LOCUS       NM_005819               4810 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens syntaxin 6 (STX6), transcript variant 1, mRNA.
ACCESSION   NM_005819
VERSION     NM_005819.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4810)
  AUTHORS   Tsurutani,N., Momose,F., Ogawa,K., Sano,K. and Morikawa,Y.
  TITLE     Intracellular trafficking of HIV-1 Gag via Syntaxin 6-positive
            compartments/vesicles: Involvement in tumor necrosis factor
            secretion
  JOURNAL   J Biol Chem 300 (3), 105687 (2024)
   PUBMED   38280430
  REMARK    GeneRIF: Intracellular trafficking of HIV-1 Gag via Syntaxin
            6-positive compartments/vesicles: Involvement in tumor necrosis
            factor secretion.
REFERENCE   2  (bases 1 to 4810)
  AUTHORS   Lu,J., Ru,J., Chen,Y., Ling,Z., Liu,H., Ding,B., Jiang,Y., Ma,J.,
            Zhang,D., Ge,J., Li,Y., Sun,F., Chen,D., Zheng,S. and Wu,J.
  TITLE     N6 -methyladenosine-modified circSTX6 promotes hepatocellular
            carcinoma progression by regulating the HNRNPD/ATF3 axis and
            encoding a 144 amino acid polypeptide
  JOURNAL   Clin Transl Med 13 (10), e1451 (2023)
   PUBMED   37877357
  REMARK    GeneRIF: N[6] -methyladenosine-modified circSTX6 promotes
            hepatocellular carcinoma progression by regulating the HNRNPD/ATF3
            axis and encoding a 144 amino acid polypeptide.
REFERENCE   3  (bases 1 to 4810)
  AUTHORS   Zhou,L., Wang,Z., Chen,X., Li,X., Ge,C., Min,X., Zhao,F., Chen,T.
            and Li,J.
  TITLE     Syntaxin-6 promotes the progression of hepatocellular carcinoma and
            alters its sensitivity to chemotherapies by activating the
            USF2/LC3B axis
  JOURNAL   Int J Biol Sci 19 (12), 3892-3907 (2023)
   PUBMED   37564208
  REMARK    GeneRIF: Syntaxin-6 promotes the progression of hepatocellular
            carcinoma and alters its sensitivity to chemotherapies by
            activating the USF2/LC3B axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4810)
  AUTHORS   Zhang,W., Lv,Q., Lu,D. and Chen,F.
  TITLE     Syntaxin 6 Enhances the Progression of Epithelial Ovarian Cancer by
            Promoting Cancer Cell Proliferation
  JOURNAL   Asian Pac J Cancer Prev 24 (6), 2003-2010 (2023)
   PUBMED   37378930
  REMARK    GeneRIF: Syntaxin 6 Enhances the Progression of Epithelial Ovarian
            Cancer by Promoting Cancer Cell Proliferation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4810)
  AUTHORS   Mosher,B.S., Fulkerson,H.L., Boyle,T., Chesnokova,L.S., Cieply,S.J.
            and Yurochko,A.D.
  TITLE     Human Cytomegalovirus Manipulates Syntaxin 6 for Successful
            Trafficking and Subsequent Infection of Monocytes
  JOURNAL   J Virol 96 (14), e0081922 (2022)
   PUBMED   35862696
  REMARK    GeneRIF: Human Cytomegalovirus Manipulates Syntaxin 6 for
            Successful Trafficking and Subsequent Infection of Monocytes.
REFERENCE   6  (bases 1 to 4810)
  AUTHORS   Steegmaier,M., Klumperman,J., Foletti,D.L., Yoo,J.S. and
            Scheller,R.H.
  TITLE     Vesicle-associated membrane protein 4 is implicated in trans-Golgi
            network vesicle trafficking
  JOURNAL   Mol Biol Cell 10 (6), 1957-1972 (1999)
   PUBMED   10359608
REFERENCE   7  (bases 1 to 4810)
  AUTHORS   Martin-Martin,B., Nabokina,S.M., Lazo,P.A. and Mollinedo,F.
