LOCUS       NM_001308330            9291 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens syntaxin binding protein 5L (STXBP5L), transcript
            variant 2, mRNA.
ACCESSION   NM_001308330 XM_005247907
VERSION     NM_001308330.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9291)
  AUTHORS   Kan,H., Liu,H., Mu,Y., Li,Y., Zhang,M., Cao,Y., Dong,Y., Li,Y.,
            Wang,K., Li,Q., Hu,A. and Zheng,Y.
  TITLE     Novel genetic variants linked to prelabor rupture of membranes
            among Chinese pregnant women
  JOURNAL   Placenta 137, 14-22 (2023)
   PUBMED   37054626
  REMARK    GeneRIF: Novel genetic variants linked to prelabor rupture of
            membranes among Chinese pregnant women.
REFERENCE   2  (bases 1 to 9291)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9291)
  AUTHORS   Kumar,R., Corbett,M.A., Smith,N.J., Jolly,L.A., Tan,C.,
            Keating,D.J., Duffield,M.D., Utsumi,T., Moriya,K., Smith,K.R.,
            Hoischen,A., Abbott,K., Harbord,M.G., Compton,A.G., Woenig,J.A.,
            Arts,P., Kwint,M., Wieskamp,N., Gijsen,S., Veltman,J.A., Bahlo,M.,
            Gleeson,J.G., Haan,E. and Gecz,J.
  TITLE     Homozygous mutation of STXBP5L explains an autosomal recessive
            infantile-onset neurodegenerative disorder
  JOURNAL   Hum Mol Genet 24 (7), 2000-2010 (2015)
   PUBMED   25504045
  REMARK    GeneRIF: Homozygous mutation of STXBP5L is associated with
            autosomal recessive infantile-onset neurodegenerative disorder.
            GeneRIF: A homozygous nonsynonymous mutation in STXBP5L (c.3127G>A,
            p.Val1043Ile [CCDS43137.1]) was implicated in an infantile-onset
            neurodegenerative disorder manifesting a predominant sensorimotor
            axonal neuropathy, optic atrophy and cognitive deficit.
REFERENCE   4  (bases 1 to 9291)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   5  (bases 1 to 9291)
  AUTHORS   Le Clerc,S., Taing,L., Ezzedine,K., Latreille,J., Delaneau,O.,
            Labib,T., Coulonges,C., Bernard,A., Melak,S., Carpentier,W.,
            Malvy,D., Jdid,R., Galan,P., Hercberg,S., Morizot,F., Guinot,C.,
            Tschachler,E. and Zagury,J.F.
  TITLE     A genome-wide association study in Caucasian women points out a
            putative role of the STXBP5L gene in facial photoaging
  JOURNAL   J Invest Dermatol 133 (4), 929-935 (2013)
   PUBMED   23223146
  REMARK    GeneRIF: In skin aging rs322458, was in linkage disequilibrium (LD)
            with intronic single nucleotide polymorphisms of the STXBP5L gene,
            which is expressed in the skin.
REFERENCE   6  (bases 1 to 9291)
  AUTHORS   Li,Y., Chang,M., Abar,O., Garcia,V., Rowland,C., Catanese,J.,
            Ross,D., Broder,S., Shiffman,M., Cheung,R., Wright,T.,
            Friedman,S.L. and Sninsky,J.
  TITLE     Multiple variants in toll-like receptor 4 gene modulate risk of
            liver fibrosis in Caucasians with chronic hepatitis C infection
  JOURNAL   J Hepatol 51 (4), 750-757 (2009)
   PUBMED   19586676
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9291)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human LLGL4 gene and mouse
            Llgl4 gene in silico
  JOURNAL   Int J Oncol 24 (3), 737-742 (2004)
   PUBMED   14767561
REFERENCE   8  (bases 1 to 9291)
  AUTHORS   Fujita,Y., Shirataki,H., Sakisaka,T., Asakura,T., Ohya,T.,
            Kotani,H., Yokoyama,S., Nishioka,H., Matsuura,Y., Mizoguchi,A.,
            Scheller,R.H. and Takai,Y.
