. cerevisiae, homolog
                     of; putative 40-6-3 protein; protein SGT1 homolog; SGT1,
                     suppressor of G2 allele of SKP1"
                     /codon_start=1
                     /product="protein SGT1 homolog isoform C"
                     /protein_id="NP_001307760.1"
                     /db_xref="GeneID:10910"
                     /db_xref="HGNC:HGNC:16987"
                     /db_xref="MIM:604098"
                     /translation="MLSQKEVAVADAKKSLELNPNNSTAMLRKGICEYHEKNYAAALE
                     TFTEGQKLDSADANFSVWIKRCQEAQNGSESEVWTHQSKIKYDWYQTESQVVITLMIK
                     NVQKNDVNVEFSEKELSALVKLPSGEDYNLKLELLHPIIPEQSTFKVLSTKIEIKLKK
                     PEAVRWEKLEGQGDVPTPKQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKNEKLEGD
                     AALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKK
                     Y"
     exon            401..470
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..541
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..595
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..612
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..635
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..732
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..840
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..931
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1113
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..14289
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="major polyA site"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="hexamer: AATACA"
     polyA_site      1673
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="major polyA site"
     regulatory      14112..14117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      14134
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
     regulatory      14269..14274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      14289
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
ORIGIN      
        1 ctccagaagt ttcccccttg ggcggtggtg gaggtggtaa ccgtgatagt agcagctccg
       61 gcggcagcaa cagcgactac gagggatggc ggcggctgca gcaggaactg caacatccca
      121 gaggtttttc cagagcttct cggatgccct aatcgacgag gacccccagg cggcgttaga
      181 ggagctgact aaggctttgg aacagaaacc agatgatgca cagtattatt gtcaaagagc
      241 ttattgtcac attcttcttg ggaattactg tgggaaaaac tgaatacctt gagtaaaatt
      301 acatagaaaa tgttaatgag acaaggaggt gaattttgtg acacagctgt attcattgaa
      361 gagctttaag aaggaagcta aatgttaagc caaaaggaag ttgctgttgc tgatgcaaag
      421 aagtctctag aactcaatcc aaataattcc actgctatgc tgagaaaagg aatatgtgaa
      481 taccatgaaa aaaactatgc tgctgcccta gaaactttta cagaaggaca aaaattagat
      541 agtgcagatg ctaatttcag tgtctggatt aaaaggtgtc aagaagctca gaatggctca
      601 gaatctgagg tgtggactca tcagtcaaaa atcaagtatg actggtatca aacagaatct
