LOCUS       NM_194356               3441 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 2 (STX2), transcript variant 2, mRNA.
ACCESSION   NM_194356
VERSION     NM_194356.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Kang,F., Xie,L., Qin,T., Miao,Y., Kang,Y., Takahashi,T., Liang,T.,
            Xie,H. and Gaisano,H.Y.
  TITLE     Plasma membrane flipping of Syntaxin-2 regulates its inhibitory
            action on insulin granule exocytosis
  JOURNAL   Nat Commun 13 (1), 6512 (2022)
   PUBMED   36316316
  REMARK    GeneRIF: Plasma membrane flipping of Syntaxin-2 regulates its
            inhibitory action on insulin granule exocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   Wang,Y.X., Li,Y.Z., Zhu,H.F., Zhang,Z.Y., Qian,X.L. and He,G.Y.
  TITLE     STX2 drives colorectal cancer proliferation via upregulation of
            EXOSC4
  JOURNAL   Life Sci 263, 118597 (2020)
   PUBMED   33075373
  REMARK    GeneRIF: STX2 drives colorectal cancer proliferation via
            upregulation of EXOSC4.
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Wang,Y., Xu,H., Jiao,H., Wang,S., Xiao,Z., Zhao,Y., Bi,J., Wei,W.,
            Liu,S., Qiu,J., Li,T., Liang,L., Ye,Y., Liao,W. and Ding,Y.
  TITLE     STX2 promotes colorectal cancer metastasis through a positive
            feedback loop that activates the NF-kappaB pathway
  JOURNAL   Cell Death Dis 9 (6), 664 (2018)
   PUBMED   29855462
  REMARK    GeneRIF: STX2 as a crucial modulator of the aggressive colorectal
            cancer phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Zha,H., Remmers,E.F., Szpirer,C., Szpirer,J., Zhang,H., Kozak,C.A.
            and Wilder,R.L.
  TITLE     The epimorphin gene is highly conserved among humans, mice, and
            rats and maps to human chromosome 7, mouse chromosome 5, and rat
            chromosome 12
  JOURNAL   Genomics 37 (3), 386-389 (1996)
   PUBMED   8938452
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Oka,Y. and Hirai,Y.
  TITLE     Inductive influences of epimorphin on endothelial cells in vitro
  JOURNAL   Exp Cell Res 222 (1), 189-198 (1996)
   PUBMED   8549663
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   8  (bases 1 to 3441)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   9  (bases 1 to 3441)
  AUTHORS   Hirai,Y.
  TITLE     Molecular cloning of human epimorphin: identification of isoforms
            and their unique properties
  JOURNAL   Biochem Biophys Res Commun 191 (3), 1332-1337 (1993)
   PUBMED   8466509
REFERENCE   10 (bases 1 to 3441)
  AUTHORS   Hirai,Y., Takebe,K., Takashina,M., Kobayashi,S. and Takeichi,M.
  TITLE     Epimorphin: a mesenchymal protein essential for epithelial
            morphogenesis
  JOURNAL   Cell 69 (3), 471-481 (1992)
   PUBMED   1581962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073912.38.
            
            On Nov 23, 2018 this sequence version replaced NM_194356.3.