  TITLE     Tomosyn: a syntaxin-1-binding protein that forms a novel complex in
            the neurotransmitter release process
  JOURNAL   Neuron 20 (5), 905-915 (1998)
   PUBMED   9620695
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296544.1, AC078854.16,
            AC079841.10 and AI279148.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001308330.1.
            
            Summary: The protein encoded by this gene is similar to
            syntaxin-binding protein 5 and contains ten N-terminal WD40
            repeats, four variable region WD40 repeats, and a C-terminal
            R-SNARE domain. Studies of the orthologous proteins in mouse and
            rat have shown that the encoded protein may inhibit exocytosis in
            neurosecretory cells, and may negatively regulate the secretion of
            insulin. A missense variant in this gene is likely the cause of an
            infantile-onset neurodegenerative disorder diagnosed in two
            siblings of consanguineous parents. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. It encodes
            isoform 2 which is shorter compared to isoform 1. Variants 2, 4,
            and 5 all encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.11899.1,
                                           SRR1803615.271219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471454.6/ ENSP00000420019.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1566              AK296544.1         1-1566
            1567-1567           AC078854.16        88953-88953         c
            1568-3813           AK296544.1         1568-3813
            3814-8932           AC079841.10        77006-82124
            8933-9291           AI279148.1         18-376              c
FEATURES             Location/Qualifiers
     source          1..9291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..9291
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="syntaxin binding protein 5L"
                     /db_xref="GeneID:9515"
                     /db_xref="HGNC:HGNC:30757"
                     /db_xref="MIM:609381"
     exon            1..130
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..327
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3627
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tomosyn-like; tomosyn-2; lethal(2) giant larvae protein
                     homolog 4; syntaxin binding protein 5 like"
                     /codon_start=1
                     /product="syntaxin-binding protein 5-like isoform 2"
                     /protein_id="NP_001295259.1"
                     /db_xref="CCDS:CCDS77799.1"
                     /db_xref="GeneID:9515"
                     /db_xref="HGNC:HGNC:30757"
                     /db_xref="MIM:609381"
                     /translation="MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAG
                     VLREEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGV
                     DCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITY
                     CHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSP
                     RDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTL
                     WNLKSPSRPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKA
                     CRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLT
                     QSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPISG
                     GAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
                     IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDI
                     ITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQ
                     AELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLY
