LOCUS       NM_003569              15845 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens syntaxin 7 (STX7), transcript variant 3, mRNA.
ACCESSION   NM_003569
VERSION     NM_003569.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15845)
  AUTHORS   Wu,J., Zhang,H., Yang,L., Chen,Y., Li,J., Yang,M., Zhang,X., He,C.,
            Wang,X. and Xu,X.
  TITLE     Syntaxin 7 modulates seizure activity in epilepsy
  JOURNAL   Neurobiol Dis 181, 106118 (2023)
   PUBMED   37031804
  REMARK    GeneRIF: Syntaxin 7 modulates seizure activity in epilepsy.
REFERENCE   2  (bases 1 to 15845)
  AUTHORS   Parveen,S., Khamari,A., Raju,J., Coppolino,M.G. and Datta,S.
  TITLE     Syntaxin 7 contributes to breast cancer cell invasion by promoting
            invadopodia formation
  JOURNAL   J Cell Sci 135 (12) (2022)
   PUBMED   35762511
  REMARK    GeneRIF: Syntaxin 7 contributes to breast cancer cell invasion by
            promoting invadopodia formation.
REFERENCE   3  (bases 1 to 15845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 15845)
  AUTHORS   Miao,G., Zhao,H., Li,Y., Ji,M., Chen,Y., Shi,Y., Bi,Y., Wang,P. and
            Zhang,H.
  TITLE     ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated
            assembly of the SNARE complex required for autolysosome formation
  JOURNAL   Dev Cell 56 (4), 427-442 (2021)
   PUBMED   33422265
REFERENCE   5  (bases 1 to 15845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 15845)
  AUTHORS   Nakamura,N., Yamamoto,A., Wada,Y. and Futai,M.
  TITLE     Syntaxin 7 mediates endocytic trafficking to late endosomes
  JOURNAL   J Biol Chem 275 (9), 6523-6529 (2000)
   PUBMED   10692457
REFERENCE   7  (bases 1 to 15845)
  AUTHORS   Prekeris,R., Yang,B., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Differential roles of syntaxin 7 and syntaxin 8 in endosomal
            trafficking
  JOURNAL   Mol Biol Cell 10 (11), 3891-3908 (1999)
   PUBMED   10564279
REFERENCE   8  (bases 1 to 15845)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
REFERENCE   9  (bases 1 to 15845)
  AUTHORS   Wong,S.H., Xu,Y., Zhang,T. and Hong,W.
  TITLE     Syntaxin 7, a novel syntaxin member associated with the early
            endosomal compartment
  JOURNAL   J Biol Chem 273 (1), 375-380 (1998)
   PUBMED   9417091
REFERENCE   10 (bases 1 to 15845)
  AUTHORS   Wang,H., Frelin,L. and Pevsner,J.
  TITLE     Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle
            trafficking to lysosomes
  JOURNAL   Gene 199 (1-2), 39-48 (1997)
   PUBMED   9358037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW500305.1, BC011975.1,
            BF064142.1, U77942.1, AJ420529.1, DA242979.1 and AL357034.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003569.2.
            
            Summary: The protein encoded by this gene is a syntaxin family
            membrane receptor involved in vesicle transport. The encoded
            protein binds alpha-SNAP, an important regulator of transport
            vesicle fusion. Along with syntaxin 13, this protein plays a role
            in the ordered fusion of endosomes and lysosomes with the
            phagosome. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.45520.1,
                                           SRR1803611.146617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367941.7/ ENSP00000356918.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AW500305.1         86-139
