LOCUS       NM_178509              15590 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens syntaxin binding protein 4 (STXBP4), transcript
            variant 1, mRNA.
ACCESSION   NM_178509
VERSION     NM_178509.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15590)
  AUTHORS   Esteves,F., Xavier,J.M., Ford,A.M., Rocha,C., Pharoah,P.D.P.,
            Caldas,C., Chin,S.F. and Maia,A.T.
  TITLE     Germline allelic expression of genes at 17q22 locus associates with
            risk of breast cancer
  JOURNAL   Eur J Cancer 172, 146-157 (2022)
   PUBMED   35772352
  REMARK    GeneRIF: Germline allelic expression of genes at 17q22 locus
            associates with risk of breast cancer.
REFERENCE   2  (bases 1 to 15590)
  AUTHORS   Bilguun,E.O., Kaira,K., Kawabata-Iwakawa,R., Rokudai,S.,
            Shimizu,K., Yokobori,T., Oyama,T., Shirabe,K. and Nishiyama,M.
  TITLE     Distinctive roles of syntaxin binding protein 4 and its action
            target, TP63, in lung squamous cell carcinoma: a theranostic study
            for the precision medicine
  JOURNAL   BMC Cancer 20 (1), 935 (2020)
   PUBMED   32993587
  REMARK    GeneRIF: Distinctive roles of syntaxin binding protein 4 and its
            action target, TP63, in lung squamous cell carcinoma: a theranostic
            study for the precision medicine.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15590)
  AUTHORS   Vargas,R.E., Duong,V.T., Han,H., Ta,A.P., Chen,Y., Zhao,S.,
            Yang,B., Seo,G., Chuc,K., Oh,S., El Ali,A., Razorenova,O.V.,
            Chen,J., Luo,R., Li,X. and Wang,W.
  TITLE     Elucidation of WW domain ligand binding specificities in the Hippo
            pathway reveals STXBP4 as YAP inhibitor
  JOURNAL   EMBO J 39 (1), e102406 (2020)
   PUBMED   31782549
  REMARK    GeneRIF: Low STXBP4 expression is associated with kidney cancer.
REFERENCE   4  (bases 1 to 15590)
  AUTHORS   Liu,L., Zhu,Y., Liu,A.M., Feng,Y. and Chen,Y.
  TITLE     Long noncoding RNA LINC00511 involves in breast cancer recurrence
            and radioresistance by regulating STXBP4 expression via miR-185
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (17), 7457-7468 (2019)
   PUBMED   31539133
  REMARK    GeneRIF: Long noncoding RNA LINC00511 involves in breast cancer
            recurrence and radioresistance by regulating STXBP4 expression via
            miR-185.
REFERENCE   5  (bases 1 to 15590)
  AUTHORS   Rokudai,S., Li,Y., Otaka,Y., Fujieda,M., Owens,D.M.,
            Christiano,A.M., Nishiyama,M. and Prives,C.
  TITLE     STXBP4 regulates APC/C-mediated p63 turnover and drives squamous
            cell carcinogenesis
  JOURNAL   Proc Natl Acad Sci U S A 115 (21), E4806-E4814 (2018)
   PUBMED   29735662
  REMARK    GeneRIF: High STXBP4 expression is associated with squamous cell
            carcinogenesis.
REFERENCE   6  (bases 1 to 15590)
  AUTHORS   Li,Y., Peart,M.J. and Prives,C.
  TITLE     Stxbp4 regulates DeltaNp63 stability by suppression of
            RACK1-dependent degradation
  JOURNAL   Mol Cell Biol 29 (14), 3953-3963 (2009)
   PUBMED   19451233
  REMARK    GeneRIF: Stxbp4 and RACK1, two scaffold proteins, play central
            roles in balancing DeltaNp63 protein levels. While Stxbp4 functions
            to stabilize DeltaNp63 proteins, RACK1 targets DeltaNp63 for
            degradation.
REFERENCE   7  (bases 1 to 15590)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 15590)
  AUTHORS   Yamada,E., Okada,S., Saito,T., Ohshima,K., Sato,M., Tsuchiya,T.,
            Uehara,Y., Shimizu,H. and Mori,M.
  TITLE     Akt2 phosphorylates Synip to regulate docking and fusion of
            GLUT4-containing vesicles
  JOURNAL   J Cell Biol 168 (6), 921-928 (2005)
   PUBMED   15753124
REFERENCE   9  (bases 1 to 15590)
  AUTHORS   Saito,T., Okada,S., Yamada,E., Ohshima,K., Shimizu,H.,
            Shimomura,K., Sato,M., Pessin,J.E. and Mori,M.
