LOCUS       NM_004604               1410 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.
ACCESSION   NM_004604
VERSION     NM_004604.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Kioumourtzoglou,D., Black,H.L., Al Tobi,M., Livingstone,R.,
            Petrie,J.R., Boyle,J.G., Gould,G.W. and Bryant,N.J.
  TITLE     Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives
            Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell
            Surface
  JOURNAL   Biomolecules 13 (12), 1738 (2023)
   PUBMED   38136609
  REMARK    GeneRIF: Phosphorylation of Syntaxin 4 by the Insulin Receptor
            Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the
            Cell Surface.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Gigon,L., Fettrelet,T., Miholic,M., McLeish,K.R., Yousefi,S.,
            Stojkov,D. and Simon,H.U.
  TITLE     Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but
            not in the release of mitochondrial DNA during NET formation
  JOURNAL   Front Immunol 14, 1272699 (2023)
   PUBMED   37885878
  REMARK    GeneRIF: Syntaxin-4 and SNAP23 are involved in neutrophil
            degranulation, but not in the release of mitochondrial DNA during
            NET formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Schrauwen,I., Ghaffar,A., Bharadwaj,T., Shah,K., Rehman,S.,
            Acharya,A., Liaqat,K., Lin,N.S., Everard,J.L., Khan,A., Ahmed,Z.M.,
            Ahmad,W., Riazuddin,S. and Leal,S.M.
  TITLE     Syntaxin 4 is essential for hearing in human and zebrafish
  JOURNAL   Hum Mol Genet 32 (7), 1184-1192 (2023)
   PUBMED   36355422
  REMARK    GeneRIF: Syntaxin 4 is essential for hearing in human and
            zebrafish.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Chen,D., Zheng,Q., Sun,L., Ji,M., Li,Y., Deng,H. and Zhang,H.
  TITLE     ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral
            egress
  JOURNAL   Dev Cell 56 (23), 3250-3263 (2021)
   PUBMED   34706264
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Mandon,B., Chou,C.L., Nielsen,S. and Knepper,M.A.
  TITLE     Syntaxin-4 is localized to the apical plasma membrane of rat renal
            collecting duct cells: possible role in aquaporin-2 trafficking
  JOURNAL   J Clin Invest 98 (4), 906-913 (1996)
   PUBMED   8770861
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Jagadish,M.N., Fernandez,C.S., Hewish,D.R., Macaulay,S.L.,
            Gough,K.H., Grusovin,J., Verkuylen,A., Cosgrove,L., Alafaci,A.,
            Frenkel,M.J. and Ward,C.W.
  TITLE     Insulin-responsive tissues contain the core complex protein SNAP-25
            (synaptosomal-associated protein 25) A and B isoforms in addition
            to syntaxin 4 and synaptobrevins 1 and 2
  JOURNAL   Biochem J 317 (Pt 3) (Pt 3), 945-954 (1996)
   PUBMED   8760387
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Li,H., Hodge,D.R., Pei,G.K. and Seth,A.
  TITLE     Isolation and sequence analysis of the human syntaxin-encoding gene
  JOURNAL   Gene 143 (2), 303-304 (1994)
   PUBMED   8206394
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Bennett,M.K., Garcia-Arraras,J.E., Elferink,L.A., Peterson,K.,
            Fleming,A.M., Hazuka,C.D. and Scheller,R.H.
  TITLE     The syntaxin family of vesicular transport receptors
  JOURNAL   Cell 74 (5), 863-873 (1993)
   PUBMED   7690687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI755734.1 and BC002436.2.
            
            On Nov 23, 2018 this sequence version replaced NM_004604.4.