            
            Summary: The product of this gene belongs to the
            syntaxin/epimorphin family of proteins. The syntaxins are a large
            protein family implicated in the targeting and fusion of
            intracellular transport vesicles. The product of this gene
            regulates epithelial-mesenchymal interactions and epithelial cell
            morphogenesis and activation. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2). Variants 2 and 9 both encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.83728.1,
                                           SRR1803617.74079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392373.7/ ENSP00000376178.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC073912.38        138609-138789       c
            182-256             AC073912.38        126732-126806       c
            257-356             AC073912.38        121228-121327       c
            357-431             AC073912.38        112496-112570       c
            432-505             AC073912.38        108170-108243       c
            506-614             AC073912.38        106521-106629       c
            615-688             AC073912.38        100954-101027       c
            689-826             AC073912.38        100692-100829       c
            827-937             AC073912.38        98064-98174         c
            938-1063            AC073912.38        95534-95659         c
            1064-3441           AC073912.38        89139-91516         c
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..3441
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /note="syntaxin 2"
                     /db_xref="GeneID:2054"
                     /db_xref="HGNC:HGNC:3403"
                     /db_xref="MIM:132350"
     exon            1..181
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1018
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epimorphin"
                     /codon_start=1
                     /product="syntaxin-2 isoform 2"
                     /protein_id="NP_919337.1"
                     /db_xref="CCDS:CCDS9270.1"
                     /db_xref="GeneID:2054"
                     /db_xref="HGNC:HGNC:3403"
                     /db_xref="MIM:132350"
                     /translation="MRDRLPDLTACRKNDDGDTVVVVEKDHFMDDFFHQVEEIRNSID
                     KITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIRAKLKAIEQSFDQD
                     ESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRIQRQLEITGRTTT
                     DDELEEMLESGKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDM
                     AMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKKWIIIAVSVVLVA
                     IIALIIGLSVGK"
     exon            182..256
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            257..356
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            357..431
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            432..505
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            506..614
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            615..688
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            689..826
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            827..937
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1063
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..3441
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3419..3424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /note="hexamer: AATAAA"
     polyA_site      3441
                     /gene="STX2"
                     /gene_synonym="EPIM; EPM; STX2A; STX2B; STX2C"
                     /note="major polyA site"
ORIGIN      
        1 gcggttgccg tggcagcgcc ggctccaggg agggctgctg gcgccgggcc gggaccgcgg
       61 ggcctgaggc ggagaccgga gagcccgagg cccggccgga ggcagctcgg gacaggcttg
      121 agcggcgggg cgcgctgccc ggccggcggg gatgcgggac cggctgccag acctgacggc
      181 gtgtaggaag aatgatgatg gagacacagt tgttgtggtt gagaaagatc atttcatgga
