LOCUS       NM_172231               2566 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SURP and G-patch domain containing 1 (SUGP1), mRNA.
ACCESSION   NM_172231
VERSION     NM_172231.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Feng,Q., Krick,K., Chu,J. and Burge,C.B.
  TITLE     Splicing quality control mediated by DHX15 and its G-patch
            activator SUGP1
  JOURNAL   Cell Rep 42 (10), 113223 (2023)
   PUBMED   37805921
  REMARK    GeneRIF: Splicing quality control mediated by DHX15 and its G-patch
            activator SUGP1.
REFERENCE   3  (bases 1 to 2566)
  AUTHORS   Zhang,J., Huang,J., Xu,K., Xing,P., Huang,Y., Liu,Z., Tong,L. and
            Manley,J.L.
  TITLE     DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1
            in cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (49), e2216712119 (2022)
   PUBMED   36459648
  REMARK    GeneRIF: DHX15 is involved in SUGP1-mediated RNA missplicing by
            mutant SF3B1 in cancer.
REFERENCE   4  (bases 1 to 2566)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2566)
  AUTHORS   Alsafadi,S., Dayot,S., Tarin,M., Houy,A., Bellanger,D.,
            Cornella,M., Wassef,M., Waterfall,J.J., Lehnert,E., Roman-Roman,S.,
            Stern,M.H. and Popova,T.
  TITLE     Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in
            lung adenocarcinoma and other cancers
  JOURNAL   Oncogene 40 (1), 85-96 (2021)
   PUBMED   33057152
  REMARK    GeneRIF: Genetic alterations of SUGP1 mimic mutant-SF3B1 splice
            pattern in lung adenocarcinoma and other cancers.
REFERENCE   6  (bases 1 to 2566)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
REFERENCE   7  (bases 1 to 2566)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   8  (bases 1 to 2566)
  AUTHORS   Sampson,N.D. and Hewitt,J.E.
  TITLE     SF4 and SFRS14, two related putative splicing factors on human
            chromosome 19p13.11
  JOURNAL   Gene 305 (1), 91-100 (2003)
   PUBMED   12594045
REFERENCE   9  (bases 1 to 2566)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
REFERENCE   10 (bases 1 to 2566)
  AUTHORS   Rappsilber,J., Ryder,U., Lamond,A.I. and Mann,M.
  TITLE     Large-scale proteomic analysis of the human spliceosome
  JOURNAL   Genome Res 12 (8), 1231-1245 (2002)
   PUBMED   12176931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC363162.1, AY072917.1 and AC003967.2.
            
            On Nov 22, 2018 this sequence version replaced NM_172231.3.
            
            Summary: SF4 is a member of the SURP family of splicing
            factors.[supplied by OMIM, Sep 2003].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142988.1, AK292085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247001.10/ ENSP00000247001.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DC363162.1         4-20
            18-2086             AY072917.1         1-2069
            2087-2566           AC003967.2         21312-21791         c
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2566
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /note="SURP and G-patch domain containing 1"
                     /db_xref="GeneID:57794"
                     /db_xref="HGNC:HGNC:18643"
                     /db_xref="MIM:607992"
     exon            1..47
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1951
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /note="splicing factor 4; RNA-binding protein RBP"
                     /codon_start=1
                     /product="SURP and G-patch domain-containing protein 1"
                     /protein_id="NP_757386.2"
                     /db_xref="CCDS:CCDS12399.1"
                     /db_xref="GeneID:57794"
                     /db_xref="HGNC:HGNC:18643"
                     /db_xref="MIM:607992"
                     /translation="MSLKMDNRDVAGKANRWFGVAPPKSGKMNMNILHQEELIAQKKR
                     EIEAKMEQKAKQNQVASPQPPHPGEITNAHNSSCISNKFANDGSFLQQFLKLQKAQTS
                     TDAPTSAPSAPPSTPTPSAGKRSLLISRRTGLGLASLPGPVKSYSHAKQLPVAHRPSV
                     FQSPDEDEEEDYEQWLEIKVSPPEGAETRKVIEKLARFVAEGGPELEKVAMEDYKDNP
                     AFAFLHDKNSREFLYYRKKVAEIRKEAQKSQAASQKVSPPEDEEVKNLAEKLARFIAD
                     GGPEVETIALQNNRENQAFSFLYEPNSQGYKYYRQKLEEFRKAKASSTGSFTAPDPGL
                     KRKSPPEALSGSLPPATTCPASSTPAPTIIPAPAAPGKPASAATVKRKRKSRWGPEED
                     KVELPPAELVQRDVDASPSPLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQE
                     MQQMYDMIMQHKRAMQDMQLLWEKAVQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKT
