LOCUS       NM_001001850            1149 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens syntaxin 19 (STX19), mRNA.
ACCESSION   NM_001001850
VERSION     NM_001001850.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   8  (bases 1 to 1149)
  AUTHORS   Gordon,D.E., Bond,L.M., Sahlender,D.A. and Peden,A.A.
  TITLE     A targeted siRNA screen to identify SNAREs required for
            constitutive secretion in mammalian cells
  JOURNAL   Traffic 11 (9), 1191-1204 (2010)
   PUBMED   20545907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034696.1, AF461456.1 and AC117474.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001001850.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034696.1, BG674749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315099.3/ ENSP00000320679.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-987               BC034696.1         14-1000
            988-1129            AF461456.1         744-885
            1130-1145           BC034696.1         1143-1158
            1146-1149           AC117474.7         132363-132366       c
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..1149
                     /gene="STX19"
                     /note="syntaxin 19"
                     /db_xref="GeneID:415117"
                     /db_xref="HGNC:HGNC:19300"
     exon            1..231
                     /gene="STX19"
                     /inference="alignment:Splign:2.1.0"
     exon            232..1149
                     /gene="STX19"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1129
                     /gene="STX19"
                     /codon_start=1
                     /product="syntaxin-19"
                     /protein_id="NP_001001850.1"
                     /db_xref="CCDS:CCDS33793.1"
                     /db_xref="GeneID:415117"
                     /db_xref="HGNC:HGNC:19300"
                     /translation="MKDRLQELKQRTKEIELSRDSHVSTTETEEQGVFLQQAVIYERE
                     PVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRESTITKEIKIQA
                     EYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFRHFQQIMFIYNDTIAAKQE
                     KCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRHKE
                     LVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKK
                     RNPCRVLCCWCCPCCSSK"
     regulatory      1125..1130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX19"
                     /note="hexamer: AATAAA"
     polyA_site      1149
                     /gene="STX19"
                     /note="major polyA site"
ORIGIN      
        1 aatctatttt cacttgctat taacagcaaa cgtacaactt tatctcttat ttgacttcat
       61 tatttggctt tcaaattaac aacatgaaaa ctatacagaa attagtctgt gccctataag
      121 acagagattt agataatttg ttcaaaacat gagatgatat tcagatattc tctcaaaggc
      181 aggactccaa caccgcaggt ggaaaaccaa caaaaggaag aaaacagaaa ggaggaaagg
      241 gaagatgaaa gaccgacttc aagaactaaa gcagagaaca aaggaaattg aactctctag
      301 agacagtcat gtatcaacta cagaaacaga ggaacaaggg gtgtttctac agcaagctgt
      361 tatttatgaa agagagcctg tagctgagag acacctacat gaaatccaaa aactacagga
      421 aagtattaac aatttggcag ataatgttca aaaatttggg cagcaacaga aaagtctggt
      481 ggcttcaatg agaaggttta gtctacttaa gagagagtct accattacaa aggagataaa
      541 aattcaggca gaatacatca acagaagttt gaatgattta gttaaagaag ttaaaaagtc
      601 agaggttgaa aatggtccat cttcagtggt cacaaggata cttaaatctc agcatgctgc
      661 aatgttccgc cattttcagc aaatcatgtt tatatacaat gacacaatag cagcaaagca
      721 agagaagtgc aagacattta ttttacgtca gcttgaagtt gctggaaaag agatgtctga
      781 agaagatgta aatgatatgc ttcatcaagg aaaatgggaa gtttttaatg aaagcttact
      841 tacagaaatc aatatcacta aagcacaact ttcagagatt gaacagagac acaaggaact
      901 tgttaatttg gagaaccaaa taaaggattt aagggatctt ttcattcaga tatctctttt
      961 agtagaggaa caaggagaga gcatcaacaa tattgaaatg acagtgaata gtacaaaaga
     1021 gtatgttaac aatactaaag agaaatttgg actagctgta aaatacaaaa aaagaaatcc
     1081 ttgcagagta ctgtgttgtt ggtgctgtcc atgctgtagc tcaaaataaa gaagctattt
     1141 taaaacttt
//
