LOCUS       NM_001317785            1411 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens serine/threonine/tyrosine interacting like 1 (STYXL1),
            transcript variant 2, mRNA.
ACCESSION   NM_001317785 XM_011516295
VERSION     NM_001317785.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   Smailys,J., Jiang,F., Prioleau,T., Kelley,K., Mitchell,O., Nour,S.,
            Ali,L., Buchser,W., Zavada,L. and Hinton,S.D.
  TITLE     The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1
            to decrease stress granules
  JOURNAL   Arch Biochem Biophys 744, 109702 (2023)
   PUBMED   37516290
  REMARK    GeneRIF: The DUSP domain of pseudophosphatase MK-STYX interacts
            with G3BP1 to decrease stress granules.
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Patel,S., Bhatt,A.M., Bhansali,P. and Setty,S.R.G.
  TITLE     Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase
            trafficking to lysosomes via ER stress
  JOURNAL   Traffic 24 (7), 254-269 (2023)
   PUBMED   37198709
  REMARK    GeneRIF: Pseudophosphatase STYXL1 depletion enhances
            glucocerebrosidase trafficking to lysosomes via ER stress.
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Wu,J.Z., Jiang,N., Lin,J.M. and Liu,X.
  TITLE     STYXL1 promotes malignant progression of hepatocellular carcinoma
            via downregulating CELF2 through the PI3K/Akt pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (6), 2977-2985 (2020)
   PUBMED   32271415
  REMARK    GeneRIF: STYXL1 promotes malignant progression of hepatocellular
            carcinoma via downregulating CELF2 through the PI3K/Akt pathway.
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Tomar,V.S., Baral,T.K., Nagavelu,K. and Somasundaram,K.
  TITLE     Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1), a
            pseudo phosphatase, promotes oncogenesis in glioma
  JOURNAL   Biochem Biophys Res Commun 515 (1), 241-247 (2019)
   PUBMED   31146910
  REMARK    GeneRIF: Silencing serine/threonine/tyrosine-interacting-like
            protein 1 (STYXL1) inhibited glioma cell growth, soft agar colony
            formation, migration, invasion, proliferation, and xenograft tumor
            growth [Review].
            Review article
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Cao,Y., Banks,D.A., Mattei,A.M., Riddick,A.T., Reed,K.M.,
            Zhang,A.M., Pickering,E.S. and Hinton,S.D.
  TITLE     Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic
            Localization, Decreases Its Phosphorylation, and Increases
            Detyrosination of Tubulin
  JOURNAL   Int J Mol Sci 20 (6), 1455 (2019)
   PUBMED   30909412
  REMARK    GeneRIF: These findings show that MK-STYX decreases the number of
            HDAC6-containing aggregates and alters their localization, sustains
            microtubule acetylation, and increases detyrosination of
            microtubules, implicating MK-STYX as a signaling molecule in HDAC6
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Meier,M., Tokarz,J., Haller,F., Mindnich,R. and Adamski,J.