                     REWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVENIG
                     YQMLMKMGWKEGEGLGSEGQGIKNPVNKGTTTVDGAGFGIDRPAELSKEDDEYEAFRK
                     RMMLAYRFRPNPLNNPRRPYY"
     exon            48..219
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            220..323
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            324..551
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..776
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..900
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1256
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1363
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1541
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1648
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1794
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1924
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2566
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /note="major polyA site"
     regulatory      2543..2548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
                     /note="hexamer: AATAAA"
     polyA_site      2566
                     /gene="SUGP1"
                     /gene_synonym="F23858; RBP; SF4"
ORIGIN      
        1 attgtgggat tggatgagtc tcaagatgga caaccgggat gttgcaggaa aggctaaccg
       61 gtggtttggg gttgctcccc ctaaatctgg aaaaatgaac atgaacatcc ttcaccagga
      121 agagctcatc gctcagaaga aacgggaaat tgaagccaaa atggaacaga aagccaagca
      181 gaatcaggtg gccagccctc agcccccaca tcctggcgaa atcacaaatg cacacaactc
      241 ttcctgcatt tccaacaagt ttgccaacga tggtagcttc ttgcagcagt ttctgaagtt
      301 gcagaaggca cagaccagca cagacgcccc gaccagtgcg cccagcgccc ctcccagcac
      361 acccaccccc agcgctggga agaggtccct gctcatcagc aggcggacag gcctggggct
      421 ggccagcctg ccgggccctg tgaagagcta ctcccacgcc aagcagctgc ccgtggcgca
      481 ccgcccgagt gtcttccagt cccctgacga ggacgaggag gaggactatg agcagtggct
      541 ggagatcaaa gtttcacccc cagagggagc cgagactcgg aaagtgatag agaaattggc
      601 ccgctttgtg gcagaaggag gccccgagtt agaaaaagta gctatggagg actacaagga
      661 taacccagca tttgcatttt tgcacgataa gaatagcagg gaattcctct actacaggaa
      721 gaaggtggct gagataagaa aggaagcaca gaagtcgcag gcagcctctc agaaagtttc
      781 acccccagag gacgaagagg tcaagaacct tgcagaaaag ttggccaggt tcatagcgga
      841 cgggggtccc gaggtggaaa ccattgccct ccagaacaac cgtgagaacc aggcattcag
      901 ctttctgtat gagcccaata gccaagggta caagtactac cgacagaagc tggaggagtt
      961 ccggaaagcc aaggccagct ccacaggcag cttcacagca cctgatcccg gcctgaagcg
     1021 caagtcccct cctgaggccc tgtcagggtc cttaccccca gccaccacct gccccgcctc
     1081 gtccacgcct gcgcccacta tcatccctgc tccagctgcc cccgggaagc cagcctccgc
     1141 agccaccgtg aagaggaagc ggaagagccg gtgggggcct gaagaggata aggtagagct
     1201 cccacctgct gaactggtgc agagggacgt ggatgcctct ccctcgcctc tgtcagttca
     1261 ggacctcaag gggctcggct atgagaaggg gaagcctgtg ggtctagtgg gcgtcacaga
     1321 gctttcagac gcccagaaga agcagctgaa ggagcagcag gagatgcagc agatgtacga
     1381 catgatcatg cagcacaagc gggccatgca ggacatgcag ctgctgtggg agaaggcagt
     1441 ccaacagcac cagcacggct atgacagtga tgaggaggtg gacagcgagc tgggcacctg
     1501 ggagcaccag ctgcggcgca tggagatgga taagaccagg gaatgggccg agcagctgac
     1561 aaagatgggc cggggcaagc acttcatcgg agacttcctg cctccagacg agctggaaaa
     1621 gtttatggag accttcaagg ccctgaagga gggccgtgag cctgactact cagagtacaa
     1681 ggagttcaag ctgactgtgg agaacatcgg ctaccagatg ctgatgaaga tgggctggaa
     1741 ggagggcgag gggctgggct cagagggcca gggcatcaag aacccagtga acaagggcac
     1801 caccacagtg gacggcgctg gcttcggcat tgaccggccg gcggagctct ccaaggagga
     1861 cgacgagtat gaggcgttcc gcaagaggat gatgctggcc taccgcttcc ggcccaaccc
     1921 cctgaacaat cccagacggc cttactactg agtgttctgg aaatacatac tttctgaatg
     1981 accaaccgtc cctggactgt ggaatgttcc ggcctgcatt tctgcccacc ccttccgttg
     2041 tcacgagtgc cgtgccgtgt aataaagtcc cagtgctcat ccaccacaga tgcctggtcc
     2101 tgttgcagga agcccctcct gttagcagcg ggatgcaaga tgctgtctcg gggctctcct
     2161 tattggcctg tggagtctcc atccccgctc agcctgggtt gcactggagg ggaggaagaa
     2221 agttgttttc agcatagtaa agctggaagg ccaggtgcag tgtctcaccc ctgtcatccc
     2281 agcactttga gaggccaagg cgggcggatc actggaggtc aggagtttaa gaccagcctg
     2341 gccaacatgg tgaaatcctg tctctactaa aaatataaaa ttagctgggc atggtggtgc
     2401 acacctgtcg tctcagctac tcgggaggca gaggcaggag aatggcttga acctgggaag
     2461 cggttgcagt gagccaagat tgcgcctttg cactccagcc tgggcaagag agcaagactc
     2521 tgtctcaaat aataataata ataataaagc tggagacttg gccaca
//
