LOCUS       NM_004177               6154 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 3 (STX3), transcript variant 1, mRNA.
ACCESSION   NM_004177
VERSION     NM_004177.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6154)
  AUTHORS   Shinozuka,T., Kanda,M., Sato,Y., Shimizu,D., Tanaka,C., Umeda,S.,
            Inokawa,Y., Hattori,N., Hayashi,M., Nakayama,G. and Kodera,Y.
  TITLE     Increased STX3 transcript and protein levels were associated with
            poor prognosis in two independent cohorts of esophageal squamous
            cell carcinoma patients
  JOURNAL   Cancer Med 12 (24), 22185-22195 (2023)
   PUBMED   38014487
  REMARK    GeneRIF: Increased STX3 transcript and protein levels were
            associated with poor prognosis in two independent cohorts of
            esophageal squamous cell carcinoma patients.
REFERENCE   2  (bases 1 to 6154)
  AUTHORS   Janecke,A.R., Liu,X., Adam,R., Punuru,S., Viestenz,A., Strauss,V.,
            Laass,M., Sanchez,E., Adachi,R., Schatz,M.P., Saboo,U.S.,
            Mittal,N., Rohrschneider,K., Escher,J., Ganesh,A., Al Zuhaibi,S.,
            Al Murshedi,F., AlSaleem,B., Alfadhel,M., Al Sinani,S.,
            Alkuraya,F.S., Huber,L.A., Muller,T., Heidelberger,R. and Janz,R.
  TITLE     Pathogenic STX3 variants affecting the retinal and intestinal
            transcripts cause an early-onset severe retinal dystrophy in
            microvillus inclusion disease subjects
  JOURNAL   Hum Genet 140 (8), 1143-1156 (2021)
   PUBMED   33974130
  REMARK    GeneRIF: Pathogenic STX3 variants affecting the retinal and
            intestinal transcripts cause an early-onset severe retinal
            dystrophy in microvillus inclusion disease subjects.
REFERENCE   3  (bases 1 to 6154)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6154)
  AUTHORS   Low,S.H., Vasanji,A., Nanduri,J., He,M., Sharma,N., Koo,M.,
            Drazba,J. and Weimbs,T.
  TITLE     Syntaxins 3 and 4 are concentrated in separate clusters on the
            plasma membrane before the establishment of cell polarity
  JOURNAL   Mol Biol Cell 17 (2), 977-989 (2006)
   PUBMED   16339081
REFERENCE   6  (bases 1 to 6154)
  AUTHORS   Martin-Martin,B., Nabokina,S.M., Lazo,P.A. and Mollinedo,F.
  TITLE     Co-expression of several human syntaxin genes in neutrophils and
            differentiating HL-60 cells: variant isoforms and detection of
            syntaxin 1
  JOURNAL   J Leukoc Biol 65 (3), 397-406 (1999)
   PUBMED   10080545
REFERENCE   7  (bases 1 to 6154)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
REFERENCE   8  (bases 1 to 6154)
  AUTHORS   Riento,K., Galli,T., Jansson,S., Ehnholm,C., Lehtonen,E. and
            Olkkonen,V.M.
  TITLE     Interaction of Munc-18-2 with syntaxin 3 controls the association
            of apical SNAREs in epithelial cells
  JOURNAL   J Cell Sci 111 (Pt 17), 2681-2688 (1998)
   PUBMED   9701566
REFERENCE   9  (bases 1 to 6154)
  AUTHORS   Galli,T., Zahraoui,A., Vaidyanathan,V.V., Raposo,G., Tian,J.M.,
            Karin,M., Niemann,H. and Louvard,D.
  TITLE     A novel tetanus neurotoxin-insensitive vesicle-associated membrane
            protein in SNARE complexes of the apical plasma membrane of
            epithelial cells
  JOURNAL   Mol Biol Cell 9 (6), 1437-1448 (1998)
   PUBMED   9614185
REFERENCE   10 (bases 1 to 6154)
  AUTHORS   Delgrossi,M.H., Breuza,L., Mirre,C., Chavrier,P. and Le Bivic,A.
  TITLE     Human syntaxin 3 is localized apically in human intestinal cells
  JOURNAL   J Cell Sci 110 (Pt 18), 2207-2214 (1997)
   PUBMED   9378770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK125660.1, BC007405.2,
            AP000640.5 and AA858058.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004177.4.
