LOCUS       NM_001080426            4170 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine/tyrosine interacting like 2 (STYXL2),
            mRNA.
ACCESSION   NM_001080426 XM_005245603 XM_043739
VERSION     NM_001080426.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Zhao,B.M., Keasey,S.L., Tropea,J.E., Lountos,G.T., Dyas,B.K.,
            Cherry,S., Raran-Kurussi,S., Waugh,D.S. and Ulrich,R.G.
  TITLE     Phosphotyrosine Substrate Sequence Motifs for Dual Specificity
            Phosphatases
  JOURNAL   PLoS One 10 (8), e0134984 (2015)
   PUBMED   26302245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Nielsen,D.A., Ji,F., Yuferov,V., Ho,A., He,C., Ott,J. and
            Kreek,M.J.
  TITLE     Genome-wide association study identifies genes that may contribute
            to risk for developing heroin addiction
  JOURNAL   Psychiatr Genet 20 (5), 207-214 (2010)
   PUBMED   20520587
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158837.14.
            
            On May 17, 2019 this sequence version replaced NM_001080426.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.216447.1,
                                           SRR5189655.145095.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361200.7/ ENSP00000354483.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL158837.14        110804-110923
            121-246             AL158837.14        111563-111688
            247-341             AL158837.14        130439-130533
            342-573             AL158837.14        134057-134288
            574-791             AL158837.14        135978-136195
            792-4170            AL158837.14        142516-145894
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..4170
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /note="serine/threonine/tyrosine interacting like 2"
                     /db_xref="GeneID:92235"
                     /db_xref="HGNC:HGNC:25034"
     exon            1..120
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     exon            121..246
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3613
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /note="inactive dual specificity phosphatase 27; dual
                     specificity phosphatase 27 (putative); dual specificity
                     phosphatase 27, atypical"
                     /codon_start=1
                     /product="serine/threonine/tyrosine-interacting-like
                     protein 2"
                     /protein_id="NP_001073895.1"
                     /db_xref="CCDS:CCDS30932.1"
                     /db_xref="GeneID:92235"
                     /db_xref="HGNC:HGNC:25034"
                     /translation="MATRKDTEEEQVVPSEEDEANVRAVQAHYLRSPSPSQYSMVSDA
                     ETESIFMEPIHLSSAIAAKQIINEELKPPGVRADAECPGMLESAEQLLVEDLYNRVRE
                     KMDDTSLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGI
                     THILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYR
                     GKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNE
                     KLMEEREEDYGREGGSAEAEEGEGTGSMLGARVHALTVEEEDDSASHLSGSSLGKATQ
                     ASKPLTLIDEEEEEKLYEQWKKGQGLLSDKVPQDGGGWRSASSGQGGEELEDEDVERI
                     IQEWQSRNERYQAEGYRRWGREEEKEEESDAGSSVGRRRRTLSESSAWESVSSHDIWV
                     LKQQLELNRPDHGRRRRADSMSSESTWDAWNERLLEIEKEASRRYHAKSKREEAADRS
                     SEAGSRVREDDEDSVGSEASSFYNFCSRNKDKLTALERWKIKRIQFGFHKKDLGAGDS