            
            Transcript Variant: This variant (3) initiates translation at an
            alternate downstream start codon and uses alternate splice sites at
            internal exons, compared to variant 1. The encoded isoform (3) has
            a distinct N-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.285293.1,
                                           SRR3476690.1061790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313843.8/ ENSP00000317714.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BI755734.1         68-91
            25-1410             BC002436.2         1-1386
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1410
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /note="syntaxin 4"
                     /db_xref="GeneID:6810"
                     /db_xref="HGNC:HGNC:11439"
                     /db_xref="MIM:186591"
     exon            1..278
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1142
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /note="isoform 3 is encoded by transcript variant 3;
                     syntaxin 4A (placental); renal carcinoma antigen
                     NY-REN-31"
                     /codon_start=1
                     /product="syntaxin-4 isoform 3"
                     /protein_id="NP_004595.2"
                     /db_xref="CCDS:CCDS10700.1"
                     /db_xref="GeneID:6810"
                     /db_xref="HGNC:HGNC:11439"
                     /db_xref="MIM:186591"
                     /translation="MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHK
                     VRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLK
                     AIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQL
                     KITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIR
                     ELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLI
                     AICVSITVVLLAVIIGVTVVG"
     exon            279..380
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            381..480
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            481..555
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            556..626
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            627..735
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            736..812
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            813..950
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1061
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1157
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1410
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /note="hexamer: ATTAAA"
     polyA_site      1410
                     /gene="STX4"
                     /gene_synonym="DFNB123; p35-2; STX4A"
                     /note="major polyA site"
ORIGIN      
        1 gctgaggctg cgggagctgg agcggggaag aaaagggaat tccaacctgt ggaaccttgg
       61 ggggtccccg gggtcggcgc cttcccattg actgtgggcg gtgcaaggga cggagcctct
      121 ggcggctcgt gggggtgttg gggtccgcag ggggagggag gggagtgtca gagtgtgagc
      181 ggggtacggg aattccaaat ttgagggcct cccggctctg gcgccgggga gggagagctc
      241 aggccgccat gcgggacagg acccacgagc tgagacaggg ggatgacagc tcggacgaag
      301 aggacaagga gcgggtcgcg ctggtggtgc acccgggcac ggcacggctg gggagcccgg
      361 acgaggagtt cttccacaag gtccggacaa ttcggcagac tattgtcaaa ctggggaata
      421 aagtccagga gttggagaaa cagcaggtca ccatcctggc cacgcccctt cccgaggaga
      481 gcatgaagca ggagctgcag aacctgcgcg atgagatcaa acagctgggg agggagatcc
      541 gcctgcagct gaaggccata gagccccaga aggaggaagc tgatgagaac tataactccg
      601 tcaacacaag aatgagaaaa acccagcatg gggtcctgtc ccagcaattc gtggagctca
      661 tcaacaagtg caattcaatg cagtccgaat accgggagaa gaacgtggag cggattcgga
      721 ggcagctgaa gatcaccaat gctgggatgg tgtctgatga ggagttggag cagatgctgg
      781 acagtgggca aagcgaggtg tttgtgtcca atatcctgaa ggacacgcag gtgactcgac
      841 aggccttaaa tgagatctcg gcccggcaca gtgagatcca gcagcttgaa cgcagtattc
      901 gtgagctgca cgacatattc acttttctgg ctaccgaagt ggagatgcag ggggagatga
      961 tcaatcggat tgagaagaac atcctgagct cagcggacta cgtggaacgt gggcaggagc
     1021 acgtcaagac ggccctggag aaccagaaga aggcgaggaa gaagaaagtc ttgattgcca
     1081 tctgtgtgtc catcaccgtc gtcctcctag cagtcatcat tggcgtcaca gtggttggat
     1141 aatgtcgcac attgttggca ctaggagcac caggaaccca gggcctggcc ttctctccca
     1201 gcagcctggg gggcagggca gagcctccag tcggacccct tcctcacact ggcccctatg
     1261 cagaagggca gacagttctt ctggggttgg cagctgctca ttcatgatgg cctcctcctt
     1321 caggcctcaa tgcctggggg aggcctgcac tgtcctgatt ggccgggaca cacggttttg
     1381 taaaaaatta aaaaacaaaa aaagagcata
//
