LOCUS       NM_001127715            9290 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens syntaxin binding protein 5 (STXBP5), transcript
            variant 2, mRNA.
ACCESSION   NM_001127715
VERSION     NM_001127715.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9290)
  AUTHORS   Wang,J., Yang,L., Li,Y., Wang,X.B., Yang,W., Liu,F. and Wu,X.B.
  TITLE     Aberrant hypermethylation induced downregulation of antisense
            lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with
            tumorigenesis of glioma
  JOURNAL   Life Sci 278, 119590 (2021)
   PUBMED   33965377
  REMARK    GeneRIF: Aberrant hypermethylation induced downregulation of
            antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate
            with tumorigenesis of glioma.
REFERENCE   2  (bases 1 to 9290)
  AUTHORS   Wang,S., Liu,Y., Crisman,L., Wan,C., Miller,J., Yu,H. and Shen,J.
  TITLE     Genetic evidence for an inhibitory role of tomosyn in
            insulin-stimulated GLUT4 exocytosis
  JOURNAL   Traffic 21 (10), 636-646 (2020)
   PUBMED   32851733
  REMARK    GeneRIF: Genetic evidence for an inhibitory role of tomosyn in
            insulin-stimulated GLUT4 exocytosis.
REFERENCE   3  (bases 1 to 9290)
  AUTHORS   Shao,S., Wang,C., Wang,S., Zhang,H. and Zhang,Y.
  TITLE     LncRNA STXBP5-AS1 suppressed cervical cancer progression via
            targeting miR-96-5p/PTEN axis
  JOURNAL   Biomed Pharmacother 117, 109082 (2019)
   PUBMED   31212131
  REMARK    GeneRIF: STXBP5-AS1 might function as a ceRNA to drive CC cells
            proliferation and invasion via regulating miR-96-5p/PTEN axis.
REFERENCE   4  (bases 1 to 9290)
  AUTHORS   Schillemans,M., Karampini,E., Hoogendijk,A.J., Wahedi,M., van
            Alphen,F.P.J., van den Biggelaar,M., Voorberg,J. and Bierings,R.
  TITLE     Interaction networks of Weibel-Palade body regulators syntaxin-3
            and syntaxin binding protein 5 in endothelial cells
  JOURNAL   J Proteomics 205, 103417 (2019)
   PUBMED   31201948
  REMARK    GeneRIF: Interaction networks of Weibel-Palade body regulators
            syntaxin-3 and syntaxin binding protein 5 in endothelial cells.
REFERENCE   5  (bases 1 to 9290)
  AUTHORS   Lind-Hallden,C., Manderstedt,E., Carlberg,D., Lethagen,S. and
            Hallden,C.
  TITLE     Genetic Variation in the Syntaxin-Binding Protein STXBP5 in Type 1
            von Willebrand Disease Patients
  JOURNAL   Thromb Haemost 118 (8), 1382-1389 (2018)
   PUBMED   29972863
  REMARK    GeneRIF: A haplotype containing the STXBP5 Asn436Ser (rs1039084)
            mutation is associated with type 1 von Willebrand disease in a
            Swedish population.
REFERENCE   6  (bases 1 to 9290)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human LLGL4 gene and mouse
            Llgl4 gene in silico
  JOURNAL   Int J Oncol 24 (3), 737-742 (2004)
   PUBMED   14767561
REFERENCE   7  (bases 1 to 9290)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   8  (bases 1 to 9290)
  AUTHORS   Widberg,C.H., Bryant,N.J., Girotti,M., Rea,S. and James,D.E.
  TITLE     Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays
            a role in insulin-stimulated GLUT4 translocation
  JOURNAL   J Biol Chem 278 (37), 35093-35101 (2003)
   PUBMED   12832401
REFERENCE   9  (bases 1 to 9290)
  AUTHORS   Yokoyama,S., Shirataki,H., Sakisaka,T. and Takai,Y.
  TITLE     Three splicing variants of tomosyn and identification of their
            syntaxin-binding region
  JOURNAL   Biochem Biophys Res Commun 256 (1), 218-222 (1999)
   PUBMED   10066450
  REMARK    GeneRIF: Characterization of a related rat gene
REFERENCE   10 (bases 1 to 9290)
  AUTHORS   Fujita,Y., Shirataki,H., Sakisaka,T., Asakura,T., Ohya,T.,
            Kotani,H., Yokoyama,S., Nishioka,H., Matsuura,Y., Mizoguchi,A.,
            Scheller,R.H. and Takai,Y.