      661 caagtagtca ttacacttat gatcaagaat gttcagaaga atgatgtaaa tgtggaattt
      721 tcagaaaaag agttgtctgc tttggttaaa cttccttctg gagaggatta caatttgaaa
      781 ctggaacttc ttcatcctat aataccagaa cagagcacgt ttaaagtact ttcaacaaag
      841 attgaaatta aactgaaaaa gccagaggct gtgagatggg aaaagctaga ggggcaagga
      901 gatgtgccta cgccaaaaca attcgtagca gatgtaaaga acctatatcc atcatcatct
      961 ccttatacaa gaaattggga taaattggtt ggtgagatca aagaagaaga aaagaatgaa
     1021 aagttggagg gagatgcagc tttaaacaga ttatttcagc agatctattc agatggttct
     1081 gatgaagtga aacgtgccat gaacaaatcc tttatggagt cgggtggtac agttttgagt
     1141 accaactggt ctgatgtagg taaaaggaaa gttgaaatca atcctcctga tgatatggaa
     1201 tggaaaaagt actaaataaa ttaatttgct ctcatcgtat tgtgtatatt cacctaatgc
     1261 ccattgtgta ttgatattgc attcttgaat tttgaacact gaatatcttt ttgaaagatt
     1321 atacttcttt acctctttgt gctttagaaa ttattttcct tcaagtgttc aagtctaatg
     1381 aagaatgaag ataacatttt atcacttctg tccttaaagg tttcagacat ggtgaaactg
     1441 aataaagcat gtcatttgct cctagataga ttcattctat ctagttgtgg ggatggagaa
     1501 atctttaatg gtatattttc ggttattgcc ttatttttga tacagtattc tgtcagtaat
     1561 ttattagacc tggcagcttt gggtgagctt agatttttca ccttcagtgt tacattgtgt
     1621 ttgcttttaa aaactgcttt tgaatggagt tgtaaataca atttttctat gaagatgttt
     1681 ggtttattta cctttttctt aagtttttaa tgagaacttt gagaaattat cacagggaat
     1741 tcccatgtag ttcttttaat gggaagaatt tgtaaattta attgcactga gatattttgg
     1801 tcgttacctt gcaagtttct gtataaaaca tagatacctg agttttaaca cactgcaagt
     1861 ttatactaag gataatctgt gaaggtaggg caaagaaggt tctaggaaag cccaactcca
     1921 cttgcttctt ttatcacgac aggattcttg aaattacagc attggtgggt tttttggtat
     1981 tttttttctt tattagaaaa tctctgttgt cacgtcccca tgattacttt ggtttcattg
     2041 gtttatggta actgctgtga gagtaaatta atgtgtatat gtttagtatt tactctgtgc
     2101 ctagaatata tagatatcat gagaatacaa aaaattaaag acatgattat taacttcaaa
     2161 gagcttataa atgtagcagg gaaaaaaaat aacattcatg aaggaactgt ggaaagattg
     2221 aatgctgaac tcggtataaa tacactttag agacaggaaa atgttctgtg attaaaattg
     2281 tttacagtct aggctgttat aaagtataga ctatggatga cctgtagatc tgactttgtt
     2341 ttctcaccat gattttctca actgtaatac cccagatgtt ggtctcagct ctgttaggtg
     2401 tcactaacat ttttatggca aagcactact ctataccctc agagcagggg gagtgggagg
     2461 caaacgggtc atcatttcag cctccaaaac agtaggaatt cagctccttc cttctcgtcc
     2521 tttgttgtgg ggtgtagggg agttactaag gaaagtttca gtaaggtgat accagatggt
     2581 gcccaaacct gttgttatag cttgtttaag cattctagag ttttcacttg tccttctgtc
     2641 cacttagagc tactagatac atttttttct tcttgaacac tgaaggaaaa ggcaaaatta
     2701 agttttggtt ggatggattt ctaaagtttt cttcttagga aaataggata gtgacttttg
     2761 tattctgtat gttaaatttt ctcagtacca ttaatcctaa gatgaagagg aaggctattg
     2821 ctgcagaggc atagttgagg acgtatagca ctataccaga gacaagaatg cttagctcta
     2881 gcaagtcttc tgtcattgac taccttcata atcttcagca ggtttaggcc tttcttagtt
