LOCUS       NM_016930               2158 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens syntaxin 18 (STX18), transcript variant 1, mRNA.
ACCESSION   NM_016930
VERSION     NM_016930.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Guillemyn,B., De Saffel,H., Bek,J.W., Tapaneeyaphan,P., De
            Clercq,A., Jarayseh,T., Debaenst,S., Willaert,A., De Rycke,R.,
            Byers,P.H., Rosseel,T., Coucke,P., Blaumeiser,B., Syx,D.,
            Malfait,F. and Symoens,S.
  TITLE     Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in
            Early Cartilage and Bone Development
  JOURNAL   J Bone Miner Res 38 (11), 1718-1730 (2023)
   PUBMED   37718532
  REMARK    GeneRIF: Syntaxin 18 Defects in Human and Zebrafish Unravel Key
            Roles in Early Cartilage and Bone Development.
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Li,X., Shi,S., Li,F.F., Cheng,R., Han,Y., Diao,L.W., Zhang,Q.,
            Zhi,J.X. and Liu,S.L.
  TITLE     Characterization of soluble N-ethylmaleimide-sensitive factor
            attachment protein receptor gene STX18 variations for possible
            roles in congenital heart diseases
  JOURNAL   Gene 598, 79-83 (2017)
   PUBMED   27816473
  REMARK    GeneRIF: The SNP rs12644497 in the STX18 gene was associated with
            congenital heart diseases Chinese Han populations.
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Bassett,T., Harpur,B., Poon,H.Y., Kuo,K.H. and Lee,C.H.
  TITLE     Effective stimulation of growth in MCF-7 human breast cancer cells
            by inhibition of syntaxin18 by external guide sequence and
            ribonuclease P
  JOURNAL   Cancer Lett 272 (1), 167-175 (2008)
   PUBMED   18722709
  REMARK    GeneRIF: Stx18 in involved in growth of human breast cancer cells
            and may possibly be used as a prognostic marker and a molecular
            target in the treatment of breast cancer.
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Arasaki,K., Taniguchi,M., Tani,K. and Tagaya,M.
  TITLE     RINT-1 regulates the localization and entry of ZW10 to the syntaxin
            18 complex
  JOURNAL   Mol Biol Cell 17 (6), 2780-2788 (2006)
   PUBMED   16571679
  REMARK    GeneRIF: RINT-1 coordinates the localization and function of ZW10
            by serving as a link between ZW10 and the SNARE complex comprising
            syntaxin 18.
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Nakajima,K., Hirose,H., Taniguchi,M., Kurashina,H., Arasaki,K.,
            Nagahama,M., Tani,K., Yamamoto,A. and Tagaya,M.
  TITLE     Involvement of BNIP1 in apoptosis and endoplasmic reticulum
            membrane fusion
  JOURNAL   EMBO J 23 (16), 3216-3226 (2004)
   PUBMED   15272311
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Hirose,H., Arasaki,K., Dohmae,N., Takio,K., Hatsuzawa,K.,
            Nagahama,M., Tani,K., Yamamoto,A., Tohyama,M. and Tagaya,M.
  TITLE     Implication of ZW10 in membrane trafficking between the endoplasmic
            reticulum and Golgi
  JOURNAL   EMBO J 23 (6), 1267-1278 (2004)
   PUBMED   15029241
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Hatsuzawa,K., Hirose,H., Tani,K., Yamamoto,A., Scheller,R.H. and
            Tagaya,M.
  TITLE     Syntaxin 18, a SNAP receptor that functions in the endoplasmic
            reticulum, intermediate compartment, and cis-Golgi vesicle
            trafficking
  JOURNAL   J Biol Chem 275 (18), 13713-13720 (2000)
   PUBMED   10788491
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB458668.1, AB028741.1 and
            AL832867.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016930.3.