  TITLE     Tomosyn: a syntaxin-1-binding protein that forms a novel complex in
            the neurotransmitter release process
  JOURNAL   Neuron 20 (5), 905-915 (1998)
   PUBMED   9620695
  REMARK    GeneRIF: Characterization of a related rat protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356415.26, AL590709.5 and AL355365.10.
            
            On Apr 19, 2021 this sequence version replaced NM_001127715.3.
            
            Summary: Syntaxin 1 is a component of the 7S and 20S SNARE
            complexes which are involved in docking and fusion of synaptic
            vesicles with the presynaptic plasma membrane. This gene encodes a
            syntaxin 1 binding protein. In rat, a similar protein dissociates
            syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S
            complex, an intermediate which can be converted to the 7S SNARE
            complex. Thus this protein is thought to be involved in
            neurotransmitter release by stimulating SNARE complex formation.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1847706.1,
                                           SRR7346977.2891720.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321680.11/ ENSP00000321826.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL356415.26        95050-95315         c
            267-364             AL356415.26        93664-93761         c
            365-446             AL356415.26        64401-64482         c
            447-547             AL356415.26        60462-60562         c
            548-682             AL356415.26        38983-39117         c
            683-746             AL356415.26        37379-37442         c
            747-830             AL356415.26        32565-32648         c
            831-954             AL356415.26        21528-21651         c
            955-1033            AL356415.26        8560-8638           c
            1034-1188           AL590709.5         10453-10607
            1189-1261           AL590709.5         11824-11896
            1262-1409           AL590709.5         14253-14400
            1410-1477           AL590709.5         14633-14700
            1478-1518           AL590709.5         14965-15005
            1519-1739           AL590709.5         15884-16104
            1740-1918           AL590709.5         16598-16776
            1919-2044           AL590709.5         25328-25453
            2045-2196           AL590709.5         27494-27645
            2197-2262           AL590709.5         34526-34591
            2263-2322           AL355365.10        1019-1078
            2323-2370           AL355365.10        1177-1224
            2371-2421           AL355365.10        15163-15213
            2422-2661           AL355365.10        20924-21163
            2662-3031           AL355365.10        25175-25544
            3032-3197           AL355365.10        25841-26006
            3198-3309           AL355365.10        35571-35682
            3310-3530           AL355365.10        44618-44838
            3531-9290           AL355365.10        46554-52313
FEATURES             Location/Qualifiers
     source          1..9290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3"
     gene            1..9290
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /note="syntaxin binding protein 5"
                     /db_xref="GeneID:134957"
                     /db_xref="HGNC:HGNC:19665"
                     /db_xref="MIM:604586"
     exon            1..266
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3572
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /note="isoform b is encoded by transcript variant 2;
                     tomosyn; putative protein product of Nbla04300; tomosyn-1;
                     lethal(2) giant larvae protein homolog 3"
                     /codon_start=1
                     /product="syntaxin-binding protein 5 isoform b"