  TITLE     Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate
            insulin secretion in the pancreatic beta HC-9 cell
  JOURNAL   J Biol Chem 278 (38), 36718-36725 (2003)
   PUBMED   12855681
  REMARK    GeneRIF: Syntaxin 4 and Synip (syntaxin 4 interacting protein)
            regulate insulin secretion in the pancreatic beta HC-9 cells
REFERENCE   10 (bases 1 to 15590)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122865.1, BC041485.2, AK123793.1, CA848494.1 and AC005177.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178509.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122865.1, SRR1803616.208176.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376352.6/ ENSP00000365530.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AK122865.1         1-480
            481-494             BC041485.2         318-331
            495-2222            AK122865.1         495-2222
            2223-2904           AK123793.1         20-701
            2905-3751           AK122865.1         2905-3751
            3752-3882           AK123793.1         1549-1679
            3883-4008           AK122865.1         3883-4008
            4009-4528           AK123793.1         1806-2325
            4529-5788           AK122865.1         4529-5788
            5789-6046           CA848494.1         366-623
            6047-15590          AC005177.1         63656-73199
FEATURES             Location/Qualifiers
     source          1..15590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..15590
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /note="syntaxin binding protein 4"
                     /db_xref="GeneID:252983"
                     /db_xref="HGNC:HGNC:19694"
                     /db_xref="MIM:610415"
     exon            1..51
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            52..129
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            130..254
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1869
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin 4 interacting protein; STX4-interacting protein"
                     /codon_start=1
                     /product="syntaxin-binding protein 4 isoform 1"
                     /protein_id="NP_848604.3"
                     /db_xref="CCDS:CCDS11584.2"
                     /db_xref="GeneID:252983"
                     /db_xref="HGNC:HGNC:19694"
                     /db_xref="MIM:610415"
                     /translation="MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEG
                     PLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWE
                     IAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNND
                     ILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAE
                     KLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAH
                     EISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQN
                     VKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYS
                     DQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
                     LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTA
                     DGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS"
     exon            255..387
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            388..494
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            495..705
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            706..781
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            782..873