            55-1139             BC011975.1         1-1085
            1140-1611           BF064142.1         14-485              c
            1612-1615           U77942.1           1530-1533
            1616-3793           AJ420529.1         113-2290
            3794-4188           DA242979.1         162-556
            4189-15845          AL357034.18        104478-116134       c
FEATURES             Location/Qualifiers
     source          1..15845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..15845
                     /gene="STX7"
                     /note="syntaxin 7"
                     /db_xref="GeneID:8417"
                     /db_xref="HGNC:HGNC:11442"
                     /db_xref="MIM:603217"
     exon            1..110
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..253
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..954
                     /gene="STX7"
                     /note="isoform a is encoded by transcript variant 3"
                     /codon_start=1
                     /product="syntaxin-7 isoform a"
                     /protein_id="NP_003560.2"
                     /db_xref="CCDS:CCDS5153.1"
                     /db_xref="GeneID:8417"
                     /db_xref="HGNC:HGNC:11442"
                     /db_xref="MIM:603217"
                     /translation="MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQD
                     SPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLT
                     NFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEI
                     TEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQ
                     QANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH"
     exon            254..323
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            324..417
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            418..555
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            556..608
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            609..705
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            706..778
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            779..861
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     exon            862..15845
                     /gene="STX7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: AATAAA"
     polyA_site      2199
                     /gene="STX7"
                     /note="major polyA site"
     regulatory      3772..3777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: TATAAA"
     polyA_site      3793
                     /gene="STX7"
                     /note="major polyA site"
     regulatory      7714..7719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: AATAAA"
     regulatory      7725..7730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: TATAAA"
     polyA_site      7732
                     /gene="STX7"
     polyA_site      7743
                     /gene="STX7"
     regulatory      9140..9145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: AATAAA"
     polyA_site      9165
                     /gene="STX7"
     regulatory      15818..15823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX7"
                     /note="hexamer: TATAAA"
     polyA_site      15845
