LOCUS       NM_033050               4181 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens succinate receptor 1 (SUCNR1), mRNA.
ACCESSION   NM_033050
VERSION     NM_033050.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Marsal-Beltran,A., Rodriguez-Castellano,A., Astiarraga,B.,
            Calvo,E., Rada,P., Madeira,A., Rodriguez-Pena,M.M., Llaurado,G.,
            Nunez-Roa,C., Gomez-Santos,B., Maymo-Masip,E., Bosch,R.,
            Frutos,M.D., Moreno-Navarrete,J.M., Ramos-Molina,B., Aspichueta,P.,
            Joven,J., Fernandez-Real,J.M., Quer,J.C., Valverde,A.M., Pardo,A.,
            Vendrell,J., Ceperuelo-Mallafre,V. and Fernandez-Veledo,S.
  TITLE     Protective effects of the succinate/SUCNR1 axis on damaged
            hepatocytes in NAFLD
  JOURNAL   Metabolism 145, 155630 (2023)
   PUBMED   37315889
  REMARK    GeneRIF: Protective effects of the succinate/SUCNR1 axis on damaged
            hepatocytes in NAFLD.
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Chen,J., Li,Z., Yue,C., Ma,J., Cao,L., Lin,J., Zhu,D., An,R.,
            Lai,J., Guo,Y. and Gu,B.
  TITLE     Human umbilical cord mesenchymal stem cell-derived exosomes
            carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2
            polarization and prevent colorectal liver metastasis
  JOURNAL   Apoptosis 28 (3-4), 549-565 (2023)
   PUBMED   36652132
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cell-derived
            exosomes carrying miR-1827 downregulate SUCNR1 to inhibit
            macrophage M2 polarization and prevent colorectal liver metastasis.
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Rabe,P., Liebing,A.D., Krumbholz,P., Kraft,R. and Staubert,C.
  TITLE     Succinate receptor 1 inhibits mitochondrial respiration in cancer
            cells addicted to glutamine
  JOURNAL   Cancer Lett 526, 91-102 (2022)
   PUBMED   34813893
  REMARK    GeneRIF: Succinate receptor 1 inhibits mitochondrial respiration in
            cancer cells addicted to glutamine.
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Atallah,R., Gindlhuber,J., Platzer,W., Barnthaler,T., Tatzl,E.,
            Toller,W., Strutz,J., Rittchen,S., Luschnig,P.,
            Birner-Gruenberger,R., Wadsack,C. and Heinemann,A.
  TITLE     SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis:
            Significance in Gestational Diabetes
  JOURNAL   Int J Mol Sci 22 (21), 12048 (2021)
   PUBMED   34769478
  REMARK    GeneRIF: SUCNR1 Is Expressed in Human Placenta and Mediates
            Angiogenesis: Significance in Gestational Diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Trauelsen,M., Hiron,T.K., Lin,D., Petersen,J.E., Breton,B.,
            Husted,A.S., Hjorth,S.A., Inoue,A., Frimurer,T.M., Bouvier,M.,
            O'Callaghan,C.A. and Schwartz,T.W.
  TITLE     Extracellular succinate hyperpolarizes M2 macrophages through
            SUCNR1/GPR91-mediated Gq signaling
  JOURNAL   Cell Rep 35 (11), 109246 (2021)
   PUBMED   34133934
  REMARK    GeneRIF: Extracellular succinate hyperpolarizes M2 macrophages
            through SUCNR1/GPR91-mediated Gq signaling.
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4181)
  AUTHORS   Rubic,T., Lametschwandtner,G., Jost,S., Hinteregger,S., Kund,J.,
            Carballido-Perrig,N., Schwarzler,C., Junt,T., Voshol,H.,
            Meingassner,J.G., Mao,X., Werner,G., Rot,A. and Carballido,J.M.
  TITLE     Triggering the succinate receptor GPR91 on dendritic cells enhances
            immunity
  JOURNAL   Nat Immunol 9 (11), 1261-1269 (2008)
   PUBMED   18820681
REFERENCE   8  (bases 1 to 4181)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   9  (bases 1 to 4181)
  AUTHORS   He,W., Miao,F.J., Lin,D.C., Schwandner,R.T., Wang,Z., Gao,J.,
            Chen,J.L., Tian,H. and Ling,L.
  TITLE     Citric acid cycle intermediates as ligands for orphan
            G-protein-coupled receptors
  JOURNAL   Nature 429 (6988), 188-193 (2004)
   PUBMED   15141213
  REMARK    GeneRIF: GPR91 is a receptor for succinate and mediates
            succinate-induced hypertension.
            GeneRIF: This paper describes function in another species.
REFERENCE   10 (bases 1 to 4181)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290420.1, AC068647.10,
            BX093329.1 and BP394710.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033050.5.
