LOCUS       NM_003164               1794 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 5 (STX5), transcript variant 1, mRNA.
ACCESSION   NM_003164 XM_938340
VERSION     NM_003164.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Hom Choudhury,S., Bhattacharjee,S., Mukherjee,K. and
            Bhattacharyya,S.N.
  TITLE     Human antigen R transfers miRNA to Syntaxin 5 to synergize miRNA
            export from activated macrophages
  JOURNAL   J Biol Chem 300 (4), 107170 (2024)
   PUBMED   38492777
  REMARK    GeneRIF: Human antigen R transfers miRNA to Syntaxin 5 to synergize
            miRNA export from activated macrophages.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Kat,M., Karampini,E., Hoogendijk,A.J., Burgisser,P.E., Mulder,A.A.,
            Van Alphen,F.P.J., Olins,J., Geerts,D., Van den Biggelaar,M.,
            Margadant,C., Voorberg,J. and Bierings,R.
  TITLE     Syntaxin 5 determines Weibel-Palade body size and von Willebrand
            factor secretion by controlling Golgi architecture
  JOURNAL   Haematologica 107 (8), 1827-1839 (2022)
   PUBMED   35081689
  REMARK    GeneRIF: Syntaxin 5 determines Weibel-Palade body size and von
            Willebrand factor secretion by controlling Golgi architecture.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Donkervoort,S., Krause,N., Dergai,M., Yun,P., Koliwer,J.,
            Gorokhova,S., Geist Hauserman,J., Cummings,B.B., Hu,Y., Smith,R.,
            Uapinyoying,P., Ganesh,V.S., Ghosh,P.S., Monaghan,K.G.,
            Edassery,S.L., Ferle,P.E., Silverstein,S., Chao,K.R., Snyder,M.,
            Ellingwood,S., Bharucha-Goebel,D., Iannaccone,S.T., Dal Peraro,M.,
            Foley,A.R., Savas,J.N., Bolduc,V., Fasshauer,D., Bonnemann,C.G. and
            Schwake,M.
  TITLE     BET1 variants establish impaired vesicular transport as a cause for
            muscular dystrophy with epilepsy
  JOURNAL   EMBO Mol Med 13 (12), e13787 (2021)
   PUBMED   34779586
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Nabeta,M., Abe,Y., Takaoka,Y., Kusanagi,Y. and Ito,M.
  TITLE     Identification of anti-syntaxin 5 autoantibody as a novel serum
            marker of endometriosis
  JOURNAL   J Reprod Immunol 91 (1-2), 48-55 (2011)
   PUBMED   21715015
  REMARK    GeneRIF: serum anti-STX5 autoantibody, which was discovered by a
            proteomic approach, is a potential new serum marker for the
            diagnosis of endometriosis.
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Hay,J.C., Klumperman,J., Oorschot,V., Steegmaier,M., Kuo,C.S. and
            Scheller,R.H.
  TITLE     Localization, dynamics, and protein interactions reveal distinct
            roles for ER and Golgi SNAREs
  JOURNAL   J Cell Biol 141 (7), 1489-1502 (1998)
   PUBMED   9647643
  REMARK    Erratum:[J Cell Biol 1998 Aug 10;142(3):following 881]
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Rabouille,C., Kondo,H., Newman,R., Hui,N., Freemont,P. and
            Warren,G.
  TITLE     Syntaxin 5 is a common component of the NSF- and p97-mediated
            reassembly pathways of Golgi cisternae from mitotic Golgi fragments
            in vitro
  JOURNAL   Cell 92 (5), 603-610 (1998)
   PUBMED   9506515
REFERENCE   8  (bases 1 to 1794)
  AUTHORS   Tang,B.L., Low,D.Y., Lee,S.S., Tan,A.E. and Hong,W.
  TITLE     Molecular cloning and localization of human syntaxin 16, a member
            of the syntaxin family of SNARE proteins
  JOURNAL   Biochem Biophys Res Commun 242 (3), 673-679 (1998)
   PUBMED   9464276
REFERENCE   9  (bases 1 to 1794)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
REFERENCE   10 (bases 1 to 1794)
  AUTHORS   Ravichandran,V. and Roche,P.A.
  TITLE     Cloning and identification of human syntaxin 5 as a
            synaptobrevin/VAMP binding protein
  JOURNAL   J Mol Neurosci 8 (2), 159-161 (1997)
   PUBMED   9188044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB155395.1, U26648.1 and
            BE409085.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003164.4.
            
            Summary: This gene encodes a member of the syntaxin or t-SNARE
            (target-SNAP receptor) family. These proteins are found on cell
            membranes and serve as the targets for v-SNAREs (vesicle-SNAP
            receptors), permitting specific synaptic vesicle docking and
            fusion. The encoded protein regulates endoplasmic reticulum to
            Golgi transport and plays a critical role in autophagy.