                     /gene="STX7"
ORIGIN      
        1 gcactgggcg tccccacgcc accgcccatc agctgagaat tgcagctgag ggctccgggg
       61 taggtgggtg acggcggtcg gaggtgtagg agggagccgt ggaggtccag gtgactgctt
      121 agaaaactgc acagcatctg atgaaattag cgaataagaa catcaaccat gtcttacact
      181 ccaggagttg gtggtgaccc cgcccagttg gcccagagga tctcttctaa catccagaag
      241 atcacacagt gttctgtgga aatacaaaga actctgaatc aacttggaac acctcaagat
      301 tcacctgaat tgaggcaaca gttgcaacag aagcagcagt atactaacca gcttgccaaa
      361 gaaacagata agtacattaa agagtttgga tctctgccca ccacccccag tgaacagcgt
      421 caaaggaaaa tacagaagga tcgcttagtg gcagagttca caacatcact gacaaacttc
      481 cagaaggtcc agaggcaggc tgctgagcga gagaaagagt ttgttgctcg agtaagagcc
      541 agttccagag tgtctggcag ttttcctgag gacagctcaa aagaaaggaa tcttgtatcc
      601 tgggaaagcc aaactcaacc tcaagtgcag gtgcaggatg aagaaattac agaggatgac
      661 ctccgtctta ttcatgagag agaatcttct atcaggcaac ttgaagctga tattatggat
      721 attaatgaaa tatttaaaga tttgggaatg atgattcatg aacaaggaga tgtaatagat
      781 agcatagaag ccaatgtgga aaatgcagag gtgcacgttc agcaagcaaa tcagcagctg
      841 tcaagggcag cagattatca gcgcaaatcc agaaaaaccc tgtgcatcat cattcttatc
      901 cttgtcattg gagttgcgat tatcagtctc atcatatggg gattgaacca ctgaagttat
      961 aaaggagcac actgtcgcac tacattgtct aaattatgta ggaagattcc tgtaatcatg
     1021 tttttttaat tattatttta aagctattgt ataaaggatg gttcccatac tttgttattt
     1081 ttattggggg ggttggggtg gttcctttgg attaaatctg atattttcta atactgaaag
     1141 attttctaaa tgtcactgct gacataactc ccttggtctt caatttaata gttgttaagt
     1201 ttttgcccac attgcatatg cctttcattt ataatttatt taccctgctt gacttagttt
     1261 tgggaattcg taaatttaaa ggtgtgtgta ttctgtttgc atctccctgt cactgtgaca
     1321 cacctagatg tgtgttactt caattaaaat tctcaaattt aattttgatt tgcttcagca
     1381 gggaaaatat tctcaataat gtaaaataat taaggtctat acatgggttg tatttttctg
     1441 gttcacaaca gcacaaagtg tctttcattt ttttgttggt tttcttttaa gatctttttt
     1501 accctgaagt cggtgaatac ttttctagtt tatttgatac tctttctgtg tatatattaa
     1561 gcttttgctg tagattgcct agtaaaatta ctaaggatag gttgttttta catatggtct
     1621 atttaagtct gatgtttacg ggggaaagtg tagttactaa aaatgtttaa cataatttgg
     1681 aagaagagta tgaacaacca ataccaatac ctattgcgtt tggattctta agaccccagt
     1741 ttgttattcc actaaactag ttatcttaac catatcatct ggttttgtgg gccattattt
     1801 accttccctt atgtcttata gaataatggt taatattttt aggtcaaaat tacttttgga
     1861 aagtaacttt cccacaatta actgtttttg agcacctgac aaaatttagt gtttaccttg
     1921 cgtgccattt tgtgtcatcc ttcattaaaa aagcaattgg aggtttgcca gttatctcac
     1981 ttcccttttt aaatcaatgt tgttttaatg cactaatctg aattctgtaa agaggattat
     2041 cttagtttat actttgtatt ttataatgtt cttgtatagc agctcggtac tgaaggcggt
     2101 gtttaacttg gcaagctctg agacttcaaa tgggaacaaa tagtaagtag ctaagtaaac
     2161 cacatctttg caaccaaaat aaagatgagt taaaaggtat ctggttaggc ctatttcatg
     2221 aggactatgc tctggtggga ccacaggtca cctgatactt agtgctgtgc tgcctgaaac
     2281 ctcagcatgg agacatcacc acatgcactg tggccattca gcatctttct ggagcaccag
     2341 ttcactccag gtttttattt tagggtgtca tcgattttac ctactttgtc agactggtag
     2401 aagttgcttt gcatatcaga aaaactccat ttttttccac aaaagggatt acagaaaact
     2461 cttttgtgag tgagtgattg gaacttagag actcctgttg ccagaatcag actgccctag
     2521 aacagaatgg acaatgcagg gaggagaatt cacacaaaca gcacctgttc tgaggcctgt