                     /protein_id="NP_001121187.1"
                     /db_xref="CCDS:CCDS47499.1"
                     /db_xref="GeneID:134957"
                     /db_xref="HGNC:HGNC:19665"
                     /db_xref="MIM:604586"
                     /translation="MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSE
                     HFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVI
                     QLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVG
                     TERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESG
                     TVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTI
                     TPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKS
                     TAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPL
                     SIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEI
                     IITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIIS
                     WCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLP
                     TPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWV
                     GGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREP
                     RSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKS
                     RKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALH
                     FCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKG
                     AILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQY
                     AVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFS
                     LPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEML
                     GELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIE
                     GVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDK
                     KWYQF"
     exon            267..364
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            365..446
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            447..547
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            548..682
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            683..746
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            747..830
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            831..954
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1033
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1188
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1261
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1409
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1477
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1518
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1739
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1918
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2044
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2196
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2262
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2322
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2370
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2421
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2661
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..3031
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3197
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3309
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3530
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..9290
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9259..9264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /note="hexamer: AATAAA"
     polyA_site      9290
                     /gene="STXBP5"
                     /gene_synonym="LGL3; LLGL3; Nbla04300"
                     /note="major polyA site"
ORIGIN      
        1 acactcccac tcctccgttt ccgcggtcga agctgccttc ggccccgggt ggtctccccc
