LOCUS       NM_017919               6885 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens syntaxin 17 (STX17), mRNA.
ACCESSION   NM_017919
VERSION     NM_017919.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6885)
  AUTHORS   Shinoda,S., Sakai,Y., Matsui,T., Uematsu,M., Koyama-Honda,I.,
            Sakamaki,J.I., Yamamoto,H. and Mizushima,N.
  TITLE     Syntaxin 17 recruitment to mature autophagosomes is temporally
            regulated by PI4P accumulation
  JOURNAL   Elife 12, 92189 (2024)
   PUBMED   38831696
  REMARK    GeneRIF: Syntaxin 17 recruitment to mature autophagosomes is
            temporally regulated by PI4P accumulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6885)
  AUTHORS   Xu,Y., Duan,S., Ye,W., Zheng,Z., Zhang,J., Gao,Y. and Ye,S.
  TITLE     SLC34A2 promotes cell proliferation by activating STX17-mediated
            autophagy in esophageal squamous cell carcinoma
  JOURNAL   Thorac Cancer 15 (17), 1369-1384 (2024)
   PUBMED   38720472
  REMARK    GeneRIF: SLC34A2 promotes cell proliferation by activating
            STX17-mediated autophagy in esophageal squamous cell carcinoma.
REFERENCE   3  (bases 1 to 6885)
  AUTHORS   Cui,X., Wang,B., Han,D., Cheng,M., Yuan,P., Du,P., Hou,Y., Su,C.,
            Tang,J. and Zhang,J.
  TITLE     Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the
            role of autophagy and inflammation
  JOURNAL   J Cell Mol Med 28 (10), e18402 (2024)
   PUBMED   39008328
  REMARK    GeneRIF: Exacerbation of atherosclerosis by STX17 knockdown:
            Unravelling the role of autophagy and inflammation.
REFERENCE   4  (bases 1 to 6885)
  AUTHORS   Zheng,D., Tong,M., Zhang,S., Pan,Y., Zhao,Y., Zhong,Q. and Liu,X.
  TITLE     Human YKT6 forms priming complex with STX17 and SNAP29 to
            facilitate autophagosome-lysosome fusion
  JOURNAL   Cell Rep 43 (2), 113760 (2024)
   PUBMED   38340317
  REMARK    GeneRIF: Human YKT6 forms priming complex with STX17 and SNAP29 to
            facilitate autophagosome-lysosome fusion.
REFERENCE   5  (bases 1 to 6885)
  AUTHORS   Jian,F., Wang,S., Tian,R., Wang,Y., Li,C., Li,Y., Wang,S., Fang,C.,
            Ma,C. and Rong,Y.
  TITLE     The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex
            mediating autophagosome-lysosome fusion
  JOURNAL   Cell Res 34 (2), 151-168 (2024)
   PUBMED   38182888
  REMARK    GeneRIF: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE
            complex mediating autophagosome-lysosome fusion.
REFERENCE   6  (bases 1 to 6885)
  AUTHORS   Petukhova,L., Duvic,M., Hordinsky,M., Norris,D., Price,V.,
            Shimomura,Y., Kim,H., Singh,P., Lee,A., Chen,W.V., Meyer,K.C.,
            Paus,R., Jahoda,C.A., Amos,C.I., Gregersen,P.K. and Christiano,A.M.
  TITLE     Genome-wide association study in alopecia areata implicates both
            innate and adaptive immunity
  JOURNAL   Nature 466 (7302), 113-117 (2010)
   PUBMED   20596022
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 6885)
  AUTHORS   Zhao,Z.Z., Duffy,D.L., Thomas,S.A., Martin,N.G., Hayward,N.K. and
            Montgomery,G.W.
  TITLE     Polymorphisms in the syntaxin 17 gene are not associated with human
            cutaneous malignant melanoma
  JOURNAL   Melanoma Res 19 (2), 80-86 (2009)
   PUBMED   19209086
  REMARK    GeneRIF: Common variants in the STX17 gene region do not play a key
            role in the pathogenesis of human melanoma.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6885)
  AUTHORS   Zhang,Q., Li,J., Deavers,M., Abbruzzese,J.L. and Ho,L.
