LOCUS       NM_004853                830 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 8 (STX8), transcript variant 1, mRNA.
ACCESSION   NM_004853
VERSION     NM_004853.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 830)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 830)
  AUTHORS   Xu,H.
  TITLE     Smuggle tau through a secret(ory) pathway
  JOURNAL   Biochem J 478 (14), 2921-2925 (2021)
   PUBMED   34319403
  REMARK    GeneRIF: Smuggle tau through a secret(ory) pathway.
REFERENCE   3  (bases 1 to 830)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 830)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 830)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 830)
  AUTHORS   McShea,A., Samuel,T., Eppel,J.T., Galloway,D.A. and Funk,J.O.
  TITLE     Identification of CIP-1-associated regulator of cyclin B (CARB), a
            novel p21-binding protein acting in the G2 phase of the cell cycle
  JOURNAL   J Biol Chem 275 (30), 23181-23186 (2000)
   PUBMED   10781590
REFERENCE   7  (bases 1 to 830)
  AUTHORS   Scales,S.J., Chen,Y.A., Yoo,B.Y., Patel,S.M., Doung,Y.C. and
            Scheller,R.H.
  TITLE     SNAREs contribute to the specificity of membrane fusion
  JOURNAL   Neuron 26 (2), 457-464 (2000)
   PUBMED   10839363
REFERENCE   8  (bases 1 to 830)
  AUTHORS   Prekeris,R., Yang,B., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Differential roles of syntaxin 7 and syntaxin 8 in endosomal
            trafficking
  JOURNAL   Mol Biol Cell 10 (11), 3891-3908 (1999)
   PUBMED   10564279
REFERENCE   9  (bases 1 to 830)
  AUTHORS   Thoreau,V., Berges,T., Callebaut,I., Guillier-Gencik,Z.,
            Gressin,L., Bernheim,A., Karst,F., Mornon,J.P., Kitzis,A. and
            Chomel,J.C.
  TITLE     Molecular cloning, expression analysis, and chromosomal
            localization of human syntaxin 8 (STX8)
  JOURNAL   Biochem Biophys Res Commun 257 (2), 577-583 (1999)
   PUBMED   10198254
REFERENCE   10 (bases 1 to 830)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009713.1 and AC087501.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004853.2.
            
            Summary: The gene is a member of the syntaxin family. The encoded
            protein is involved in protein trafficking from early to late
            endosomes via vesicle fusion and exocytosis. A related pseudogene
            has been identified on chromosome 12. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.526261.1, BC009713.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306357.9/ ENSP00000305255.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               BC009713.1         12-116
            106-106             AC087501.16        53836-53836
            107-467             BC009713.1         118-478
            468-468             AC087501.16        130316-130316
            469-830             BC009713.1         480-841
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..830
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /note="syntaxin 8"
                     /db_xref="GeneID:9482"
                     /db_xref="HGNC:HGNC:11443"
                     /db_xref="MIM:604203"
     exon            1..29
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..723
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /note="CIP-1-associated regulator of cyclin B"
                     /codon_start=1
                     /product="syntaxin-8"
                     /protein_id="NP_004844.1"
                     /db_xref="CCDS:CCDS32565.1"
                     /db_xref="GeneID:9482"
                     /db_xref="HGNC:HGNC:11443"
                     /db_xref="MIM:604203"
                     /translation="MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTI
                     RALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGA
                     EPDLIRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSS
                     IISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSASCGMIM
                     VILLLLVAIVVVAVWPTN"
     exon            30..129
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            130..224
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            225..335
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            336..460
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            461..553
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            554..655
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     exon            656..830
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      808..813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /note="hexamer: AATAAA"
     polyA_site      830
                     /gene="STX8"
                     /gene_synonym="CARB"
                     /note="major polyA site"
ORIGIN      
        1 ggagtctgca ggatggcacc ggacccctgg ttctccacat acgattctac ttgtcaaatt
       61 gcccaagaaa ttgctgagaa aattcaacaa cgaaatcaat atgaaagaaa aggtgaaaag
      121 gcaccaaagc ttaccgtgac aatcagagct ttgttgcaga acctgaagga aaagatcgcc
      181 cttttgaagg acttattgct aagagctgtg tcaacacatc agataacaca gcttgaaggg
      241 gaccgaagac agaacctctt ggatgatctt gtaactcgag agagactact tctggcatcc
      301 tttaagaatg agggtgccga accagatcta atcaggtcca gcctgatgag tgaagaggct
      361 aagcgaggag cacccaaccc ttggctcttt gaggagccag aggagaccag aggcttgggt
      421 tttgatgaaa tccggcaaca gcagcagaaa attatccaag aacaggacgc aggccttgat
      481 gccctttcct ctatcataag tcgccaaaaa caaatggggc aggaaattgg gaatgaattg
      541 gatgaacaaa atgagataat tgacgacctt gccaacctag tggagaacac agatgaaaaa
      601 cttcgcaatg aaaccaggcg ggtaaacatg gtggacagaa agtcagcctc ttgtgggatg
      661 atcatggtga ttttactgct gcttgtggct atcgtggttg ttgcagtctg gccgaccaac
      721 tgatggcagt aaagagacca ccagcagtga cacctgccaa tgacagatgc aagcccaaca
      781 cccttttggt acgcaaaacc tgctctcaat aaattccccc aaagctctga
//
