LOCUS       NM_014283               5625 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SUN domain containing ossification factor (SUCO),
            transcript variant 1, mRNA.
ACCESSION   NM_014283
VERSION     NM_014283.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5625)
  AUTHORS   Sha,Z., Sha,L., Li,W., Dou,W., Shen,Y., Wu,L. and Xu,Q.
  TITLE     Exome sequencing identifies SUCO mutations in mesial temporal lobe
            epilepsy
  JOURNAL   Neurosci Lett 591, 149-154 (2015)
   PUBMED   25668491
  REMARK    GeneRIF: neurons have abnormal development due to lack of SUCO,
            which may be a generalized-onset epilepsy-related gene
REFERENCE   2  (bases 1 to 5625)
  AUTHORS   Sohaskey,M.L., Jiang,Y., Zhao,J.J., Mohr,A., Roemer,F. and
            Harland,R.M.
  TITLE     Osteopotentia regulates osteoblast maturation, bone formation, and
            skeletal integrity in mice
  JOURNAL   J Cell Biol 189 (3), 511-525 (2010)
   PUBMED   20440000
REFERENCE   3  (bases 1 to 5625)
  AUTHORS   Yu,N., Zhao,Z., Fu,Y.X., Sambuughin,N., Ramsay,M., Jenkins,T.,
            Leskinen,E., Patthy,L., Jorde,L.B., Kuromori,T. and Li,W.H.
  TITLE     Global patterns of human DNA sequence variation in a 10-kb region
            on chromosome 1
  JOURNAL   Mol Biol Evol 18 (2), 214-222 (2001)
   PUBMED   11158380
REFERENCE   4  (bases 1 to 5625)
  AUTHORS   Rosok,O., Pedeutour,F., Odeberg,J., Lundeberg,J. and Aasheim,H.C.
  TITLE     The C1orf9 gene encodes a putative transmembrane member of a novel
            protein family
  JOURNAL   Biochem Biophys Res Commun 267 (3), 855-862 (2000)
   PUBMED   10673381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB093941.1, BC137125.1, AL035291.1 and AJ250075.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014283.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and 5'
            coding region and initiates translation at a downstream AUG,
            compared to variant 2. The encoded protein (isoform 1) is shorter
            than isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ250075.1, SRR1660807.64791.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263688.4/ ENSP00000263688.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               DB093941.1         33-214
            183-4543            BC137125.1         1-4361
            4544-5623           AL035291.1         4477-5556
            5624-5625           AJ250075.1         5635-5636
FEATURES             Location/Qualifiers
     source          1..5625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..5625
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /note="SUN domain containing ossification factor"
                     /db_xref="GeneID:51430"
                     /db_xref="HGNC:HGNC:1240"
                     /db_xref="MIM:619434"
     exon            1..348
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..4051
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; membrane protein CH1; SUN-like protein 1;
                     osteopotentia"
                     /codon_start=1
                     /product="SUN domain-containing ossification factor
                     isoform 1 precursor"
                     /protein_id="NP_055098.1"
                     /db_xref="CCDS:CCDS1303.1"
                     /db_xref="GeneID:51430"
                     /db_xref="HGNC:HGNC:1240"
                     /db_xref="MIM:619434"
                     /translation="MKKHRRALALVSCLFLCSLVWLPSWRVCCKESSSASASSYYSQD