                     RSSDLYQRQPRSPRKNKQFIAGLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSC
                     SSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSIS
                     SIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEP
                     VMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSS
                     SASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLAC
                     FCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYS
                     QEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSL
                     AQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKH
                     AHELMLKYKDKKWYQF"
     exon            328..425
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            426..507
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..608
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..743
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..807
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            808..891
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1015
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1094
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1249
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1322
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1470
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1538
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1579
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1797
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1970
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2096
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2248
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2314
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2485
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2725
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..3086
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3252
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3364
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3585
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..9291
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4311..4316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="hexamer: AGTAAA"
     polyA_site      4331
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="major polyA site"
     regulatory      4836..4841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="hexamer: AATATA"
     polyA_site      4856
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
     regulatory      6140..6145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="hexamer: GATAAA"
     polyA_site      6160
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
     regulatory      9266..9271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="hexamer: AATAAA"
     polyA_site      9291
                     /gene="STXBP5L"
                     /gene_synonym="LLGL4"
                     /note="major polyA site"
ORIGIN      
        1 gactgctcgg ttaggacctc ggagagcgcc aggcgccgcg accagagggc ccagagaagc
       61 ggccggagcc cgcctacctc ggccccctca gcttcccggg ctggcaggcg gctagaggcg
      121 tctgaggaag tgtttaaaat gaagaagttt aatttccgaa aagttttgga tggcttaact
      181 gcctcctccc ctggcagtgg tagcagcagt ggcagtaaca gtggtggtgg ggctggaagt
      241 ggttccgtac atccggcggg gactgcaggg gttctcagag aggaaattca ggaaactttg
      301 acttcggagt atttccagat ttgcaagaca gttcggcatg gttttcctca tcagcccaca
      361 gcattagcct ttgatccagt tcagaaaatc ttggctattg ggacgagaac aggtgctata
      421 cgaatactcg ggagacctgg tgttgattgc tattgccaac atgaaagtgg tgcagctgtc
      481 ctacagctcc aatttttgat caatgagggt gccttggtca gtgcaagttc agatgataca