  TITLE     The subcellular localization of syntaxin 17 varies among different
            cell types and is altered in some malignant cells
  JOURNAL   J Histochem Cytochem 53 (11), 1371-1382 (2005)
   PUBMED   15956034
REFERENCE   9  (bases 1 to 6885)
  AUTHORS   Steegmaier,M., Oorschot,V., Klumperman,J. and Scheller,R.H.
  TITLE     Syntaxin 17 is abundant in steroidogenic cells and implicated in
            smooth endoplasmic reticulum membrane dynamics
  JOURNAL   Mol Biol Cell 11 (8), 2719-2731 (2000)
   PUBMED   10930465
REFERENCE   10 (bases 1 to 6885)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC318495.1, BC101566.1, AL358937.16 and AI375996.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017919.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.66623.1,
                                           SRR1803614.138644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259400.11/ ENSP00000259400.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DC318495.1         22-63
            43-1099             BC101566.1         1-1057
            1100-6521           AL358937.16        130627-136048
            6522-6885           AI375996.1         5-368               c
FEATURES             Location/Qualifiers
     source          1..6885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..6885
                     /gene="STX17"
                     /note="syntaxin 17"
                     /db_xref="GeneID:55014"
                     /db_xref="HGNC:HGNC:11432"
                     /db_xref="MIM:604204"
     exon            1..53
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            54..238
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1024
                     /gene="STX17"
                     /codon_start=1
                     /product="syntaxin-17"
                     /protein_id="NP_060389.2"
                     /db_xref="CCDS:CCDS6745.1"
                     /db_xref="GeneID:55014"
                     /db_xref="HGNC:HGNC:11432"
                     /db_xref="MIM:604204"
                     /translation="MSEDEEKVKLRRLEPAIQKFIKIVIPTDLERLRKHQINIEKYQR
                     CRIWDKLHEEHINAGRTVQQLRSNIREIEKLCLKVRKDDLVLLKRMIDPVKEEASAAT
                     AEFLQLHLESVEELKKQFNDEETLLQPPLTRSMTVGGAFHTTEAEASSQSLTQIYALP
                     EIPQDQNAAESWETLEADLIELSQLVTDFSLLVNSQQEKIDSIADHVNSAAVNVEEGT
                     KNLGKAAKYKLAALPVAGALIGGMVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQ
                     RKKQKMMEKLTSSCPDLPSQTDKKCS"
     exon            239..304
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            305..530
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            531..646
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            647..697
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            698..784
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     exon            785..6885
                     /gene="STX17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4628..4633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX17"