                     DNCALENEDVQFQKKDEREGPINAESLGKSGSNLPISPKEHKLKDDSIVDVQNTESKK
                     LSPPVVETLPTVDLHEESSNAVVDSETVENISSSSTSEITPISKLDEIEKSGTIPIAK
                     PSETEQSETDCDVGEALDASAPIEQPSFVSPPDSLVGQHIENVSSSHGKGKITKSEFE
                     SKVSASEQGGGDPKSALNASDNLKNESSDYTKPGDIDPTSVASPKDPEDIPTFDEWKK
                     KVMEVEKEKSQSMHASSNGGSHATKKVQKNRNNYASVECGAKILAANPEAKSTSAILI
                     ENMDLYMLNPCSTKIWFVIELCEPIQVKQLDIANYELFSSTPKDFLVSISDRYPTNKW
                     IKLGTFHGRDERNVQSFPLDEQMYAKYVKMFIKYIKVELLSHFGSEHFCPLSLIRVFG
                     TSMVEEYEEIADSQYHSERQELFDEDYDYPLDYNTGEDKSSKNLLGSATNAILNMVNI
                     AANILGAKTEDLTEGNKSISENATATAAPKMPESTPVSTPVPSPEYVTTEVHTHDMEP
                     STPDTPKESPIVQLVQEEEEEASPSTVTLLGSGEQEDESSPWFESETQIFCSELTTIC
                     CISSFSEYIYKWCSVRVALYRQRSRTALSKGKDYLVLAQPPLLLPAESVDVSVLQPLS
                     GELENTNIEREAETVVLGDLSSSMHQDDLVNHTVDAVELEPSHSQTLSQSLLLDITPE
                     INPLPKIEVSESVEYEAGHIPSPVIPQESSVEIDNETEQKSESFSSIEKPSITYETNK
                     VNELMDNIIKEDVNSMQIFTKLSETIVPPINTATVPDNEDGEAKMNIADTAKQTLISV
                     VDSSSLPEVKEEEQSPEDALLRGLQRTATDFYAELQNSTDLGYANGNLVHGSNQKESV
                     FMRLNNRIKALEVNMSLSGRYLEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQD
                     QRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQSYLVISLVLCVVLGLMLCM
                     QRCRNTSQFDGDYISKLPKSNQYPSPKRCFSSYDDMNLKRRTSFPLMRSKSLQLTGKE
                     VDPNDLYIVEPLKFSPEKKKKRCKYKIEKIETIKPEEPLHPIANGDIKGRKPFTNQRD
                     FSNMGEVYHSSYKGPPSEGSSETSSQSEESYFCGISACTSLCNGQSQKTKTEKRALKR
                     RRSKVQDQGKLIKTLIQTKSGSLPSLHDIIKGNKEITVGTFGVTAVSGHI"
     exon            349..463
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..574
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..729
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..867
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1018
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1142
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1267
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1335
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1443
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1549
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1570
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1626
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1718
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1784
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1853
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1944
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..3111
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3199
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3304
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3459
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3551
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3607
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..5625
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5598..5603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /note="hexamer: AATAAA"
     polyA_site      5625
                     /gene="SUCO"
                     /gene_synonym="C1orf9; CH1; OPT; SLP1"
                     /note="major polyA site"
ORIGIN      
        1 atggggcggc agtggcggct gcaggaggcg ggcgtggacg agccggtggc tgcagcggcg
       61 gcggtccccg gagtcctgtg aagcgcccct gtccgcgcct ctgtggggcc ctcagagagg