            
            Summary: The gene is a member of the syntaxin family. The encoded
            protein is targeted to the apical membrane of epithelial cells
            where it forms clusters and is important in establishing and
            maintaining polarity necessary for protein trafficking involving
            vesicle fusion and exocytosis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125660.1, SRR1660805.201991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337979.9/ ENSP00000338562.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK125660.1         318-357
            41-2982             BC007405.2         1-2942
            2983-6153           AP000640.5         142015-145185
            6154-6154           AA858058.1         28-28               c
FEATURES             Location/Qualifiers
     source          1..6154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..6154
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /note="syntaxin 3"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
     exon            1..260
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1100
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin 3A; syntaxin 3B"
                     /codon_start=1
                     /product="syntaxin-3 isoform 1"
                     /protein_id="NP_004168.1"
                     /db_xref="CCDS:CCDS7975.1"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
                     /translation="MKDRLEQLKAKQLTQDDDTDAVEIAIDNTAFMDEFFSEIEETRL
                     NIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHI
                     EEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKT
                     TDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDI
                     AMLVENQGEMLDNIELNVMHTVDHVEKARDETKKAVKYQSQARKKLIIIIVLVVVLLG
                     ILALIIGLSVGLN"
     exon            261..344
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            345..444
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            445..519
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            520..587
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            588..696
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            697..770
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            771..905
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1016
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1130
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..6154
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /note="hexamer: AATAAA"
     polyA_site      2982
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /note="major polyA site"
     regulatory      6134..6139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /note="hexamer: AATAAA"
     polyA_site      6154
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
ORIGIN      
        1 ggatttggag cgcgaggcgc cggtgggggc ggagggggct gcgcggcgga ggctcccgtg
       61 gcctcggacg ctcctcctag ctagcggccg ccgcccgccg ccgcctgcgc ctccagctcc
      121 ttcgccccgg cgggcccggc cgccgcttcc ggcagctcac ctgggaagcg ctcacctggg
      181 acgcgctcac ctgggacgcg ctacctgcct ccgggcgcct gggcttcagg atgaaggacc
      241 gtctggagca gctgaaggcc aagcagctga cacaggatga tgatactgat gcggttgaga
      301 ttgctatcga caacacggct tttatggacg agttcttttc tgagattgag gaaactcggc
      361 ttaacattga caagatctca gaacatgtag aggaggctaa gaaactctac agtatcattc
      421 tctctgcacc gattccagag ccaaaaacca aggatgacct agagcagctc acgactgaga
      481 ttaagaaaag ggccaacaac gtccggaaca aactgaagag catggagaag catattgaag
