LOCUS       NM_018423               2771 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine/threonine/tyrosine kinase 1 (STYK1), mRNA.
ACCESSION   NM_018423
VERSION     NM_018423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2771)
  AUTHORS   Yang,Y., Liu,L. and Tucker,H.O.
  TITLE     Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK
            transgenic mice
  JOURNAL   Biochem Biophys Res Commun 626, 51-57 (2022)
   PUBMED   35970044
  REMARK    GeneRIF: Induction of chronic lymphocytic leukemia-like disease in
            STYK1/NOK transgenic mice.
REFERENCE   2  (bases 1 to 2771)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 2771)
  AUTHORS   Wang,Y., Liu,S., Jiang,G., Zhai,W., Yang,L., Li,M., Chang,Z. and
            Zhu,B.
  TITLE     NOK associates with c-Src and promotes c-Src-induced STAT3
            activation and cell proliferation
  JOURNAL   Cell Signal 75, 109762 (2020)
   PUBMED   32871210
  REMARK    GeneRIF: NOK associates with c-Src and promotes c-Src-induced STAT3
            activation and cell proliferation.
REFERENCE   4  (bases 1 to 2771)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 2771)
  AUTHORS   Li,X.L., Huang,Y.Y., Yuan,T.J., Lian,X.P. and Bi,H.L.
  TITLE     STYK1 promotes the malignant progression of laryngeal squamous cell
            carcinoma through targeting TGF-beta1
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6166-6174 (2020)
   PUBMED   32572882
  REMARK    GeneRIF: STYK1 promotes the malignant progression of laryngeal
            squamous cell carcinoma through targeting TGF-beta1.
REFERENCE   6  (bases 1 to 2771)
  AUTHORS   Amachika,T., Kobayashi,D., Moriai,R., Tsuji,N. and Watanabe,N.
  TITLE     Diagnostic relevance of overexpressed mRNA of novel oncogene with
            kinase-domain (NOK) in lung cancers
  JOURNAL   Lung Cancer 56 (3), 337-340 (2007)
   PUBMED   17298854
  REMARK    GeneRIF: NOK mRNA was highly expressed even at the early clinical
            stages of the cancer. These results suggest that NOK mRNA might be
            a new tool to support the diagnosis of lung cancers, irrespective
            of the clinical stages.
REFERENCE   7  (bases 1 to 2771)
  AUTHORS   Liu,L., Yu,X.Z., Li,T.S., Song,L.X., Chen,P.L., Suo,T.L., Li,Y.H.,
            Wang,S.D., Chen,Y., Ren,Y.M., Zhang,S.P., Chang,Z.J. and Fu,X.Y.
  TITLE     A novel protein tyrosine kinase NOK that shares homology with
            platelet- derived growth factor/fibroblast growth factor receptors
            induces tumorigenesis and metastasis in nude mice
  JOURNAL   Cancer Res 64 (10), 3491-3499 (2004)
   PUBMED   15150103
REFERENCE   8  (bases 1 to 2771)
  AUTHORS   Ye,X., Ji,C., Huang,Q., Cheng,C., Tang,R., Xu,J., Zeng,L., Dai,J.,
            Wu,Q., Gu,S., Xie,Y. and Mao,Y.
  TITLE     Isolation and characterization of a human putative receptor protein
            kinase cDNA STYK1
  JOURNAL   Mol Biol Rep 30 (2), 91-96 (2003)
   PUBMED   12841579
  REMARK    GeneRIF: cloning and characterization; mapped to chromosome 12p13;
            widely expressed in human tissues
REFERENCE   9  (bases 1 to 2771)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: SuRTK106/NOK/STYK1 was first identified, classified and
            shown to have predicted pseudokinase domain.
            Review article
REFERENCE   10 (bases 1 to 2771)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF251059.1, AC021049.12 and AL353940.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018423.2.