                     /note="hexamer: AATAAA"
     polyA_site      4655
                     /gene="STX17"
                     /note="major polyA site"
     regulatory      5308..5313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX17"
                     /note="hexamer: AATAAA"
     polyA_site      5346
                     /gene="STX17"
     regulatory      6863..6868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX17"
                     /note="hexamer: AATAAA"
     polyA_site      6885
                     /gene="STX17"
                     /note="major polyA site"
ORIGIN      
        1 gctcctgcgc ctgcgccgtg cccaccgacc ggcctcgagc gccccggcgg gaggtttttc
       61 tatatgagtg gagaagacag ctgttaccag ggaggtcata caacattttt ttaggatgtc
      121 tgaagatgaa gaaaaagtga aattacgccg tcttgaacca gctatccaga aattcattaa
      181 gatagtaatc ccaacagacc tggaaaggtt aagaaagcac cagataaata ttgagaagta
      241 tcaaaggtgc agaatctggg acaagttgca tgaagagcat atcaatgcag gacgtacagt
      301 tcagcaactc cgatccaata tccgagaaat tgagaaactt tgtttgaaag tccgaaagga
      361 tgacctagta cttctgaaga gaatgataga tcctgttaaa gaagaagcat cagcagcaac
      421 agcagaattt ctccaactcc atttggaatc tgtagaagaa cttaagaagc aatttaatga
      481 tgaagaaact ttgctacagc ctcctttgac cagatccatg actgttggtg gagcatttca
      541 tactactgaa gctgaagcta gttctcagag tttgactcag atatatgcct tacctgaaat
      601 tcctcaagat caaaatgctg cagaatcgtg ggaaacctta gaagcggact taattgaact
      661 tagccaactg gtcactgact tctctctcct agtgaattct cagcaggaga agattgacag
      721 cattgcagac catgtcaaca gtgctgctgt gaatgttgaa gagggaacca aaaacttagg
      781 gaaggctgca aaatacaagc tggcagctct gcctgtggca ggtgcactca tcgggggaat
      841 ggtagggggt cctattggcc tccttgcagg cttcaaagtg gcaggaattg cagctgcact
      901 tggtggtggg gtgttgggct tcacaggtgg aaaattgata caaagaaaga aacagaaaat
      961 gatggagaag ctcacttcca gctgtccaga tcttcccagc caaactgaca agaaatgcag
     1021 ttaaaaacca aatttcagta ttattggtgc caacatgtct atcctgagga cctttgctgc
     1081 tgttggacac tccgtcacct tttggaacac aagtatatca agatagtggc tactgatgtt
     1141 caagtgggat tgaagtgtga taaatggata tattttgttg tttgctgggg tgttcatgga
     1201 gatgttaaga gattgaggcc ctgggctgag ggtatataat gtatgtcagg taaagtttga
     1261 agactgccaa ggagcagatt ttctccctgg aaatgtgaaa actgaaccta taactctgat
     1321 aaggacttga gatgtgtaga aacgttgggt tatggaagac tagtttcttc cataaccctg
     1381 aattggagac cttaatgcta agtgtagatt attgaggttt gttagtgagg aaaagaataa
     1441 gagttcagaa gcctttgtta tcagatagcg aaatcagggc ctagtgagga gcacaggtcg
     1501 actacataat ggagtccatt ggcgaaccct attgcaattt ggtccaacta tatcttctgg
     1561 tgaaggaaat taatgatgta agaaaatgca agaggctcaa cttctcttcc aaaaatcttc
     1621 tggcttctga actcttcctc tgcctctctt taaataaata acacagaatt tcaagtggta
     1681 ggagacttat taagccagtc accaagcttg gtctgtcagc ctgtcttcta acacctcaaa
     1741 gatcttgtgc cctgtgctgt ccctcccttg taattatgaa aagttctttg gtttctgggg
     1801 tgaattctac ccatgtataa tgaggaattc tctcataacc ttttttgtct tgtctgtcat
     1861 ctctgttcat cccttcctat aacctctagg taaaaagaaa agaaaaaaag aaatttcgag
     1921 atattttcaa cattgttaga gtttgggcta aaatgagcaa ggagaaaaaa accaccaaga