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            874..970
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1062
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1152
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1218
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1395
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1512
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1562
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1696
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1754
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..15590
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6243
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /note="major polyA site"
     polyA_site      6258
                     /gene="STXBP4"
                     /gene_synonym="Synip"
     regulatory      12730..12735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /note="hexamer: AATGAA"
     polyA_site      12752
                     /gene="STXBP4"
                     /gene_synonym="Synip"
     regulatory      15568..15573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STXBP4"
                     /gene_synonym="Synip"
                     /note="hexamer: AATAAA"
     polyA_site      15590
                     /gene="STXBP4"
                     /gene_synonym="Synip"
ORIGIN      
        1 aggtggcagc gcttgcagtc gggctacgga ggccgggttg ccagattacg ggaaagccat
       61 ttaagaagtt cctggaataa tattagtcag agtaatatag gatctgcagg aagtgtctca
      121 agatagttgg aaaagaagaa tttctagact cttcatcaag atcttcattt atacagctgt
      181 taaatccaag gctactttgg tgaaagcatg aataaaaata catctactgt agtatcaccc
      241 agtctacttg aaaaggatcc tgcctttcag atgattacaa ttgccaagga aacaggcctt
      301 ggcctgaagg tactaggagg aattaaccgg aatgaaggcc cattggtata tattcaggaa
      361 attattcctg gaggagactg ttataaggat ggtcgtttga agccaggaga tcaacttgtc
      421 tcagtcaaca aggaatctat gattggtgta tcatttgaag aagcaaaaag cataattacc
      481 ggagccaagt tgaggttaga atctgcttgg gagatagcat tcataagaca aaaatccgac
      541 aacattcagc cagaaaatct gtcatgtaca tcacttatag aagcttcagg agaatatgga
      601 cctcaagcct caacattaag tcttttttct tctcctcctg aaatactaat cccaaagacc
      661 tcatccactc ccaaaacaaa taatgacatt ttatcttctt gtgagataaa aactggatac
      721 aacaaaacag tacagattcc aattacttca gaaaacagta ctgtgggttt gtctaataca
      781 gatgttgctt ctgcctggac tgaaaattat gggctacaag aaaagatctc cctaaatccc
      841 tctgttcgct ttaaggcaga gaaactggaa atggctctaa attatcttgg tattcagccc
      901 acaaaggaac aacaccaagc cctgagacag caagtacaag cagactcaaa agggacagtg
      961 tcttttggag attttgtcca ggttgccaga aacttgtttt gcttgcagtt ggatgaagta
     1021 aatgttggtg cacatgaaat ttccaatata ttagattcac agcttcttcc ttgtgattct
     1081 tcagaagcag atgaaatgga aaggctcaag tgtgaaagag atgatgcctt gaaagaagta
     1141 aatacactta aggaaaaatt attggaatca gataagcaaa ggaaacaatt gacagaagag
     1201 ctccagaatg tgaaacaaga agccaaagct gtagttgaag aaacaagagc cctgcgtagt
     1261 cggattcatc ttgctgaagc tgctcagaga caggcacatg gaatggaaat ggactatgaa
     1321 gaagtgatcc gtctgttaga ggccaagatt acagagctaa aggctcagct tgctgattat
     1381 tctgaccaaa ataaagaaag tgttcaggat ttaaaaaaga gaatcatggt actcgactgc
     1441 caattacgaa aatcagaaat ggctcgaaaa acttttgagg catccactga aaagcttctt
     1501 cattttgtag aggctattca agaagtattt tctgataatt ctactccttt atcaaattta
     1561 agtgaaagaa gagctgtgtt agcttctcag acttccctca caccactggg aaggaatgga
     1621 cgtagcatcc cagcaacgct ggcgcttgaa tctaaggaac ttgttaaatc tgttcgtgcc
