LOCUS       NM_006713               3449 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens SUB1 regulator of transcription (SUB1), mRNA.
ACCESSION   NM_006713
VERSION     NM_006713.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3449)
  AUTHORS   Zhao,T., He,X., Liang,X., Kellum,A.H. Jr., Tang,F., Yin,J., Guo,S.,
            Wang,Y., Gao,Z. and Wang,Y.
  TITLE     HMGB3 and SUB1 Bind to and Facilitate the Repair of N2-Alkylguanine
            Lesions in DNA
  JOURNAL   J Am Chem Soc 146 (32), 22553-22562 (2024)
   PUBMED   39101269
  REMARK    GeneRIF: HMGB3 and SUB1 Bind to and Facilitate the Repair of
            N[2]-Alkylguanine Lesions in DNA.
REFERENCE   2  (bases 1 to 3449)
  AUTHORS   Yan,B., Luo,P., Qiu,H., Wang,J., Xiong,Q., Hu,W., Wang,F., Liu,G.,
            Zhi,Y., Fang,Q., Shi,C. and Li,W.
  TITLE     PC4 promotes bladder cancer progression and stemness by directly
            interacting with Sp1 to transcriptionally activate the
            Wnt5a/beta-catenin pathway
  JOURNAL   Pathol Res Pract 259, 155369 (2024)
   PUBMED   38820928
  REMARK    GeneRIF: PC4 promotes bladder cancer progression and stemness by
            directly interacting with Sp1 to transcriptionally activate the
            Wnt5a/beta-catenin pathway.
REFERENCE   3  (bases 1 to 3449)
  AUTHORS   Wang,H., Chen,W., Wang,Y., Gao,Y., Zhang,Z., Mi,S., Wang,L. and
            Xue,M.
  TITLE     SUB1 promotes colorectal cancer metastasis by activating NF-kappaB
            signaling via UBR5-mediated ubiquitination of UBXN1
  JOURNAL   Sci China Life Sci 67 (6), 1199-1211 (2024)
   PUBMED   38240906
  REMARK    GeneRIF: SUB1 promotes colorectal cancer metastasis by activating
            NF-kappaB signaling via UBR5-mediated ubiquitination of UBXN1.
REFERENCE   4  (bases 1 to 3449)
  AUTHORS   Pan,Q., Luo,P., Hu,K., Qiu,Y., Liu,G., Dai,S., Cui,B., Yin,D. and
            Shi,C.
  TITLE     Periodic changes of cyclin D1 mRNA stability are regulated by PC4
            modifications in the cell cycle
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38349334
  REMARK    GeneRIF: Periodic changes of cyclin D1 mRNA stability are regulated
            by PC4 modifications in the cell cycle.
REFERENCE   5  (bases 1 to 3449)
  AUTHORS   Mustafi,P., Hu,M., Kumari,S., Das,C., Li,G. and Kundu,T.K.
  TITLE     Phosphorylation-dependent association of human chromatin protein
            PC4 to linker histone H1 regulates genome organization and
            transcription
  JOURNAL   Nucleic Acids Res 50 (11), 6116-6136 (2022)
   PUBMED   35670677
  REMARK    GeneRIF: Phosphorylation-dependent association of human chromatin
            protein PC4 to linker histone H1 regulates genome organization and
            transcription.
REFERENCE   6  (bases 1 to 3449)
  AUTHORS   Brandsen,J., Werten,S., van der Vliet,P.C., Meisterernst,M.,
            Kroon,J. and Gros,P.
  TITLE     C-terminal domain of transcription cofactor PC4 reveals dimeric
            ssDNA binding site
  JOURNAL   Nat Struct Biol 4 (11), 900-903 (1997)
   PUBMED   9360603
REFERENCE   7  (bases 1 to 3449)
  AUTHORS   Kaiser,K., Stelzer,G. and Meisterernst,M.
  TITLE     The coactivator p15 (PC4) initiates transcriptional activation
            during TFIIA-TFIID-promoter complex formation
  JOURNAL   EMBO J 14 (14), 3520-3527 (1995)
   PUBMED   7628453
REFERENCE   8  (bases 1 to 3449)
  AUTHORS   Ge,H., Zhao,Y., Chait,B.T. and Roeder,R.G.
  TITLE     Phosphorylation negatively regulates the function of coactivator
            PC4
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12691-12695 (1994)
   PUBMED   7809103
REFERENCE   9  (bases 1 to 3449)
  AUTHORS   Kretzschmar,M., Kaiser,K., Lottspeich,F. and Meisterernst,M.