      541 cttcatttgt ggaaccttag acaaaaaagg ccagccatac tccattctct taaatttaac
      601 cgggaacgaa ttacttactg tcatctacct ttccagagta aatggcttta tgttggaaca
      661 gaaagaggaa atacacatat tgtaaatatt gaatctttca ttctttctgg atatgttatc
      721 atgtggaaca aggcaattga actatccact aagactcatc caggtccagt tgtacattta
      781 agcgatagcc caagagatga aggcaaactg ctaataggtt atgaaaatgg tactgtagta
      841 ttctgggact tgaaatctaa aagagcagaa ctgagagttt attatgatga ggctattcat
      901 tcaattgatt ggcatcatga gggcaaacag ttcatgtgca gccattcaga tggtagtttg
      961 actttatgga acctgaaaag cccaagtcgc cctttccaga ccacaattcc acatggaaaa
     1021 agtcaaagag aaggaagaaa atctgaatct tgtaaaccaa ttcttaaagt agaatacaag
     1081 acctgcaaaa acagcgaacc attcataata ttctctggtg ggctgtccta tgacaaagct
     1141 tgtagaagac caagtttaac catcatgcat ggaaaagcaa ttacagtact tgaaatggat
     1201 catcctattg ttgaatttct aactttatgt gaaacgccct atccaaatga atttcaagaa
     1261 ccctatgctg tcgtggtact tctggagaaa gatctcattg tagttgatct gacacaaagc
     1321 aattttccaa tctttgaaaa tccatatccc atggacattc atgaatcacc agttacatgc
     1381 acagcatact ttgcagattg tcctccggat ttgattctag tactgtattc tataggagtc
     1441 aagcataaaa aacaaggata cagtaataag gagtggccaa tcagtggagg agcttggaac
     1501 cttggagcac aaacatatcc agaaattatt attactggtc atgcagatgg atcaataaaa
     1561 ttttgggatg cttctgcaat aactctgcag atgctgtaca agctaaaaac ttcaaaagtg
     1621 tttgaaaaac agaaggtagg agaaggaaaa caaacatgtg aaattgtaga ggaagaccca
     1681 tttgccattc agatgattta ctggtgtcca gagagcagaa tattctgtgt atcaggagtc
     1741 tctgcatatg tcataattta taaattcagc agacatgaaa ttacaacaga aatagtgtca
     1801 ttagaggtac gacttcagta tgatgttgaa gatattatta cccctgaacc agaaacaagt
     1861 cctccgtttc cagatctctc agcccagctt ccttcttcaa ggagtctttc tgggagcact
     1921 aacactgttg ctagtgaagg agtaacaaag gacagtattc catgcctcaa tgtgaagaca
     1981 cggccagtgc gaatgcctcc aggatatcaa gcagaacttg ttattcaatt ggtgtgggta
     2041 gatggtgaac ctccacaaca gattactagt cttgctgtaa gctcagcata tggaatagtt
     2101 gcatttggga actgcaatgg gttggctgtg gtggatttta tacagaagac agtactgtta
     2161 agcatgggga ccattgacct atatagatca agtgacttat accagcgaca accacggtct
     2221 cctcgaaaaa acaaacagtt cattgcaggt ttaactgaac tgaatgacag tccagttccc
     2281 ctagaacttg agcgctgcaa gtctcctacc tcagaccatg taaatggaca ctgcacaagt
     2341 ccaacttctc agagttgcag ttctggaaaa cgtctttcta gtgccgatgt ttcaaaagta
     2401 aatcgctggg gtcctggaag accaccattt cgaaaggccc agtcagcagc ctgcatggag
     2461 atttctttac cagttacaac agaagaaaac cgagaaaatt cctataatcg ttctagaagc
     2521 tctagtatct ccagtattga caaagattct aaagaagcaa ttacagcact atacttcatg
     2581 gactcctttg cacggaaaaa tgactctacc atctctcctt gtctgttcgt tggaaccagt
     2641 ctgggaatgg tgttaatcat ctccttaaac ctaccattag cagatgaaca aaggtttaca
     2701 gagccagtca tggtattgcc aagtggtaca ttcctctcat tgaaaggagc tgtgctaaca
     2761 ttctcctgta tggaccgaat gggtggatta atgcaaccgc catatgaagt ttggagggat
     2821 ccaaacaaca tagatgaaaa tgaaaaatct tggagaagga aagtggtaat gaactcatct
     2881 tctgcatccc aagaaatagg agatcatcag tatacaataa tctgctcaga aaaacaagcc
     2941 aaagtcttct cactgccttc tcagacttgc ctttatgttc ataacatcac ggagacatct
     3001 tttatactgc aagcaaatgt ggtggtcatg tgtagcagtg cctgcttggc atgcttttgt
     3061 gctaacggac atatcatgat aatgagccta cctagtcttc gcccaatgtt ggatgttaat
     3121 tatttgccac tgacagacat gaggatagca cgaacatttt gttttaccaa tgaaggacag
     3181 gcattatacc tcgtctctcc tactgaaatt cagcggttaa catacagcca agaaatgtgt
     3241 gataatctac aggacatgct aggagatttg tttactccca tagagacacc agaagctcaa
     3301 aacagaggct ttctcaaggg actgtttggt ggaagcggac aaacatttga cagagaagag
     3361 ctctttgggg aagcttcggc aggaaaagca tcccgcagcc ttgcgcaaca cattcctgga