      121 gctgccagga cgcgagccac tgaggagccg ctcagccagc gccatagccc ttaggactat
      181 cggtcacatt ctcgcgctcc tgctccggct cctccatctt ggcctcggca gtggcggctg
      241 ccgggaggat gtgccgcctt ctggcagggg gaagaaggag gagaagatga agaagcaccg
      301 gcgggccttg gccctggtct cctgcctctt tctgtgctct ctggtctggc ttcccagctg
      361 gcgtgtatgt tgtaaagaga gttcttcagc ttcagcgtca tcatattact ctcaagatga
      421 caactgcgca ctagaaaatg aagatgtaca attccagaaa aaggatgaaa gagagggacc
      481 tatcaatgcc gaatcattgg gaaaatcagg ttcaaattta cctatttctc caaaagaaca
      541 taaattaaaa gatgattcta ttgtggatgt acaaaataca gagtcaaaaa agttaagtcc
      601 accggtggtg gagacactcc ctacagttga tttgcatgaa gagtcttcca atgcagttgt
      661 ggacagtgaa actgttgaaa atatttccag ctcatctacc tcagaaatca ctccaatctc
      721 aaagcttgat gaaatagaaa aatctggtac tattccgata gccaaaccaa gtgaaactga
      781 gcagtctgaa actgattgtg atgttggtga ggcccttgat gctagtgctc caattgaaca
      841 accttccttt gtcagtccac ctgacagcct tgttggccag catatagaaa atgtatcatc
      901 ttcacatggt aaaggaaaga taacaaaatc agaatttgaa tcaaaagttt cagcaagtga
      961 acagggcggt ggtgatccaa aatctgcatt gaatgcttca gataatttaa aaaatgagag
     1021 ctctgattat acaaaaccag gagacattga ccctacatca gtagcaagtc ccaaagatcc
     1081 agaagatata ccaacatttg atgaatggaa gaagaaagtt atggaagtag aaaaagaaaa
     1141 aagtcagtcg atgcatgcat cttctaatgg aggttcacat gccaccaaaa aggtccagaa
     1201 aaatcgaaat aattatgcct cagtagaatg tggtgccaaa attctagcag ctaatccaga
     1261 agccaagagc acatctgcta ttcttataga aaatatggat ctttacatgt tgaatccttg
     1321 cagcactaaa atttggtttg ttattgaact ttgtgaacca attcaagtaa aacagcttga
     1381 tattgcaaat tatgaattat tttcttctac tcctaaagat tttctggttt ctatcagtga
     1441 cagatatcca acaaataagt ggattaagct gggtactttt catggtagag atgagcggaa
     1501 tgtacagagt ttccctttag atgaacagat gtatgcaaaa tatgtcaaga tgttcatcaa
     1561 gtacataaag gttgagttgc tatcacattt tggatcagag cacttttgtc cattaagcct
     1621 tataagggta tttggcacta gcatggtgga agaatatgaa gaaattgctg attcccagta
     1681 tcactcagaa cgccaggaac tatttgatga ggactatgat tatccactgg attataatac
     1741 tggagaggat aaatcctcaa aaaatcttct tggttctgct acaaatgcca ttctaaatat
     1801 ggtgaatatt gctgctaata ttctgggagc aaaaactgaa gacctgacag aaggaaataa
     1861 aagtatatct gagaatgcca ctgccacagc tgcacctaaa atgcctgaat caactcctgt
     1921 ttcaactcct gttccatctc ctgagtatgt aaccactgaa gtacacacac atgacatgga
     1981 gccgtcaaca ccagatactc caaaagagag tcccattgta cagttagttc aagaggagga
     2041 agaggaggca agtccatcta cagtgaccct tctgggcagc ggtgaacagg aagatgaatc
     2101 atcaccctgg tttgagtcag agacacaaat attttgcagt gaactgacca caatttgttg
     2161 tatttctagt ttttcagaat acatatataa atggtgttca gttagagttg ctctttatcg
     2221 gcagcgcagc cgaactgctt tgagtaaagg aaaagattat cttgtgttag ctcaaccacc
     2281 cttactactt cctgcggaat cagtagatgt ttcagtattg caacctctga gtggagaatt
     2341 ggaaaatacg aatatagaaa gggaagctga aactgttgtt ctgggtgatt taagtagtag
     2401 tatgcaccag gatgacttgg tgaatcacac tgtagatgca gttgaacttg aaccaagcca
     2461 ttctcaaact ctttctcagt ctcttctttt agatattacc ccagaaatca atcccttgcc
     2521 taaaatagaa gtatctgagt ctgttgaata tgaggcagga catataccat caccagtgat
     2581 tccccaagag agttctgttg agatcgataa tgaaacagaa caaaagtctg agagctttag
     2641 ttctatagag aaaccatcta ttacctatga aacaaataaa gttaatgagt taatggataa
     2701 tattataaaa gaagatgtga actccatgca aattttcaca aagctgtctg aaacaatagt
     2761 gccaccaata aatacagcca ctgtacccga caatgaagat ggggaagcca aaatgaatat
     2821 agctgacaca gcaaagcaaa ctttgatttc tgttgtggat tcttcttcat tacctgaagt