  TITLE     A novel mediator of class II gene transcription with homology to
            viral immediate-early transcriptional regulators
  JOURNAL   Cell 78 (3), 525-534 (1994)
   PUBMED   8062392
REFERENCE   10 (bases 1 to 3449)
  AUTHORS   Ge,H. and Roeder,R.G.
  TITLE     Purification, cloning, and characterization of a human coactivator,
            PC4, that mediates transcriptional activation of class II genes
  JOURNAL   Cell 78 (3), 513-523 (1994)
   PUBMED   8062391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX472106.1, BC010537.1, BC071655.1 and AC074134.3.
            
            On Nov 22, 2018 this sequence version replaced NM_006713.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071655.1, SRR1660807.205718.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265073.9/ ENSP00000265073.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               BX472106.1         60-498
            440-1327            BC010537.1         401-1288
            1328-2209           BC071655.1         1303-2184
            2210-3421           AC074134.3         8541-9752           c
            3422-3449           BC071655.1         3397-3424
FEATURES             Location/Qualifiers
     source          1..3449
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..3449
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="SUB1 regulator of transcription"
                     /db_xref="GeneID:10923"
                     /db_xref="HGNC:HGNC:19985"
                     /db_xref="MIM:600503"
     exon            1..69
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            70..142
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..454
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="activated RNA polymerase II transcription cofactor
                     4; positive cofactor 4; SUB1 homolog, transcriptional
                     regulator"
                     /codon_start=1
                     /product="activated RNA polymerase II transcriptional
                     coactivator p15"
                     /protein_id="NP_006704.3"
                     /db_xref="CCDS:CCDS3897.1"
                     /db_xref="GeneID:10923"
                     /db_xref="HGNC:HGNC:19985"
                     /db_xref="MIM:600503"
                     /translation="MPKSKELVSSSSSGSDSDSEVDKKLKRKKQVAPEKPVKKQKTGE
                     TSRALSSSKQSSSSRDDNMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKG
                     ISLNPEQWSQLKEQISDIDDAVRKL"
     exon            143..265
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            266..374
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /inference="alignment:Splign:2.1.0"
     exon            375..3449
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      606..611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="hexamer: ATTAAA"
     polyA_site      624
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
     regulatory      678..683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="hexamer: AATAAA"
     polyA_site      697
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="major polyA site"
     regulatory      1307..1312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="hexamer: AATAAA"
     polyA_site      1327
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
     regulatory      3431..3436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
                     /note="hexamer: AATAAA"
     polyA_site      3449
                     /gene="SUB1"
                     /gene_synonym="p14; P15; PC4"
ORIGIN      
        1 acttccggtt ctctgtcagt cgcgagcgaa cgaccaagag ggtgttcgac tgctagagcc
       61 gagcgaagcg atgcctaaat caaaggaact tgtttcttca agctcttctg gcagtgattc
      121 tgacagtgag gttgacaaaa agttaaagag gaaaaagcaa gttgctccag aaaaacctgt
      181 aaagaaacaa aagacaggtg agacttcgag agccctgtca tcttctaaac agagcagcag
      241 cagcagagat gataacatgt ttcagattgg gaaaatgagg tacgttagtg ttcgcgattt