  TITLE     Co-expression of several human syntaxin genes in neutrophils and
            differentiating HL-60 cells: variant isoforms and detection of
            syntaxin 1
  JOURNAL   J Leukoc Biol 65 (3), 397-406 (1999)
   PUBMED   10080545
REFERENCE   8  (bases 1 to 4810)
  AUTHORS   Wong,S.H., Xu,Y., Zhang,T., Griffiths,G., Lowe,S.L.,
            Subramaniam,V.N., Seow,K.T. and Hong,W.
  TITLE     GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with
            syntaxin 6
  JOURNAL   Mol Biol Cell 10 (1), 119-134 (1999)
   PUBMED   9880331
REFERENCE   9  (bases 1 to 4810)
  AUTHORS   Simonsen,A., Lippe,R., Christoforidis,S., Gaullier,J.M., Brech,A.,
            Callaghan,J., Toh,B.H., Murphy,C., Zerial,M. and Stenmark,H.
  TITLE     EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
  JOURNAL   Nature 394 (6692), 494-498 (1998)
   PUBMED   9697774
REFERENCE   10 (bases 1 to 4810)
  AUTHORS   Bock,J.B., Lin,R.C. and Scheller,R.H.
  TITLE     A new syntaxin family member implicated in targeting of
            intracellular transport vesicles
  JOURNAL   J Biol Chem 271 (30), 17961-17965 (1996)
   PUBMED   8663448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA311923.1, BC009944.2 and AL162431.17.
            
            On Nov 22, 2018 this sequence version replaced NM_005819.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.121934.1,
                                           SRR1660807.170609.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258301.6/ ENSP00000258301.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA311923.1         252-277
            27-1568             BC009944.2         1-1542
            1569-4810           AL162431.17        114831-118072       c
FEATURES             Location/Qualifiers
     source          1..4810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4810
                     /gene="STX6"
                     /note="syntaxin 6"
                     /db_xref="GeneID:10228"
                     /db_xref="HGNC:HGNC:11441"
                     /db_xref="MIM:603944"
     exon            1..232
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..965
                     /gene="STX6"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaxin-6 isoform 1"
                     /protein_id="NP_005810.1"
                     /db_xref="CCDS:CCDS1341.1"
                     /db_xref="GeneID:10228"
                     /db_xref="HGNC:HGNC:11441"
                     /db_xref="MIM:603944"
                     /translation="MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEID
                     WTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDM
                     KDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQA
                     QQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNV
                     MKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL"
     exon            233..402
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            403..497
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            498..560
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            561..686
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            687..793
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            794..888
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     exon            889..4810
                     /gene="STX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX6"