            
            Summary: Receptor protein tyrosine kinases, like STYK1, play
            important roles in diverse cellular and developmental processes,
            such as cell proliferation, differentiation, and survival (Liu et
            al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL353940.1, SRR1660809.181095.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000075503.8/ ENSP00000075503.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AF251059.1         241-1094
            855-891             AC021049.12        120019-120055
            892-2755            AL353940.1         880-2743
            2756-2771           AC021049.12        130633-130648
FEATURES             Location/Qualifiers
     source          1..2771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2771
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /note="serine/threonine/tyrosine kinase 1"
                     /db_xref="GeneID:55359"
                     /db_xref="HGNC:HGNC:18889"
                     /db_xref="MIM:611433"
     exon            1..87
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            88..213
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            214..333
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1550
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /EC_number="2.7.10.2"
                     /note="protein PK-unique; novel oncogene with kinase
                     domain"
                     /codon_start=1
                     /product="tyrosine-protein kinase STYK1"
                     /protein_id="NP_060893.2"
                     /db_xref="CCDS:CCDS8629.1"
                     /db_xref="GeneID:55359"
                     /db_xref="HGNC:HGNC:18889"
                     /db_xref="MIM:611433"
                     /translation="MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVI
                     LWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPA
                     LAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQD
                     FLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG
                     LLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEV
                     YTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTS
                     ILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAV
                     LQVPELVVPELYAAVAGIRVESLFYNYSML"
     exon            334..468
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            469..732
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            733..914
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            915..998
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1207
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1248
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1345
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..2771
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2491..2496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /note="hexamer: ATTAAA"
     polyA_site      2517
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /note="hexamer: AATAAA"
     polyA_site      2771
                     /gene="STYK1"
                     /gene_synonym="NOK; SuRTK106"
                     /note="major polyA site"
ORIGIN      
        1 acaccttgcc ctacccaacc ctgtcattat ttcccctccg actgggccgg tgccatcgga
       61 aaccggagtg accagaggag ggacacgcat ccaatttcac tgggctgcaa gatatcaata
      121 agccttgcct ctttaaacta cttatgtaca aataaaagtg atggtgagaa cctggctcag
      181 gaaatgcagt agcaggccat attgcatcca aaggaattac tcacagctgt gctgtgtgca
      241 ttctctgtgg gcctagcagg gaaggggaca gccctgtggc aatgggcatg acacggatgc
      301 tcctggaatg cagtctcagt gacaagttgt gtgtcatcca ggagaagcag tatgaagtga
      361 ttatcgtccc aactttgttg gttactatct tcctcatcct tcttggggtc atcctgtggc
      421 tttttatcag agaacaaaga actcaacagc agcgttctgg acctcaaggc attgcccctg
      481 ttcctccacc tagggaccta agctgggaag caggacatgg aggaaatgtg gctttgccac
      541 ttaaggagac atccgtggaa aactttctgg gagctaccac acctgccctg gctaagctgc
      601 aggtgccgcg ggagcaactc tctgaagttc tggagcagat ttgcagtggt agctgtgggc
      661 ccatctttcg agccaatatg aacactgggg acccttctaa gcccaagagt gttattctca
      721 aggctttaaa agaaccagct gggctccatg aggtacaaga tttcttaggg cgaatccaat
      781 tccatcaata cctggggaaa cacaaaaacc tggtgcagct ggaaggctgc tgcactgaaa
      841 agctgccact ctatatggtg ttggaggatg tggcccaggg ggacctgctc agctttctct
      901 ggacctgtcg gcgggatgtg atgactatgg atggtcttct ctatgatctc acagaaaaac
      961 aagtatatca catcggaaag caggtccttt tggcgctgga attcctgcag gagaagcatt
     1021 tgttccatgg ggatgtggca gccaggaata ttctgatgca aagtgatctc actgctaagc
     1081 tctgtggatt aggcctggct tatgaagttt acacccgagg ggccatctcc tctactcaaa
     1141 ccatacctct caagtggctt gccccagaac ggcttctcct gagacctgct agcatcagag
     1201 cagatgtctg gtcttttggg atcctgctct atgagatggt gactctagga gcaccaccgt
     1261 atcctgaagt ccctcctacc agcatcctag agcatctcca aagaaggaaa atcatgaaga
     1321 gacccagtag ctgcacacat accatgtaca gtatcatgaa gtcctgctgg cgctggcgtg
     1381 aggctgaccg cccctcacct agagagctgc gcttgcgcct agaagctgcc attaaaactg
     1441 cagatgacga ggctgtgtta caagtaccag agttggtggt acctgaactg tatgcagctg
     1501 tggccggcat cagagtggag agcctcttct acaactatag catgctttga agagtctcgg
     1561 gcaagaaaca ttcatgcatg agtatatgtt cttggaatca attcctctaa gaacagagaa
     1621 tggtctttcc cagggacaca aagggagaaa tgggacatgg attcttgatc ttcctttaca
     1681 catttctcgg gaaatctgaa atgatgctgg atgggactct acacatcctg agctaagaca
     1741 tactgtcagt ctcacttctg ctgtcccagt cctagaaatc ctgggtagaa gtggtggacc
     1801 tgtgcaaagg aggttttaga actctgcagt atttgttggg gcatggcaca aataagctca
     1861 tccctcccgt ccgaggctag tttcctctgg aaccacattt ttatctagat gaaaatttgg
     1921 aatgaaatga aggaatagaa atccaataaa agagttgaag ggaaagaaaa tttaaggttc
     1981 ttcttgctca ggattacaga tatggaccaa cacctccttc aagaaaaggt ggtaggacac
     2041 aaagttcttc agtcctgagc cctacatgtg gggttggagg agaactataa cggaaaaacc
     2101 tctgagtttc accttaggta tagataaaag aaagatggtc cccttttatc tgattctgag
     2161 acaggtaaat tctgtttgtt actacgttta attagaaggt ggaggagtca tttcatgatt
     2221 aagaacattc aacatgtatt gttcattaag ctagcttcct agttccgatt agactaagga
     2281 gactaagcct agagagtcaa tgttagaaca gtgaaaagaa ttctgtgtgt gtgtgtgtgt
     2341 gtgtgcacaa taaataggaa atgtagaaac caagcaagaa ggcttagtag ctcagtcttt
     2401 aacaagggct agaaaagaat gtaatctgat atggaaggat agcagcttct aattttcaat
     2461 catctgttga tatactgtga aacttatttt attaaattaa tatttattaa atggaaatat
     2521 gcttttctgg tttataacta ctaaaaatat catagggagg ataaaagtaa ataagtgaaa
     2581 gttaatgcca atagaaaaat tcaagagata atgtacaatg tcagaaaagg gattctttat
     2641 gtgtaaatgg ggataatacc tatttcacaa ggttgttctg aggattgata cgttttgagt
     2701 atgtatttgt acactatctg gcacatatgc gctcaataaa cgtgtttctc cttttctttt
     2761 gcccttccta a
//