     2941 cctttgtaaa taatccatag agtcttagag ttataattaa aggtccatgg ttctaaatac
     3001 agaagcatat ttttgccgct taactttttc tttcttaaag atgacactat taaaatagct
     3061 gtttctgacc aggtgcagta gctcatgctt gtaatcccag cattttggga ggcggaggtg
     3121 ggcagatcac ctgaggtcag gagttcaaga ccagcctggc caacatggtg aaaccctgtg
     3181 tctactaaaa atgcaaaaat tagctgggtg tagtggcatg cacctgtagt cccagctact
     3241 tgggaggctc aggcagggag aattgcttga accgggaggc agggggtgca gtgagccaag
     3301 atcatgccac tgcactccag cctgggcgac tccatctcaa aaaaaataaa tagctgttta
     3361 aaaaaaaaaa atctggtact atctttagtt ggttttaaag gatatattat ctagaatatg
     3421 cttacccatt ggctagattt gctaagtgtt gtgggatttg ggattttgct ggtctgaagg
     3481 gagtttgtaa aacacatgac tgaaagcatt ataaaacata ccttgtcaaa tacattagat
     3541 tcattatagg tcaagggaat tttgaaaagt aggctagatt gctgcctaag aatcccactc
     3601 taaagtactg ctttgtttaa tcattctaga taatggaagc ttgtaagcct ccagaaagtt
     3661 aaaacaaaaa acttctttct gattaagagc ctcttaactc tatccttatc ctctgctatc
     3721 tcaatgtagc tattaattgt tccctctttg tttctagact ccaattttca tttctcaaat
     3781 tttggttctc agtgctgtta gtattagtag ccttttgttt cttcagaatg tatgtatttt
     3841 tcctcttaaa tgtttccttt cccttttaag gttagtcctg gaatacatgt ttttcttggt
     3901 cttgtagact tcatctcttc tgatttccat aataatttgc accttgatga atccagaatt
     3961 ctcccactgt cttcaaagaa tcttgaatag aataatctgc tttttgaact ctgctatcta
     4021 gtaatctctt tagatatcta taccacaagt ttgaaacatc aaggtcaatt ttgataattt
     4081 cctgtcttat gtcttaatac ccattcagag ttgactgcca actaacaagc tcagccttta
     4141 gcactggcac ttactggcca atctgttttc tgtctatagg gagtgaaatg gaatggagaa
     4201 agaggatggc ttgcattaat aactctagtt tttaaaaaca tttttattcc ttttttaaaa
     4261 atttgtttag agacacggtc ttcttctatc acctaggctg gagtgcagtg gtgcgatcat
     4321 ggctcactgt agcctccaac tcctaggctc aagtaatcct ctttcctcgg cttcccaaag
     4381 tgctgggatt acaggtgtga gtcactgtgc ctggcccaca ttttcattct tggctcactg
     4441 tagccttaat ctttcaggct caaatgattc tcccatctca gcctcccaag tagctgggac
     4501 cacaggcatg catcaccacg actggctaat ttttgtattt tttttgtaga accgggtttc
     4561 accatgtgcc caggctggtc ttgaacttct gggctcaagt tatctacctg cctcagccta
     4621 cccaaagtgc tgggattaca ggagtgagcc accatgccca gttatgaact tcaagtaaat
     4681 atttaaaatg gagatacatc acaatgctat tatgaataat ttagatagaa attttaattt
     4741 agttcagtac ttaaatattt tttggctctt ctttcccact ttacctttct ctattccttc
     4801 ctcagttatc tacatatcag attagattat tgatatctga gatatatcac tgacccagag
     4861 caaaattgca tattagttta ccatctaatc agcctaatgc acttaaattc ccttggaatc
     4921 tttcctgttc agattggtgt gcatctctct gaacttgtag ctttactgac atttccaaaa
     4981 aaaggtagac ggtttctagg tggtgtgtgt ttttgttagt tactagagcc acttaccctt
     5041 tgtaactagc tctaaagaag tacatctttt gctcatacct gctactgtaa ccatatgaca
     5101 gtatggattt aagttatttc tgcctagagg aattagatga taaaagctaa aaggacaaaa
     5161 tactggtttc tgtgcaggga agggtcatat gtagttttaa ataaaagggt tcatctcttt