      301 taaaggcaaa gtgctaattg atattagaga atattggatg gatcctgaag gtgaaatgaa
      361 accaggaaga aaaggtattt ctttaaatcc agaacaatgg agccagctga aggaacagat
      421 ttctgacatt gatgatgcag taagaaaact gtaaaattcg agccatataa ataaaacctg
      481 tactgttcta gttgttttaa tctgtctttt tacattggct tttgttttct aaatgttctc
      541 caagctattg tatgtttgga ttgcagaaga atttgtaaga tgaatacttt tttttaatgt
      601 gcattattaa aaatattgag tgaagctaat tgtcaacttt attaaggatt actttgtctg
      661 cccaccacct agtgtaaaat aaaatcaagt aatacaatct taactgttgt ggcctttttt
      721 gatcataaga gttggtactg tttaaggcca aaagtaacag tttttataga tcttttagtt
      781 tcaactcagc ttttacaata aaaaggattt gtattgcatt gagtttataa acttttggtt
      841 tgtgaacttc atatttgatc ttttctcttc caatcaaatg tctaggcttg tttgacttcc
      901 acccccaatg gtttttcact ctttttattt acttcatttt cctttaataa cttaatctct
      961 tcatgttcag tttttacttc actctttatt cttttctttg attatggtat gcttatttgg
     1021 aaagtcagtg aaactgtcaa aatgttatct caataagata cttatatgag aactacaatc
     1081 accgaatcta ctgtattcaa tattagcaga tctaatttga taaacaacat ggcttgtgtg
     1141 aaaactgagc aggtgtttgt ttacccatag tgttctgtgt agttattgct tagtctgcag
     1201 aaaataatga cttagatgag atgtctgact tgctttcact tattaaacat gttcaccatg
     1261 ggatgatgtc tgtaacatca gatattgttc aactagacta ggatttaata aaaattgtga
     1321 aagcttactg gcctaacatt ttattttata atattgggta tgaattatat gtagccagag
     1381 atgtcattaa gctttactgt tatagtaggt aatatggtta gtttgtaggg aaaagagcat
     1441 atgagcacat gcttgtgtat tttggccttt gccccagtag aacagaccaa tggcattcta
     1501 gacttgatga tactaagttt tagcagacac tagtaagtgg tttgtattta accatactga
     1561 tgaagcagac agattgaggc acagatttta gtggctttgt ggcaataaat agggcatggt
     1621 gtgccttagg aaaagaatgt ttataaaggg aattataact gaaattaaag gaggcggcag
     1681 tgaagaggaa ataattctct tctatctaaa tgatatacat atgatatttt gagattttta
     1741 taacagcagt ggaacacaat tctaggtaga gtagaaaaag gaaagtttta aagacatata
     1801 aaagattctt gttgacaaat tatttttggt agcaaatctc aaatggttac ctgctattaa
     1861 ggtctgccat attagagttt tgcactattt tgctaccaag tttgattcat acatctaaaa
     1921 cattttgtag ttacttgtca aggacttaat ttgaaaatca tttgccaggc cacatagtta
     1981 tcaatttttt tttctatcag ctattctgtt gtatttctaa aacatttttt agatgacttt
     2041 ttaaagtata tttagcagta accttatgag gttcaaattg gtaaatctct tgtaatttag
     2101 ccttcatcga ataataggta ccagtgtatt aaaaatgtgt attttttgca gccccttgaa
     2161 ccagagtagg ttcagagaaa ctcccaaagt ttgtacttta gacacatcat gcttgattgg
     2221 taacttccct ccttttttgg ggaacatgtt tgtgtcctat taacttaatt ggatagattt
     2281 ttaaatattt cttatttttg gcacacggaa agggtagttc gagtacagaa ctttgatttt
     2341 tggtgtagat gcagagggaa tgatgggtaa atttcctagg tttatgtgaa tttagggggt
     2401 gtatgcattt tgaaacaatc tactaacaga tggtgctgaa atctattacc tacatgtttt
     2461 ctagttgttc agcattatgt taatgaagcc tccatataag gagtgtttct ctggcacagt
     2521 tggtaagttg actgctaact tcatttaaat gtgttactgg atatgcagta tactgaaatt
     2581 attaatcagt ttgtgtatag gaaaagagaa ctgggttaaa agcaaattaa cttgttctga
     2641 aaagaaagta tagattaatt ttgttttctg tttaaatttt atctccttgg taaagatttt
     2701 tttttcctgg gcagaaaact tggcattttt aggcgtagat accttacctt acaatgccaa
     2761 aatgaattta attccagtac tcaggttttt ccctttaaca gactctatgt gtatcagggc
     2821 tttctaatgg gtttttcctc ttcgttttta aaatgtgagt agcatttgac caatttccag
     2881 tgctcttagc attttactta aagaacaacc actacaaaag aaaatctttg taatttgatt
     2941 gtcttttgct ttgcttcatt aatgcctaag aacttaagaa tactcctacc tcattagcta
     3001 ctcaagatgc tgtgacgatc aaatctattc tacataatgc gtttagaaac aaagacttgg
     3061 gtgaaaaatg aaataagtat attctgactt ggctattgag gggaaaattc agtattaagt
     3121 gttcctcaca ggagatatgt tagcagaata ctataaaagt ttgaaatttt taaaaagtaa
     3181 aagtacttaa atttaggtat ctctcctgaa attctttgca gttcattttt tatggcagtt
     3241 aatccagtga aacactcaaa agtttttttt tttttaaaag tgtttttcca gataaactgt
     3301 agggtgaaca ttcacataat cacaaatatg taattctgta attgtggaat gcttgtatgc
     3361 tttgttttcg tacatcttcc atggagatgt ctgaatataa tactccatct gtgaatattt
     3421 taaatgttga aataaaagta agaaatgtg
//