       61 gcccggggac cccctgtgcc tcccctcccg ggctgcgggg gagcccctcc gagaccatga
      121 ggaaattcaa catcaggaag gtgctggacg gcctgaccgc cggctcgtcc tcggcgtcgc
      181 agcagcaaca gcagcagcat ccgcctggga accgggagcc ggagatccag gaaacgctcc
      241 agtccgagca ctttcagctc tgcaagactg ttcgccatgg atttccctat caaccctcag
      301 ccctggcctt tgatcctgta cagaagatcc tggcagtggg aactcagact ggtgctttaa
      361 ggctctttgg tcgtccagga gtagaatgtt attgccagca tgacagtgga gctgcagtaa
      421 tccagctcca gttcctgatt aatgagggag cgcttgtgag tgccttggct gatgacacct
      481 tacacttatg gaatttacgt cagaagaggc ctgccatact acattcgctt aaattttgca
      541 gagaaagggt tacattttgc catctgcctt tccagagtaa gtggctctat gtgggcactg
      601 aacgaggtaa tatacatatt gtcaatgtgg agtccttcac actctcaggc tacgtcatta
      661 tgtggaataa agccattgaa ctgtcatcta aatctcaccc aggacctgtg gtccatataa
      721 gtgataatcc aatggacgag ggaaagcttt tgattggctt tgaatctgga acagtagttt
      781 tatgggacct caaatcaaag aaagccgact acagatacac atatgatgag gctatccact
      841 ctgttgcttg gcatcatgaa ggaaaacaat ttatttgcag tcattcagat ggcaccttga
      901 ctatatggaa tgtaaggtcc cctgctaaac cagtacagac aatcactcca catggaaaac
      961 agttaaagga tgggaagaag ccagaaccat gcaaacctat cctcaaggtg gaattcaaaa
     1021 cgactagatc tggggagcct tttattattt tatcaggagg tttgtcatat gatactgtag
     1081 gaagaagacc ttgcttaaca gtgatgcatg ggaaaagcac tgctgtgcta gaaatggact
     1141 attcaattgt tgattttcta acgctgtgtg aaacaccata cccaaatgat tttcaagaac
     1201 catatgctgt ggttgttctt ctagaaaagg atttagtact tatagacctt gcacaaaatg
     1261 gatatcctat atttgaaaat ccctaccctt tgagtataca tgagtcccct gttacatgtt
     1321 gcgaatattt tgcggattgt cctgtggacc ttattcctgc actttattct gttggagcta
     1381 gacagaaacg tcaaggttac agcaaaaagg aatggcccat caacggaggt aattggggct
     1441 tgggtgctca aagttaccca gaaataatta ttacagggca tgctgatggg tcagttaagt
     1501 tctgggatgc ttctgcaata actctacaag tattatataa gctaaagaca tctaaagtat
     1561 ttgaaaagtc aagaaataaa gatgacaggc caaacacaga cattgtagat gaagatccat
     1621 atgccattca gatcatctcc tggtgtccag aaagtagaat gctgtgcatc gctggagttt
     1681 cagctcatgt cattatttat agattcagca agcaggaagt aatcacagaa gtcattccga
     1741 tgcttgaagt tcgattatta tatgagataa atgatgtgga aactccggag ggtgagcagc
     1801 caccaccttt gccaacaccc gtgggagggt ccaaccctca gcccatccct cctcagtctc
     1861 atccatctac cagtagcagt tcatctgatg ggcttcgtga taatgtacct tgtttaaaag
     1921 ttaaaaactc accacttaaa cagtctccag gttatcaaac agaactagtt attcagttgg
     1981 tttgggtggg tggagaacca ccacaacaaa taaccagcct ggcagtcaat tcttcctatg
     2041 gactggtggt ttttggcaat tgcaatggca ttgctatggt tgactacctc cagaaagcag
     2101 tgctgctcaa cctgggcact attgaattat atggctctaa tgatccttat cggagagaac
     2161 cccgatctcc tcgtaaatct cgacagcctt caggagccgg tctgtgtgat attagtgaag
     2221 ggactgttgt tccagaggat cgctgcaaat ctccaacctc tggttcttca tcaccacaca
     2281 attcagatga tgaacaaaaa atgaataatt ttatagaaaa ggtgaagacc aaaagcagaa
     2341 agttttccaa gatggtagcc aatgatatag caaagatgtc aaggaagtta agcttaccta
     2401 ctgacctaaa gcctgattta gatgtaaagg ataactcctt tagccgatca cggagttcaa
     2461 gtgtaacaag cattgacaaa gaatcccgag aagcgatctc cgctcttcat ttctgtgaaa
     2521 cgtttactcg aaagacggac tcgtcccctt ccccttgtct atgggttgga acaacgctag
     2581 gaacagtgct tgtcattgca ctgaaccttc ccccaggggg agagcaaaga cttcttcagc
     2641 cagtaattgt gtctccaagt ggtactatat tgaggttaaa aggtgcaatc ttgagaatgg
     2701 catttctgga taccacaggc tgcttaatac cacctgcgta tgaaccctgg agagagcaca
     2761 atgttcctga agaaaaagac gaaaaggaga aattgaaaaa acggcggcct gtctcagtat
     2821 ccccctcctc ttctcaggaa attagtgaaa accagtatgc agtgatatgt tctgaaaagc
     2881 aagcaaaagt aatctcactg ccaacccaga actgtgctta taagcaaaat attacagaga
     2941 cctcgtttgt gcttcgtgga gatattgtag cattgagtaa cagtatctgc cttgcctgtt
     3001 tctgtgccaa tggacatata atgactttta gtttgccaag tttaagacct ctgttggatg
     3061 tgtattactt gccccttacc aatatgcgga tagccagaac gttctgcttt accaacaatg