     5221 tgatgtggtt tccctttctc catctgtgca ttttttaaat cgtaagatca ttttacacac
     5281 accaagagat tttattttgg gaacttgtgg ggaaaatatt gatttaccta caaatgttac
     5341 tatttggagc catccttgtg attggtttct gagattaatt taactcttag cctcacttcc
     5401 taccttagta aagttgctcc tccaaatcag ctaaaatcat atacaatgaa tgctgactca
     5461 ttactgcaaa tagtggtagt tactgtgtac tagcatttct tatggattgg gtggcattat
     5521 ctcattttta atcgcccttc aatagcatcc cattattgca aatcagaaag atgatggggc
     5581 caaagtaaag ttctttgccc aggtcactct actagtaagt aattgcaata gctgggattt
     5641 gaacccaggc ctatcagact ccattaccca tacttctgac aactgcaatc ctctcatcag
     5701 gttaataagc tagatgtgga atgaatgatt tttattacca aatcagctga ctggaaatga
     5761 agcagagaat attcaagtta aagaactaat tctttttttt tttttttttg agacagtctc
     5821 actctgtcgt tcagggaagg aatgcagtgg tgcaatcttg gctcactgca acctccacct
     5881 cccaggttca agtaattctt ctgcctcagc ctcctgagta gctgggatta caggcatggg
     5941 ccgccatgcc cagctaattt ttgtattttt agtagagacg aggtttcacc atgttggtca
     6001 ggctggtctt gaactcctga cctcatgatc cgcccacctt ggcctcccaa aatgctggga
     6061 ttataggcgt gagccactgt gcccagccaa gaactaattc ttatatagga gctgggaaga
     6121 taaattccta gagatcctca ctttcttaag taggaaagct tattaggaat ccaaatcttt
     6181 tgcctcatac tggaagtaat gcaaagaagt agtctgattt ttgagagggt gctgtttttc
     6241 tcaaatctag atcattacag agaaacagtg tacttttaac aactgttgca tgtgtaagaa
     6301 gactggtaca tgatgccaat gaaattcttt ttttccttta acttgggagc tctcatacca
     6361 gttccgttgt acaaatgctg agattgtttc aaggttttat tcctacagac atgttaggat
     6421 ttgtgtatca ctgatttctc caataaaatt tgaatatttc aggttatttc ctttttccta
     6481 acttatgtta gcattttgta tatatatata tatttgaatt ttggcttgtc tggagtctta
     6541 aatatttggt atgccttcac atttggattt ttagttttat ttttacattg agacttctac
     6601 ctatatcatt gactttattt tttcctatga ttaaaggatt cagttataca aaaagatgtt
     6661 tcagaaacac tgctatttac ctaaaggtaa ttttcagttt ctttagaagg agttaggaaa
     6721 atggtcctta atacctatat agggtttttt aaaaaactgt accctataat gcagccacag
     6781 aagatctaaa taataaacaa ttgcgcatac tattaatata tatttagagc ttttgttaag
     6841 tacatgaaaa gacagtattg catagtggtt aaatgcatgg actctgaagc catcctgttt
     6901 gggatcatcc tggctacatt gcttactagc tgtgtgacaa tggatatagg tgcttaatgt
     6961 ctctgtgcct cagtttttgt gtctatgtaa aggagataat aggatccccc tcatgcctca
     7021 tggtcttagt tgaatgaatt catgtaactc cacaggtatc ttaatccaga aggctcaaaa
     7081 tactaatgtt ttgtgtgtgt gtgtgtgtgt gcatgtgcat ctgtatgaca agtgatataa
     7141 aacgtgacct gaatttataa tatgaatagt cacattttgc agcagaaata ttaaatgttt
     7201 aattatagaa tgctagcact gatcctgctg aaattgttac aaaatacagc agttgcccct
     7261 taactgtggc agatacattc caagaccccc agtactgaat gctgtatgta cattttttat
     7321 acatgtatac ttatgataaa gtttataaat taggcacagt aagatattaa taatagaata
     7381 tacaatatac cgcaataaaa cttatgtgaa cagttatttt tggacagcag ttgactgtgg
     7441 gtcactgaaa ttgtggaaag caaaaccatg gataaagggg aactattaat agtctatctg
