LOCUS       NM_003848               2350 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens succinate-CoA ligase GDP-forming subunit beta
            (SUCLG2), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_003848
VERSION     NM_003848.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Wu,B., Qiu,J., Zhao,T.V., Wang,Y., Maeda,T., Goronzy,I.N.,
            Akiyama,M., Ohtsuki,S., Jin,K., Tian,L., Goronzy,J.J. and
            Weyand,C.M.
  TITLE     Succinyl-CoA Ligase Deficiency in Pro-inflammatory and
            Tissue-Invasive T Cells
  JOURNAL   Cell Metab 32 (6), 967-980 (2020)
   PUBMED   33264602
  REMARK    GeneRIF: Succinyl-CoA Ligase Deficiency in Pro-inflammatory and
            Tissue-Invasive T Cells.
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Lin,S.R., Wen,Y.C., Yeh,H.L., Jiang,K.C., Chen,W.H., Mokgautsi,N.,
            Huang,J., Chen,W.Y. and Liu,Y.N.
  TITLE     EGFR-upregulated LIFR promotes SUCLG2-dependent castration
            resistance and neuroendocrine differentiation of prostate cancer
  JOURNAL   Oncogene 39 (44), 6757-6775 (2020)
   PUBMED   32963351
  REMARK    GeneRIF: EGFR-upregulated LIFR promotes SUCLG2-dependent castration
            resistance and neuroendocrine differentiation of prostate cancer.
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Huang,J. and Fraser,M.E.
  TITLE     Tartryl-CoA inhibits succinyl-CoA synthetase
  JOURNAL   Acta Crystallogr F Struct Biol Commun 76 (Pt 7), 302-308 (2020)
   PUBMED   32627745
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Lambeth,D.O., Tews,K.N., Adkins,S., Frohlich,D. and Milavetz,B.I.
  TITLE     Expression of two succinyl-CoA synthetases with different
            nucleotide specificities in mammalian tissues
  JOURNAL   J Biol Chem 279 (35), 36621-36624 (2004)
   PUBMED   15234968
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Johnson,J.D., Mehus,J.G., Tews,K., Milavetz,B.I. and Lambeth,D.O.
  TITLE     Genetic evidence for the expression of ATP- and GTP-specific
            succinyl-CoA synthetases in multicellular eucaryotes
  JOURNAL   J Biol Chem 273 (42), 27580-27586 (1998)
   PUBMED   9765291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC068602.1, BC007716.2 and
            AF131748.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_003848.3.
            
            Summary: This gene encodes a GTP-specific beta subunit of
            succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the
            reversible reaction involving the formation of succinyl-CoA and
            succinate. Alternate splicing results in multiple transcript
            variants. Pseudogenes of this gene are found on chromosomes 5 and
            12. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR, and 3'
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068602.1, SRR11853562.23584.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000307227.10/
                                                  ENSP00000307432.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BC068602.1         4-38
            36-1367             BC007716.2         1-1332
            1368-2080           BC068602.1         1371-2083
            2081-2350           AF131748.1         1356-1625
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..2350
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /note="succinate-CoA ligase GDP-forming subunit beta"
                     /db_xref="GeneID:8801"
                     /db_xref="HGNC:HGNC:11450"
                     /db_xref="MIM:603922"
     exon            1..110
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1325
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /EC_number="6.2.1.4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; GTP-specific succinyl-CoA synthetase beta
                     subunit; succinyl-CoA synthetase, beta-G chain;
                     succinyl-CoA ligase, GDP-forming, beta chain,
                     mitochondrial; succinyl-CoA ligase [GDP-forming] subunit
                     beta, mitochondrial; SCS-betaG; succinate--CoA ligase
                     [GDP-forming] subunit beta, mitochondrial; GTP-specific
                     succinyl-CoA synthetase subunit beta; succinate-CoA ligase
                     GDP-forming beta subunit"
                     /codon_start=1
                     /product="succinate--CoA ligase [GDP-forming] subunit
                     beta, mitochondrial isoform 2 precursor"
                     /protein_id="NP_003839.2"
                     /db_xref="CCDS:CCDS43104.1"
                     /db_xref="GeneID:8801"
                     /db_xref="HGNC:HGNC:11450"