     1981 acatttcctg gggcatgttc cagttttgag gggtgatata tctgccagat agggggtatc
     2041 tgacccagtc ttcttttcag ctggtctctg gggggagctg agaactcgct tgctacctca
     2101 catccttttc cccagacttt ttatctccta tgcatccctt tgctttctat agctggtgtt
     2161 tcttccccaa aatggcgttc ccatgcttac ctttctcaca ttctagacaa tgatggacaa
     2221 agacgcatgc aagactcaga cccggggaat ggtgtggtgc taatctcaac acctgacatt
     2281 cacagcaagc atggcccagc ccaactgcat gtctatctca aaccgcagaa aggctttaat
     2341 actggaaaaa aagaattcaa gactacaggc agctcccctc tgtaccccaa ctcatttaaa
     2401 ataggaggaa tcactttttg ccttacttaa cgcttttttc tgagcacagg gatgggcacc
     2461 tgcaccccag aaggtgtgag ctgtctctct gccaggagct aaggttcatt aggggattgg
     2521 atggtttatc acttctttct ttctgagttt acttttagta acttttattg atggctacct
     2581 ttcatgtccc tgtctaaaga gactttctct ttcatacgtc ttaaatctca tcaatgaaat
     2641 ccagtgaaac agcaccattt cttagtatca ttaaataact agaaagtatc aagtattgct
     2701 ctctgctgct ttatatcatt aacatattaa taataccaag aaggaaatac tttgaataag
     2761 tgtcagattc tgatccagta ttggacacct gtgatattgg acacctgtga ggctgggata
     2821 attacttttg aattacacct cttctctagt ttctggacct tgctctgtca ctttaacaca
     2881 gggtgatcaa acctgaatga ggatcagaac tcacccaggc acatactaaa gcaagattcc
     2941 taaacctcag ttccaggggt aattctgaca tcacccgtcc agcatagtca gctgaaatta
     3001 taaatctaag aaacagttac atcaagattc tgctgtgtca tttaattctg aaactcccag
     3061 tattctaccc ttcttcatca ctgcatatta ccccactctt ccatcccaaa ttggctatcc
     3121 tttcagccca ccaacttagc ggcagcacta gggattcatt ataaggtaaa tctggtttac
     3181 ataaagacct gaaggaggcc tgtatttgaa gctcacactt ggtattggta tctctcattt
     3241 ttactgagcc agtgtggaat accactgtat gtactcatat aagcccttga cttttactgc
     3301 tcatcaggat tggaatatta ctctagcagt cttcacacat aggcaagtta cagtcctttt
     3361 aaaaagtatc tcatttccct ataatggaac ctaatagcca actttttcat agaaattgct
     3421 agaagagttt gatcaactat aaatgataaa gtgtttataa gcatagtcag tgtgacacag
     3481 aaaccaatct taaaattgaa tttaatgttt tatcatatca gattaaatat tttctccatg
     3541 tcttattttt actgcaacaa gttagaaagt gggaacactt tgattaatgt cttaaaattt
     3601 gtgggccctc atttggataa aggcagcaat cctaaggact tttttttttt ttttaacata
     3661 atctgagaat ttctctgtag agcagagact ttcaaacctt ttggctgtaa cccacagtaa
     3721 aaaacgcatt tatatcaaac cttagaatat gtttaatgaa caatacttac cattctgatg
     3781 ctttttattg tttcagtttt taaaatatgc cagttgcaac ccactaaatt gatatctacc
     3841 aatgggttgc aacccttagc ttgaaaaaaa caccctcaca gaggaactgg tatttcttga
     3901 ataccttctg tttgccaggc acttcaccag gcattttaca agtaaggaaa ctgggcttca
     3961 gagaaaataa tttgcagagg tttactcaac tacaaagggg tgaagccagg aatgttaact
     4021 aggtctgttg agctacaaaa acttttatgt ctctcagact atacagcctc tatacaaaat
     4081 tgagatgggg gttgggggca ggggctcatg cctgcaatcc cagcacttag ggaggcagag
     4141 gccagaggat cacttgagcc caggagtttg agaccagcct gggcaacata gtgagactct
     4201 tgtctgtatg aaaaaaatta agaattagct gggtgtggca tagcacacac ctgtggtccc
     4261 agctacatgg gaagctgaag tgggaggatc acttgaactc aggagcagcc ttggtgacag
     4321 aacaagaccc tctctcaaaa aaatatttaa aaaaaggtgg gtcatccatt ctcctttacc
     4381 aaacaggctt tgaaatgaca cattccattc atttgcatct ttttaaaaaa cttctgattc