     1681 ttacttgata tggattgttt accttatggg tgggaggaag cttacacagc agatggaatc
     1741 aagtacttca tcaatcatgt aacacagact acatcctgga tccatcccgt gatgagtgtc
     1801 ctgaatctat ctcgctcaga ggagaatgaa gaggattgct ctagagaact ccccaaccag
     1861 aaaagttgat ggttttcctt aggaagtgga gctacatgga tgatgtgagc agagacgcat
     1921 aacatccaat tctgagatga aacagtctaa aataggagta aagcatgcac tacttgttga
     1981 agtgtgaaat ggagactctg gactttgggt atttttgtaa aacttttgat atttctgtat
     2041 acatttaaaa aatcaattgc cactacagta gttccttaag aataatctag ttatattttt
     2101 tgaaatcaca tataattaga ctttataata tatatacttt ttcatatata attagatctt
     2161 tctttgtaat ttcatatgta gttcttcata gggtctcaga tacaatggtt tttataattg
     2221 acatattgaa aaagtatatg aacataatga aacacctcat ttatttgata attcactaat
     2281 gttttatatt catatattag gaaagtgaac ttagcaagct ttttggaatt taaggatcac
     2341 atttagacat ctcatgggct gatgaataca gctggtatct ttgtggagct ttctaattta
     2401 caaaatgctt tgtagacccc attgtcttta aaccatacaa catgcccgtg aagctgatct
     2461 ggtgggtatg tttattcttg gttttcagta gggaaatagc agttcagaga gaggaagctc
     2521 tctgtcccag caccgagact cactcctaag tcttctgatt ccatgagcag tcccccttcc
     2581 cccataccct gctgtctcca cggagggagg tcacagccca tcacgcagga cactgtgatt
     2641 gtgttgatgc agctggctcc acagctgtgc attccacaga gattcagaag gcacctcttc
     2701 ggtcaaacat ggcccctcta taaccccact attcttctcc tataaaccct tcccccttct
     2761 ctgcacccaa gccttcgcca agtaggcgca ctctttgtga tattgtttca gcagacttct
     2821 ttcagcagct cgtgtttttc taaagtgaaa ggcatggttt gtcctgctta ggttgccctt
     2881 cccagaggga tggtttgagg ggagctgatg agaagagagg tatctgttaa aacattactg
     2941 ctctactcga aacaagatgg aagcctaaag cccaagtcga gcagctccca gcactgctgt
     3001 gcagacctag aggtccttag aacatagtct aagaaccatt cattgtagcc attttatagt
     3061 tgagtaaact gagatcttaa gtctcctagt ctactgaatt tcatatggtg tataatacag
     3121 atttatatgg taaagatata catatacatt gtgctcaact atacattcct gaatccattt
     3181 aggatttgtg atttatgtct tgagtaataa tataaagtca actccagact gataggtagt
     3241 cattagccat gagaaatgtt tcaggatggc tagggaagac ttgtgttttg cctgacagcc
     3301 atttgaatgt taggaagctt cggggagaca agttttgaga gaagccccag agggagctat
     3361 ttccttgcac cccccagagg tgaatgaggt attctataag ttagtgtcta taattgtgaa
     3421 agtacaaact tcttgttttt gtcaaattaa tggtatgaaa tttctctccc cctgcttgaa
     3481 gagttttcta attcgtttct agtgagcaaa acaaagaagg tgcttgagtc actgaaatca
     3541 aagtactcag gcacacagcc cactgacaag agacacctca tccattaact gctgttttgt
     3601 accacttgcc gccctgtttc tgtcaaatac ctagtgaaaa aggcctaaac aattgtaatg
     3661 atattattta ttgggcattt tgtgccatac atggtgatga gcagtttgca tatatttatt
     3721 tatgatcttc ttaaaaccat tccatgaaat aggaactgta attatcccca attctaaaag
     3781 aaaaaactta gttttagaga gttagtaatc tttgcctaag ggtcacaaag cacctatgtg
     3841 tagaagctag ggttcaaggc agatctgtga ttccagaagc tgttctctaa accactatgg
     3901 agaactgctt agattcattg tctatgggta cattttataa aaaggcagat tctagttcag
     3961 tgtcataagg aactttctag taattagagc tgataagaaa agaattcccc aggagaaaat
     4021 ggaaacacta tcccagcaat ctgaattcct tacttgggga atgttgctga ggaggttcag
     4081 tgtgtgaatg gactgaacca gttggccact ctctcagatt ccctcttcat aaagcttccg
     4141 tgacttctaa accatcaggt cggtgccata agagatgctc aaaaaagcat ggtcagggct
     4201 tagcaagaat ccttttccag tgcaaatacg accctcatat tatgttttgg cgagtagcca
     4261 gtctttcttt aacatcaatc aaccgtagca atgtggtcat cacgaagtct tcattgactc
     4321 actggcttgg attttagggt tagaaaatct gaatgttctt atgtccttcc gtctcacttt
     4381 actagagtgc ccaagttgac tcatccttac tcactcattc cctcaaaata tttattgagc
