LOCUS       NM_022491               4724 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SDS3 homolog, SIN3A corepressor complex component
            (SUDS3), mRNA.
ACCESSION   NM_022491 XM_045014
VERSION     NM_022491.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Cook-Sather,S.D., Li,J., Goebel,T.K., Sussman,E.M., Rehman,M.A. and
            Hakonarson,H.
  TITLE     TAOK3, a novel genome-wide association study locus associated with
            morphine requirement and postoperative pain in a retrospective
            pediatric day surgery population
  JOURNAL   Pain 155 (9), 1773-1783 (2014)
   PUBMED   24909733
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
  REMARK    GeneRIF: studies reveal that loss of FAM60A or another component of
            the Sin3 complex, SDS3, leads to a change in cell morphology and an
            increase in cell migration
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Fleischer,T.C., Yun,U.J. and Ayer,D.E.
  TITLE     Identification and characterization of three new components of the
            mSin3A corepressor complex
  JOURNAL   Mol Cell Biol 23 (10), 3456-3467 (2003)
   PUBMED   12724404
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Wysocka,J., Myers,M.P., Laherty,C.D., Eisenman,R.N. and Herr,W.
  TITLE     Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone
            H3-K4 methyltransferase are tethered together selectively by the
            cell-proliferation factor HCF-1
  JOURNAL   Genes Dev 17 (7), 896-911 (2003)
   PUBMED   12670868
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Alland,L., David,G., Shen-Li,H., Potes,J., Muhle,R., Lee,H.C.,
            Hou,H. Jr., Chen,K. and DePinho,R.A.
  TITLE     Identification of mammalian Sds3 as an integral component of the
            Sin3/histone deacetylase corepressor complex
  JOURNAL   Mol Cell Biol 22 (8), 2743-2750 (2002)
   PUBMED   11909966
REFERENCE   9  (bases 1 to 4724)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   10 (bases 1 to 4724)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098404.1, AK024460.1, AC026367.14 and AA916093.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022491.2.
            
            Summary: SDS3 is a subunit of the histone deacetylase (see HDAC1;
            MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex
            (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.31967.1,
                                           SRR1660803.224777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543473.2/ ENSP00000443988.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2606              BC098404.1         26-2631
            2607-4290           AK024460.1         2592-4275
            4291-4693           AC026367.14        151884-152286
            4694-4724           AA916093.1         8-38                c
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..4724
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="SDS3 homolog, SIN3A corepressor complex component"
                     /db_xref="GeneID:64426"
                     /db_xref="HGNC:HGNC:29545"
                     /db_xref="MIM:608250"
     exon            1..279
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1124
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="sin3A-associated protein, 45kDa; 45 kDa
                     Sin3-associated polypeptide; suppressor of defective
                     silencing 3 protein homolog"
                     /codon_start=1
                     /product="sin3 histone deacetylase corepressor complex
                     component SDS3"
                     /protein_id="NP_071936.2"
                     /db_xref="CCDS:CCDS44993.1"
                     /db_xref="GeneID:64426"
                     /db_xref="HGNC:HGNC:29545"
                     /db_xref="MIM:608250"
                     /translation="MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRE
                     SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL
                     DQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKM
                     IENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIME
                     DLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIY
                     LESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA"
     exon            280..349
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..405
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            406..477
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..497
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..654
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..750
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..812
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..834
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..940
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1025
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..4724
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="hexamer: GATAAA"
     polyA_site      2685
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="major polyA site"
     regulatory      4149..4154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="hexamer: AATAAA"
     polyA_site      4169
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="major polyA site"
     regulatory      4393..4398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="hexamer: AATAAA"
     polyA_site      4416
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="major polyA site"
     regulatory      4705..4710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
                     /note="hexamer: AATAAA"
     polyA_site      4724
                     /gene="SUDS3"
                     /gene_synonym="SAP45; SDS3"
ORIGIN      
        1 ggagacgggg aaggggtcgc cgtggctgcc ggtcctcgag ttgggggctg ccgcggacac
       61 tgctaggcag acggcgagta ccgagcgcgg gtggccgcgg tgtccgtggg ccacgctcag
      121 ctgcggtcag aggcgacatg agtgccgcgg ggctgctggc cccggccccg gcccaggctg
      181 gagcgccgcc ggcccccgag tactaccccg aggaggatga agagctggag agcgccgagg
      241 acgacgagcg cagctgtcgg ggccgcgagt cggacgaaga cactgaggat gctagtgaaa
      301 ctgacctggc aaagcatgat gaagaagact atgtagaaat gaaggaacag atgtatcagg
      361 acaaactggc ttctctcaag aggcagttgc aacaactgca agaaggtaca ttacaggaat
      421 atcagaagag aatgaaaaaa ctagatcagc agtacaaaga gaggatacgg aatgcagaac
      481 tcttcctcca gctggaaact gaacaagtgg aacgaaatta cattaaagaa aagaaggcag
      541 cagtgaaaga atttgaagac aagaaggttg agctgaaaga gaacctgatt gctgagctag
      601 aagaaaagaa gaaaatgatt gaaaatgaaa agctgacaat ggaactgact ggagattcta
      661 tggaggtgaa acctatcatg accagaaagt tgcggaggcg accaaatgat cccgtcccca
      721 tcccagacaa gaggaggaaa cctgctccag cccagctaaa ctatttgtta acagatgaac
      781 agatcatgga ggatctgaga acattaaata agcttaagtc acccaagaga ccagcatctc
      841 catcctctcc tgagcacttg cctgcaacac ccgcggaatc tccagcccag aggttcgaag
      901 ctcggataga agatggcaaa ctgtactatg acaaaagatg gtaccacaag agccaggcca
      961 tctatctgga gtcaaaggac aaccagaaac tgagctgcgt gatcagttct gtaggagcca
     1021 atgagatctg ggtgaggaag acaagtgaca gcaccaagat gaggatctac ctgggccagc
     1081 ttcagcgcgg gctcttcgtg atccgccggc gctcagctgc ttgactttct acagtgctct
     1141 tctcttgacc ctttttctgg agtgggtttt atttttgttt tgtttcgttt tctccttaat
     1201 agaaaaatgt taacttactg ggaatagcta ctcagccttg gaaatggaga gcactgcagt
     1261 gaattcttta gggcactttt gtggccggat gcttccaact ttgtcagtct tttctgcctc
     1321 aacttcttcc agacatcagt caccatgaga ctgttttact ttcaggcgta ttggggggtt
     1381 tgatttactt tccttttatt tctttatttt ttgcttatac ttgtttttga aaacctcctc
     1441 tgagtttgaa gggacagcta tttttattga ttatctttaa gtctctctac catggagaag
     1501 agcaggaagg gatacactct ccagtgcatt ttcatgtttt gaatctgatt agtggatcac
     1561 gtagctactt tccctgtcgc gtccaattca ctatttgccc agaagcttgg ggcagaggtc