     2581 gccagcccac caggcctgct caaatgtggt ctttacttca agtgcacaga ggcacatgag
     2641 gtttctggtg ataaaccagc gtcttaccgc tgttttaaag tcccatcccc atggctttca
     2701 caatcagttc cgtttttttt gctgtacttg ataaaatgtt tattctcata caggtcaagt
     2761 acatttactt ctattcacag tgagtaccca ataacaacaa aagcgcttac aaatttgggg
     2821 ggcgtgattt tagtaccttt atttgaagtg taatcatttt aaattattat tattttaact
     2881 ggggcagtta tcagtggttt aaacaggaac tttagtggct tcaatttgtt taagaaacat
     2941 attaagtttg agggaaaaat ttcccatgaa atatttggaa cgtaagagta gtattgatta
     3001 gagaaaatta aataagaaac atagtatggt agccaaattt tttaaaaaat cttgaacttt
     3061 tctgtaggtc agttttagaa ctgctgtgaa aagtgaaggt tgccctgtgg agattaaaat
     3121 tagagttgtt ttcataactg acagcatggt gaatccattt gagtcaaagt gaagaatttc
     3181 ctcatcaagt gactatacat ttgtttttgt gtgctcaaaa gaaatactca aacacagact
     3241 gatattaacc agccaggtaa attgaacgac aatgtggcat taggtatttg gctgtttatt
     3301 ggtcgttaaa tactatggtt ttgcaatatg attgatggta aaagagtgat gtcatattga
     3361 tactagagta gcttgttttt ttagtaggtg tgggaccatc tcttttacaa gtgcaactca
     3421 gtctaggaca gccatggatg cagtgtctgg agttggaccc tctgagcccg ctggctgccc
     3481 cagtagcatc tgcattggtg accaaggaca ctgcactttg aagaggtcgc cactgggtta
     3541 tttagtgtct tcactgcttt tgttaaaaat tgtaaaattt tgtacacaaa aagttgtgtt
     3601 tttgaatatc aattgtttag acacacctac aatgataaat aagtgccttt aaaggcccct
     3661 ctttccatga aatacatctg tggtttagca aggaaagtac aaaatagttt atgtagttgg
     3721 tataattttt atttgtgtct tcatgtagaa aaaatgaatg tcataataaa atataaaact
     3781 tacgtaaaga aaataaagtc attgtccacc ttaatagcta aggtccacaa gggtaactta
     3841 tgcagcattt attttttttg aaagtcaaaa ttgaatttat ttctttcaca tggctggttt
     3901 gctgcaatat gaagtttcag aatgggctga agtaagttga ttgagggatt tgagttgaat
     3961 gacattttca agttcattta aatatgataa aaattcattg gtggtaaata acatctgtct
     4021 ttcctggaaa aaaaaaagtt gtgtattttc atgattcagt taaaacaaaa aatgagcctg
     4081 tgaatcccag gcctttttag tcctccataa catttgaaca gtttgacttg tcagcaaaga
     4141 aatacactta tcaaatttta aaccaatggg agcctgaaag tgttacagtg tactgcttct
     4201 ttgacaaaat tctgtttaac aactacccta acataattta taaatcaatt aagataaaac
     4261 catttttttc tgagtattta ggaatttgtg tcctcaaaat actgtgacat gaaagatagg
     4321 aaagaaatta cctggttgcc agacatgcac gattatcttt cctcatttca gctggatttt
     4381 ccaaagtcag tagattggat aaagcagcat ctcattcact gaggtcacaa gataggtagg
     4441 aaacttcttt aatgtgaatt ttgcatattt taacaattca gttagaaaaa cagaaaccac
     4501 ttgatggatt ataagtgtaa agtgttttaa catagggaat tagacatcaa aagggtgggt
     4561 gaggaaggtg tctgcggccc caaagtgggt ggatctcagg agctggccca ggcactgctg
     4621 tgactcttga gaacatccag aaggctgtgc tgttggcgtg cagcactgac agtgtgtctc
     4681 agggagctgt ccccagctgt cagctgttaa tagctccaaa gccagtgcct tgcaagagat
     4741 tttgaaactg ctgtgaaact catgtcctct gcccgcctac acttctgtct gcagtggcct
     4801 ctgaggaaag atggtctctc cttttctcat ggtcaactct caacttagaa ccagagacag
     4861 aaggagtttg tgggaagtgt ggtttctggt ctacctgcac tgcagaggac attctagaaa
     4921 gagaagtgag ttgacagtct agcataattg tgaaacaaac actgagatgt acagttcaaa
     4981 ccacgtgaag tggaagcctc agaattttcc tcactttcat taaagattct ttgatggaaa
     5041 aatttagaag cattggctct agatggtaag caagtcattt ttttccaacc aaaataaaaa
     5101 atacatatac taagcttctg gggccccagg acttaacaca gtttccttcc ttccttccct
     5161 tcttccttcc ctcccgtagt agttgcttaa taaatactta atttggcact tatttggggc
     5221 cggctttttg ccaggctact acatgcctgg gcatagtgtt ctaagagtga accaaaagaa
