LOCUS       NM_177424               3034 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 12 (STX12), mRNA.
ACCESSION   NM_177424
VERSION     NM_177424.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Ambrosio,A.L., Febvre,H.P. and Di Pietro,S.M.
  TITLE     Syntaxin 12 and COMMD3 are new factors that function with VPS33B in
            the biogenesis of platelet alpha-granules
  JOURNAL   Blood 139 (6), 922-935 (2022)
   PUBMED   34905616
  REMARK    GeneRIF: Syntaxin 12 and COMMD3 are new factors that function with
            VPS33B in the biogenesis of platelet alpha-granules.
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Bowman,S.L., Le,L., Zhu,Y., Harper,D.C., Sitaram,A., Theos,A.C.,
            Sviderskaya,E.V., Bennett,D.C., Raposo-Benedetti,G., Owen,D.J.,
            Dennis,M.K. and Marks,M.S.
  TITLE     A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into
            endosome-derived tubular transport carriers
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33886957
  REMARK    GeneRIF: A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into
            endosome-derived tubular transport carriers.
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   McBride,H.M., Rybin,V., Murphy,C., Giner,A., Teasdale,R. and
            Zerial,M.
  TITLE     Oligomeric complexes link Rab5 effectors with NSF and drive
            membrane fusion via interactions between EEA1 and syntaxin 13
  JOURNAL   Cell 98 (3), 377-386 (1999)
   PUBMED   10458612
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
REFERENCE   8  (bases 1 to 3034)
  AUTHORS   Prekeris,R., Klumperman,J., Chen,Y.A. and Scheller,R.H.
  TITLE     Syntaxin 13 mediates cycling of plasma membrane proteins via
            tubulovesicular recycling endosomes
  JOURNAL   J Cell Biol 143 (4), 957-971 (1998)
   PUBMED   9817754
REFERENCE   9  (bases 1 to 3034)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   10 (bases 1 to 3034)
  AUTHORS   Tang,B.L., Tan,A.E., Lim,L.K., Lee,S.S., Low,D.Y. and Hong,W.
  TITLE     Syntaxin 12, a member of the syntaxin family localized to the
            endosome
  JOURNAL   J Biol Chem 273 (12), 6944-6950 (1998)
   PUBMED   9507000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM148993.1, AL035306.1 and AF070635.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177424.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.156651.1,
                                           SRR1803611.83271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373943.9/ ENSP00000363054.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BM148993.1         38-58
            22-3032             AL035306.1         1-3011
            3033-3034           AF070635.1         1614-1615
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..3034
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /note="syntaxin 12"
                     /db_xref="GeneID:23673"
                     /db_xref="HGNC:HGNC:11430"
                     /db_xref="MIM:606892"
     exon            1..207
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..920
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /codon_start=1
                     /product="syntaxin-12"
                     /protein_id="NP_803173.1"
                     /db_xref="CCDS:CCDS310.1"
                     /db_xref="GeneID:23673"
                     /db_xref="HGNC:HGNC:11430"
                     /db_xref="MIM:606892"
                     /translation="MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIK
                     NLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQ
                     KERLMNDFSAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEE
                     WNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDS
                     IEANVESSEVHVERATEQLQRAAYYQKKSRKKMCILVLVLSVIILILGLIIWLVYKTK
                     "
     exon            208..277
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            278..377
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            378..515
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            516..559
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            560..665
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            666..738