      541 aagatgaggt caggtcatcg gcagaccttc ggattcggaa atcccagcac tctgtccttt
      601 ctcggaagtt tgtggaggtg atgaccaaat acaatgaagc tcaagtggac ttccgagaac
      661 gcagcaaagg gcgaatccag cggcagctcg aaattactgg caaaaagaca accgatgagg
      721 agctggagga gatgttggag agtggcaacc cggccatctt cacttctggg atcattgact
      781 cacagatttc caagcaagcc ctcagtgaga ttgagggacg acacaaggac attgtgaggc
      841 tggagagcag catcaaggag cttcacgaca tgtttatgga catcgccatg ctggtggaga
      901 atcagggtga gatgttagat aacatagagt tgaatgtcat gcacacagtg gaccacgtgg
      961 agaaggcacg agatgaaacg aaaaaagctg tgaaatacca gagtcaggcc cggaagaaat
     1021 tgataattat cattgtgcta gtagttgtgt tgctgggcat tttagcattg attattggac
     1081 tttccgttgg gctgaattaa gagtggccta agaggctgct gcactgaaat aaactgattt
     1141 cactccagac tggtgtggcc acccttgtct tcagatgaga atggagtctg aatggccttc
     1201 ctgagagcga gtgcgacccg ttcctttgtt tccttgcaac cacccttgga cctgactcag
     1261 ctaacaatct agccctgggg gaatgtgatc tacctgatgc gaccctgagt tctccccaga
     1321 gcctcctcct gccccaccag ctctcaagta ccttttctcc tggactgtgt ggacccaccc
     1381 agctttcttc ctccctgttg tgtgtcagat tatgccttgc acttgggaaa gctcttgtga
     1441 gactctccca aggtgctgta tttttctacc tcatggagta ttctcccaga aactgcaatg
     1501 tattttttta ggggagtatc tttaacaaag cagaatgatt cttctaagtt tggcaacaag
     1561 aaggcttgga tctgagtctt ctacctggca ggatgccaat cctgtttgtt gtccgtatgt
     1621 cctgaaaaca tgagggactg gcagatgtca ttttggtcta aagagctgac ttgtttgaaa
     1681 ttcagcctta aattaagctc ttagttgttc agcttggggg gcaactttga tttttctctg
     1741 tgttgtagtc tctcatattt actcaaggag ggaccaggat gatacagtca tctgaggtta
     1801 tgctttgcaa aaggctgacg gtatggaata tgtttccatg tctgagtctt agaaactggc
     1861 tgctcattgt tagaaagtga tgctttgtga gactattgtc ttggggccaa aaataatcag
     1921 ggattttaaa ttgggcaagg gacaaggtgc tagaatccta agctctggaa atatttcatg
     1981 acactggtgt attcactcat gtgttccaga tgtattctaa ttgtgtatga aatgtatgta
     2041 cacataagtg tgtgtgtctc aggaagtagg aaataaaaat ggaagctatt atgacctcaa
     2101 aaaaaaaaag ccaactttga gctaggataa aaattgggta aaggacattt gcttacctgc
     2161 aaatgaatca ctgtggaaat gtgatcttcc catatcatca agaaacttgt tttctggatg
     2221 aatactggga gaataaaatg agaactctgg agtgagctaa attgatccca attaagtttt
     2281 tctgcttagc agacagaagg tataattttt tgacaccctt tcccacctgg tgcctatgct
     2341 aggcttgtcc tgagaacatc cctcagtaac ttgatattca catgacctac aggatgtccc
     2401 atctgcaggg ctgagtcagt tggggaacac cagaggctac acagtagctc ttcctgctac
     2461 tcggttaatg agcttggcag gttctttgtc tcactgaatt cttatcatgg aaacagcagc
     2521 agcagccgct aggaaatctt caagtgtagt gtctgtgcta acccagtggt aaatccctta
     2581 gatcccctgc tggtctctgg cagtctcctt gattttgggt accatgtata ttttccgctt
     2641 tgactttaac gctttctagg atagggtaag cacccttaat tcaggcactg tccattagct
     2701 tcctttgcaa aggctactta tggccggtca caatccagca ctcagacaga gccaaggcaa
     2761 tatcctcttg cccatggcta tgatgtcaga cagtggatgg gctccagcaa caagagacaa
     2821 aataactaaa ggcctttgct ctcctctgac attgaggcct ggggcttaca gtttggaata
     2881 caacatgtga aggtttttgt tgttgtttgt attttttaga tgtaaacttg attattttat
     2941 tgctaattta aaaataaaaa tgactttgta ttgattgtga aacggttctg gctctgtctc
     3001 gatgcagaaa cacaatgatc tggtgccacc atgtggtgat ttttattcag gttttagaat
     3061 gcagttcaca cctttttaag ccatgtgctg gatcagatgg ttcaaaagtg caatttttga
     3121 acatggttta actcccacag aatgcagtgt aactatgttt gtgtttcaga tttgaggtgt
     3181 tccccccaaa agaatttggt tcagtccttg ggagtatctg gctttaggag gaaatggggg
     3241 agatctgtca cgatgttatc tagaaggtgg aatgaccata ccaaacatcc ttttaatcta
     3301 acttgaatgt ctcaccaaaa ataacatttc tgttggcatt ctgggtccta gaagccagat