     5281 taagcttcct gccctcaggg agtttatgtt ttgttatttg gcatataaaa agaacttggt
     5341 gtgttaaaag aagggaaata gctgtgtgaa aggaatgagg caaggaagaa agggaatgtc
     5401 taaatataaa tctccgtttg gaccagcctc ctgtttatcc agttttcctt actaagtaac
     5461 tgaatttcat tttcttttct taattgacag actaccagaa aattgctagt tttctaaaga
     5521 gaaactactg atttgagtga tgatctgtgt gtaatggctc caaaaaggag ccgttctctt
     5581 ggtggcagca gttggattca gagcttgggc atcctgatca tcaggacaga catttacagg
     5641 atatgtatag aattactgcc ccaaatagag ggcaaagcac tagacagaag ggtgagatcc
     5701 aaggggaatt tggaatctat atttcatcag aatgcactca aagcaaaaac agtaagtatg
     5761 ctccatataa agaaatgttt cttaaaatgt ttttaattta accctaccca tcccttggca
     5821 aatctttttc ttttaaatca aataggaata aagaagaaaa tcttcctatt ggcccatttt
     5881 ctcattattc aaataccata tcaatacacc aattttaatt ctttgttttt gtaatcattt
     5941 ggttaacatg aatattatgt aatatttttc tccaaataat cctaatttta aatgcagaaa
     6001 tagagctaaa taacacacta aataggtttt tgtagacact gtagcttctg gcaagttttt
     6061 aagaggttgg tcacttaatt gcttagagtg ggattcccgt aggttttgtg tagtgatggc
     6121 atttatgctt aaaatgtaag tggtggaagg caaaaccaga tttcctgtcc agtcgttaca
     6181 cgcacaacac ctctacttgt tgacgaggga gttttctaga actgaattga atctttaaat
     6241 aaacttgaaa gggcattaat tcccactttg gccaacccaa agtacaaatt tttaagtgtt
     6301 tactgtaagt atcgttaggc agtagttact aactccaaca cctaatagca ttggtagaaa
     6361 gcttataaat gcagttattt agcctcgact aagatttttc tgatacctag tttcactttt
     6421 taatgccctc tgaaagtttt ttgatcagtt gtttaatggg agatctgaaa tgttaaactc
     6481 agaccagaaa gaagagaacc tgttttctag aaattaggtt tttaatccaa gtaagatgca
     6541 agcttttgct tttttaataa cttgtatagc taaaaacttg acggtgaaaa gctctcagat
     6601 caaagctgat ccttctgtca gtaatgattc taaaaataag caagatttta atggggaata
     6661 tattttattt cattcttatc tcaaacctag gtactgtggt cgttttgagt tcatttcgag
     6721 gcattttcaa tgtgcctcag gccacatcca acctcttccc agggccagat ttaatgttca
     6781 gcctcataaa ggttatcata gttttaacat ttaagtacta ttttgcagtg ggtatatacc
     6841 aaaatttgct aatagtaaga taaccttagt tatatatcat tcacgttagt tctatcttgg
     6901 aggcaataaa catttcttgt tcaagaaatt catgttctat cttggaggca ataaacaaac
     6961 attttttgtt caaaattagg gctaccctat tgtccttatg tcttttcctg atctgtggtc
     7021 aaacattttt cttagtcatt tagaaatttt ctatgttgtt ttaaattttc tttaaatcta
     7081 gaatggagta tgtgaccaat actttccttt ggaatggtat ggacatttga aatagagccc
     7141 attctttata aagtataaaa tatgtttaat gctagtattt ttaactaaac ttttgagaaa
     7201 ctagattcac atgctgttgt aagaaataat acagagacct ctttcgtgta cctttcactt
     7261 tgtttcccac acagtgaaca tctttcaaaa ctgtcataca atatcatacc caggatactg
     7321 acactggtat agctaagata gagaacgttt ccacacagaa ctttttctag cacagggatc
     7381 cctcatcttg cttttgatga ccatacccac ttcactccca tccctactcc cttcttaacc
     7441 cttggcaacc ataatctgtt ctccattttt atagtttttt tttttttcat ttcaataaag
     7501 ctgtataact ggaatcataa taatatgtaa ccttttggga ttggcttttt ttcatttagc
     7561 atgattttct ggaggttaat ccagcttatt atgtgtatca agtctattga caggtacttt
     7621 ttagtgtgaa tagaatccca tagtatagat gtaccacagt ttgtttaact gttcacctgc
     7681 tgagagacat tgggccagtt tttggctact ataaataaag ttgctataaa catttgtgta
     7741 caagtttttg tgtgaacata atctagtttt ctgggtcaaa tgcccagcag ttatatagta
     7801 gttgggtcat atagtagttg aatgtttagt ttttaagaaa ttgccaaact tataccaagt
     7861 agctgtacta ttttatatac ccaccagtgg tgtatgagtg atctagttgc ttcatgtcct