            
            Summary: This gene encodes a G-protein-coupled receptor for
            succinate, an intermediate molecule of the citric acid cycle. It is
            involved in the promotion of hematopoietic progenitor cell
            development, and it has a potential role in renovascular
            hypertension which has known correlations to renal failure,
            diabetes and atherosclerosis. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290420.1, BC030948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362032.6/ ENSP00000355156.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AK290420.1         1-185
            186-186             AC068647.10        123131-123131
            187-1425            AK290420.1         187-1425
            1426-3537           AC068647.10        124371-126482
            3538-3686           BX093329.1         1-149
            3687-4181           BP394710.1         1-495
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..4181
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /note="succinate receptor 1"
                     /db_xref="GeneID:56670"
                     /db_xref="HGNC:HGNC:4542"
                     /db_xref="MIM:606381"
     exon            1..64
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /inference="alignment:Splign:2.1.0"
     exon            65..120
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1110
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /note="P2Y purinoceptor 1; G-protein coupled receptor 91"
                     /codon_start=1
                     /product="succinate receptor 1"
                     /protein_id="NP_149039.2"
                     /db_xref="CCDS:CCDS3162.1"
                     /db_xref="GeneID:56670"
                     /db_xref="HGNC:HGNC:4542"
                     /db_xref="MIM:606381"
                     /translation="MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIV
                     VYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVL
                     HANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPL
                     INPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRN
                     RQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSF
                     YIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
                     "
     exon            121..4181
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /note="hexamer: AATAAA"
     polyA_site      3256
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /note="major polyA site"
     regulatory      4158..4163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
                     /note="hexamer: AATAAA"
     polyA_site      4181
                     /gene="SUCNR1"
                     /gene_synonym="GPR91"
ORIGIN      
        1 gtcagaagct atatccagct gctggcagag ttcctgtcaa gggatcaagt cttccaacag
       61 aatggttatg gtttaactca gcagaatttg ttgaacaact acgacatgct ggggatcatg
      121 gcatggaatg caacttgcaa aaactggctg gcagcagagg ctgccctgga aaagtactac
      181 ctttccattt tttatgggat tgagttcgtt gtgggagtcc ttggaaatac cattgttgtt
      241 tacggctaca tcttctctct gaagaactgg aacagcagta atatttatct ctttaacctc
      301 tctgtctctg acttagcttt tctgtgcacc ctccccatgc tgataaggag ttatgccaat
      361 ggaaactgga tatatggaga cgtgctctgc ataagcaacc gatatgtgct tcatgccaac
      421 ctctatacca gcattctctt tctcactttt atcagcatag atcgatactt gataattaag
      481 tatcctttcc gagaacacct tctgcaaaag aaagagtttg ctattttaat ctccttggcc
      541 atttgggttt tagtaacctt agagttacta cccatacttc cccttataaa tcctgttata
      601 actgacaatg gcaccacctg taatgatttt gcaagttctg gagaccccaa ctacaacctc
      661 atttacagca tgtgtctaac actgttgggg ttccttattc ctctttttgt gatgtgtttc
      721 ttttattaca agattgctct cttcctaaag cagaggaata ggcaggttgc tactgctctg
      781 ccccttgaaa agcctctcaa cttggtcatc atggcagtgg taatcttctc tgtgcttttt
      841 acaccctatc acgtcatgcg gaatgtgagg atcgcttcac gcctggggag ttggaagcag
      901 tatcagtgca ctcaggtcgt catcaactcc ttttacattg tgacacggcc tttggccttt