            
            Summary: This gene encodes a member of the syntaxin family of
            soluble N-ethylmaleimide-sensitive factor attachment protein
            receptors (SNAREs) which is part of a membrane tethering complex
            that includes other SNAREs and several peripheral membrane
            proteins, and is involved in vesicular transport between the
            endoplasmic reticulum (ER) and the Golgi complex. The encoded
            protein is important for the organization of the smooth, rough, and
            exit site ER subdomains. A pseudogene of this gene has been
            identified. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.137274.1,
                                           SRR1803616.130772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306200.7/ ENSP00000305810.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                DB458668.1         1-81
            82-1652             AB028741.1         1-1571
            1653-2158           AL832867.1         918-1423
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3-p16.2"
     gene            1..2158
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="syntaxin 18"
                     /db_xref="GeneID:53407"
                     /db_xref="HGNC:HGNC:15942"
                     /db_xref="MIM:606046"
     exon            1..252
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1092
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     growth-inhibiting gene 9 protein"
                     /codon_start=1
                     /product="syntaxin-18 isoform 1"
                     /protein_id="NP_058626.1"
                     /db_xref="CCDS:CCDS3377.1"
                     /db_xref="GeneID:53407"
                     /db_xref="HGNC:HGNC:15942"
                     /db_xref="MIM:606046"
                     /translation="MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPR
                     PKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQI
                     FMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRV
                     VDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTW
                     GDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQ
                     QEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYD
                     S"
     exon            253..320
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..436
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..514
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..581
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..697
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..786
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..845
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..915
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..996
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..2158
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="hexamer: AATATA"
     polyA_site      1652
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="major polyA site"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="hexamer: AATAAA"
     polyA_site      2158
                     /gene="STX18"
                     /gene_synonym="Ufe1"
                     /note="major polyA site"
ORIGIN      
        1 agtccttcag cggccgggtt cgcgccgcgg tcgccggctg cttacgtggg cgggcctagt
       61 gtggggctga gggtgcgggt cgctatggcg gtggacatca cgctgctatt ccgggccagc
      121 gtcaagaccg tgaagacgcg gaacaaggcg ctgggagtgg cggtgggcgg cggggtcgat
      181 ggcagccggg acgagctgtt ccgccggagc ccccggccca agggcgactt ctccagccgg
      241 gcccgcgaag tgatttctca cattggcaaa ctgagagatt ttcttctgga acacaggaaa
      301 gattatatta atgcttatag ccataccatg tctgaatatg ggaggatgac agacacagaa
      361 cgagaccaga tagaccagga tgcccagata ttcatgagga cctgttcaga agcaattcag
      421 caactacgaa cagaagctca caaggagata cattcccagc aagtgaagga gcacaggacc
      481 gctgttttgg atttcattga agattacttg aaaagagtat gtaaacttta ctcagaacag
      541 agagccatcc gagttaaaag agtggtggat aagaaaagat tatctaagct ggaaccagaa
      601 ccaaatacaa agacaagaga atccacatct tctgagaaag tttcacagag tccttcaaaa
      661 gactctgaag aaaaccctgc cactgaagaa cgtccagaaa aaattttggc tgaaacacaa
      721 cctgaattgg gaacgtgggg agatggcaaa ggcgaagatg agttatcccc agaagaaata
      781 caaatgtttg aacaggaaaa tcagcgacta attggtgaaa tgaacagctt gtttgatgaa
      841 gtgaggcaaa tcgaagggag agtggttgag atttccagac tccaagagat attcacggaa
      901 aaggttttgc aacaggaagc tgagattgac agcattcacc agttagttgt gggggcaact
      961 gaaaatatca aggaaggcaa cgaagacata agagaggcca ttaaaaacaa cgctggcttc
     1021 cgcgtgtgga tcctcttctt cctcgtgatg tgctccttct ccttgctctt cctcgactgg
     1081 tacgacagct agccagggcc acgggggccc agcacgagag tcctcatggg cactcacaga
     1141 ctgcgtgctt tcatgtactt ccagtgctgg agcatggtat gaccagattt tatcacagtg
     1201 ccatttgaag ggaaaggagt tcagacagac agacgtattc cccaaaaagg gataccccag
     1261 gccgatggtg ttcagccatt tagcagctga aaaaggaaac agtgcacacc aatgggaggc
     1321 agcctgcgta gccctcatca ggcaagacag actgaatgca ggagtgggtg attagctgct
     1381 ccttgaactt gaggctgcct tggcagcagg ggcacagcag gcctcaagag cccctaattg
     1441 tctcagggtt caaaggaaga cactgacctt tcccatcccg gtagcttcag ggaagatcat
     1501 agttaataac gtctctcaac aaatgattac ttctttgttt ccttgtggct tcttgtctgt
     1561 ctgagtcaac gaatacacag acttactgga ttatagaaga gaaaattcac atctgccttg
     1621 ttaatctaat aaatataatt acagcccctt aatgtgttgt caatgagtct aagttgacaa
     1681 attcagtggc agcccagcca cctcctatca atcaatcagg gaagaaatgc aggggagact
     1741 ggggccctca gtgaggggct gcctggcatt actcctccaa agactgctgc ccccagaaca
     1801 ggcagggggt gtgggagggc cagtttcccg ccactgggtc caaggagcct ttgttcaaag
     1861 gaagaagtgg gccacggaag aacgggcctg cttctctcgt gcctgtgctt ctgacctcca
     1921 ggaactgtaa acaggaacac ctatgtgtaa ctgaaggcat gagacatctg tacaggaagc
     1981 atcccagcgc ccacatgggc atgagacagt ctgcactgcg cctggtgaaa tgcgtgtgtg
     2041 tacagacagt ccactgggca gcacaggtat cctcatgttc tttatttgca cagagtgaaa
     2101 tgtcagaagt tacatgtaaa tgaattcaca gtcaataaag tccacgtcta cctggaaa
//