     4441 accaacaatg tcacaagcac tgtgctaaac actgtggtga agtagaacaa ttgctaatca
     4501 tttcctgggt tccacttact cttgatttaa aaaaaaaaaa acaacaaaag agtttgtgtg
     4561 tggccaggac taaacagctg cttcttaatt tttgaatttt aaaactaatc tattttattt
     4621 aaaaaaaatc aagtactttg gaagtgaata aagtaagaga tagcctgtct cactttccag
     4681 aggtagcagt cactaatact gtggtgagtg attttactca aaggaaatca cactattaag
     4741 cagcttggtt ttgacatgtt atgttgtggt catcttttca tgtcaataca tagattaatc
     4801 ttttatttca aatgtctaca taaaatatca ctacccacat aacctataat ttgtgtggcc
     4861 agcaatttat tgaacactaa aatgttttaa gttttcttat tgctaacaat gtcacagtga
     4921 acatttatat attcattaaa tccttttcct catgtatctt tgcactcttg tgctagtatg
     4981 tctatagtgt gaatacattc ataaatttct tgatcaaagc taggtcaaag ttacattcat
     5041 tttaattttg gtacatatcc ataaattctc cataaaagta ggaccaactt acattaccac
     5101 caatagtgta tgtgagcctt atttttatgt atgataggac tttttttagt ccaaatgttc
     5161 ctatagattt tctgggtttt tttttttttt ttgtccttgg aagaataacc ttccttccac
     5221 caagtccaag aacctgagat ttttaatcat taggttttag atttccttta gcagcagaga
     5281 ctgacttgct gtatagaggg aagtcaagta gtgactaact cactatatgt caaacacatc
     5341 attactcttc tcttttccta ctttacatgt aatggttgcg aggaccaact ttcaaatgag
     5401 ctaacttggg tgagacgttc actaaagtac caagcacaat acaaatgcat cttcgagttc
     5461 tttgggcctc actttcccta tctgaataat aaggatagta atcccttgcc ttttctcaaa
     5521 ccagttcaac tcagcaaaca cttcctgagc acctgctaca tgccaggcaa aatgtgaaat
     5581 ttgcatgcta tgaggctaaa tggtactgat tctcaaaaca aggagctcat agtctaaaac
     5641 catttttctt tctttttttt ccccctaaac aacctcttaa aggggtaaga agttaggggg
     5701 ttgtttatta agaacccctg aagagcaacc ctttaccact ctcttaaatt tgaaaaattc
     5761 caaaataata ttaacacctc ttgactagaa aaggaaaaaa aaggaacatg ccgtatgaag
     5821 agcctctcca ataataaatg caaagcagct gtcaaaatat agagtcaagt gatactttca
     5881 taaagtgttt gcacaattag aaaatgttat cctttttctc gggagaaatg ggacattttt
     5941 attttctctg ctaagtgaaa tgcaactttt tgaagaatca acacgcttga catttttaca
     6001 atgtacataa agaactgaac tattattaaa acaacttaca cactccattg cttataactt
     6061 ttgagagaat gaaaagaacc ttaaacagaa tgtgcctgtg gagcttcgct ttagaaatga
     6121 aatacccaag gtgttttaac tacaactgtc tacatgtaat agtgtgtctg cataatgact
     6181 ttgtaaatat taactgcaat tctgtatttg ctttcttgat atgactttta acatttaaac
     6241 ttatactgtt tctgtctact tttttcaaaa gttcaatttt tacttttggg ggttggactg
     6301 ttctgaggga aagggcgatc agatcaatag ttctgtcccc cattccattc ccccatcacc
     6361 caattattct ctatatcact ctaccctgtt tatttctttt tttttttttt tttttttttg
     6421 agacggagtc tcgctctgtc gcccaggcgg gactgcggac tgcagcggcg caatctcggc
     6481 tcactgcaag ctccgcttcc cgggttcacg ccattctcct gcctcagcct cccgagtagc
     6541 tgggactaca ggcgcccgcc accgcgcccg gctaattttt tttgtatttt tagtagagac
     6601 ggggtttcac cttgttagcc aggatggtct cgatctcctg acctcatgat ccacccgcct
     6661 cggcctccca aagtgctggg attacaggcg tgagccaccg cgcccggcct atttctttta
     6721 cattatttat cagtttgccc taaccttgtt ttgtttgtta tcttcctcaa tagtgggagt
     6781 aataatggga gtcagcttcg tgagggcagg gattttgtct tcttgtattc atttactcac
     6841 ttacacactt accgagagct actagaggcc agacacttca ctgagtagta gggatacaat
     6901 gtgagatata tgtgtttcta gcccttgtgt aattcgtatt ctatgcaaag gatatacgat
     6961 tgaaattaac caaaactttt tccatttatt ttctttctcc gcattcttta tcagatattt
     7021 gaactactgg accatttaat gttcattacg ttaacaaaga gtgtgatatc agaaagcaga
     7081 aaaaagcatg ttcttttgca tttcaaaaat ttagctcctt ggggaactag aaaggattta
     7141 tgatttaggt caaagatttg agagcacata tgatgaggaa gatgaggctt tcttactcac
     7201 tgtctaggaa ataattctcc tggctgtgag aaggagaaaa aagaacaaaa atgttggtag