     1621 ctagcaggag atgatgaatt ctcgtggctc tcggccttct cagagaaata aatgctttgt
     1681 gtaacatctg tgcacaccat ccattccgct cgctgagcga tggaaaagct tgcctggaag
     1741 actatgtgca ctgaagtaaa tggggttggg ggaggggaca tttcatattt ataatgtgct
     1801 gaaggtacca tattttaaat gttatttaat gcaggtgatt tattcaaaca tttgttctag
     1861 cttaagctgg aataagcagt ggtcatttca gaagttttca tttgtaattc cttcctctcc
     1921 cttgttccca agtaggtagt agtaagtatg tgccacaggc tgattatctg ggtaatcttt
     1981 tacgggtggg aggtgagatt gatagtgcaa taatcagtga tctatagacc ctcatgcacg
     2041 attcaagttt cactcttgtg gctgatgcca ttattgcaca ttggccattc caaacctgtg
     2101 gagaactttg ttgtcaggcc ctgagcgctc acagcttcat ttggcccagg ttgaagacaa
     2161 ggaaagctct gctgtggctg cctctggact gacaccctcc ctaatgagtc ctgatgaaac
     2221 agcctttcct acatccttcc ctcactccca tgattggaga aatgattcat tgggtgatga
     2281 gtgttggggt tttctatact catgttgcca tcttgagatg ttcaaaaaat ttggggttag
     2341 agcaactgtt agcgtctcta tgagcaatca gtagaactta cacatcctag gaaatctttc
     2401 tttgtaagta attcttttgg tctcaagtga ttctcttcat gttgtctctt gatgtacata
     2461 cccccaagca agttgggggg actgtgatga caattaaatc accttctctg aagttctggc
     2521 tctgcagaga ccaaacctta ctgacttgta cagacttgta caagtaaaga cttatacaga
     2581 tagatttttg ttttaactta caatccgttt tttcctcttt tttttttttt tttctggtgt
     2641 tggagtctta tttagaaaac aggataaatg acgctgttat caaaagttgc ctggggttct
     2701 gtatttcttc tctgccctcc aatccccgac tgctatgatg tttactacag tgaacccagc
     2761 ccatggtaaa cacaggcttc acctgttctt gtttgttagc cttgactgtg aggcaggact
     2821 tccctcgctt gaactgttac acatacgatg tgtgtgtcac atcacatatt gtgcagctgt
     2881 tggttttcat gtagtgccct gcgatggaaa ttagatatat ttcatgtatt tttccattga
     2941 aggtggagtt tttcaatgat catgtgtttt gtcctcctaa acagtatacc aaagtttgtt
     3001 tttatagttg aggattgtat tgataaccac tggggttccg cattgaagca ggaacaaatt
     3061 gcctcttttt ctggccttct ctgtgggacc tctgcttttg tgaagcaact atttatttga
     3121 agaccagggt atgggcactt ttgccttctc tcctctctga cttttgaggg tattgagggc
     3181 gcccttagtc atagtctcga ctccgccatt gccttctcct cggcgtcctc acaactctta
     3241 attgggccta gtgaaaatgg gggcaggtga gaagtccatt ttgagaatca gcatagtaaa
     3301 ttacatttct aatcccagag gacttaatat tttcttttgt caccccagag gtgaaaaatc
     3361 agcagttgaa gcctgacagg cctcagtggt gaccaggaac agaagcagcc ttcctgttag
     3421 tagatggggg tacttctgtg gtgggcagaa gccttactaa aggggaagac agactttgaa
     3481 gtttctagac gagaaggagg ctagcttcta gcctgggtgg ccattattcc aaaaggtcat
     3541 tgtttctcac tagaccccag ggcaccagat gaatttccaa gtttaaactc tttcctgcag
     3601 gtgattactt tgaaaaaggt tggtccagac cattttgatc aagaacctgt atatgtgttg
     3661 tgttagaggc atctgcctca agtctatgta cagtgtttgc tgcgggtgtg ttccaatatt
     3721 cattttacct ctgcttgggg gttttgtgtg ttcccctccc cccatgccct gcctaccccc
     3781 ttttccctga accacgtcct tttgaataat ttccagatgg atttctgtag ccataccaaa
     3841 gccagggtgt tttcattcat gcggatacta gtatttatag atgtctgact acctaactta
     3901 atttttgttt ttgaacttct aattggggcc agtgtaaggt cgatcccaga ggctgatctg
     3961 caaatcaagc tacatgtatt tgtgtataag accctgtgtt caggactggg tgacttttct
     4021 aagaaatatg gggtttagaa tggggttgac tgtatttttt aacctaattc tggagagaag
     4081 attgtatttt ttacagtttt ttgggtttgg cttccttctc acatttcttt agctttgaat
     4141 ttttactaaa taaatttcct cctgattaat tttttttttc tcatctggga atttgaaatc
     4201 tcggtgctta ctgttacacc aatttgtcca aagagttgaa atcactttaa tgccagaaca
     4261 tggtaaattt gcagccattt caagcaggtg atggtctttt tttataacat cgttaacggg
     4321 taccattaaa tattctgaga ggtgaatgta aaatataaaa ggtataggtt tttttttttt
     4381 tttaaagaaa acaataaact ttcaaagaga aaaccagcat gaagtctgta ttgtatccat
     4441 tgacttgata agtgatagaa atttatttta ggtttttgat ccattgctta tggggaaagg
     4501 aagttagggc agaggaaggg atattctaga catttaattc ttagtgaaga ctaagataca
     4561 gaatgatgtc aggctaatac tcagttttgt aaagagcaat ctggggtgtt gacccttaaa
     4621 tgtttgtgca ctcttcttgt tgcagataaa agtcattaaa aatcaagtga atagaatgga
     4681 tcttgggtgg aaaaacaatc ttgaaataaa cttgtgattg agga
//