     7501 tattgcatta tcttctaaaa tccaaaattc tgacttcaaa aactcatctg agggttttgg
     7561 aattgtgtat ctatgtgtgt gaagtgcaaa gagcagtgct tcatgtgaca gataacatca
     7621 gatgatccta ggctggaagg tggaaatcct agagaagatt tttttgtgtt gtaagttcag
     7681 tctttcaaga tgtggaattc tgtctgagga aagtatatca cctagttaac aattgttact
     7741 gtaatttata aaatttgtac tttggagagc ataagaattc atgaaaagtt tttaataatt
     7801 ttacttaaac agagcttaat tatgtaagta ttgtcagcac tttataaaga atcgtaaaat
     7861 aaaatagtgg cagaaaatat aaactagatg tagaatgtta aggaactttc ggaagttctc
     7921 tggttttcat ttcaatttca aagctcaaaa cagaaggtaa aactattagg atttgtgaaa
     7981 aatacaaggt acaaaatcac gcagtttata aaccacagat tgtcttgtta ttcccatcag
     8041 tgaaaagaag ctgatatttg tttgtgtttg tttttgtttt tgtttttgag acggagtctt
     8101 gctctgtcgc ccaggctgga gtgcagtggc gccattttgg ctcactgcaa gctccgcctc
     8161 ccggttcacg ccattctcat gcctcagcct cccaagtagc tgggactaca ggcgtccgcc
     8221 accatgcccg gctaattttt tgtattttta gtagagacaa gagtttcacc gtgttagcca
     8281 ggatggtctc atctcctgat cttgtgaccc gcccgcctcg gcctcccaaa gtgctgggat
     8341 tacaggcgtg agccaccatg cccagcctgc tggtagatgt ttttatgagt taattcatca
     8401 atcttattat tcttgcccca aatgaatcag tgtggagcat atacaagtgt gtagacatta
     8461 atatgggctc actgtcagct gggagttctc acaactacca ctttttactg attatctgtt
     8521 ttctaaactt tttctgtggc ttgaagtgac tgaaagtgaa cacattcata agtaatgagc
     8581 ttaggctgag gatatatatc cagtggggga tgaaacatgc ttaagaaatt gagtgcattt
     8641 cctttattat tgttattatt ttgctatttc aaaacaattg actttaaaaa attatacttc
     8701 accacagaga caggtgttgt tttgtaatgg aaggagtagt aacttatgaa tctagactct
     8761 taaaatccca gttctgatac tttcataatt gtgtgttttg agggcaagtg acttatctga
     8821 acttttttct tttttataac actggatgat aattaaccct caggattgtg aggatttaat
     8881 aactaagtcc tgactcaaat tatgttacca ataaatgcta cttaaatgta aagtccttga
     8941 tttatttttt cccctcagtc ctgtttagtg ttgaaattct tcaaaggagg gtgagtctgg
     9001 catttacctg ctattcaaga gttttcagaa ttcaacccca gccaaaattt ttggccacat
     9061 ctcttgtcac tgctttgctg tgtactaaag ctcccagaca cacaagaatc ttctagtcat
     9121 ggtcaaactt tttctgcaaa gggcacttac agtctattgc atattctttg tttttagtgt
     9181 tcagacatct gctgtttctg aatatgtcgt gtattttcat tcctttttct gcccctcctg
     9241 ggcatctcca gtttcctact gatgtgtcaa aactgagttt gtatgctacc tccaggaaag
     9301 cagtctaatc ttttgcaact ctgttactga cttttgtggc attggattgg gttatttgct
     9361 tatggttgag acatcactgg atcctttgat ggagtcatac caaaaccaca acatgtcatg
     9421 agcatgcttg agagtgctaa tctattcctt gtttgtcaga ccagtacatt acagttggtt
     9481 catttcttcc cccgtgtgac tgagtttctt gagggcgcgg tctagcttcc atctttgtat
     9541 gtgtagcacc tggtacatag agaacaggct cccagaattg gatggatttg ctcatggtct
     9601 tatcactgca cagaatgccc ttattttctt ccattcattc tatgagatct caattaaaat
     9661 gtcagtactc ttgtggaact cccctctcca tgccctctac tgaaatgcat tgccactcta
     9721 gttgtgatgt gggagtgcct tgtttatgcc tctatttatg acaccttcat ggtgtcacat