     7261 ggcacagaga aggacctggg cttaaccttc tggaccaagt tccagggagc agcaaaacct
     7321 caattacatt tgtcccctag aatggaaatg attatgtggt atgtttaggc agtgggacct
     7381 tggacaacgc cagtgagctt cctccagccc aatgtggtca acattggagg attagattga
     7441 tttctgtgaa cccaaaagga tcacaggagt agcaataaca cctgctggac ctgaatgagg
     7501 atcttttcca ttcaatccac atgttctctc aatggaaatc aattcggaca ataacattag
     7561 accatcttaa cccagagtgc cttagcacta gataagcctc tgctgtggtc tggatgtttg
     7621 tgcccagccc ctaatttcat atattgaaac ctaaccccca aggtaccagt attaagaggt
     7681 acggctctga ggaggtgatt aggtcatgag gctccatcct ggtgaatggg attaggaccc
     7741 ttatgaaaga ggcttcaggg aacctgtttg ccccttctgc cttgtgagga tgcagcaaga
     7801 agttgccatc tttgaagcag agagcaagcc ctcaccagaa gctaaatctg ctggcatctt
     7861 gatcgtacac ttcccagcct ccagagctgt gaacaataca tttatattgt ttataaatta
     7921 cccagtctga gatattttgt tatagcagct cctgaatgga ctaagacagc ccacagagtt
     7981 tagcagtgac cccaaggaaa ggaaagaact gcaagttgcc tgagattaat gttgctcagg
     8041 atccatttat tccctattcc tggtgtttct ttgtagagag tgctccatta aagtaacact
     8101 tttgtcctgt ctctgcttct tccttaggca gcgatttacc taattggtga gtttaggatt
     8161 aaaaaaagga atacatccta gaacatttct taaatatatt cccttttctc tgtttcatgc
     8221 aaacatggct tatttatttt tcaagtcttt ctcatttctt acctggatgc tttcaacaca
     8281 ggtgatatag cttcttcctt ctccaccaca cctgtcccca tcaatctacc catcacattt
     8341 ctgtcagaat tatctttcta taacacaaaa ttgcttctat tcctcccttg ctagtcttca
     8401 gtagttccct agcaccttct actatctgag tccctggctt tctccctagc ctcatgtctt
     8461 atcaccaaca gttgctcaga tatactgttt tctgtctagg aaacttctct tgccccattc
     8521 ctgcatcaga tttcttctca tacatcaaga ttctgctctc attttacctc ttctttgaag
     8581 agctccttga cacatgctgc cttccccatg cccagagctg gcactctatg gatgccatgc
     8641 ctgcattttt acacacctgc ccaaccccac ttcccactca ggagtggtag agcaagaact
     8701 tccacctcaa gagagttgct ggcctgtttg tccggacact catttggtta ctatatttac
     8761 taatttactt ttatctactg agctgggtta ctgagtctta gaggcttgaa atctggttct
     8821 accttctctt tctccatgtg gtaatgaaaa ccggaactct ggttaaagct aagtggtctc
     8881 tctcactgtg gctgttccac tcaacatcag tagctaggtg agtaaatcag gtggaggtgg
     8941 gaaggaaatg ggaaaacaga atactggcca ggatggtctg ttgtttctta tctgttgttg
     9001 gctttggggt attttattct aaaaccctag aggctgagaa ggttaactgg aaggcttcca
     9061 actctgaaat cctaccgcag tcccctattg ctgcatacct tttaataaag tatcaatcac
     9121 actatatatg taattaattt ggataggaaa gtagggcatg tgtcatctct cctagtagac
     9181 tgtgagtcct ttattactga ctcagagtcc atatattatt ttttatttct catgcaagac
     9241 atgacacagt aaaatctaat aaaagtttac aaaataaatt taaaatgtaa cattaacata
     9301 aaaaactctt ttagctgttt cctgcttctg gcagggaaac aaagattgaa ttaagaagga
     9361 aatgaggtgg gggtttaagt aagcatgtct gtactaacta gttccactaa tgtgggaaca
     9421 atataatgga ttttgctgaa gaaggaagtg tatgctactt aagttgggcc ataaaactca
     9481 cagtatgatc gcagtaaaag gattgtaaag cacatactca cacattgttg atttgcccaa
     9541 ggttctgaag aaataccaca gaatgatttt ggtatagaag ggtagataaa gcctgaaacc
     9601 aaaatacaag gttagtgcat ttcagagcag cagcaaactt ctgttcttat gggttaatta
     9661 atcatgttac tgaagaattg atttggcaca agggagctat gtattgccac agaactctga
     9721 aattgcagaa attatctcat ctataagtaa ccccactgga attgcttgac tgttctgttt
     9781 cacagtggag aaattcatct ttcatcagca cacacgagaa gagacaacag gaagacaaaa
     9841 caaattgagt agataataaa gttaccttat aggaataggt aatatagaca ggtaaggtca
     9901 gaaatttctg tggaatggaa tatgaaaaga tgtttatgag cagattctat ttctttaggc
     9961 agttttatca ttcagagaag taatctatgc atttaatcta atgccagctt ttatttttct
