LOCUS       NM_001001433            4937 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens syntaxin 16 (STX16), transcript variant 1, mRNA.
ACCESSION   NM_001001433
VERSION     NM_001001433.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4937)
  AUTHORS   Odom,J., Bacino,C.A., Karaviti,L.P., Bi,W. and Hoyos-Martinez,A.
  TITLE     Intrafamilial phenotypic heterogeneity in siblings with
            pseudohypoparathyroidism 1B due to maternal STX16 deletion
  JOURNAL   J Pediatr Endocrinol Metab 37 (1), 84-89 (2023)
   PUBMED   38095637
  REMARK    GeneRIF: Intrafamilial phenotypic heterogeneity in siblings with
            pseudohypoparathyroidism 1B due to maternal STX16 deletion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4937)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4937)
  AUTHORS   Kiuchi,Z., Reyes,M., Hanna,P., Sharma,A., DeClue,T., Olney,R.C.,
            Tebben,P. and Juppner,H.
  TITLE     Progression of PTH Resistance in Autosomal Dominant
            Pseudohypoparathyroidism Type Ib Due to Maternal STX16 Deletions
  JOURNAL   J Clin Endocrinol Metab 107 (2), e681-e687 (2022)
   PUBMED   34477200
  REMARK    GeneRIF: Progression of PTH Resistance in Autosomal Dominant
            Pseudohypoparathyroidism Type Ib Due to Maternal STX16 Deletions.
REFERENCE   4  (bases 1 to 4937)
  AUTHORS   Chen,Y., Gan,B.Q. and Tang,B.L.
  TITLE     Syntaxin 16: unraveling cellular physiology through a ubiquitous
            SNARE molecule
  JOURNAL   J Cell Physiol 225 (2), 326-332 (2010)
   PUBMED   20589833
  REMARK    Review article
REFERENCE   5  (bases 1 to 4937)
  AUTHORS   Chua,C.E. and Tang,B.L.
  TITLE     Syntaxin 16 is enriched in neuronal dendrites and may have a role
            in neurite outgrowth
  JOURNAL   Mol Membr Biol 25 (1), 35-45 (2008)
   PUBMED   17852734
  REMARK    GeneRIF: Syntaxin 16 may thus play a role in neurite outgrowth and
            perhaps other specific dendritic anterograde/retrograde traffic.
REFERENCE   6  (bases 1 to 4937)
  AUTHORS   Dulubova,I., Yamaguchi,T., Gao,Y., Min,S.W., Huryeva,I.,
            Sudhof,T.C. and Rizo,J.
  TITLE     How Tlg2p/syntaxin 16 'snares' Vps45
  JOURNAL   EMBO J 21 (14), 3620-3631 (2002)
   PUBMED   12110575
REFERENCE   7  (bases 1 to 4937)
  AUTHORS   Mallard,F., Tang,B.L., Galli,T., Tenza,D., Saint-Pol,A., Yue,X.,
            Antony,C., Hong,W., Goud,B. and Johannes,L.
  TITLE     Early/recycling endosomes-to-TGN transport involves two SNARE
            complexes and a Rab6 isoform
  JOURNAL   J Cell Biol 156 (4), 653-664 (2002)
   PUBMED   11839770
REFERENCE   8  (bases 1 to 4937)
  AUTHORS   Simonsen,A., Bremnes,B., Ronning,E., Aasland,R. and Stenmark,H.
  TITLE     Syntaxin-16, a putative Golgi t-SNARE
  JOURNAL   Eur J Cell Biol 75 (3), 223-231 (1998)
   PUBMED   9587053
REFERENCE   9  (bases 1 to 4937)
  AUTHORS   Tang,B.L., Low,D.Y., Lee,S.S., Tan,A.E. and Hong,W.
  TITLE     Molecular cloning and localization of human syntaxin 16, a member
            of the syntaxin family of SNARE proteins
  JOURNAL   Biochem Biophys Res Commun 242 (3), 673-679 (1998)
   PUBMED   9464276
REFERENCE   10 (bases 1 to 4937)
  AUTHORS   Haldeman-Englert,C.R., Hurst,A.C.E. and Levine,M.A.