     7921 tttcagcatt tggtggtgtc tcttttttat tttagtcatt ctgataagtg tatagtgaca
     7981 gctcattgca gttttgattt accattttcc cttcgctaat ggcaatgatg ttgagcatct
     8041 ttgtttcata tgcttatttg ccacctgtat ctcttcttta gtgacatgtt tcttcatgtc
     8101 ttttctaatt ggattttttt tctgttgagt tttgagggct tttaaataat gtgtgtgtgt
     8161 gcctctgtgt gtgtgtgtgt gtattttttt ctagatacta gtcctttgtt ggatgtgtga
     8221 tttgcaaata tttcctccca gtcagtagca tgtcttttca tttctctttt ctgggccttt
     8281 cacagagcag aagtgtttaa ttttgatgaa gtccactcta tccatttttc tttttatgga
     8341 tcatgcttct ggtatcaaga actttgcctc tctccttaga tcccccaaat tttctctttt
     8401 atgttgtttt ctaaaagtat tatagtttac gttttacttt taagtctata ttccattttc
     8461 agttaatttt gtataaaatg tgagacttag gtctgggttc attttttttg ttgttgccta
     8521 tggatattca attactccaa catgatattt gtcgaaaagg ctcttttttg tccattgaat
     8581 tgtttttgca cctctgtcaa aaatcagttg agcaaaaatg agttaatgag aaatcagttg
     8641 ggcacattcg tgtgggtcta tatctgggtt ttctattctt ttccattaga ctatgtgtct
     8701 atacctccac caacaccaaa atcttgatta ctgtagtaag tcttgaaatc aaataggctg
     8761 gtttattcca ctttcttttt caaaattgtt ttagccactt agttcctttg tcttcccgta
     8821 taaactttgg aataatcttg tctgtatcta ttcaaatatc ttactgggat tttgacagga
     8881 actatgttat acctatacat caatttgggg agatttgaca tctttaccat gttaagcctt
     8941 cccgatcatg atcacaggat cacttcactt catttcagtt aaattttgtt ttccttcatc
     9001 agtattgtgt ggttttcagc atacaaggtc tgtacatgtt ttgttagatt tatacctaag
     9061 caatttaatt tttgagagag attgtaaatg gcattgtatt ttgaatttcc tgttcacatg
     9121 tctattctaa gtacatagaa ataaagtgaa tttttctatt ttgtatactg agaccttatt
     9181 gagcccactt actcatttta ggggattttg attgattcct tgggattttt tttttatata
     9241 gatagtcatg tcatctgcaa ataatgaata gttttatctc ttcatttctg acctatattc
     9301 cttttttttt tcctttcagt cccttaatgc agtgggtaga aattccagca gaaataaaag
     9361 cagtgagagt agagatcctt ggcttgtttc tggtcttagg cagaaaggat tcagtgtttc
     9421 accatgaagt ataatgttag ctgtaggttt ttaaagtaga tgctcttgct aaagttaagg
     9481 aagttatctt ttattccttt ttttctgcaa gtttttatta tgaattttat gttgaatttt
     9541 gtcaaatgct ttttctgcct taatttacat aatgccattt ttcttcttta gcccattcat
     9601 gtggtagata cattgattga tttttgaatg ttgagccatt gttacatccc tgagataaac
     9661 tccacttggt cgtggtgtat ctttgtatat atagcttaat tcttttggct aatattttgt
     9721 taaggatttt tgcatctgtt ttaatgcgac atactggttg gtggtatcag ggtaatacta
     9781 gcttcaaaat gaactggaaa gtattccttt ctcttctgtt ttctaaagcg gattgtatag
     9841 aattggtgtc agcgcttttt aaaacatttg atagaacttt ccaatgaaat catctgggcc
     9901 tggagatttt gggggaggga gttcttttta ttgtaatttc cacttttaca atagttatat
     9961 ggctgtttaa tttatctatt tcatattgag ttgtgacagt ttgtattttt agatgaatta
    10021 gtccatttca tctaagctct cagatttata tgtagagttt ttggttgtat tttttgttag
    10081 acttttgatg tctgatattc caaaactcct tcatttatca tttcctttct gtttagagca
    10141 ctcctttagc cttattatta ttattgtagt tccattggca acaaattctc tcagttttct
    10201 ttcatctgaa aatgtcttga ttttcccttg atatctgaag aatatttaca ttagacatag
    10261 acttgtaggt ttatagttct tttctttcag cacttgaaaa ttgttctgcc acttccagcc
    10321 aagaggggtg gctcacgcct gtaagcccag cactttggga agccaaggcg ggcagatcac
    10381 ttgaggtcag gagtttgaga ccagcctggc taacatggcg aaaccccgcc tctactaaaa
    10441 atacaaaaat tagccggcat ggtggtgcac atctgtaatc ccagccattt gggaagctga
    10501 ggcaggagaa tcacttgaac ccgtaggcgg agattacagt gagctgagat cgcaccactg