    10021 ttggtgatta ccacacaaaa ataagaagtt ggcaccaaat taaatgcatg gattacttct
    10081 ctgataaaag tactcgatat aagggaaatt tgaaggaaat agaatgcata catacacaca
    10141 catacactta gtatatgtgt gtgtgtgtgt gtgtatatat atatatctgt gtgtatatac
    10201 acaccacaca cacacacaca cacacgtatt ggaggaataa gaaatattta ataaaatcta
    10261 cacaatttca aaaatatgac caaatactgg tggttcctca tttaccagta gaactctctc
    10321 tacaaatgga aagtgagaag tctatgaagt taccttagtt tttccaatta agactgttca
    10381 ttgattgtat ttcttctgtc tctataagta ccatattccc aattagtatt tcatcagtta
    10441 taagacccat cattattttg tgtgtaactg aaaatgaaaa aaagatttaa aatatgactt
    10501 agtagttaga atttttatct tatacgcctt taagtaaata caagagaact gtttcagcat
    10561 agatttttaa aaatcatgtg tgtaaaagag aatgaaatat taattatgat atttacaaag
    10621 ctctgtacat tcagaattga actctttctg catctctttt ttgaatcaga gttgtcataa
    10681 accacaattt ttcacggtaa caccctctct gccatcagga taaataacat ttcttaaagg
    10741 aatattctac tgcagtctct gagatttttt tccctgtctt agacatccat tctacaactc
    10801 tgatgctggc acatttttta tcttggcaaa aggacttaat agaaaaattt tagataacaa
    10861 tcaggattca tactcttctc aatagtcctt aaatggttta ttgaccaaaa agtaaagaag
    10921 taacagtcca gtcatatcat ggaaagaaca accaaattca tgcatgcaca ggcaaagaca
    10981 accatatcac tatgaccacc tggctgacag taactgcagg acatcaatta ttgtaagaca
    11041 cttcctgtaa tatgtttaat tcctctgaca taaggattta tgtgaattag gaagtggccc
    11101 aagggtgaaa agtaataggg aaatagagaa atagaaccga tccaaaggaa agggggaaaa
    11161 aaacccacaa aaagtgtgat gtcaagcaaa gcctattctg gagatgactt tggttcactc
    11221 ccacgggaga gccctagaga caaaaaggtt ctacagtagg ttcaagtcag aggccagaga
    11281 acccagagta tttatacctc tgcaccatca gttattgaat gggggtgggg gtgggggtgg
    11341 gtgtaaattt ccaggtgctt ccagcctgca atgcagtcaa agcatgttcc tgtagcctga
    11401 ggacagccgt ccaacaaaga ggtgcaggtg ctgaatgttg agagtgaaag cacagggagc
    11461 tgtcatgcat gagagtggta gagggatctg aaagtgctag cagtgcctat tatacatcca
    11521 aatactaaag acgcttagat gtgaaaaatg tgtgtcttag aatcgataaa atatggtata
    11581 gagaatcaag tctccttgtt cctggtttat ctcatagcat acttaaaatt cagctaaaga
    11641 tgaaatgcct taacaagtga aatgggcttt ctgaaaaatt atttcaatca aaattgtgtt
    11701 aaaagctatt tctaaaaacc ctaacatgaa atacttagaa gagatcaagt ggtttgtccc
    11761 tggacattca agcaattgaa tgtctaaaca atccaagaca gataattttg tagtatttac
    11821 tgtgtgaagt gaacctttaa ggctgtggac aatgcaaact ccctcatgta ccttgctcct
    11881 tgccaatttc aaacaaacct tctcacctat gatataaggc ttccttagaa ttattgatta
    11941 attatttaag atacaataaa accaaagtat ttttaaaaca cagtaattat gttagtgcag
    12001 gtacatgaca tagatatcct caaatattct taggacatct ataaatcacc acaaacattc
    12061 tggaaagcag tcttggaaca tctatcaaag gccttaaaaa tttcttcttc tgtgaattta
    12121 tcctcacaaa tgaccccaag tttagaccaa aataaaaaaa tgcttaaaag gcttattaaa
    12181 gcatgattta aaatagaaat gattgcctaa attcctgaaa acaggggaat gtctaaataa
    12241 aatatggtat ctaacatgat agaaaatgtt tactaatgtt taatgatacc aagaaagtat
    12301 cacaataata acatcaagtg gtaataacag gaaacagatc tgtatacaat ataaaaccaa
    12361 cagtattgta tatataaaca ccatagaaga tctgaaaaaa aattagatga cattatttgt
    12421 gatatctatt ttatttatta tatttttctg catactactc tacagtgagc ctgtccttta
    12481 taagaaaaaa tgctaatgat ttattgtgta tgaaaaaagt gtatctgatt tgattatata
    12541 tttttatttc cacttatatt ttctaggatt attttgcttt agaattctat gtataatcct
    12601 gtgaaaattt gtagtgttgt agggactgga aagatcagag attatgttat ggccatgaat
    12661 gaggcctgac ctgcattgtc aataactaaa ttgattattg tggaaacaac aaaaaaattc
    12721 attttttgaa atgaaaatct ttattgaaat aactatttta ccattgtgtg gtcagattca
    12781 ctgcatttga tgctttttca ggatttgttt ttcctgctag aaatgctaga gttgtcacag