                     /db_xref="MIM:603922"
                     /translation="MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQ
                     SKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKG
                     GVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDR
                     SCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLK
                     SQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAM
                     DDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLG
                     GGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVR
                     LEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK"
     exon            111..252
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            253..352
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            353..443
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            444..596
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            597..686
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            687..783
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            784..945
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1088
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1209
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2350
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2324..2329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /note="hexamer: AATAAA"
     polyA_site      2350
                     /gene="SUCLG2"
                     /gene_synonym="G-SCS; GBETA; GTPSCS"
                     /note="major polyA site"
ORIGIN      
        1 gccccgtgcc gagtttcctg tttaagatgg cgtcccccgt agcagcgcag gccgggaagc
       61 ttctgcgagc cctagcgctg cggccccgct tcctggcggc cgggtcccag gcagttcaat
      121 taacctccag aagatggctg aacctgcagg aataccagag caagaaactg atgtctgaca
      181 acggagtgag agttcaaaga ttctttgtag cagacactgc aaatgaagct ctcgaggctg
      241 ctaagagact aaatgcaaaa gaaattgttt taaaagccca gatcttagct ggaggaagag
      301 gaaaaggtgt cttcaatagt ggtttgaaag gaggtgttca tttaacaaaa gaccctaatg
      361 ttgtgggaca gctggctaaa cagatgattg ggtacaatct agcgacaaaa caaactccaa
      421 aagaaggtgt gaaagttaac aaggtgatgg ttgctgaagc cttggatatt tccagagaaa
      481 cctacctggc aattctgatg gaccggtcct gcaatggccc cgtgctggtg ggcagccccc
      541 aggggggcgt cgacattgaa gaggtggctg cttcaaaccc ggagctcatt tttaaggagc
      601 aaattgacat ttttgaagga ataaaggaca gccaagctca gcggatggcc gaaaatctag
      661 gcttcgttgg gcctttgaaa agccaggctg cagatcaaat tacgaagctg tataatctct
      721 tcctgaaaat tgatgctact caggtggaag tgaatccctt tggtgaaact ccagaaggac
      781 aagttgtctg ttttgatgcc aagataaact ttgatgacaa cgcagaattc cgacaaaaag
      841 acatatttgc tatggacgac aaatcagaga atgagcccat tgaaaatgaa gctgccaaat
      901 atgatctaaa atacatagga ctagatggga acattgcctg ctttgtgaat ggtgctgggc
      961 tcgccatggc tacttgtgat atcattttcc ttaatggtgg gaagccagcc aacttcttgg
     1021 atcttggagg tggtgtaaag gaagctcaag tatatcaagc attcaaattg ctcacagctg
     1081 atcctaaggt tgaagccatc cttgtcaata tatttggtgg tatcgtcaac tgtgccatca
     1141 ttgccaatgg gatcaccaaa gcctgccggg agctagaact caaggtgccc ctggtggtcc
     1201 ggcttgaagg aaccaacgtc caagaggccc agaagatact caacaacagc ggactcccca
     1261 ttacttcagc cattgacctg gaggatgcag ccaagaaggc tgtggccagt gtggccaaga
     1321 agtgatgtct ttgtcctgat ccaatggaga aagaaagcca tttttccgta aaaagggatg
     1381 gttcatcatt gtgaaagaaa tggttatctc attggggaag aaaaggggag ggggaaggca
     1441 agaatcactg aaaaatctta aatctgtgtt ttctggaata agatatctag acagcctaaa
     1501 tctgattttg gtctttataa aaataatatc ttgtgttctc atacttttct gtcactgtaa
     1561 gcctgcccag taggcagtgt tttgcagact ttggggagtg gtctatgtgg ccaaatattg
     1621 tgtgtataga cagaatttga aatcaagtcc tgcttcattt acaagaattt tggtgggcat
     1681 ctaatcctac ataatgaaaa agaaaaacag accatttaaa aactcagaca agattatatt
     1741 taatatatta attactaaaa aggcataaga ttacactgaa catattagct actaaaaagg
     1801 cactgctaag acattcaagc aaatagctat tacacactac tgcagatttt acaggtttct
     1861 aattctaaca tatgtttgaa aaatccgtga gtattccaaa atatatttaa taatggaata
     1921 tctgcattaa tataccatcc atgtgttttt accatttgcc ttaatattga atatactgtt
     1981 tacctcacac taaaaagaaa accagaagcc ttatttgtga ttttgggagt ggaagcttcc
     2041 atttttgtgt caaaaatgaa tcctgattct tatggaaatc tctgttatta agatatttca
     2101 agatgagaca acactgaaga tcaaattgtg tttagtatca ctatcttctc tcctcgtttc
     2161 tctcttactc ctcatcctcc cagaatctac cagtttatgg tagaaagatg ggaaccttat
     2221 ttgaatgtgt tttttttttc catgatgtcc aattttgttg tgggaaagga tttggataaa
     2281 atttttgttt aaattttggt agatttttat ctatacaaat ttaaataaaa ttatgttttg
     2341 taagctgtaa
//