     3421 ccaggtagta tagaagggat gaaaggcgct gctggagggg tgatgggaga gctgacccgt
     3481 gcacggattg cacttgatga aagaggacag aggctaggag agctggaaga gaaaactgca
     3541 ggcatgatga ccagtgcaga agcattttcc aaacatgcac atgagttaat gctgaaatac
     3601 aaggataaga aatggtacca attctgactt ctaaagaagc tgtgactgct ttgagaaacc
     3661 atattcaggg aaaccaaatt tattcccagc atcactactc aactgctaga agccagtttc
     3721 ttctacaaaa tgttccattt acagtcaatc tgaaattttc ataaaagaga tgtatcagag
     3781 acactgtgca acccaaaggc tggagccctg gttaaaatcc caaaatacgg ctgaatttgc
     3841 cttttcccat gtggaatgga gctatcatct tggcatgtca ttcgataagg atttatattt
     3901 agtaactacg gggagtcctc ttgatttgaa aattcctgta caaacaaaag cattaatgca
     3961 cttaatgaaa aaaaatcttt gcatgataaa ttaacatctt aaggggaaaa gaaaaaaaag
     4021 catgttgtga tagaagaaaa aaagattcat ggtaaactat ttctatcaat tgggccacac
     4081 tcaacaattt aaaaaatctg catttgaaga tgtcagtgca tttcaaatat atttgccata
     4141 cccaactgaa acggaaaaca aaacaaaaca agaacccaga gttttctcct catctgtaac
     4201 tttcattgta ctagaacctt attgaattct tatggcaaga gtctgattaa tgttctctct
     4261 ccatgtttta catcattcac agttgtgtca aaatcaaata ttgccagtat agtaaattat
     4321 tcccaacaca atcagtttca tttctatcac cttcagaatg ggttgctgtt tttagcacaa
     4381 accatgcagg gttgggtcac ctcaaagcat tttcttcagc ctggcttgta ctctataggg
     4441 gagttggtag taggtgtggg gaatctatag gaacaataga gttagctatg agaactgact
     4501 tcacaaaaag ggaaatttca cacaccccaa tttcagcttc taaagtgata tattttaaaa
     4561 gcttcatttg tatccttgtc tgccagttac acagtatatt actgttcaaa cccagtaggg
     4621 tctgcaatcg aaaggtgctc ttgcagcctg acattcacaa accaaactgg tcattctctt
     4681 tagtgtgatt cagtaaaatc tcagttaatg ttttgggaaa gggattctga tttatgacat
     4741 ttctgattta caagggcttt ccttagaaaa tacctttcgg tttgatactt accactggaa
     4801 attggttcga tacttaccac tggaaatctt tataaaatat agtgatctgt ttgctatctt
     4861 ggtctcagtc atcattatag acaatagaaa tacataaaga gtttaatgat acaaaatcaa
     4921 tgcttttgtc cctaggtcaa ataatataag ccactagatt atgtcaatag atgccaaaca
     4981 cttgtccctt attaaagact cttttaaagc tggaataaag aatatcctta acatgataca
     5041 aggtatctat aactcaccag aaaagcacca gagtcaaaac caaatagaga cacctactac
     5101 catttaacat gattctggaa gtcaaaagtt ataggaatgt atatatacac attccaggac
     5161 ccatcctgta atatgttgtt tcgtcaagaa aagttttaat tatggttttg gcttattgaa
     5221 tttttgttta tcaaggtctc attggattta catttgtgtt tcttaagact tcacaatttt
     5281 cctggatttc aggttatttt attagccaaa aaatcgtatt tttatttcct ttttagtcta
     5341 attttttgct agaagttgta ctttctagca aatgtttcta gtggtacaat gttctcagta
     5401 attttgagga gaacaaagat gagtgaaaga gttagataat gtacactagg atagcatttc
     5461 tcagagtcct tgaatcctct tgttaagaaa gcctctctga atctcccaga ctcctgtgaa
     5521 cagccttacg gtaacagaat ctggcttgga aacacagaca ttacatgact gtataattta
     5581 tagaattata aaattatatg gtaaaaatat taaagaaact taagagtagg atctagaaaa
     5641 tactagtggc caaattgcaa tgtattcttt gtaccatctg tttcaaagac ttagttttct
     5701 gattttcaga acaaatactt tatcgtttct gtattttaaa aaaaactaaa agagtaaaat
     5761 attagtttat tttagaaata atgaaattca gtccaaagta gcagtacatt tgatgagtat
     5821 ttctgaagcc ttcaataaga tttaacttgt tttaacttga tctacatcga gatttctcaa
     5881 aagcagcact attagctgaa agtctttgtt gtggggaact gtcctgtgta ttgtaggatg
     5941 ttagcaacat ccctggcctc tgtctactag atgccagtaa gaacctccta gtaatgacaa
     6001 tcaaaatgtc tccagtcatt gccaaaattt ctcccagttc acagccacta ttctacatca
     6061 tacaaagagg tagattgtgt gaatatgtaa tatatgttgt tgtataaaac tgtacaataa
     6121 gtatacaatg tcttagcaag ataaattatt atacccaaaa ttacatgtgt ggttcatatg
     6181 caataagata caattttgaa gaaagcttat aggaatcagt gaaaaataac aactacagaa
     6241 tattttaagg cacacagaga aaatatcaaa aaggacatta tagcatttca ctgtagaagt
     6301 gcttaaaacc ttggcctcag tgaatagatc aaaagtttat aattagcaca ccaattggaa