     4441 cttactgagt gtccagcagc ctcaaagttt ttaatggtag ctgatgcaga cataaacagt
     4501 gctcaatttg gcccttaaac tataaaatca agaaagagta tttcaatccc atccacctgc
     4561 ctgcaagatt tcttaatgtt cactagttat aaccattgtt taaacagtgc tttttgtgta
     4621 atttaaaaat aaactttaat gctttttaaa acaaatttat cataattcat agatcaaatg
     4681 attatccttt aaaatgatac ccttgggaaa tcatgtactt actgtagtga tgctagtatt
     4741 aatattactt agaccaattt tgaaactgtt ctttcagaat tgcctccaaa gacattttgc
     4801 agatcatccc agaaaagggg gtatgatggt gctgtgtaga actgaccaga gttcctggag
     4861 gattttgagg ttatactgaa actgagtgct gtacagggag aattgcatga gtccagaaac
     4921 ttccttctgt gggctgcctg ccttcctgcc ctcccttaag tgctctaaga tttttgtaca
     4981 ggagtaagaa tcaaatactg gtaacatcaa tcacaagaag ttgaggaaac ctgtaatata
     5041 gctagataat atacaacgtt tgtcttccat cagagtgcag aaaccaaacc atgctttgtg
     5101 ttaaccttaa atatgaaagg tgtttctcag ggtccccttt gtccttcgtt gctgccatat
     5161 gaaatcttac aaggaaggat gaggaaaagc ctggggggag gttctcctcg gaaatgaggt
     5221 ggtttttttt gttattaagt agaacgtggc tgtggttcac aggtacttaa cgaatgttag
     5281 atgatgttct taagtaatca gaggcctaat aaaaggcagg ggagtttctc ttctagccta
     5341 aattaatatt aaaagttcag gggtattttt tgtttttaaa ttaatacttt attgttttta
     5401 acaggtggtt ctcataattt acattcatta atttgatgcc cttttacaaa gaaacttctt
     5461 aggtattata aaccatcaat gtaaaggatc cacatggtat gtatccacat tgctactctc
     5521 aaatagaaat gggagataag aaatatatct gtgcaatatt aaattgaaaa aaaaaaaccc
     5581 ataaaaagtg tcaaaggcaa ataatttgct ctagatcaca aaactagtta gcacaaggct
     5641 aggattataa ccagggtcta ggaaaaaatc ctgaaggtga tttaactgag tgttaggccc
     5701 tgtcaagcca cctgctaagg ctcatggtct ttcagactag cttcaacatt ccaaatcagg
     5761 caatagctac aacggaaaga taattggacg gggaatcctg agatcagagt cctagtttgg
     5821 ctttgtctct tgtagcagga ttttttaaat caggggcagc tctcttctcc catcccagcc
     5881 atgaatcttt caaccttagt ggtcaccaac ttgactccat tccttatatc aagacttgtc
     5941 ctgtcaattc tcccttaaat gttagttgca tccatttcta aatatatcca tggccatcac
     6001 cctagtaaaa agactattac ctcacacccc gcacttgatc ttcccccaac tttaagtgac
     6061 tcagttcctt atatcactgc cacaagaatt aacaaccatg tccatctttc atttttctgc
     6121 tgaaagattt tcagtggttc ccactgaata ccaaataaag ttcgaatccc ttagattggc
     6181 attcacagcc ttctacgttc tggccccagc tttatctctt gaaactcact actcaccatc
     6241 tgacaatgcc actaaaaatc cacaagagtg attttaaggt ttttctatgg tgaaggttca
     6301 aactggtaat aaaccatgtt tacatttttc tggtctaaaa taatttctat attactttat
     6361 aatagtcagc tgggggttat ttaagctctt ggacgagcct aaaacttgta tcctgaagaa
     6421 aatatttttt tccaccagaa gaaattgctt tcaatttctt aaccttcaaa acaatgtcag
     6481 tgttgtcacc tgtgcatttg atagccacag cacaagtatt cttcaggagc ataaatcctc
     6541 cagccttgaa tggaccattg tccagctcct gtgaaaaact taatatttga gaaagacatt
     6601 caatggtaca tgttttctgt acacttcatg agtagttgag attttcttgt attaaggtta
     6661 atcactaaaa aggtgtttac ttgggtttcg ttaactaaac cccctaaaga tgttttccat
     6721 tttattgtta aacacttggt gttagcaagg gtcagcacga gaaaaggccc aatggcaaga
     6781 atttctgcaa actctgtaaa gcttactgaa ttcatttgtc atttattaca ttgctgagtg
     6841 gtgcttgaat aaggaaacat gcaataaatt tacttattta accaa
//