  TITLE     Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1)
            proteins are inactive enzymes but conserved among species
  JOURNAL   Chem Biol Interact 178 (1-3), 197-205 (2009)
   PUBMED   19026618
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   10 (bases 1 to 1411)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     Gathering STYX: phosphatase-like form predicts functions for unique
            protein-interaction domains
  JOURNAL   Trends Biochem Sci 23 (8), 301-306 (1998)
   PUBMED   9757831
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF069762.1, BC024035.2, BM824947.1, AC006330.5 and BM972220.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001317785.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024035.2, SRR18074967.1459278.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359697.8/ ENSP00000352726.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AF069762.1         4-40
            38-302              BC024035.2         1-265
            303-332             BM824947.1         280-309
            333-369             BC024035.2         296-332
            370-370             AC006330.5         22059-22059
            371-1086            BC024035.2         334-1049
            1087-1087           AC006330.5         51600-51600
            1088-1408           BC024035.2         1051-1371
            1409-1411           BM972220.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1411
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /note="serine/threonine/tyrosine interacting like 1"
                     /db_xref="GeneID:51657"
                     /db_xref="HGNC:HGNC:18165"
                     /db_xref="MIM:616695"
     exon            1..339
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            340..446
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1285
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /note="isoform a is encoded by transcript variant 2; map
                     kinase phosphatase-like protein MK-STYX; dual specificity
                     phosphatase 24 (putative);
                     serine/threonine/tyrosine-interacting-like protein 1; dual
                     specificity protein phosphatase 24; dual specificity
                     phosphatase inhibitor MK-STYX; inactive dual specificity
                     protein phosphatase MK-STYX"
                     /codon_start=1
                     /product="serine/threonine/tyrosine-interacting-like
                     protein 1 isoform a"
                     /protein_id="NP_001304714.1"
                     /db_xref="CCDS:CCDS5580.1"
                     /db_xref="GeneID:51657"
                     /db_xref="HGNC:HGNC:18165"
                     /db_xref="MIM:616695"
                     /translation="MPGLLLCEPTELYNILNQATKLSRLTDPNYLCLLDVRSKWEYDE
                     SHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKDDDDDSDSDGDGK
                     DLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYP
                     IEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPE
                     AQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYV
                     KKCKNNMCPNRGLVSQLLEWEKTILGDSITNIMDPLY"
     exon            447..508
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            509..650
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            651..796
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            797..942
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1040
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1153
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1411
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1411
                     /gene="STYXL1"
                     /gene_synonym="DUSP24; MK-STYX; MKSTYX"
                     /note="major polyA site"
ORIGIN      
        1 acttccggga gtcggaaagg aaagctgtgg gaccatcctg gcaaccccgg tgtttggctg
       61 ggttctagcg tagccgtctg tgtggccggt gggggacctg cggtcggagt gggagggcca
      121 gtctgcaccc aagaggtgga agaggacggg ctttaggctg gaagcgcctt agaggagcca
      181 tttttccagg tggggcccca ggcagaggct ccgacaggga gcctggccat agtcgcgcag
      241 ccggggaggt ggagcgcgtc ccagacccga gcccccgacc tcagccaaac ccattccttc
      301 tgcccttgga ggccagaggg gactctgagc tccggaaagc aggatgcctg gtttgctttt
      361 atgtgaacca acagagcttt acaacatcct gaatcaggcc acaaaactct ccagattaac
      421 agaccccaac tatctctgtt tattggatgt ccgttccaaa tgggagtatg acgaaagcca
      481 tgtgatcact gcccttcgag tgaagaagaa aaataatgaa tatcttctcc cggagtctgt
      541 ggacctggag tgtgtgaagt actgcgtggt gtatgataac aacagcagca ccctggagat
      601 actcttaaaa gatgatgatg atgattcaga ctctgatggt gatggcaaag atcttgtgcc
      661 tcaagcagcc attgagtatg gcaggatcct gacccgcctc acccaccacc ccgtctacat
      721 cctgaaaggg ggctatgagc gcttctcagg cacgtaccac tttctccgga cccagaagat
      781 catctggatg cctcaggaac tggatgcatt tcagccatac cccattgaaa tcgtgccagg
      841 gaaggtcttc gttggcaatt tcagtcaagc ctgtgacccc aagattcaga aggacttgaa
      901 aatcaaagcc catgtcaatg tctccatgga tacagggccc ttttttgcag gcgatgctga
      961 caagcttctg cacatccgga tagaagattc cccggaagcc cagattcttc ccttcttacg
     1021 ccacatgtgt cacttcattg aaattcacca tcaccttggc tctgtcattc tgatcttttc
     1081 cacccaaggt atcagccgca gttgtgccgc catcatagcc tacctcatgc atagtaacga
     1141 gcagaccttg cagaggtcct gggcctatgt caagaagtgc aaaaacaaca tgtgtccaaa
     1201 tcggggattg gtgagccagc tgctggaatg ggagaagact atccttggag attccatcac
     1261 aaacatcatg gatccgctct actgatcttc tccgaggccc accgaagggt actgaagagc
     1321 ctcacctggg ggcattttgt gggtggaggg ccagagtgtg tatacccagg cttgtctgga
     1381 aggagaaggc ctttgctgcc tgaaagtctc a
//