    10561 tactccagtc tgagcaacag aacgagactc cttgtcaaaa aaaaaaaaaa ggaaagaaaa
    10621 tttcatggtt ccccatgaga aatccagttt tttaaattgt tttggtccct atagataggt
    10681 gtcatttgtc ttttttcttt ttcttttttt cctttgtgtt tagtttttag ttgtttaacc
    10741 atgatgtatc ttgtagattt ggggggttta ttatatttga ggtcttctca ccatctatat
    10801 gtttatgtct tttgccaatt ttggggagtt ttcagctgtc atttttttca agaacttttt
    10861 cagtcttcct tctttcttct ttcttttgag actctgatga cacaaatgtt agatttattg
    10921 tagttccgta agtccctgag gttctgttca tctttgttct gcctgttttc ttctgttgtt
    10981 cagactgtgt aatttctatc attttatctt cagatttatt cattctttct gcagtagctt
    11041 ccattctgct attgagccta tcaattaagt gtttcatatt gattcctgca tttttcaatt
    11101 ttaaaatttc tggcccttta ccgaaaatgt tggttgaccc ctggagtata aacctatact
    11161 atagaagaga gtatcaattt tttttttttt gagaggatca atttaaacaa aagttggtct
    11221 ctttaaataa ataaagtaca cataacttgg tgaaaccgat ttggaaaaaa acagaagaca
    11281 taaaaaattt aggaatgaaa gtacagataa ataaccaaac atagatttta aaataataag
    11341 acactataaa caactttatg ccaatatatc acaaaacaga aaatgaataa tttatatgaa
    11401 aaatgcaaat taccaaaatc aactacgaag tagatgattt ctgcttcctg ccatatggtt
    11461 gactaggtat actcaaggat cctcctgcta aaatacagtt agttcttgga taaaatacaa
    11521 cacacataat attagttcat ttcctggctc attagaaaga aagataatca ctaaaggcta
    11581 ttaccaatga gagtgggcta aaattaaagt agttgagaaa caggaaaact gtgcctctga
    11641 gacttaagcc atggactcca ggcaaagtaa agaaagtgaa cctaagattc cttcataaaa
    11701 ccaggaatgc tttaaagcat taaagtagtc ctaagtcagt ggactctggt ggttactcta
    11761 agaagtggat gaaaatcccc tccgaaggaa agcctcccta attaatgctt ctagattaat
    11821 caaacatgca aggaaacaca ccatttgcat tgagaaacag tagatttaga tattcaagga
    11881 attcaggtat tgcaattagc agaagtagaa taacagttat atgtttaaat aatgtatgaa
    11941 ttaaaacgaa catgaaatga gagatgtgtt aaaaggcaga tattaaaaag aaccaaagac
    12001 aacttaggta tgaaatttaa ttattgaaat atataacata atgaatggtt taagagcaga
    12061 ttcaccacaa ctaaaggaat tgttgactat caagttttaa ctgaggaaac aacatattgc
    12121 agcaaaaaca ggtaaaggga tagaaaataa gaattagaga ttatgagacc tgaaggatag
    12181 aatgggaagg tttaatatgt gctgattgga gtctaagaag taaaaaatag aaaaaaattg
    12241 aggtaattgc tgacaaattt ccagagctaa gaaaagcctg ggacctggta tggtggctta
    12301 tgcctgtaat cacagcattt tgggaggcca aagcagaagg atcacttgaa gccaggagtt
    12361 tgagatcaac ctgggaaatg aagcaagagc ccccactcca tctctacaaa aaaaattaag
    12421 aattagccag atgtggtgac atgaaccagt agtcccagct acttgggagg ctcaagtggg
    12481 aggatcactt gagcccaaga gtttaagacc agcctgagca acatggtgaa actccatctg
    12541 tacaaaaaat acaaaaatta gccaggcatg gtggcacaca cctgtggtcc cagctactca
    12601 agaggctgag gagggaggat cacacgagcc caggagttca aggctgcagt gagctatgat
    12661 ggtgccactg taccctgtct aaaaaaaaaa aaagtggatc cacatataca agaagcaaaa
    12721 tgtatatcaa ccaggaaaag gaagccaatg tatattcatt atactcaaac ttcagaacaa
    12781 taaaggcaaa gatatcttaa aagcagccag aataacttat ccacttttaa aggaataacg
    12841 aattgacaga cctttttttt tttttttttt ttttgagaca gagtcttgct ctgtcaccca
    12901 tgatggagtg cagtggtgtg atttctgctc actgcaacct ccatttcccg ggttcaattg
    12961 attctcctgc ctcagcctcc cgagtagctg ggagtacagg tgtgcgccac cacaacctgg
    13021 ctaatttttt tgtattttta gtaaagacgt gattttgcca tgttggccag gctgttctcg
    13081 aactcctgac ttcaggtgat ctacctgcct tggcctccca aaatgctggg attagaggca
    13141 tgagccactg cacctggcca acagtagact tttcagtgcc aaaactggaa ggcaaaagac