    12841 atgtgatatt tatgttttca ttgtctgggg agggccaagt ttcatgacag agaaagactg
    12901 gggccaattc tgtgattatg gatgtcaact tatctcagag cagtatcatt ggttgagcag
    12961 tcctgcagga catctaagtt taccgtcttt atcttgccat tgtcaaagat cctggaccta
    13021 tttttttctg ccttgaaaac ttttgtgcag taaaaccagc aatggatttt agcagagttg
    13081 atgcatcatt aggattttca cattaactct ttggacttag agccatgtct aaagtgtcct
    13141 tcttttggat atagtgcctg gtgcagaact ctaccacaaa acatcaggtg tgcctctgaa
    13201 tagtctttgc aagaagcaca aaatcctaga attgaggtga atttgtaagt tcctctagtc
    13261 caaccacctt tcaaatgaaa gaatccttcc aaagcacccc tggccaatag ctcatcaaga
    13321 ttttgcttag atattcttat tgagggggaa cttactaact cctttaattc ttattttgct
    13381 taaggctgag tttttaaaac atctaacatc agccaagatt attgatttat ctataaggaa
    13441 taatctgtga attaaccttc tgtagctttt ccttgctgac cagggaatac ctccccattg
    13501 aagcctaggc cagattccag tccgttttga ccatacccca tcatggtatt ttagagtaca
    13561 cctgaataag atacatggtg ccatgtacat ggaaactgac tgctctcatg ttacgggttg
    13621 aactgtgtcc ccccaaaatt tgtatgttga agtcctaaaa ttggcactgt tgccataagc
    13681 cagggaacta cctaggagat gctaggagag aggcctagaa tggaaccctc cctcccccgc
    13741 ccctggggcc ttcagaggga gcggtgccca gctgacacct tgaccttgga cttctagcct
    13801 ccaaactgtg agacaataca tttctgttgc ttaagccact cagttagtgt gctttatttt
    13861 ggcagtctta gcaaactaat acatccccca atccagaact gtcctccttt ggataataaa
    13921 aacagcaata attatagtgt cattaccctg agtgactggt cccactgttg gtcattcttt
    13981 gtagatgtga gttattgccc tattgagatc agaagtcctc tcacttagag gcatatctaa
    14041 gacttttttc ttgtggaggg agctcactca actgtaggta aggtttgact catctgggtt
    14101 agtagtaaga acaaacttcc aagtggcacc atcttaaagg tgcaagccca tgtgggcgat
    14161 gaccaggtct ggtatattaa gaggctcttg gtagcacatt agaaacacct ggagagattt
    14221 taaaatttac aaagcctagc caaaccccag acccattaac cctgactctc tgagaatagg
    14281 accctggcac ctgtgtttta aggattctag gtgatttcaa tgtgtagcca aggttcactg
    14341 ccatagcctg tcctggaatg caggtaacta aaacttcagc agattatgaa aaacaaaagt
    14401 tactttcttg gatgcatata ttcttatagc ctcaaaactg aaactgcaaa ctgaacaatg
    14461 ctgcagtcag atacacacac atatttcaac tgcataactt cctttaataa tacttttatt
    14521 tttccaaatt tgaagactgt ccctaagtca tttcttctaa aagttagtaa taatcccacc
    14581 aactcacatt tacatagaag ttacagttta aagtttgcat ctcgtaataa cttggtgaga
    14641 tagggcaagc attatttcta atttgcatat gagaaaaaac taaggctcgg atgagttatg
    14701 tgacttccct gagtcatgtt agagtaacta actcctgatt tgtaaactga aggtcccaaa
    14761 tcctgggaac tccctcagct ctgggcaagc caggacaggt aggtcaccct gcacctacac
    14821 aaggactgag ctgagttcta gttacctgct gtgaaggact gtagaggtta tctaagccag
    14881 ctcctccttt tactggaaaa ggaaaagact gagataagtt tccaaaaccc ctgctggagc
    14941 accttctact tctagaaaga tgttgagggg cttccagggc acaaaggaaa gagaagtaac
    15001 tgtgtctcct tccccaacca tgtatgtgat acattcattc tctaggattg gaaattccca
    15061 gaaagctgtg tcagcaatga gatttgtttc attgttttgc cttgttttgt cattgagttg
    15121 ttatagttaa agtttattat tttttaatgc agaaaaaagt gacttttggg ggagtgcaga
    15181 gttctatgaa tttttaacac atgtctagtt atttgaccac aaccgtaatc aagatacaga
    15241 acagttttat catttcaagt gctctcctgc tatgctttta taacacaccc ttccccaccc
    15301 caactcctgg caattactgc tctattctcc gtaactgtag ttttgccttt tcgagaatat
    15361 catataaata atcatgtatt atgtaacatt ctgagacagg cttctttcac ccagcataat
    15421 gcctttgaga ttcatccaga tcgttgtgtg tatcagtagt ttgtttttat tactgggtta
    15481 tagttcattg tatggatata ccacagtttc tttagccatt cacccactga aagtcatttg
    15541 ggttgtttct aggctttggt gattatgaat aaagctgcta tcaacatcca
//