     3121 gacaagcatt ataccttgtt tcacctacag aaatccagag acttacttat agtcaagaga
     3181 cctgtgaaaa tcttcaggaa atgttgggtg aactcttcac tcctgtagaa acacctgaag
     3241 caccaaacag gggattcttt aaaggcttat ttggaggtgg tgcacaatct cttgacagag
     3301 aagaactatt tggagaatcg tcctcaggaa aggcttcaag gagccttgca cagcatattc
     3361 ctggccctgg tggcattgaa ggcgtaaaag gggcagcatc tggagttgtt ggtgaattag
     3421 cacgagccag gctggcacta gatgaaagag ggcagaaact tggcgatctg gaagaaagaa
     3481 ctgcggccat gttatcaagt gcagagtcat tttctaaaca tgctcatgag attatgttga
     3541 aatacaaaga taagaagtgg taccagttct gacaaccaga atccaataag tccaacttca
     3601 gccagaagga aaaaagtttt ccatttttat tacattcttt aggaaagtta acgttaaagg
     3661 gatgttcgtc actgaatact gttctttcct agcacagtca tgcactgttt tacctcagtc
     3721 atgtggcttt aactgaggag tgttcacacg cactcgaaat ggagtatatg gtgtgtgcca
     3781 gttatgagtt gaccatttgg gaattaaaca ggtcacacgt gacagatgaa gaaaccaagg
     3841 gggctgctga ggagacctgg tgcagggact aatcctggat cattcctgta ttaaactttc
     3901 atatgccaaa agggtttgtg ccgttttatc tgccatcagt gtttgacctg tttagggcag
     3961 aggcaataag tcagaagtct tgaagttgaa atagttatat gtgtgtcatt ggactggatt
     4021 ataaacagct gtcttggact ttccctctct taacactgac tggtcatcag tatcattagt
     4081 gaaaaagaaa caaattgttt gttatcatct ctttagacag ataagctgaa tggtgggctt
     4141 taaataataa aaacatacac atagttgact tgtgtatgag ctactcttgg attcttgtta
     4201 ttatagactt gtatttagtt catattttgt caaaagcaaa acaagaagat acatcacttt
     4261 tcattgaaaa gaaaagtgta gagcatgact gaattgctca tcattctggg agtttccatg
     4321 tagtggctat gcagtgtgga aagtgagaaa aacctccatt gtggtgagga gaatacttca
     4381 atgtcccttg tccttgttct cattaattca gctaaaggtg gatttgacca aaataatgct
     4441 ggttaaattt gtagaaatgt tgaaattggc tgtgttttaa attttgcttg aatttttata
     4501 aaatgtttaa ccaaatgtac ctttgcattc tttaattaaa attgcttaaa aaaaaacttt
     4561 cattatttca gtaaaatgct cagctccctt ttcaaaatgc cctttatttg ctaactgttc
     4621 caatacactc aggtgatgag ccaattaaat gttagtgcac atgctatcgc atggaaaatt
     4681 acaagcatct gttgtcaata attatataag agtttagtct gatgacctac aaaatatttt
     4741 gtgtagaaat atactataaa tctgtacata tcctttcaag gttttaaaaa accaaaaaga
     4801 aaggaaaata tgtacactgt gataactaaa ttatttctgt attggaatat aatacaattt
     4861 gagaccagca atggacaatg aatgattgtt tcatagaata gcattacggg caggaaagaa
     4921 accacctagt agatctagaa gtaagcaatc tcagaataca gactaatctg agattattat
     4981 tgattgttgt taaagcaacc cagcaaaagc aaaatggaag cattaaaatt aatgttaatg
     5041 aaatttaaat attgtcttct ataaaaaatt cctttaaatg attttgtttt ttcattaaga
     5101 gataatcaga gcacaaattg atagtaaaca ggatggttgt ttttctattc tatatgatca
     5161 ttaaaggaat atgtaggaca tcttaacttt ttcatacagt ctgttatgca tattttcctc
     5221 tacttttcat taataaagct tttatgttta cattttataa catgcactac tagatgcaaa
     5281 agtttacatc aaagtttact ttaaatatca tttggtaggg actaaatgtg tgtgatagag
     5341 ataattgatc aagccaaaag aaatattttt taaataagcc cttttcaaaa gtttttgaat
     5401 ttatagaaag caccaatgaa taacatattt ctgtttcgtt aatgtcagct gcctgaacat
     5461 tcagcagttt ataaattgct taatttgtgt tatctattat ccagtaaacc catagttcca
     5521 tgatatgtca caggaattgt taggtcctat tttaaaggta cagttttgtg aatgtcatca
     5581 ataaaatcaa cagttatgga tttgaagaag ttgggaaagc attatgtaga ttaatatact
     5641 ggttggttcc ctatctatgt ggaaggtcat attagctgca attatttaat ttgctgtgtt
     5701 attttgtgtt atataacaca aatatatttg tatattaact tcatttttac tgtcattttt
     5761 cctgttgtat acaaaatgaa ctaatcttgt aattattttc aaatatagaa gtatatacat
     5821 tagatggatt tccaagattt tgtaagaaaa tcttaaatca gtgttttgag ttatttaatt
     5881 tttaaattaa tctacaaatt atgcacaaca aactagagac tcagttagga ttagaaagct
     5941 taaagtatgt ttgagtgtag gaaataagct tctcagagtt atacttgatt ctgtctgtag
     6001 ataagagaca gtctacagta ataactaacc cagggaattt actgtaattt gagaggtaac
     6061 atctctattt ttttcttttt aaatacagaa agtaatagtc accagcaagc cacgatttca
     6121 ggaaaactga ctaaaaaaaa aagtcaaaat agaaaatatc agaaaaatga aagatttttg
     6181 tgtgccctct ccatatcctc attgtttttg ttgcatttgt ccttgactct aaaatcactg