     3361 ccatctcctt tttccttctg ttgctctctt ccttcacacc ctcttccatg tccacatgca
     3421 cttatctccc tgcagaatac tttttgcgat gatgtttctc atgtattctt tctttccttg
     3481 tctggatgag cagaagaaga tcatgatcat gatctgctgt attatccttg cgatcatctt
     3541 agcttccacc attgggagca tatttgcctg aaaaaggtga gccatctgtg gggagggtca
     3601 gaccttcttt cactgacttg aaacctttgt gtcttggggg cactctaggt gccttaatct
     3661 gggtgggatt aggtgctaat aatggttaga gaaaactaaa gaaagggatg tttcagagac
     3721 agaaaagtga gtgaagaatg aactgttagt aggtagtctg tgggaggagg ggggagacag
     3781 aaggtggcaa tctgtcctat aacctggtgt ggcagaatgc tttgtacagg tgaaggatag
     3841 tgattcctgc taaacagttt gagccttggt atctggaagt gacaaaaaga acaagaatta
     3901 gttcttgcat taggtgcatc ttgaactttt tggaagaggg ccggccacac agtaaattca
     3961 aattaaattt cttccctttc aaggttaatg aaagttaaca cagccttgta tgtagtcctt
     4021 taccccgggt aagagggatt tggtgatccc agccacgaac accatgctat ataatctatg
     4081 atttttttcc tccatttttc tgttatctcc cacagccctc acagattgat cgactggcat
     4141 ttctaatcct ccttccactt ctgtggtacc atcacttctc cacgcagact cctcatcagc
     4201 ttctcctctt tccattatga aacttcttaa gaaacagggc accaatcaac tacttattaa
     4261 gaattatgca aagaataaac gtatacagaa ttgggcggag gacagggaca gggagtacag
     4321 atacatagct gattaggcag atggtttaaa ggaggactgc agggtagaga agcaagcaga
     4381 gtgggcgcct ctttaggaag tgacacagcc tgcatgtgca gtatggctgt gaaggggcag
     4441 atatcatagc acacctaact caacaggatc ttacttgaac tgctgtgagt tggtcaagtc
     4501 agggcacttc tgctcttcag gctcctctag gtcacacctt tgaccaccct acatctgttt
     4561 cctctttcag gctccagtag tagtcttaaa agtgaagttt atctaaggat aagcacatgc
     4621 ctatcttgct cactgctgtg tccccacttt ttagcacagc gcctgctgct tacaggtact
     4681 caaatatctg ctgacttaat tacttataat taagctctta tttcagtcat ggacaaatcc
     4741 ttgggtttga ctcctaaact ctttaaggta ccaatgagaa cgtggtttgt tactgtcaga
     4801 ggctgtgtaa agccgcttgg gaatgggctg atctgcttat gcaaaaatgc taccaacctt
     4861 tcaaacccca ttaccacaac atgaaaattt aaagtgcttt ttctatgggt ggtgatggtg
     4921 gagttctagc aacagcctct taatctgtgg agaagatggc tggctccagg actgtggttc
     4981 aataacgaaa tacaggccca caaaataaaa taggtttata gcatgactga actcacacat
     5041 cagtagaaca ctctgtgaac cataacaaag aacagataaa ggtgtcaagt gagaaaggtg
     5101 aaatgaggtt atcactcact tcacctctca cctgatttgt gttgctagct gaaactgctg
     5161 gccagtaacg tatgtataag aaactgttat aggccgggca cggtggctca tgcctgtaat
     5221 cacagcactt tgggaggcca aggcaggtgg atcaccagac tgaccaacat agtgaaaccc
     5281 cctctctaca aaaaatacaa aaattagcca ggcatggtgg cttgcacctg tattcccagc
     5341 tacttgggag gctgaggcag gagaattgct tgaatgcaag aggcggaagt tgcagtgagc
     5401 cgagatcgcg ccactgcact ccagcctggg caacaagagc taaattccat ctaaaaaaaa
     5461 aaaaaaaaca aaaaaaaaaa actgttctta atacttaata ctgtccccaa ttccattcaa
     5521 ggttcagttg tgttcagctt taaaaccagc tatgtgaatg tgagttctag tgcagattat
     5581 ttagtgatta tgtaactaaa attgatgaaa aaatcacact atacaactgt gaggagcaca
     5641 caactgctaa gtttgtactt ttgaaagtaa attattcttt gtttgatacc ttatttttta
     5701 agaaagtggg attaaaaata ttttggtcag tgctgttttc tacccacctt caaaagccaa
     5761 tggtttgata tttctattaa tttgtgcttc ctttagtttt aataggggat agaagactgc
     5821 agctggttgg gtctggaaaa cattaatctg ggcaaacgga gctggagcta tgaggatctg
     5881 agtcctaggg ggccctcatt cactagcagt aagaatttaa gtggtgcatg gcacatagca
     5941 ctgtactaga ttctgcaggg gcacaaacat agagccaaac actctccctc ttggagaatt
     6001 tcagacccag aaaaggccac gcagttctaa cttttgtcat cggttccttt tgctaaaagg
     6061 caaagggtat gttccttgcc tattgtccaa catacccctt ccaagattgt gagaagatgg
     6121 gtagctgggc atcaataaat attgaatcaa ttga
//
