LOCUS       NM_001017392            6189 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SURP and G-patch domain containing 2 (SUGP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001017392
VERSION     NM_001017392.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6189)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 6189)
  AUTHORS   Sampson,N.D. and Hewitt,J.E.
  TITLE     SF4 and SFRS14, two related putative splicing factors on human
            chromosome 19p13.11
  JOURNAL   Gene 305 (1), 91-100 (2003)
   PUBMED   12594045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC335817.1, BX647813.1,
            AL832488.1, AC004447.1 and BG166266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001017392.4.
            
            Summary: This gene encodes a member of the arginine/serine-rich
            family of splicing factors. The encoded protein functions in mRNA
            processing. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1). Variants 1-4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.237642.1, BX647813.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452918.7/ ENSP00000389380.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DC335817.1         55-72
            19-707              BX647813.1         2-690
            708-887             AL832488.1         682-861
            888-4714            BX647813.1         871-4697
            4715-6182           AC004447.1         14994-16461         c
            6183-6189           BG166266.1         363-369
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..6189
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /note="SURP and G-patch domain containing 2"
                     /db_xref="GeneID:10147"
                     /db_xref="HGNC:HGNC:18641"
                     /db_xref="MIM:607993"
     exon            1..81
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            82..213
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3341
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 14; SURP and G-patch
                     domain-containing protein 2; arginine/serine-rich-splicing
                     factor 14"
                     /codon_start=1
                     /product="SURP and G-patch domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001017392.2"
                     /db_xref="CCDS:CCDS12392.1"
                     /db_xref="GeneID:10147"
                     /db_xref="HGNC:HGNC:18641"
                     /db_xref="MIM:607993"
                     /translation="MAARRITQETFDAVLQEKAKRYHMDASGEAVSETLQFKAQDLLR
                     AVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSY
                     FRKECGRDLEFSHSDSRDQVIGHRKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQ
                     EYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRALNI
                     VDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTP
                     SPDVTLGTNPGTEDIQFPIQKIPLGLDLKNLRLPRRKMSFDIIDKSDVFSRFGIEIIK
                     WAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSA
                     LKTPRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAY
                     ELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEAVGLQDIA
                     PSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEI
                     QAKAPSSLSDAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENS
                     LEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRGL
                     LRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPD
                     PVGPSPQDPSLEASGPSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQV
                     GPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFELCPSICFTSSPHNLHTGGGD
                     TTGSQESPVDLMEGEAEFEDEPPPREAELESPEVMPEEEDEDDEDGGEEAPAPGGAGK
                     SEGSTPADGLPGEAAEDDLAGAPALSQASSGTCFPRKRISSKSLKVGMIPAPKRVCLI
                     QEPKVHEPVRIAYDRPRGRPMSKKKKPKDLDFAQQKLTDKNLGFQMLQKMGWKEGHGL
                     GSLGKGIREPVSVGTPSEGEGLGADGQEHKEDTFDVFRQRMMQMYRHKRANK"
     exon            214..1821
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1942
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2430