  TITLE     Disorders of GNAS Inactivation
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29072892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050327.6, AL139349.37 and
            KF456959.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001001433.2.
            
            Summary: This gene encodes a protein that is a member of the
            syntaxin or t-SNARE (target-SNAP receptor) family. These proteins
            are found on cell membranes and serve as the targets for V-SNARES
            (vesicle-SNAP receptors) permitting specific synaptic vesicle
            docking and fusion. A microdeletion in the region of chromosome 20
            where this gene is located has been associated with
            pseudohypoparathyroidism type Ib. Multiple transcript variants have
            been found for this gene. Read-through transcription also exists
            between this gene and the neighboring downstream
            aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also referred to as
            isoform B).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.213711.1,
                                           SRR1803617.15616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371141.8/ ENSP00000360183.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-856               AL050327.6         109826-110681
            857-868             AL050327.6         118166-118177
            869-976             AL139349.37        2765-2872
            977-1117            AL139349.37        3262-3402
            1118-1280           AL139349.37        4566-4728
            1281-1329           KF456959.1         1-49                c
            1330-1372           AL139349.37        5836-5878
            1373-1516           AL139349.37        6429-6572
            1517-1597           AL139349.37        8906-8986
            1598-4937           AL139349.37        11462-14801
FEATURES             Location/Qualifiers
     source          1..4937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..4937
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="syntaxin 16"
                     /db_xref="GeneID:8675"
                     /db_xref="HGNC:HGNC:11431"
                     /db_xref="MIM:603666"
     exon            1..856
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     CDS             725..1702
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaxin-16 isoform a"
                     /protein_id="NP_001001433.1"
                     /db_xref="CCDS:CCDS13468.1"
                     /db_xref="GeneID:8675"
                     /db_xref="HGNC:HGNC:11431"
                     /db_xref="MIM:603666"
                     /translation="MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHITSSPLHSRSIAA
                     ELDELADDRMALVSGISLDPEAAIGVTKRPPPKWVDGVDEIQYDVGRIKQKMKELASL
                     HDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRARACSEQEGRLLGN
                     VVASLAQALQELSTSFRHAQSGYLKRMKNREERSQHFFDTSVPLMDDGDDNTLYHRGF
                     TEDQLVLVEQNTLMVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVE
                     QSCIKTEDGLKQLHKAEQYQKKNRKMLVILILFVIIIVLIVVLVGVKSR"
     exon            857..868
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            869..976
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1117
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1280
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1372
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1516