     9781 gttatagggt tagttgcggc tgtgtctgtt ttaccttgtg tgtcttggtc agttagtgtt
     9841 atttacttaa gctttggatc tttgatacat agcgtagtgc ctttcacata gtatgtactc
     9901 aaatattgga agttactcat cccaaaccat agtgtttaaa attggggttt tttaaaaatg
     9961 tcaagccctt aaagttgatc atttatttgt caatgtaaat agaatagtaa tttgttttca
    10021 aaaagatgag gtcttgctgt ggtgctcagg ctggagtgca gtggctgttc acaggcgtga
    10081 taattgtgtg ttacagcctc aaagtccagg gctcgagtga tcttctcact tcagcctcct
    10141 gagtagctga gactaggcgt gcaccaccgt ttctgacagg attttaattt ttaagtaggt
    10201 ttttaaccca cagccacgag agctaatttt aactacattg ttagaggtag taacagttat
    10261 ataactaatc aaaaccagtg tgatatccaa gtactttttt tttttttttt ttttgctatt
    10321 taattttgag ataccatttt ttggaggggt gtcctgattt attttattta ttttatttat
    10381 ttatttttat tttttatttt tttagataag gtcttgctct tgcccaggct ggaatgtaat
    10441 ggcatggtcg cagctcactg cagcctccgt cttctgggct caagcaatcc tccttcctca
    10501 gcctcctgag tagctgggac tacaggtgtg tgccaccact cccagctaat ttttaaattt
    10561 tgtgtagaga tggggtctcc ctgcattgcc caggttggtc tctcaaactc ctgggttcaa
    10621 gcagtcctcc caccttggcc tcccaaagtg ttgggattat aggcgtaagc cactgtgccc
    10681 ggctgttttt tgttttgttt tgttttgtgt tttaattgaa cggactgaag tttactttct
    10741 aactaggtta gccctccatt catacaaaat tatgagccca aatgtcttgg ggagagtaca
    10801 ggagaggcca gatcttaaaa gccaggagtg gaattaggtt tgagcatatg tagcaatatg
    10861 gaaacaaaga gtgagtcaat ttataagcat accaatcttc ttggagacaa aagtttgaat
    10921 tgctcacgtg tccatttttt ttctggaatc cctgaagaaa ttttgagata ctgagtacta
    10981 gaaaaccctc tttgatgagg gttgtatact ttatttttaa acagtatcaa caccgttgag
    11041 gcccttcaag tctttgcagt caaaagccat acactttttc tttgagtgag cctttacttt
    11101 aaggtatgta gtagaataat ataggtatct gaaaaagaac ttggttcatg acatccactc
    11161 attcatttat gcacttagca aatattcatt gattgccaaa tacgcatcag acactgagct
    11221 aggtgctagg tactaggtaa acaaaattcc ctgccttcat ggagcttagc ttgtggtggt
    11281 ggaaagaagc cctcagcctg aatactcaac ttatgtctgc cgtttattcc ttaacacatt
    11341 aaactatagg taatagcata tgttagtcta atctttgttt agcaaagcta tttcttgttc
    11401 tggaatataa gtacagttac agcagaataa gtaccaaggc aagattggag aatgaccggt
    11461 tgtgaacagg gacttaggaa tatgtgtagc ataggatttt attttagagt tgttaaaatc
    11521 agatcaacag agcatgtttt tatgggccat ctgacaagac tagaggtagc tttggaacct
    11581 cttattccct ggaatgcaaa catgtatttg catttcatcc actgtcagta tgaggagaca
    11641 aaaacgaagt caggattttg gagctggaat ggatcttaaa tactatgtag tccaaacgtt
    11701 tggttttaca gatgcacttt ttccagagtg ctgtcatctc atatactttt ttcttcatac
    11761 aggtttttaa tgtaactcac tcagatcgtt ggtgatagac tctctcttaa aacttattta
    11821 tcctaatctt tttttttttt ttttttttaa gagacagggt tttgctctgc tgtccaggca
    11881 cacaatagct cactgtaacc tccaactcct ggagtcaagt gatcctcctg cctcagcctc
    11941 tcaggtagct gggactgcac tactagtgca ctaagctaat ttttaaattt tttttgtaga