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2542
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..3021
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3083
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3220
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3341
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..6189
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6169..6174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /note="hexamer: AATAAA"
     polyA_site      6189
                     /gene="SUGP2"
                     /gene_synonym="SFRS14; SRFS14"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgcct cgcgcggcgg cggcggcggg tgaggagcct gaggcggcgg cgggggtggc
       61 tccgcgcgcg gtggtctcgg gggcaaaata acatggcagc cagacgaatt acacaggaga
      121 cttttgatgc tgtattacaa gaaaaagcca aacgatatca catggatgcc agtggtgagg
      181 ctgtaagcga aactcttcag tttaaagctc aagatctctt aagggcagtc ccaagatcca
      241 gagcagagat gtatgatgac gtccacagcg atggcagata ctccctcagt ggatctgtag
      301 ctcactctag agatgccgga agagaaggcc tgagaagtga cgtatttcca gggccttcct
      361 tcagatcaag caacccttcc atcagtgatg acagctactt tcgcaaagaa tgtggccggg
      421 atctggaatt ttctcactct gattctcggg accaggtcat tggccaccgg aaattggggc
      481 atttccgttc tcaggactgg aaatttgcgc tccgtggttc ttgggaacaa gactttggcc
      541 atccagtttc tcaagagtcc tcttggtcac aggagtatag ttttggtccc tctgcagttt
      601 tgggggactt tggatcttcc aggctgattg agaaagagtg tttggagaag gagagtcggg
      661 attatgacgt ggaccatcct ggggaggctg actctgtgct taggggcggc agtcaagtcc
      721 aggccagagg tcgagctcta aacatcgttg accaggaagg ttccctccta ggaaaggggg
      781 agactcaggg cctgctcaca gctaaggggg gtgttgggaa acttgtcaca ttgagaaatg
      841 tgagcacaaa aaaaataccc accgtgaatc gtattactcc caaaactcag ggcactaacc
      901 aaatccagaa aaacactcca agtcctgatg tgaccctggg gacaaaccca gggacagaag
      961 atatccagtt ccccattcag aagatccctc tggggctgga tctgaagaat cttcggctcc
     1021 ccagaagaaa gatgagcttt gacatcatag ataagtctga tgttttttca agatttggga
     1081 tagaaataat caaatgggca ggattccaca ccataaaaga tgatattaaa ttttcccaac
     1141 ttttccagac tctctttgaa cttgaaacag aaacctgtgc taaaatgctt gcctcattca
     1201 aatgttcctt aaaaccagag cacagagatt tttgcttttt tactatcaaa tttttaaagc
     1261 actctgcttt gaaaacaccc agagttgata atgagttttt aaacatgctt ttagacaaag
     1321 gtgctgtgaa gaccaaaaat tgcttttttg aaatcataaa gccttttgac aagtacataa
     1381 tgagacttca agaccggctt ctgaagagtg tcacaccttt gcttatggcc tgcaatgcct
     1441 acgagctaag tgtcaagatg aagaccctca gtaaccccct ggacttggct cttgccctag
     1501 aaaccaccaa ctctctctgc cggaagtctt tggccctttt gggacagaca ttttccttgg
     1561 cctcttcttt ccggcaggag aaaatcttag aagctgtcgg cctgcaagat atagctccct
     1621 cacctgctgc gtttccaaac ttcgaagact ccactttgtt tgggcgagag tacatagacc
     1681 acctgaaggc ctggctagtc agcagcggat gtcccctcca ggttaagaaa gccgaaccag
     1741 agccgatgcg agaggaggag aaaatgattc ctcctacgaa acctgaaatt caggccaagg
     1801 ctccaagtag tctgagtgat gctgtccccc agcgagcaga tcacagggta gtgggcacca
     1861 tcgaccagct tgtgaaacgt gtcatcgaag gcagcctgtc tcccaaagag agaactcttc
     1921 tcaaagagga ccctgcttac tggtttttgt ctgatgaaaa tagtctggag tataaatatt
     1981 acaagctgaa gttggcagaa atgcagcgga tgagcgagaa cttgcgagga gccgaccaga
     2041 agccgacctc agcagactgt gcagtgaggg ccatgctgta ctcccgggct gtccgcaacc
     2101 tcaagaagaa actccttccg tggcagcggc gggggctcct ccgtgctcaa gggctccggg
     2161 gctggaaggc gaggagagcg accaccggga cccagaccct cctatcctca ggcaccaggc
     2221 tgaaacacca cggccggcag gctccaggcc tctcacaggc aaaaccatcc ctgccagaca
     2281 gaaatgatgc tgccaaggac tgcccgccag acccagttgg accttctcct caggacccca
     2341 gcttagaagc ctcaggccca tcccccaagc cagcaggagt ggacatctct gaagcacctc
     2401 agacctcttc tccctgccca tctgctgaca ttgacatgaa gacaatggag actgcagaga
     2461 aactggctag atttgttgct caggtgggac cagagatcga acaattcagc atagaaaaca
     2521 gcaccgataa ccctgacctg tggtttctac atgaccaaaa tagttctgct ttcaaattct
     2581 atcgaaagaa agtgtttgaa ctatgtccat caatttgttt cacgtcatct ccgcacaacc
     2641 ttcacactgg tggtggtgac accacgggtt ctcaggagag ccccgtggac ctcatggaag
     2701 gggaagcaga gtttgaagac gagccccctc cgcgggaggc tgagctggag agcccagagg
     2761 tgatgcctga ggaggaggac gaggacgatg aggatggggg agaggaggcc cccgctcctg