     2881 aaaagaagaa gaacagtctc cagaagatgc ccttttgaga gggttacaga ggacagctac
     2941 agatttttat gctgaattgc aaaattctac agatctagga tatgctaatg gaaatcttgt
     3001 acatggatca aaccaaaagg agtcagtatt tatgagactt aataatcgta ttaaagcctt
     3061 agaagttaac atgtctctca gtggtcgcta tctggaggag cttagccaaa ggtaccgaaa
     3121 acaaatggaa gaaatgcaaa aggctttcaa taaaacaatc gtgaaacttc agaatacttc
     3181 aagaatagca gaggagcagg atcagcggca aactgaagcc atccagttgc tacaggcaca
     3241 gctgaccaac atgacacagc ttgtttcaaa tttatcagca acagtagcag aattgaaacg
     3301 ggaggtttca gatcgacaaa gctatcttgt catatctttg gttctttgtg ttgtcttggg
     3361 actgatgctt tgtatgcagc gttgtcgaaa tacttctcaa tttgatggag attatatttc
     3421 aaaacttcct aaaagtaatc agtatccaag ccctaaaagg tgtttctctt cctatgatga
     3481 tatgaatttg aaaagaagaa cttcattccc actcatgaga tccaagtctc tacagttaac
     3541 tggcaaagaa gtagacccaa atgatttgta cattgtagaa cccctcaagt tttctccaga
     3601 aaagaagaag aagcgctgca agtacaaaat tgaaaaaatt gagaccataa agcctgaaga
     3661 accattgcac cccatagcca atggcgacat aaaaggaaga aagcccttta cgaaccagag
     3721 agatttttct aatatgggag aagtttatca ctcttcttat aaaggtcctc catctgaagg
     3781 aagctcagaa acttcatcac agtcagaaga gtcctatttt tgtggcattt cagcttgcac
     3841 aagtctgtgc aatggacagt ctcaaaagac aaaaactgag aagagggctt taaaacgaag
     3901 acgatctaaa gtccaagacc aaggaaaatt gataaaaact ctaatacaga ctaagtcggg
     3961 atcattgccg agcctgcatg acataatcaa aggaaacaaa gagatcaccg tgggaacatt
     4021 tggtgttaca gcagtctcgg gacatatcta aaattaattg aacttttcat acagaagact
     4081 tttttgttgt tgttctttga agaacagtct gtagtatttg aagggtttgg gggagggaga
     4141 aaatattaat gggaaaggca ttcagaaatt atggtttcta cctttttaaa aagtagatgg
     4201 gattgtgtca atcttggtta atgagctaca gttttacaaa gctgatcact tcctataagg
     4261 acaatggtag acattttata aagatgtttt ttcacaagat taattactgg gacaaaagta
     4321 atttggaagc ccagttcctt aggtgggata ggaatgaaag cctaaacctc ttcctttagc
     4381 tttgttccta tttcttgcac cttcccatat ttatgtgcct tttgtctatt tataatgcca
     4441 ctggaagagg agggataact ttttctgtta tttgatttct tttataactt tgttaggttt
     4501 ttgaagctgc aaacactaca atgctttgag ggggtctgtg cctgaagctc aggagtgtgg
     4561 atcagacagt ctaaagatcc taaaaacttg ccaactggat ctttgtttag caaactcact
     4621 ggaaatgaac acttaatgga atttttaagt ctgttctgtt aggtagatgg tgatgctctt
     4681 gttattttca cttattcaga ctggattact tcttacttag ttactaactc aatgaggaaa
     4741 aatccctaca ggatcttttt ttgcaaacaa ctgatatatg cagacaaatt tttgacaaat
     4801 tcacctttta aacacactta accatttgtg aaggttttct ttagcttaca ttttaaacat
     4861 acacaataaa cactaatcct ccaaactttc actgttttta ttagtatgaa tataaaattt
     4921 gaaggtttgg ccaattagta caagtctcat gatataatca ctgcctgcat acatatgcac
     4981 agatccagtt agtgagtttg tcaagcttaa tctaattggt taagtctaaa gagattatta
     5041 ttccttgatg tttgctttgt attggctaca aatgtgcaga ggtaatacat atgtgatgtc
     5101 gatgtctctg tctttttttt tgtctttaaa aaataattgg cagcaactgt atttgaataa
     5161 aatgatttct tagtatgatt gtacagtaat gaatgaaagt ggaacatgtt tctttttgaa
     5221 agggagagaa ttgaccattt attgttgtga tgtttaagtt ataacttatt gagcactttt
     5281 agtagtgata actgttttta aacttgccta atacctttct tgggtattgt ttgtaatgtg
     5341 acttatttaa cgcctttttt gtttgtttaa gttgctgctt taggttaaca gcgtgtttta
     5401 gaagatttaa atttctttcc tgtctgcaca attagctatt cagagcaaga gggcctgatt
     5461 ttatagaagc cccttgaaaa gaggtccaga tgagagcaga gatacagtga gaaattatgt
     5521 gatctgtgtg ttgtgggaag agaattttca atatgtaact acggagctgt agtgccatta
     5581 gaaactgtga atttccaaat aaatctgaac acttgtcttt attaa
//