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            739..821
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     exon            822..3034
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /note="major polyA site"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="STX12"
                     /gene_synonym="STX13; STX14"
                     /note="major polyA site"
ORIGIN      
        1 cccagtttct ccgtcagcct gcgggtcccg gctggcggct gcttccggta ggagagcggt
       61 gtagagcgag caggtctcag ctcctcgtca tgtcatacgg tcccttagac atgtaccgga
      121 acccggggcc ctcggggccc cagctccggg acttcagcag catcatccag acgtgcagcg
      181 gcaacatcca gcggatcagc caagccactg ctcagataaa gaatttgatg agccagctag
      241 gaactaagca ggactcaagc aagctacagg aaaatctgca acagttacaa cactccacaa
      301 atcagctcgc caaggaaaca aatgaattgc tgaaagaatt agggtccttg ccccttccct
      361 tatctacttc agaacagcgc cagcagagac ttcagaagga acgcctcatg aatgacttct
      421 ctgcagcctt aaacaatttc caggctgtgc agagaagggt atctgaaaag gaaaaggaga
      481 gtattgccag agcaagagct ggatctcgtc tttctgcaga agagaggcaa agagaggagc
      541 agctggtctc atttgacagc catgaggagt ggaaccagat gcagagccag gaggatgagg
      601 tggccatcac tgagcaggat ttggaactta ttaaagaaag agaaacggca attcggcagc
      661 tggaggctga cattttggat gtcaatcaga tatttaaaga tttggccatg atgatccatg
      721 accagggtga tctgattgat agcatagaag ccaatgtgga aagctcagag gtgcacgtcg
      781 aaagagccac tgaacagtta cagcgagctg cttactatca gaaaaaatct cgcaagaaga
      841 tgtgtatcct ggtgcttgtc ctgtcagtga ttattctaat cttgggactt attatctggc
      901 tagtttataa aacgaagtga ttgcctccga tcgttctccc gctgagctgt tttcaagggc
      961 aagtgcttgt tgaagtcttg ccagaacaaa ctgatcacaa gaagacagca tatatcagaa
     1021 cgtcctgtaa tcatttagtt agaaactaac tactaactag tctttggaat tcgtgaccta
     1081 tggagacagt aattatcaat ttattgattc tattgatttc tcaaattagg aattaactta
     1141 tgtggatttt gcttcctctt gtattctgat tgcccttcat cccaagtgtt tactgaaaat
     1201 tccattctag atattcttgt tttgacaaat gacactacag tctcgtaata ttgtctttta
     1261 tgtatataca aaatttacct ttttactagc atctgagata gagttacttt ctggtaccca
     1321 gtatattgga gtctgtcaga aactctataa taggccacca gtttttatta tttaacattt
     1381 ttatttgaat ttctaagaag cctattctct atctattttg aaagattttg gcactatatt
     1441 taattggaag gtaaaatatt gtacatgtga tccagagtaa atgagaagtc tctatctgag
     1501 ctggtcagtt actggagtac atgttactaa tctgggttta aagtttactt cattatctgc
     1561 tagtgtcatc cacagcagtt catcctcatc cacactaagc catcctgtta gcttttaaag
     1621 gaagttaatt taattaacat taatatactc tatgggctcc ctctcccacc tgtctgcata
     1681 gaaaggcaga attagacata gcatgctttg gaaaagcaaa taggaattgt tgggaatgat
     1741 ttaatcttgt tgttgttgtt gttgttgttc acttgtggtt ctacattcct ggtgaatgat
     1801 gaatgttgct gtcaaagggc tgccccctac cttataaggg ttgctgggca tttgaaggca
     1861 ggaagatttt taaagataga ttgaggttgg tttaaaatta ttcctgtaaa ccaacaataa
     1921 agcaaagaag aggttcattt ttgtaaataa cactggtttc aaatagtgat gttagactta
     1981 acctaattta taaacaagag attaatatct ccatgcatag ttttagacaa aaaaagatgt
     2041 ttcaataaaa ttactgtctt gtaatataaa tgttgtccac ttcccttttc cacaggccta
     2101 gaacagttaa agggaacata atttgtttag gctcccacat aaatgtgaat ctggccaaca
     2161 actttggttc atcctttagt gaattagagg atttggctac cctgagtata tttatattca
     2221 tttcttctgt tctccttctg ttattatact taatcttcta aactaaacta atgtgaacag
     2281 tagggaagca agggcccaaa tgcataagtt tctttgcact gttgcactta cttaatacaa
     2341 ataaatgttt tttaaagctt ttgtagtatg tttttatgag ttaacatcct aatgtggtag
     2401 gtattaggta atgtgctgtc atgagaaaaa ttgagacttc caagaaaact ggacaccagg
     2461 tgagggttgg tttggagacg gaataggtgt agctgccttt ccttgaaaaa cagtgtgtag
     2521 agatggctga gtgcaatggc tcacacttgt aatcccaaca ctttggaagg ctgaggcggg
     2581 aggatcagta tatcggtacg tctgagccca agagttcaag atcagcctgg gcagtatagc
     2641 aagaccccat ctccattttt tttttaatga ttttttaatt aaaaaaaaga acaacaggat
     2701 agagctgttg gggtggcaca gtggcccaaa gagcagcttc agagataatt ccttggttct
     2761 atgatccctg tttaactcca aattacagtc ggacttggat acatcatttg taacattgta
     2821 ggaaagaaaa aagtcttggt tgtgaaaaac gatttgcatt tgggtaaaat aaagtgacca
     2881 tgcttttgtt ctgtaatact gtgtgacctg tggttgttgt aatggtgatc atggagagca
     2941 aatatgaact tggcctggat tttaaatggc ctagaatttg tggtagttgc caaagaggtt
     3001 ctcctaggtg gtcttaataa acctattcac agaa
//