                     /note="hexamer: GATAAA"
     polyA_site      1552
                     /gene="STX6"
                     /note="major polyA site"
     regulatory      4326..4331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX6"
                     /note="hexamer: AACAAA"
     polyA_site      4370
                     /gene="STX6"
     regulatory      4475..4480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX6"
                     /note="hexamer: AATAAA"
     polyA_site      4496
                     /gene="STX6"
                     /note="major polyA site"
     regulatory      4790..4795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX6"
                     /note="hexamer: AATAAA"
     polyA_site      4810
                     /gene="STX6"
ORIGIN      
        1 gattcggcca gtggtgctga gcgagtgctg gaccagcggc cgtcctgtgc acctggcctg
       61 tgcgcgtgcc cgctgctcgg cttcacccag actaaggcgc gggcagctgc gggaacaggc
      121 ggggtgggcg gagggagacc gggaggcacg ggcgccctgt gcgcggagga ggtgaaggcg
      181 gccggggccg ggacgccatg tccatggagg accccttctt tgtggtgaaa ggagaggtac
      241 agaaagcagt caacactgcc cagggattgt ttcagagatg gacagagctc ctccaggacc
      301 cctccacagc aacaagggaa gaaatcgact ggaccaccaa cgagctgaga aataacctcc
      361 ggagcataga gtgggatcta gaggaccttg atgaaaccat cagcatagtt gaagcaaatc
      421 ctagaaaatt taaccttgat gcaactgaat tgagtataag aaaagccttc attacaagta
      481 ctcggcaagt tgtcagggac atgaaagatc agatgtcaac ttcatctgtg caggcattag
      541 ctgaaagaaa aaatagacag gcactgctgg gagacagtgg cagccagaac tggagcactg
      601 gaacaacaga taaatatggg cgtctggacc gagagctcca gagagccaat tctcatttca
      661 ttgaggagca gcaggcacag cagcagttga tcgtggaaca gcaggatgag cagttggagc
      721 tggtctctgg cagcatcggg gtgctgaaga acatgtccca gcgcatcgga ggggagctgg
      781 aggaacaggc agttatgttg gaagatttct ctcacgaatt ggagagcact cagtcccggc
      841 tggacaatgt gatgaagaaa cttgcaaaag tatctcatat gaccagtgat cggcgccaat
      901 ggtgtgccat agccatcctc tttgcagtcc tgttggttgt gctcatcctc ttcttagtgc
      961 tgtgacggcg gggcctctgg gtgcgagttc ctcctgcata tgaaccgagg ggaggaggag
     1021 aagctgagca cgtgtgacat tgccgtctac tcacattcct atcctggaaa catactgctg
     1081 cactgacttt tctccgtgtg accccacaat tgacatggct cctccatccc agcgctggaa
     1141 gggccagtgg gaagaggaaa tagatgtctg cactcctggc tgcagctgga caacagaagc
     1201 cccatgccgc ctgtccagtt cggaggagaa ctagctgctg ccttgccttc cgggacctcg
     1261 tttgctgagg agggacttac agactccact ggtgttttgc tgttgctcat tccatgcatc
     1321 tttggcagct cttttcttct gctcagaccc ttccccgtgc tcagacagtg caccgctgtc
     1381 ccatctaaag aaacctgtca ggaatacgag cttctgggta tgtttcgttt cccattgctg
     1441 tagcatttct tatcccctga gagctgatga ttattgagga cagaaggctc agaaacagtt
     1501 tgtgacagaa aatgcagtgt ttcatttttc agggataaat gctaagataa aattgctttt
     1561 ccaggtcatt tttttttgtg gtaagaataa ctaatggaaa ataatgaaac accctggggt
     1621 ttgggggtgc taacaacttg tggctttaac tgacaggagc aattaaaaag agcaagaggg
     1681 ttctgcattg gcatagctta gggaagggtt aatgatgtcg ccacaggtca gctcctgatc
     1741 cttgccgact tgatgttgct gtaccagggc ttcctcccca gaggtgcagc ttgcgttttg
     1801 agggtgattg ctacatatgt tgttgctaaa cagctcagta acacacttga atgaatttgg
     1861 ataccagatt gtcctcatta cagttctttt actcttaggg cactctacac tgggggttgg
     1921 ggttgggagt ggttagtaca tttattacat ttattaagaa acgtaatgac ataaaaggtt
     1981 agctctgggc cagacttctc ttactctgtg ggtaatggca aggatgtgta ggtaaacttg
     2041 gttctttttt ttccctaaga tgacagcttg attttatcat ctgcagtcaa ataactgagc