     2821 gaggggcggg caagtctgag ggcagcaccc ctgccgacgg ccttcccggc gaggctgccg
     2881 aggacgacct ggctggagca cctgccttgt cacaggcctc ctcaggtacc tgcttccctc
     2941 ggaagaggat cagcagcaag tcattgaagg ttggcatgat tccagctccc aagagagtgt
     3001 gtctcatcca ggagccaaaa gtccatgaac cagttcgaat tgcctatgac aggcctcggg
     3061 gtcgtcccat gtccaaaaag aagaaaccca aggacttgga cttcgcccag cagaagctga
     3121 ccgataagaa cctgggcttc cagatgctgc agaagatggg ctggaaggag ggccatggcc
     3181 tgggctccct cggaaagggc atcagggagc cggtcagcgt gggaaccccc tcggaagggg
     3241 aagggttggg tgctgacggg caggagcaca aagaagacac attcgatgtg ttccgacaga
     3301 ggatgatgca gatgtacaga cacaagcggg ccaacaaata gatcaaaacc actgatgtga
     3361 aagataagcc ttgaagcagc aattgccctt aaaacatcat ccctgccctg gatcggcctg
     3421 gagccagtgc ccaagtacgg tttggtgtgt acatgaaaac aaacgtctct gcagtctctg
     3481 gggcggaggt ttcgctggct tttctttctc tcaaagaaaa aaacatgcac cattttcaat
     3541 gtgcttttgc ctctcctctc tgttcacatg cttttagcag caagtcccct ccaaatctgt
     3601 cttggttccc cttcagaagg tggcgctgcc cccgaaaggc acctcagcct gtgagtgctg
     3661 aggaaccagc tcctctggct gattttccag ttggactggc cattgctctc cagaagtgct
     3721 ctgttagcaa acgtgatgtg gaaacgatca cagatggtgt tttctcgttg ttcgccagaa
     3781 tttatacggg ggagacaaat tcccggtaat taccaagtct gcactcgggt accaaagctc
     3841 tgaagctctc tgaacagttg ccatacttga gttgatgaat gtgttattca tggtgtctca
     3901 tctcatcaat gcatcttgag agacttaatg aaattttagc aacagtatag aatagctcta
     3961 tcgggtgggg agtaatcatt aaacagatga aatcggcccc agatttacat gtctctttag
     4021 aatccacagt gtaagcaaac tacagttaca aagggatggg ggttgtaaac cctctgagac
     4081 tctgcacttt tcgcacgtat ggcatcgtca agtgctgtct tattacagcc tttgtaagga
     4141 gaggcaggct cctcctgggg tgggctctgc agctgctcta tttccaggca tgtgatcgcc
     4201 cccgctctcc agattcccca gcactctgct gcgtgtaact ccactcaatt ctccactcat
     4261 ccttccttgt gaagcaggat cgttgaagtt ttaagtatgg gcaaaaatct ggaaaactta
     4321 ggatccctct gacaccccag gattagggga cacagcagtg gctagggcat cagccacaga
     4381 actgagcggg aaatgccact tgtattggct gtaaagaaat cctggctttg ggccaggcac
     4441 agtggctcaa gcctgtaatc ccagcacttt aggaggttga ggcggatgga tcacctgagg
     4501 tcaggagttt gagaccagcc tggccaacat ggtgtaaccc cgtctctact aaaaatacaa
     4561 aaaaattagc caggcgtggt agcgggcacc tgtaatccca gctactcagg aggctgaggc
     4621 aggagaatca cttgaaccgg ggaggcagag gttgcagtga gctgagatca tgccactcca
     4681 ctccagcctg ggcgacagag caagactcca tctccaaaaa aaaaaaaaaa aaaggccggc
     4741 acggtgactc acgcctataa ttccagcact ttgggaggcc gaggcaggtg gatcacgagg
     4801 tcaagagatc gagaccatcc tggccaacat ggtgaaaccc tgtctctact aaaaatgcaa
     4861 aaaattagct gggcgtggtg gcgggcgctt gtagtcccag ctactcagga ggctgaggca
     4921 ggagaatcac ttgaacccgg gaggcggagg ttgcagtgag ccgagattgt gccaccgcac
     4981 tccagcctgg caacagagcg agactctgtc tcaaaaaaaa aaaaggaaat cctggctttc
     5041 tttaagccac agacttccta ggctgtggtc ccagctcctt gtctgcctgg tccctgtcac
     5101 cttgcagtgc caccaccccc aggggctctg cttgcttcca gtggcttctg tagctttggc
     5161 aactggcaga tctttatggc agtagaggtg ccagcatgga ggatggagtt tgggtttata
     5221 acccaaccct cgaacgaacc agcctgtggg ggcctggagt ggagctggtt ttggggagtc
     5281 acaggtgcgg ggggttcatc ttctcctttc tccttctcct ttcctgaccc ctccgacagc
     5341 ttccatgttg gccatgggtc aggtgaatgg atggagctcc aagcggggct cagcccattg
     5401 acccgagcga ggcgcacaca cctgcagcgt ggatcaagcg cactctctcc agcatcgccc
     5461 tgaccattcc atgtgctttg tcctagcatg ttcattcttg actttctcca cttcatttta
     5521 ttaaaaagtt aaatgcttta ggaatctgtg gcgtgtggcc actgaccgcc ccccacctcc
     5581 tgccgctcct ccaagtttga gctgagatgg ttctgtgagt ccttggcagg ggtcaaaggg
     5641 cacatctcct tgaacctaga aagcccccta cactctcaga ggacacctct cctgtggatt
     5701 cagcgctggg gcagtgaagg tgtcgggagc cagcagagca tggtgcgtgc tgccagctgc
     5761 cggccagccg ggatagagga gatgccactg gccctccgtg cccccagccc ctccctctta
     5821 accgaggctg tccttgctct ctgcagaggc cgctctgcag gatcctcgtg tcgcgcgtga
     5881 tgtgtggtgg cacagccgtg tcaaagtcac agtgtctttt ctgtcgttct agttccaggg
     5941 tcacccccga gaggacaaca ggcatctgga agtgctctct cgccactctg ggtgctttac
     6001 tgtctctggc ttgtttccat cactggaaat cacttagaga attgtagtgt ttttggtcct
     6061 tgataaagcc tagaagacat ttgtgatgtt acaaaatgga agttttcttt tgtttctgtt
     6121 ttttaagatc taagaagttg tgaatgttgt taatcattta gccgttgcaa taaatgtaga
     6181 ggaaatgca
//