    13201 agtggaataa catcattaag gtactgagag aataactcaa tagaatgagt gcccagtgaa
    13261 attatctttc aaaatcaagg gtatattaaa aacacttttt tctcaaaatg agaatttaca
    13321 aacaagggac tttcacttaa gaataaagat gaattttaga gtacagcaaa atgactagga
    13381 ggaaagtctg agatgcaaga aggtatggtg agctaaaaaa tcagtaatca tgggaaatgt
    13441 aaataaatac tgtctatatt aagaagtatt tactctgtgg agtaaaaaag agcgtaatta
    13501 aaatactagc aacattttac ataactcagg aaatgtatat gtggggaaag tgtccgggag
    13561 cacttagaag ttagtgtgag tgctccaaga tcctgatact ctttaggatg gaagttaaga
    13621 taatgaatga ctttagatgt tgttaatcta agtacttaac agaaaatttt cagataacct
    13681 ttaaagaata gcaatacaat ataactttca aaccagtaga gaggaaacat tctgaaataa
    13741 gggaaaaaca ctttagaaat cccaactttg atagaccaca aaaatgcaag aaggaagaaa
    13801 aagcatagaa aaagcaaaga aatggcatag tatataataa atggttacaa taaatataaa
    13861 ttgcctatct caccagatta ataaaaaaaa aagtctacct tgttcaatat atacagttta
    13921 caaaagacag tacaaggaca gagaaagaca aaaagtagaa ttagggaaaa taaaacaagc
    13981 aaatatacct ggttaggata gctgtatcag tattagcctt acaaatatta aagtgaaaag
    14041 cattaataag gataaggaga ctctcaaaaa taataaaaat ttcaactgaa gtaggtataa
    14101 cagttctaaa caaagttatt aaagtaaaaa tgtagagggc aaaacggaaa aaaaaactat
    14161 tatgttgtat ttgaagtcac tcaattttta gctcgagcag caaaaaagta aatagaacaa
    14221 catggtaacc aaagttgatt caattaatac ataaaggatc atgttccccc aatttagagc
    14281 atgtgcatat ttcttaagca tgtataaaag atttagaagg aaaatgataa aggaatgttt
    14341 tggggacctc tgatagggaa agatttctta gaaaatctgc aaaagatatt aaccataatc
    14401 tacataaagt caactgtttt atttcaagcc tctctggaaa tagttttgtt gactgataag
    14461 aaacgctcta tgtcagtcag ctaatcaatg tctagtgagt ctaactcttt ccactacaca
    14521 gtaagttcca tcttagggtg ttttacttaa aagcctggtg tcaaatgtta cacgcacaaa
    14581 aacttattag tatcttttta accaatgtat cttaggagat acggaattat ttctaacaca
    14641 ctggttgtat ttactaattt tccgctgagc catcataaaa atagaagtca catcgtcact
    14701 atttcttgct tgtccaaccc agtgtctatg gtaccctcgg cagttattca tggctcctag
    14761 gccttctttt agagtactgt ctctcttcta ttggctttgg atggaattga ctccatccta
    14821 actgcagaaa tgataggcac tgctttacat aaatcagtca gcctaatagc attctttttg
    14881 cctcagagat tggttcagag atggggaaaa acccactcta ggcaatcagc ttgtgactta
    14941 ctttcctcca attggtgatc caattagggc agtgtgtgga atgtgctgct ctgtatgtgc
    15001 agccagatgc tcatgttcat aaaaaacatt ttaatactgt gatggaagat acagcttcga
    15061 gacaaagaca caagcttggg tagagtcatt cattcattta gtaagcattt gctgagtgct
    15121 taataaatgc tgggccctga gaaaaagcaa aatcttattc agcacattct gacattgggg
    15181 acaatgcgat agttgatagc ttccacactt aattagaaac aaagattatc tcttaaaacc
    15241 tcattcttgt atctaggaag acttttgttt tcccaatcag aaattgtggt tccagaaaaa
    15301 gaacaagaca atgaaaacat tgtataaaag gtttctttca aacttttttc aattgacagt
    15361 ttttcacccc aatcatcttg atgcagagag gcttcagaaa cacaagtgac tctgtgttca
    15421 gaccaagtac ttggcctcga gaagatgaat gatcagacca actcaccata tgattataag
    15481 ggtcaggtag tttaaaaaga aattacaatc tgaattgaac catggatgaa cagtgttgct
    15541 attgagcttc gaatcccagc taataagcat aaccttgtaa agagaggtta ctgtttggga
    15601 aactgcatgt tcttgcagga gggcaaagct tttgcaatat aaatagttgt aagggtacta
    15661 gctttcatct ttaatacctt aaccctctgt gtttagagtt tttgtatcca gggctgaatt
    15721 gagaatttta gaaaccttga acactgaaga gattgtaata acaaccccat gtgtaattta
    15781 taaaatcttc aaaagaaaat ttactttttc aaaatgttat aaaactctga atactgaaat
    15841 gaaaa
//