    12001 gacagggtct tgctgtgttg cccgggctgc tctcttaact cctggcctca agtaatcctc
    12061 ttgccttggc ttcccaaagt gctgggatta caggcgtgag ccaccatgct tagctgattt
    12121 gccctaatcc tctgctgaca ttctgatatc ggacaactaa aattataaca ttgggcagct
    12181 attttgtatg atatataggg tagtggttct taagcttatt ggtgagtaac cttcacttgg
    12241 gaagcttatt tttaaaaatg tagaccttca ttactttcct cctgagattt tgaatcagta
    12301 cctttgagag agggtccagt aaatctttgt tttgaatgaa ctgatggttt tgaagcaggt
    12361 gacctggagg actgcatgta gaacacagtg atgtcaagga gtaaaggaga gaacagaagt
    12421 gagattagca ctaatcacct ctaatgcctt atttccagta aagtttagag aagaggaaaa
    12481 gctacttggc ttgctccttt gaaggttttg tttccctctt aacacagaaa ttaaaaggta
    12541 gaggagagat gctgaatgat gctttttttc ttcttaatct tggggggtca ttatgattaa
    12601 gttattgaat ccatatcacc gtatgacagc acatgatgaa agaaaatcaa atgtttgttt
    12661 caatcaaagt gaaacaaaat gagaataact atttgggcaa aacactttta tcactgctaa
    12721 gatattacta gaactgagca gagaaatact cagagagagc catggcatag tactaattaa
    12781 taatggggta ccatttagca actggaatat tctccgatga tgcctgttta attacccata
    12841 ggtgctaagt gaatgttaaa aattacggtg ctggttgagt aggccgagta gaatttgtgt
    12901 tagggcacat cccatggaga tcttttttac tgcttaattt tttggagtta cctcagtaac
    12961 ttaacaggca ggaatatggt tttaatggaa aggaaaccat ttgcctttaa cagcattagt
    13021 cccgctaaga gaaagttttt gcttgtctag tttattacag gtctttgact ttgtcagtat
    13081 atggcaaatt tagtataaaa gatgattaat tatcaaggct gatgaaatat aggcagctga
    13141 aaagaaaatt cttagcaatt cataccttag aaggaaccct gaaggacagg acgccataga
    13201 aatcctgttt ttttaaaaaa gtaatttcaa gtaagtttgc aaatgcaatg ctagtaaaaa
    13261 gtatatagag gtatgtcttt cacactatct tgttactatt agaatttttg tagccatgtg
    13321 cagaggagag aaaaggtgtt ggattttctg cagttctgat tcagttctaa gaatttggtg
    13381 tgaaaagaat gtttgcaaag gagcaggcac aaaggtgaga acaggaatac gaaacacaac
    13441 atctgtaaat gactaaattc agagggaatt tagtggggca tatctcttaa atggttttga
    13501 ataatttggt gttttaacca atgacttaat ttaacttagt gggtatactg ttcccagtcc
    13561 cattactgat ttttattcct ctgtgataac atacacccaa ataaagactg ctatgtattt
    13621 gactttaaaa ctataaagat gtaaaaaagg ttcactaagc caaacacctt agaaaatagc
    13681 ctcagctatt tgctatgttt atattatacc tgcataaaag tatttatgta tagatgtact
    13741 taccttacac agtaagtacc taaaatttgt aaattgaata cttttgaatg taagcagttg
    13801 aagtaaaacc tgtagtgagt tcttcagtca gtcaacacta aacctgtttt gtaaatttga
    13861 tgctagtatt atactggact ttctcaaaat gaagtacacc tatatatgca tatagtatat
    13921 gagcatgtgt atttgtacaa aagcccttca aaaggagttc agcttttata aacaccaaaa
    13981 cactctctgc ctgtaaaatg tttttgctga aatttgtatc attaactctc aaatttacat
    14041 cttcatgttt gagatacgct tttaggactg tctatgcatg tagactttgg tcaactctct
    14101 cctcctccct caataaatca gttaacttaa aaaatatatt gtgaccattt ttataaaata
    14161 catgttcata aaacagatca acatatttag cttatacaga aataaaatta agtcaatcca
    14221 ctcacaaaga atttctattt tgtaaaaatg tagcttgtat ttcagtataa taaaatctga
    14281 tgtaagaaa
//