                     SGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKVGSENKEEVVELSKGEDSALAKKRQ
                     RRLELLERSRQTLEESQSMASWEADSSTASGSIPLSAFWSADPSVSADGDTTSVLSTQ
                     SHRSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISIASIQNWIANVVSETLAQKQN
                     EMLLLSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLGGCLLPQSQARPSSDMQSV
                     LSCNTTLSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKEKEMQMELREKMSEYKM
                     EKLASDNKRSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSSRSNSQKPETDTCSS
                     LAVCDHYASGSRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRGKYTRSSLLRETE
                     SKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHKFSRSTYNETS
                     SSREESPEPYFFRRTPESSEREESPEPQRPNWARSRDWEDVEESSKSDFSEFGAKRKF
                     TQSFMRSEEEGEKERTENREEGRFASGRRSQYRRSTDREEEEEMDDEAIIAAWRRRQE
                     ETRTKLQKRRED"
     exon            247..341
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     exon            342..573
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     exon            574..791
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     exon            792..4170
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4111..4116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /note="hexamer: ATTAAA"
     polyA_site      4135
                     /gene="STYXL2"
                     /gene_synonym="DUSP27"
                     /note="major polyA site"
ORIGIN      
        1 aggagaagaa gccctgagga aggaggtggc tggttcctgt ctcactggcc ggagcttcag
       61 cttcagtcat ttcatctggg tccctcagcc cttggtgggg aacatccagg caggttagag
      121 aggttggcag gttgtcatgg cgaccagaaa ggacacagag gaggagcagg tagtcccaag
      181 cgaggaggac gaagccaacg tgagggcggt gcaggcccac tacctccgaa gcccctcccc
      241 tagccagtat tcgatggtct cagatgcaga aacagaaagc attttcatgg aacccattca
      301 cctctcctca gccattgcag ccaaacagat catcaatgaa gaactcaagc caccgggggt
      361 cagagcagac gcagagtgtc caggcatgct ggagtctgct gaacagctgc tggtggagga
      421 cctgtacaac cgcgtcaggg agaagatgga tgacaccagc ctctataata cgccctgtgt
      481 cctggaccta cagcgggccc tggttcagga tcgccaagag gcgccctgga atgaggtgga
      541 tgaggtctgg cccaatgtct tcatagctga gaagagtgtg gctgtgaaca aggggaggct
      601 gaagaggctg ggaatcaccc acattctgaa tgctgcgcat ggcaccggcg tttacactgg
      661 ccccgaattc tacactggcc tggagatcca gtacctgggt gtagaggtgg atgactttcc
      721 tgaggtggac atttcccagc atttccggaa ggcgtctgag ttcctggatg aggcgctgct
      781 gacttacaga gggaaagtcc tggtcagcag cgaaatgggc atcagccggt cagcagtgct
      841 ggtggtcgcc tacctgatga tcttccacaa catggccatc ctggaggctt tgatgaccgt
      901 gcgtaagaag cgggccatct accccaatga gggcttcctg aagcagctgc gggagctcaa
      961 tgagaagttg atggaggaga gagaagagga ctatggccgg gaggggggat cagctgaggc
     1021 tgaggagggc gagggcactg ggagcatgct cggggccaga gtgcacgccc tgacggtgga
     1081 agaggaggac gacagcgcca gccacctgag tggctcctcc ctggggaagg ccacccaggc
     1141 ctccaagccc ctcaccctca tagacgagga ggaggaggag aaactgtacg agcagtggaa
     1201 gaaggggcag ggcctcctct cagacaaggt cccccaggat ggaggtggct ggcgctcagc
     1261 ctcctctggc cagggtgggg aggagctcga ggacgaggac gtggagagga tcatccagga
     1321 gtggcagagc cgaaacgaga ggtaccaagc agaagggtac cggaggtggg gaagggagga
     1381 ggagaaggag gaggagagcg acgctggctc ctcggtgggg aggcggcggc gcaccctgag