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1597
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..4937
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4794..4799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="hexamer: AATAAA"
     polyA_site      4827
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="major polyA site"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="hexamer: AATAAA"
     regulatory      4901..4906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="hexamer: ATTAAA"
     polyA_site      4909
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
                     /note="major polyA site"
     polyA_site      4937
                     /gene="STX16"
                     /gene_synonym="SYN-16; SYN16"
ORIGIN      
        1 agatccgggg atggagggag ccggagaaga ggagtgagaa ggccggggag gcaggccctg
       61 ctgtcttcct gcaggccggc agcctgctgg cagtggagga ccaggccgtc caggaaagga
      121 aggggtcagg aggtcgggca gggcctcagc aggttcagac aagtccccag aagggagctg
      181 caggcgccct cgagtccagg ccccaagcct ggctccggtt gtccaaagag ggcctaggcc
      241 aggcctctgg tgcggaaact gagtcacagc cagacctcag ggcacggcct agacgcttac
      301 gagccaaagt taggggtaga gagcagagac ctccgggggg tctcagggag tagggggctt
      361 cagggcctcc cagtctagag ccggattggc gagttagacg cttgtagatc caaggttgga
      421 ttggggtggg gtctctggga cgttggatcg ctacgcaagg attgggggga ttcaagtgct
      481 tagagatcga agtctgccct gggtaggggg agtcagacaa ttggaaagcc taggtagtta
      541 tttggggagg ggtctctacg ccttggcgaa gcgcacagct gcatcttttt ggcttgaggc
      601 ctgaggcctt gtcgagaagc ttccgtgaaa gggtgggcca gccgggccac gagaaagaaa
      661 gtgaataaat caggaatata agtgggcggg gggcccctga gaggggggtc gcaaagggtg
      721 agacatggcc accaggcgtt taaccgacgc tttcttgttg ttgcggaata attccatcca
      781 aaaccggcag ctgttagccg agcaagtgag tagtcacatc acctccagcc ctctgcattc
      841 acgtagcatt gctgcggagc tggacgagct tgctgatgac cgtatggcac tggtgtcagg
      901 catcagctta gatccagaag cagcgattgg tgtgacaaaa cggccacctc ctaagtgggt
      961 ggatggagtg gatgaaattc agtatgatgt tggccggatt aagcagaaga tgaaagaatt
     1021 ggccagcctt catgacaagc atttaaacag acccaccctg gatgacagca gcgaagagga
     1081 acatgccatt gagataacta cccaagagat cactcagctc ttccacaggt gccagcgtgc
     1141 cgtgcaggcc ctgccgagcc gggcccgggc ctgctccgag caggaggggc ggctgcttgg
     1201 gaacgtggtg gcctcgctgg cgcaggccct gcaggaactc tccaccagct tccggcacgc
     1261 acagtcaggc tacctcaaac gcatgaagaa tcgagaggaa agatcccagc attttttcga
     1321 cacatcagta ccactaatgg atgatggaga cgataacact ctttaccatc ggggttttac
     1381 agaggaccag ttagttctgg tggagcagaa cacactgatg gtggaagagc gggaacgaga
     1441 gattcgccag attgtacagt ccatttctga cctgaatgaa atattcaggg acttaggggc
     1501 gatgattgta gaacagggta cagtccttga cagaattgac tataacgttg aacagtcctg
     1561 tatcaaaact gaagatggtt tgaaacagct tcacaaggca gaacagtatc aaaagaagaa
     1621 tcggaagatg cttgtgattt taatattatt tgtcatcatc attgtgctca ttgttgtcct
     1681 cgttggcgtg aagtctcgat aagtggcatt gggttttcgt gtgtgccgcg cgtgtggatc
     1741 tcccgggtgt gaggggcttg gcctgcgccc cgccagctgc ccgcagaggt gcagcctcga
     1801 ggaatctgag ggcgtcgggg cagcgaacct ttgcatccac ggactcctcc ttccctagtc
     1861 ctgctcaagc ggtccgggga atgggttttt gtttttcctt cattgttgag aatttaagga
     1921 cctttgatac tgctgcacaa tagagattga gttctgggat cagttataat atatattttt
     1981 tttagaaaga gaaaatgagc tgagagttta caggcactgc agaagctgtt cagtattata
     2041 tgtgtatatg ctattttttt agcagccatg tctgagcaga atgttaacat aatttttgga
     2101 aaaattttct ttaaaccatc tggtttttaa gaaatttggt accaaaaatt gatgagtaga