     6241 aagtattcat gattagtagt ttgtaagtag gaagtggttt ttctgtatgt accatatatc
     6301 cagttcattt cagttttcaa actaaaatcc atatgtattt gctgagaaag ttatttgaaa
     6361 tcttatattc tgacaaattc tgtacattac atccatttga agttttgcat catcttaaca
     6421 cttttgcttt gcatttcaat tgtacaaagt gtttccaaaa aaatggttat agattcgact
     6481 gagctattac taacttctcc atttgatttt ttatggatgt gaaaaatgct gctacttgtc
     6541 tatgttatta tgtgtaagta tattacaatt taattaagta caatagttta aagaacgaag
     6601 caattttttt ttttttggct tagaacttct taattgtagg ttcctctgaa gcgatttcat
     6661 gtagatatgt gagtgtttta aacaagtctg aaagtgttac atacttttag gttacagggg
     6721 tgctggggag acagctgagg aaaggaagaa tatgtggaag acaccacgga gttcaaagtt
     6781 ttaccctgag ttctatcttc catgtatgtt ttgcttaagg catttctcat gtgacattag
     6841 aaaagctata tccaaaggta aattttttgt ggcaaagatt tattttacac tttaactttt
     6901 gggattttat ttgtttcagc aaaataaaga gcactgaact ttaaacttga attttttctg
     6961 cactttttta ggtaatgaaa actttttatt atcatttaat ccacattgct cagtttaaac
     7021 caagtgatac atgtgtataa aacataccaa aatcatgaat atgctgctag ctgtacctta
     7081 aataaactga tcagttttaa aacctttaat agggttttat atagatttaa aaaatagtaa
     7141 aataatctgc tgtatgtttc agtgttcttg gtcttaaatt attgcaacac tttcagattt
     7201 gttttaagat catacagtaa catgttatat ttatacatac tgctagaaaa tatactttta
     7261 gttttaaaat ggaattttta taaatgtact ttaattttaa aatggtgaac ttgttaagtt
     7321 taagtcaaag tacttaaaaa gtatgtatat tatccataca aaaagttatg ttttacgctt
     7381 ataataagaa atactggtat ctcatatcga gatacaatta attttaaaaa atcatacatc
     7441 atttaaaaat cttcacacat gaacaggaaa gatatcattt ctatgcttta aaaaaccctc
     7501 tattgagcat tttcaaatat taattttatt ttgggggaaa atgcccacaa caataattgc
     7561 aagatctttc tcaatagctt cagtttgctg ttggatgcct accttaacta ttgttttaaa
     7621 atatagatat atatatatat atttaaaata gttttccagg tattttcttc tacctttttt
     7681 aaaaataaat ttccaaaaat gaaaacagag tttatgtatt tttgtcaatg aaggttttta
     7741 ttttgtagtt tatagaattt gttccttatc agtttgatac ttgatcaaca ttcttagact
     7801 ttttaatctg tatttacttt ggggggaaaa aagcactcct atatcttaaa tgtccttctt
     7861 ttttcttttc ccttttaggg tatttgttct cttggattga aatttatgcc cacagatttt
     7921 tcttttcatt tgaaaatgaa tgtgaagata ctgtttacag cttttgttaa ttgcactttt
     7981 catcactctg atcaatttct tgtaaagtgc tatgggaatt atttttcctg tgaatattaa
     8041 tgattttact actgcctccg aagttttaaa aaaggttctg tagacagaaa acagttgttg
     8101 caaccaaaaa caaccaaaaa aagaaaaaaa gggaaaactg gcttaccttt ctcagatgaa
     8161 ttaaatgatt ttaataactt cccaattacc agggttataa cattgctttc ttcagttatt
     8221 aatacagtca aattaatttt aacaatatag gcacaattca tttacaaatt cagtacagta
     8281 gtccagggct acatgtaagt ggtctcttta ttttattctt tacatcagaa aaatcatgaa
     8341 tgtcagtttt gccagtattt tacaatgagg cttatcgttt aaaattttat agtgtatgac
     8401 atgtaaataa accagtattt attgtaggtt gtttgattca ggcatttcaa atggatatag
     8461 gttaatggca atggaatcct atttatttgg tagttggttt tgtttgtttt tgtttattta
     8521 cttttgctat ttgttttgta ttgtctaaac tttgcttcaa ctgaagacag tgtaaggagt
     8581 tgaaaataca atcaacatag caatggaaag caatgcaaag agggtaaatc ttgttttaat
     8641 ttttttaact tttttttttt gtaaataaat agtactgtga tactttaggt gtgacctcta
     8701 ttccacatga tagttagaac cagaaaaaca cttttgcttt ctagttatac tattggttca
     8761 ttgtaaatgc attaccaaaa gacaatatga aaaagagcaa gattaagttt ttctaacatt
     8821 gtccacttca ggggcaagca tgcttggtat agagctctag cttgtgtata ccttaaactg
     8881 taacttgcag gtgtttttca gttgctgcac tttttattta atcttgctca gtcccagtaa
     8941 ctatctcaaa ggtaattgct ggaatatgca ttttgaaata cggtttaaaa aaaatctgtg
     9001 tattgtttca tctaaaaaga aaagcactat tggaaacact aaaaacgtgt taaactttgt
     9061 agttattttg cattcctgta ctttacaaac tgtcatcaca gcaaaaagtt taaaattagg
     9121 taatgaaata tttttgtaaa taaataccgt taagctggta ttttaaaaaa tgtattataa
     9181 attaattaat gtttctggaa aatgttcata tatatgtata tgaatgtctc tttatgctga
     9241 agggctctga ttgggcaaaa taaaatactc taatctctcc tgaaactaaa
//