            Autoantibodies targeting the encoded protein may be a diagnostic
            marker for endometriosis. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.472156.1,
                                           SRR3476690.304092.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294179.8/ ENSP00000294179.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               CB155395.1         41-628
            589-1513            U26648.1           336-1260
            1514-1794           BE409085.1         1-281               c
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1794
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /note="syntaxin 5"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:HGNC:11440"
                     /db_xref="MIM:603189"
     exon            1..98
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            99..342
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1185
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin 5A"
                     /codon_start=1
                     /product="syntaxin-5 isoform 1"
                     /protein_id="NP_003155.2"
                     /db_xref="CCDS:CCDS8038.2"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:HGNC:11440"
                     /db_xref="MIM:603189"
                     /translation="MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPP
                     VTLVPPPPDTMSCRDRTQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIG
                     KDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAK
                     GSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSA
                     LPLAPNHLGGGAVVLGAESHASKDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNI
                     ESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRW
                     LMVKIFLILIVFFIIFVVFLA"
     exon            343..413
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            414..469
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            470..540
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            541..657
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            658..714
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            715..796
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            797..903
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1025
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1794
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /note="hexamer: ATTACA"
     polyA_site      1757
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /note="major polyA site"
ORIGIN      
        1 agtctttggt cgggtttcgg cggcttcagt gctcggggag gaggcagtga cggccggtga
       61 gattggaagt ggcggcggcg gcaggcggca gaggggagtc cgaggttatg cgtctcaatg
      121 atcccgcgga aacgctacgg gtctaagaac acggatcagg gtgtctacct gggtctctca
      181 aagacacagg tcctgtcccc tgcaactgct ggcagtagca gcagcgacat cgcccctctg
      241 ccccccccag tgaccctcgt ccctccccct cccgacacca tgtcctgccg ggatcggacc
      301 caggagtttc tgtctgcctg caagtcgctg cagacccgtc agaatggaat ccagacaaat
      361 aagccagctt tgcgtgctgt ccgacaacgc agtgaattca ccctcatggc caagcgcatt
      421 gggaaagacc ttagcaacac atttgccaag ctggagaagc tgacaatctt ggcaaagcgc
      481 aagtccctct ttgatgataa agcagtggaa attgaagagc taacatatat catcaaacag
      541 gacatcaata gcctcaacaa acaaattgct cagctccagg atttcgtgag agccaagggc
      601 agccagagtg gccggcacct gcagacccac tccaacacca ttgtggtctc cttgcagtcg
      661 aaactggctt ctatgtccaa tgacttcaaa tcggttttag aagtgaggac agagaacctg
      721 aagcagcaga ggagccggag agagcagttc tcccgggcac ctgtgtcagc cctgcccctt
      781 gcccctaacc acctgggcgg tggtgctgtg gttctggggg cagagtccca tgcctccaag
      841 gatgtcgcca tcgacatgat ggactctcgg accagccagc agctgcagct cattgacgag
      901 caggattcct acatccagag tcgggcagac accatgcaga acattgagtc gacaattgtt
      961 gagttgggct ccatctttca gcagttggca cacatggtta aggaacagga ggaaaccatt
     1021 cagaggatcg acgagaacgt gctaggagcc cagctggacg ttgaggccgc ccattcagag
     1081 atcctcaagt acttccagtc tgtcacctcc aaccggtggc tcatggtcaa aatcttcctc
     1141 atcctcattg tcttcttcat catctttgtg gtcttccttg cttgaaccct ctctactctg
     1201 aggcactctg ttggggtttg ggaccctcct gggaaggcaa gtggccagtg ctgccactga
     1261 gcctgtgcag ggtacttggg agaaaggccc tgtttccctg gaactgctaa gaatgaccac
     1321 tgcccctgat cccccacccc ttgcctctgg ccaccctgtc ctccccccac caccctcagg
     1381 cctatgaaac acacagggtt ctagatttga actctgctgt gaagtgactg gaagggagca
     1441 gaggccagct gggggccagt gggggaggtt gtttccacta ggagattttt ataaaccctc
     1501 tccagcctct cccaaaggaa gcgttggcag caaagggaga tgatgccctt acccaccttc
     1561 ctgtgagtga agagaggaag cagccccagg gaccaatttt cccaattgac ctctttcttc
     1621 ctctttcacc atgtgaggca gggagccctg agcccttcag ctgcctgcac aacccctgac
     1681 attggctgct ggtgactcaa tctgccaaat gtgctgcagc tcgttttctc ccaattacag
     1741 caagactgtc agcctcacta gccatgtcat catttctggg tgggagcgtc gaag
//