     1441 cgagagcagc gcctgggaga gcgtgagcag ccacgacatc tgggtcctga agcagcagct
     1501 ggagctgaac cgcccggacc acggcaggag gcgccgcgca gactcgatgt cctcggagag
     1561 cacctgggac gcatggaacg agaggctgct ggagattgag aaggaggctt cccggaggta
     1621 ccacgccaag agcaagagag aggaggcggc agacaggagc tcagaagcag ggagcagggt
     1681 gcgggaggat gatgaggaca gcgtgggctc tgaggccagt tccttctaca acttctgcag
     1741 caggaacaag gacaagctca ctgccctgga aagatggaag atcaagagaa tccaatttgg
     1801 atttcacaag aaagacttgg gagcgggaga cagcagcggt gagcccggtg cagaggaggc
     1861 agtaggggag aagaacccct ccgacgtcag cctgacagcc taccaggcct ggaagctgaa
     1921 acaccagaag aaggtgggca gtgagaacaa ggaggaggtg gtggagctca gcaaggggga
     1981 ggactcggcc ttggctaaga agagacaacg gaggctggag ctgctggaga gaagccggca
     2041 gacgctggag gagagccagt ctatggcaag ctgggaggcg gacagctcca cggccagcgg
     2101 gagcattccc ctgtctgcgt tctggtctgc agacccctca gtcagcgctg atggggacac
     2161 gacgtcagta ctgagcaccc agagccaccg ctcccacctg tctcaggctg caagcaacat
     2221 agcggggtgt tcaacctcca accccaccac acccctgcct aacctgccag tggggcctgg
     2281 agacaccatt tccattgcca gtatccagaa ctggattgcc aatgtagtca gtgagaccct
     2341 tgctcagaag caaaatgaaa tgctgctgtt gtcccgctca ccgtctgttg caagcatgaa
     2401 ggcagtacca gcggctagct gcctggggga tgaccaagtc tccatgctta gtggacacag
     2461 cagctcctcc ttgggtggct gcctgttgcc tcagagccag gcaagaccca gctctgacat
     2521 gcagtctgtg ctgtcctgca acaccacact gagctcaccc gcggaaagtt gcagaagcaa
     2581 agtgaggggg accagcaagc ccatcttcag cctctttgct gacaatgtgg acctaaagga
     2641 acttggccgg aaggagaagg agatgcagat ggagcttagg gagaagatgt ctgagtacaa
     2701 aatggaaaag ctggcctcag acaacaaacg cagctccctc ttcaagaaga agaaggtcaa
     2761 ggaagatgag gatgatggtg tgggtgatgg ggatgaggac actgacagtg ccatagggag
     2821 cttccgatat tcttcccgca gtaattccca gaaacctgaa acagacacat gctcctccct
     2881 ggctgtctgt gatcactatg caagtggcag cagagttggc aaagagatgg atagcagtat
     2941 taataagtgg ctcagtggcc tcaggacgga ggaaaaacct cctttccaaa gtgactggtc
     3001 tggaagttcc agagggaagt acaccagatc gtccctgctc agggagacag agtctaaatc
     3061 ctccagttac aagttttcca aatcccagtc agaggaacag gacacctcct cctaccacga
     3121 ggcaaatggc aactctgtaa gaagcacttc acggttctca tcttcctcca ccagggaggg
     3181 cagagagatg cacaagttct ccaggtccac gtacaacgag acctcaagtt cccgagagga
     3241 gagcccagag ccctacttct tccgccggac cccagagtcc tcagaaaggg aagagtcccc
     3301 agaaccacag cgcccaaatt gggccaggtc cagggactgg gaagatgtgg aagagtcatc
     3361 caagtcagac ttctctgaat ttggagccaa gaggaagttc acccagagct ttatgaggtc
     3421 tgaagaagag ggagagaaag agaggacaga aaacagagaa gaagggaggt ttgcatctgg
     3481 acggcggtcc cagtatcgga gaagcactga cagggaggaa gaggaagaaa tggacgatga
     3541 agccatcatt gctgcttgga gacgccggca agaagaaacc aggaccaagc tgcagaaaag
     3601 gagggaggac tgagctgggg aaaatctgag aacactgaaa gaaaccactc acgttagcat
     3661 agggctcagg gcacacgttg ccaccactca tcgcaggatg aggatacaga gaggatcttc
     3721 cagaggggca gagccaaaat gagaggtacc aagcataagg gcagcagagg tggagtaggg
     3781 aggaggcaag gagggggaga accatcaata cgaatacgag gtccgaatgc ggaccaactg
     3841 ataccatttt ctgttgctca gcgccctcta agctttggtg tttcacttaa tgtatttggc
     3901 agtgttcatc acaggctaga gaggtgagct tggaaaagca ctgtagtttg tcagagactc
     3961 cagtttacat ccagaaaggc catgaacata ggacacgctt ctgtctgtag aggcttcata
     4021 tgagacccag aaagtctatc ctatggcaag tctgacctct cctggcaatg ctcagttctg
     4081 attttttttt ttttaatgtt ttgagtctcc attaaaaatg gtatgttggc aaatagttct
     4141 tctttattct ggtcatgttt aactttttgg
//