      241 tgatttcttc catcaggtgg aggagattag aaacagtatt gataaaataa ctcaatatgt
      301 tgaagaagta aagaaaaacc acagcatcat tctttctgca ccaaacccgg aaggaaaaat
      361 aaaagaagag cttgaagatc tgaacaaaga aatcaagaaa actgcgaata aaattcgagc
      421 caagttaaag gctattgaac aaagttttga tcaggatgag agtgggaacc ggacttcagt
      481 ggatcttcgg atacgaagaa cccagcattc ggtgctgtct cggaagtttg tggaagccat
      541 ggcggagtac aatgaggcac agactctgtt tcgggagcgg agcaaaggcc gcatccagcg
      601 ccagctggag ataactggga gaaccaccac agacgacgag ctagaagaga tgctggagag
      661 cgggaagcca tccatcttca cttccgacat tatatcagat tcacaaatta ctagacaagc
      721 tctcaatgaa atcgagtcac gtcacaagga catcatgaag ctggagacca gcatccgaga
      781 gttgcatgag atgttcatgg acatggctat gtttgtggag actcagggtg aaatgatcaa
      841 caacatagaa agaaatgtta tgaatgccac agactatgta gaacacgcta aagaagaaac
      901 aaaaaaagct atcaaatatc agagcaaggc aagaaggaaa aagtggataa ttattgctgt
      961 gtcagtggtt ctggttgcca taatcgctct aattattggc ttgtcagttg gcaaatgatg
     1021 gtgtggataa cgtcagtgtg catgcctctc tgccagggtg ggaaaattga tgttcattat
     1081 tatttgtgta attgttttgc ttgtgatcct tggaattatc ctagcaacaa cattgtccta
     1141 gcaaccatat cccaagagcc atttatcctt gagactcaga ccacatctgc aaccaaatca
     1201 gcatcctgtc atttcgtgaa tgaatctcag acgctgtaac ccggcatcga gtgctgacct
     1261 tgtaatgtat gagttcacgg aagaagcaca accgaacgtc ttgttcagtg acagcgccgt
     1321 aagcacagtg ggtgtgatgc gtgaccctga atgacacact acagaatgtg agcagtgtga
     1381 gacttctctc actggccttg aaataagaaa atattgaaca ttttaatatt aaaaatattt
     1441 cagtgttaac aaatgtgcat gaagtttaat taggaaggaa tgctttatgt tatgaaggct
     1501 tttttttttt tttttgagac ggagtctcgc tttgtcatcc aggctggagt gcagtggtgc
     1561 gatctcagct cactgcaacc tcggcctccc gggttcaagc aattctcctg cctcagcctc
     1621 ccgagtagct gggattacag gcatgggcca ccacacccag ctaatttttt gtgttttctt
     1681 tttagtagag acggggtttt accatgctgg ccaggctggc ctcaaactcc tgaccttgtg
     1741 atccacccac ctcagcctcc caaagtgctg ggattacagg cgtgagtcac cgggcaggct
     1801 gttctgaagc ttttagatct caggtctaag gcttcctttc cctccctctc ccagctagtt
     1861 tgtgctaatt aagagacctt ttatactgtt ttattgcctg tttgaagaaa taatttttat
     1921 cacgtttttg taagatatct ataattttaa atgtttataa attgtttaat ttattagcat
     1981 cttaatgtac cccattttta tatactgaat gtggcctttt gagtgaaata ggaagcttca
     2041 tggtgttgga gccacctttg tacagttgtt taaagtttcc cattgtcacg gaaaacattg
     2101 gctgcaaagc ccctcaaagc cctcaagtgc cttctgtgag tttaaatgtg ctggtgccct
     2161 ccagaaaagc ctcggcctca gctccgtttc cgcctgttcc ctcccccagg ataatgaatg
     2221 gttactgcac tgtaaagacc gtggtctctt ttcactaaat aggagattcg agtttcccag
     2281 tttacatgaa tgaagtctga atttaagacg gtgatgaaac tgaggttcag tactctcggg
     2341 actcgaggaa attattcctg agacatggag taattcttac aaatttaaac tattgtacag
     2401 atccacatac atgttgttaa gtacctaatg ttttgctgaa cttttaaaag ttaatttcca
     2461 aaatgtatag ggattcatga taattaaacc tttttattgc tcattttttt agtagaagaa
     2521 tatcacttat ttttagactt gtaaaatgta tgaactggtg agcggacatc tgttaagaga
     2581 gtcactagtc agaatgttaa aggagtgcat gcaggatgcc ccaaatgtcg tgaactcttg
     2641 ttactcctgt atgtagtagt gtaagcatgt gacttttaac accatttggt ttgaaactaa
     2701 tgtagagatg cctgattcca aacaggtgtg gagaatattg aatggctcag aagccgcgtc
     2761 ccttacttaa cacaattccg aatctccctc atccatgatg cgtccattgg atcactcgct
     2821 ggtggtcact gtgtggcagt tactagggga attctgcctc tgactgttct ttttcttttg
     2881 gtctttaaac accctgtcgt gggatgtgct cactgatttg tggctatgtt gaaggtatca
     2941 cttgtcttga gggttttcaa tatttcagga tcatgctggt ggcaaaagga ctccacgcct
     3001 ctgtggaatc atgtccacag ggggacctgc ctcccgtgat gtcccacctt tccttcaagg
     3061 tctgtcatat gagtcctccc cttttacaac acttattatg gtatttttca agttattctt
     3121 cttagatttg cagtacctac tgaaatttgt gtttttatag ttgaagttag gaaaatgcta
     3181 tttgatttgt atttagatat ttaagtcact tgtccaatga tgtgtatgtc taagcctcat
     3241 gtaccgattt gaagtcagac ttaaaaatgt atttacagat tcacttgaga ctttttaatc
     3301 ggttcttcaa atatttcatg tttacattaa aaatttccag agaagcataa aagtattcac
     3361 tttcctgcct tgtcatttct ggaaagattt tggggagata ttttattgca tattaattaa
     3421 taaattgttc tactaggaaa a
//