     2161 ggcaaaaatg ccccttcatc tttctctata tattttccag ttgaaaacaa actaagaagt
     2221 cctttaagaa tttataatcc gttccccatt aacttaattt agcttttcca tcactgttaa
     2281 tgatcagagt aacaaagtgt gaaaaataag aaaccatcat tgatgttaat taacacattt
     2341 agatgggcca gttaaaacag cttcataagt tttaaattaa ttgtaaatgg aatattcctc
     2401 atttaaaatt tttgcactgc attttctact gtaaaccaaa agaggttact aagcaaaacc
     2461 acctaaattt aagttggtga tttaaatgaa tctcacatta aaagaaagct tgacagtgtt
     2521 atgaaagcca ccagactcag ccagtgtgtc cccatgggta tccccagcca tccttgctca
     2581 atccattact tatatactaa ctacataatg acctgttcaa accagactct atttaatgaa
     2641 ctgtgaattt acacagaggc cattttaaat gggtcacccc atttaggatt agtggatctc
     2701 aaattattaa ccaaacatca ctccatttca aagtaaaata ttccaccagc gatttgattt
     2761 attggctctt ccattgccac tgagcaatgc ccaggaagca ggcacattgc caaggactgg
     2821 gggcatcttg actaggaagc tcctcgtttg tgtgagcgtg ggtcagaccg ccaaagtagg
     2881 acttcatcgt ttacctacct attatcaata tggtgcttga atatattcct ataactgtag
     2941 aacagtgtgg aaagtgatgg taactttgaa gttgttcatg ttttattggc tttgttttaa
     3001 ttgacactag tagagtttta atggtctttg tgtaaatttt aatggctttt ccattgtttt
     3061 tgcttctctt aaaaagttta agaagaatat gacctcatta aatgtgctgt tttatttgga
     3121 ccagtcacac aaaatgtctc tctagagttg actttaaagt tgtttacaga aatttaaact
     3181 caattccaga gattgaagtt gtccaaacag ctcatgggct tagtgtccaa acccctgccc
     3241 agccttccct ttccaagttg gtgccacctc caggtagcca ttggtggttt tcctattact
     3301 gatgtggctg tggaatgata aggtcctaga ggggccctgg catttcagga agcggacctg
     3361 gtattccctg acaaacattg cttaggaaag agggccggag aataagaagc cagcacctca
     3421 tcagtcagcc ctgcaatgtg agacttccgt agctgttgag agtcactgca ggtgttcttt
     3481 catcccatct gattttaacc catggttgag acgttccaag ttagatctgc tgctcttagg
     3541 tgtggggctg tccacattag ggaacttgcc tcaaaaacag tccacagtgg caataccgga
     3601 cttctgttca agctttttaa agtgctgagc cttacaaacc cctgaaggaa agtgaccctt
     3661 taagagagga tcatcttttt ttatatttat tttcaccaaa tagggtgatg agggttggtt
     3721 tttgttccct caacccattt gggtaaaata acggatctga ttagaaactg ttttaaggag
     3781 gggctgggct cggtggctca cgcctgtaat cccagacttt gagaggccaa ggcggtcacg
     3841 aggtcaggag ttcgagacca gcctagccaa catggtgaaa ccccgtctct acaaaaaata
     3901 caaaaattag ccgggtggga cacgcctgta atcccagcta ctcaagaggc tgaggcagga
     3961 gaatagcttg aacccgggag gcagaggttg cagtgagccg agatcacacc actgcactcc
     4021 agcctgggtg acagagcgag gctccgtctc aaaaaaaaaa aaaaaaaatt gttttagcgc
     4081 tgggtttccc aaggtgggag agacagaccc agcctggagc tggcccctgg cctgtgtgct
     4141 gacttcttgg ggtcctcaaa ccactgtatt tttctgttga gcctgtactt ggggagagat
     4201 cagtagcatt tgaggaagta agagaaaaga atcatggtac ctcagggttt ctttcccttt
     4261 actcgctggc agccattgtc tgtgggcacc tcatgttttt ccacactcta ctgggccgtg
     4321 gaggtaacga tcacccaggc cagtctcctc tgcctgggat gcgccctctg agaggaggcc
     4381 tagcagggca ggctccctct gggcatccct ggatgcagcc tctggacaca tgcctccttt
     4441 aaagtgtccg ggtgcagctc aggttgagtg gaggtagaag gagaaacaga catgtttacc
     4501 acgcgttttc caaagctcct gatctttccc aagattgtaa ctgaaaactg ctgtctcttg
     4561 ttttgttcgt tttgggggtg gtggtgctgg ctgggccatg cttgtgaagt gatgtgtgtc
     4621 tctgatttaa cggattcact gttttctctg ctaattgaga gagcgttatt tacattattt
     4681 atttgttttg acacaagtgc tttcagtgtt ttatcctagc taatggcttc ttaaaggtaa
     4741 taaaaccctt ccaacgtaat tggtcagata aaactttttt tcttgtatgc ttaaataaag
     4801 caattagtga agcacttcta tccaaaatga cttttttgtc cttttttaaa accaatttac
     4861 tgttactgga aactttttgt acaataaagc aatcacgcag attaaagaac atcctgcaat
     4921 cctagtatta attttaa
//