     6361 gtaaacaggt gcttctcaaa tgcttgaaaa gaaaaggctc tttgaagtag ttaaaacgtg
     6421 tctttcaaaa ttgcttttat aagcccttcc ttaacgtaag ggtaacttca tctcacaaac
     6481 tcctggttag tggaatccaa attaatgagg ttttactgta tcaaaattat ttttataatt
     6541 caaagagatg atagcaataa gaagaatcta atgtggatgt gatttttctc tttgaacaat
     6601 tctgttctgt tgcactgacc ttagcacgca cgcacacaca cacacaccat cgccaccact
     6661 accatcatca tcttatcctc atctttggaa aataagtact gttgatccat gtaatccttt
     6721 gcatagtctc atctttacta tctttcttct atttcggaac ataagaaaaa tactcctaat
     6781 aacttggaca atgatacaga aagtgactct gagccttagt taccatcaaa attacattct
     6841 atctgctaaa gcgacatcag aagataaggc ttgcaaacca cagtcccaac aagttgacct
     6901 tgtctcccta tgatttcctt ggaagataag gcctttttag tgttacagta gaaaatgggc
     6961 cttttcattt attcatctgt gagaagctag aggtatttgt ttccctgata ataacgtgag
     7021 caatagtccc taccttgaaa tcatccatta gtcttggagt ttggagggag gaatgattga
     7081 ttcctcattt gttttaatca cctacaaaag cagtactact gactttgctt cttacacttc
     7141 actgagcccc agactttagg gccccaatca ttgtcaagat cattgtctaa ctggaactct
     7201 gaaaggacag tgacagaact gaatgagatg ttttccagtg attcagtcac aaagacaatt
     7261 ttctcagatc ttttgaaagt gattctcaaa taaataaatc aaaatccaac tcctttccct
     7321 caaagtttct agggatctga aggaaaaggt ttactgttgg agtccctttt tatgtgaccc
     7381 atgtaccagt tttaaaggca tcatctatac tttatctaca tgaagggatc accatgactt
     7441 tgagagaaaa aagaatcaga ttaggcctaa cattggttga agaagattaa aatagattct
     7501 tatattcaag cagaagggaa aaatgaagcc aatctagaaa agtaagctaa aaatcctctc
     7561 cttggcttag gatcattggg tcaaactggg agtatatctg tgtgattaca acctgctgct
     7621 atgagaaaaa agaattgtaa cttgaccatg ttggctcaca cagggcaatg caaaagaagt
     7681 caaaacattc atatcaggtc ttggtatctg tgtcaggaga aacgtggtgg ctttcacagc
     7741 ttcttcacct ctgtcctctg tcatgcaact ccatttttgg ctaggtacta tttcacatgc
     7801 acactgtcct gggtgccaga aatacttgtg gtgtacttgg tttgagcagt acctctagta
     7861 tgcaccattc cagggaacat ggttgtcaac ataacaagtt tagtgtgtgt atttgcagac
     7921 aacatagccc tgaaagcatg aaatgtagaa taggtaaggt ctgtcttaga aaaggaggag
     7981 gaagtaccaa tttggtgcaa gaagatcgtg gtgaggaagg acatgggagc cacagtgaag
     8041 tgaaagaggc tttaaggaat cagatgcaca gatggatgct ttgatttaca catttatcta
     8101 gaggagtgat tctcaacctt gactgtacat aagaatcacc tcaggaaatt tttaaattcc
     8161 caattatatt aaaatcattt ggagtgggaa ccagacacca atatttgcga aagcctccaa
     8221 ggcggttcta atgtccagcc aaagttgatt atcactgctt tatggccaac taaggaaacc
     8281 ttgtttgtct gccttggctg gtgctccagc cccagttctg agtggtcagg gaaggcaaga
     8341 tgtaagatat agtaatggta tttattctgt atgtctcaca gaacaaaagc atttgagaat
     8401 ttctgaccag gcagtgctcc atcaactctt aataatcatc tttgtgatat tctcctatgt
     8461 gacttgtcca tcaattattc caattcaaag gtctaggttt tttttcaatt gtcttacaca
     8521 tgtgacatca caagatacca gaagtagcac agtaaattca agagcatata aagctaagtg
     8581 gaaaactaat tcttcatatt tagacagtgg aaattctcaa aacaatcatt tgctaaatta
     8641 ggtccaaatt tattattcat tcttcttctg gaggagacat gggtaccagg tacctgttct
     8701 gctgtaggta tatttcactg gacttggtct tagcaaaaag gaagaacaaa tcttcctttt
     8761 tgattgttat ctcaatcaaa agctcccagg gccacttgga tttattttct tagtctttgg
     8821 acatgtgttt aaaggaaaag aatacctgta acttcctata tgacatccag tgccctgaaa
     8881 gggtgcttac accttcaaaa aaggagagtc cagcctatca aaggcagtaa cacataatga
     8941 gaagaaactc agagttattg cctttcatac tgctttccct ctgctgttgg cccacccttc
     9001 ttgactgcaa agccagaaaa taaactagat ggtggttttg gacaattgta cacaggaaca
     9061 gaatctctaa taacctataa tttttagtac ttaattatgt gatgttttat tctaggaaat
     9121 aagaaacaga tgacatcatt gatgtatctt tctttcatct tcagaatttt tgcatctttt
     9181 cagaaaatga caaattacta tttttctgtt gcactcagca attgtgacta tacttaacaa
     9241 aattcttgta gtctgtagag atatcaataa aattgtatat gtttgtacat a
//