     2101 caatccaaat ttaaatgata gatgctttaa ttgagtttaa gtagctgaaa ctgctgagac
     2161 actaaacttt aaccttctga tgacttttta aaatgcctca aatgtgcaca tgtatatagg
     2221 atatttttat aacttccctg atgaataatc tgatattaaa gtagtatttg gacccagagc
     2281 cagaactcgg tggtggaggc tgctggtctc tcctcaccac cttcttttgc acttggaaag
     2341 aacagcaaca tctggataga gttctagctt tgacttctca tttccttgtc tttttgggtg
     2401 cattcctcag cacacttttt ttttaaacct ttttgttttg ttttgtttgt atttcatgtg
     2461 gttttatttg ggggttttgg ttttttcacc cttttttgtg atttgcaatg atgtgcttgc
     2521 ccagctaact tttgaattgc actttttaat aaatattctt aacaattttt gaagaaggat
     2581 attttatctc atttgagatc atggtaggtt aagaaaatat gcctgttgat gaaagctaaa
     2641 agcaaattta tgaaactaaa agggtgattg acatccatgt ttacactccg ctctaatgtt
     2701 tgatatataa ataagttatt ttcaaattag gaaaaaacag tgagtattac aaagggcttc
     2761 agatgtttag agtactaggt tatttatgtt ttacaaagtt tgaatcttct ataaactaag
     2821 aaaggggatg atccttagat ttgcattaaa atatagaagt cttttaaagt aaatgtgaac
     2881 cttgtctaag tactgtaatc cacacaacac attataagaa gcaaaccagc atcttaagga
     2941 attataaaat taccctattt aaaagccatg ctattgttct gctattacca gatttattgt
     3001 gccacacaaa aggatcatgt gtgtcagcag gggccgtttg gaacaaacct agtcattaat
     3061 gagtaagata ctcctgttag ttcagggacc aagttttatg acccagaggc ttaatgatgt
     3121 ttggatatat ttcaaatcgg cgtgcttacc tcactgattt aaattatttt ctaaatagtg
     3181 gccattgtag acctgactca ggctgaagct aaatagagaa caatttagaa agttaactaa
     3241 caatacagtg cattctaccc gtagggccac catgcccttc tgcccctggc tgatttgatc
     3301 ctgtgtctga tcccattgca ccctgactgg gcagtcccta cagaaccagt gttaatttga
     3361 agggcctcca ctcaggctcc aaatgtggca gccaaagaga acaatccagg gaacctacat
     3421 ttatttttaa ggacaaatat ttcctcctca gtggtcctaa tgttcagggc tttagaggga
     3481 acccaggtgg tctcttcacc ctgtgtccta gaatgggaga gtaagtagac agtggtgata
     3541 accccacact gcttataagt gcatctttat agtatttggg gctttcctac ccctttagcc
     3601 ttctgtacct agtaccatat tccagtttta aagaactggc agaatgtgat ggataacaga
     3661 ggaagagctc aatttatgtt tattggaaga acattttact taaatgattt gaggggtggg
     3721 agggagtgaa ctactgagtt tgccagagtg aaaatccatc tgaaaaactc agctaccttt
     3781 agtttttagt cctcattttt ggtcttgtct ctgcggactg tgaagaatca caatgctcta
     3841 tatgccctgg actgtgtggc aaatgcaggt tgcagcgtgt gtgttacatg aggatcttcc
     3901 acaatttcag aatgcacgcc agagctgaag ggggaaactt ggtaacttgc ccattattct
     3961 ctgcttttag ccagagttaa acagactgat gggtctggta gccaacaact tggcaacttc
     4021 cactccttct cacctcgtga gattaagggc tgtgaaaaga aatctagtct aactccaaca
     4081 gaaatctgtc tctgttaagt gttttacctt ctgtaagtag agatggtaga gccaagattt
     4141 ttcttttggt aatttccctg tctataaagt gagaccaaag ggatatctgt tccctgttac
     4201 ctttttggag aattcataac atttgaagat caaaaaattg aatgataaat atgaatggct
     4261 tttcaattct gtggactttg taccatttgg cttcaccttg tactgcaaga tgaatttgta
     4321 aacaaaacaa aattggactg tctggaaagc taaagttctg aaatatggaa tgtactgcct
     4381 ctaatttttc tttgtcttcc tctcactggc atttttttct ctcccaggtt tcttaagaat
     4441 aatgtttttt aaaggaggct ttttgcccat caagaataaa aagaaataaa accaaagggt
     4501 taccggactt aagcccccgc agtcactgtg cgccatccct gagcaaagtc cgcccctgag
     4561 gacagtgccc ctgccccagt gacaggcctt actcctccca gggcctttgc ttctaatagg
     4621 gggtggtctt tcttttcttt ctctcctttt tttttttttg attaaaaaat aaaaccaaac
     4681 cagaatttgc tgaaagcagg tacctttcag tagctccgat cagagtaact cagcttagag
     4741 atactgttac tcaggacaac agtatgtaca aaagtctccg gaaaaggaaa ataaaacaac
     4801 ctgaaaagaa
//