      961 ctgaacagtg tcatcaaccc tgtcttctat tttcttttgg gagatcactt cagggacatg
     1021 ctgatgaatc aactgagaca caacttcaaa tcccttacat cctttagcag atgggctcat
     1081 gaactcctac tttcattcag agaaaagtga ggggcttgtg aaacagattg ttctacagat
     1141 gaatctgtaa gccagttaca gtttgcctta actcatagac atcaatcaga gagtgtcaca
     1201 gatttaacct tgatctaaag acaagttgta cccagagtat gtgaaaagaa tgggacgaca
     1261 agaatgtact ggtttcttcc tctaagaatt gaaaggagtt gaactgcctt atgtttgggc
     1321 atgtaactcc aaaatactag gtagtataag gctttctcaa tcagtgcaaa aatggaagat
     1381 atataaagca acaagttgtc tgcatttgat cactggtcag attgtaaaaa aaaaaaaaat
     1441 tgttttggca acattctcta tgttattctt attcacatga tcctagaact ttatgtgaga
     1501 actgaatagc agaagatata ttattaaata gtttttggaa gttgtgctgt taagcaaatg
     1561 taaagtcaac agtaacaatg attaagaaag gaatataatg agttcaaaga tatctatctg
     1621 atatattttt tatattcatc atgaatcggg gtagtcttgt aatttatcta acctttttgt
     1681 tgtatgggtt tatagtggaa agaatcttaa tttaaataaa aagaacctga agagataatt
     1741 caacaaaagt agagaatatg tttgagcttg tcagagaatt taagtatcaa aatactagag
     1801 agatacacca aggatatttg aataaaaaaa aaatttgtag aacacaaaat gcctatcagg
     1861 aaacccaaag caaaacagaa caaaaagtga atacatcgtt ttaaatgatg attttgccat
     1921 ctggtatttt attatcataa tttgaccacc agtgcatgaa aatatattaa agttcattag
     1981 ccttctgctc ttgatttaat agtgaacttt aaaatatatt aatatcataa accagcaaat
     2041 aaggagaaat aaactgataa tactagattc attgggatag ttttcccttt tggagggaaa
     2101 gtcacaattt ttctccatga tcccccattt tttgtaaaca ctggaataat ttacaaggat
     2161 aactttattg tagcgagagc aaatcacatc tggagtgagc cttgttttca tgcaacatta
     2221 ccataagacc attggagtaa atgtttcaaa caaaatgtac ttcatgaaat tatagaacat
     2281 aaaaatattt atgtgcatat taacctgtat tatcccagga gggttaatga ggccccattt
     2341 cctgcacaaa acaaatgtag gggaaaaaat gggtgctgca ttagcttttt aaagtcaaac
     2401 aactatcaca taataattcc ttgatatgca acataaagta cctatggcca catatctaag
     2461 ttcctttcct tgatgtcatt agctataagg agtgagtaat gtgaaggaca aaataagcat
     2521 tatgaataca gagacataaa attccactgt cccttccttt tctgaaatac tctgggaggt
     2581 attctgatat ttttaaatcc cccaattttc ccagttgata tctctagact tcaagcaact
     2641 gaaatattat aaaaatgcat tagtcacaaa agatttattt tcttacatca caccaggctt
     2701 taagatattt tctgccatgc cttgccttta gtatcaatat tttaaaaatt tcactgtaat
     2761 tttataactg cctaataaca aactgaaaac agaacttctg agtttcctta tcagaaaggg
     2821 ccacagaaaa ggccttaaga aagaaagatt cacttacttc tgcaaacttg gcaatccgta
     2881 atttaacttt aatttgtatt ttatgcatga attttacttg taaagacaaa attaaatttg
     2941 cttcccctac atcccaactc caagaagtca caggaataga ctctttctaa tagtgcagtg
     3001 aaatattttt tcaaaccata aactcacata tatatatata tatatatata tatatatata
     3061 tatatatgta ccttgtaaac aagaggttaa gaaattttat agcacatttt aaaattattt
     3121 tcttcctcaa atctatcatg tggtaactta atctttaaca gactttaggg ccctaaacta
     3181 aaattataag agctatttca tttgcttgtt gtactgggta attgtaagaa tcacaaacaa
     3241 taaatcatga aaatcctttc tgggtttgtg gtttctaaag gaaataatat tgagcttttg
     3301 tattttgtct tttaattggc tccctggtat cttcagaatg atgtctagat tcttcagtct
     3361 ggacccacct actcttctca cattatctcc catcactgtt gtcacaaacc ataccctata
     3421 gctaaagatt gctactttag tttattacat tcagaacttt cttcactttg ttcacctgtt
     3481 gcccatcttt gttctatcat acctgaatgg tataataatt ctaaacaact ttcaaggttc
     3541 atctcatctg tcattctttg ttgaagcttg cccttatatc ctctcttccc caaacctaaa
     3601 agtaaaactt tctaccactg gggcttcaga tacttttaat actacttatt tgaatttcat
     3661 tatttttatt atagtttatt attgtcttca tagctgagta ctcttaaaat tactgtttat
     3721 tataagtgaa tgtcttacag aacaaactca aagtcaatgc ttcttttgca tgtgaataat
     3781 caagctattt ttttgtcatc attactttag taagtaacat tattttatat gaagaataga
     3841 gtgtatatac ataaacccat gtgccagctg ccattgcact gcctcacatt ttcctttaga
     3901 tgtttgagca tagttttaat gactgtttga aatctctgtc tcctagttcc aaatatgggt
     3961 catcttggag ttggtcttca ttggtgcctt ttctcttcag tatgagtcat aattttcctg
     4021 tttctctata tgcctagtaa attagaattt tattctagat gatgaataat gtgtggcaga
     4081 gattctggat tctgttacat tccatcaaag agtattgata ttttgtatat acatttacaa
     4141 atgtacatgt acacaataat aaaaataatt tttttctcag a
//
