LOCUS       NM_003764               5504 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens syntaxin 11 (STX11), mRNA.
ACCESSION   NM_003764
VERSION     NM_003764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5504)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    GeneRIF: Patients and mice with deficiency in the SNARE protein
            SYNTAXIN-11 have a secondary B cell defect.
            Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c.. PMID: 38771261]
REFERENCE   2  (bases 1 to 5504)
  AUTHORS   Wang,J., Li,D.L., Zheng,L.F., Ren,S., Huang,Z.Q., Tao,Y., Liu,Z.,
            Shang,Y., Pang,D., Guo,H., Zeng,T., Wang,H.R., Huang,H., Du,X.,
            Ye,H., Zhou,H.M., Li,P. and Zhao,T.J.
  TITLE     Dynamic palmitoylation of STX11 controls injury-induced fatty acid
            uptake to promote muscle regeneration
  JOURNAL   Dev Cell 59 (3), 384-399 (2024)
   PUBMED   38198890
  REMARK    GeneRIF: Dynamic palmitoylation of STX11 controls injury-induced
            fatty acid uptake to promote muscle regeneration.
REFERENCE   3  (bases 1 to 5504)
  AUTHORS   Ganesan,S., Alvarez,N.N., Steiner,S., Fowler,K.M., Corona,A.K. and
            Roy,C.R.
  TITLE     Syntaxin 11 Contributes to the Interferon-Inducible Restriction of
            Coxiella burnetii Intracellular Infection
  JOURNAL   mBio 14 (1), e0354522 (2023)
   PUBMED   36728431
  REMARK    GeneRIF: Syntaxin 11 Contributes to the Interferon-Inducible
            Restriction of Coxiella burnetii Intracellular Infection.
REFERENCE   4  (bases 1 to 5504)
  AUTHORS   Bahadir,A., Kader,S., Cebi,A.H., Erduran,E., Mutlu,M. and Aslan,Y.
  TITLE     Familial Hemophagocytic Lymphohistiocytosis With Heterozygous STX11
            and Homozygous UNC13D Mutations Diagnosed in the Neonatal Period
  JOURNAL   J Pediatr Hematol Oncol 44 (4), e866-e868 (2022)
   PUBMED   35293882
  REMARK    GeneRIF: Familial Hemophagocytic Lymphohistiocytosis With
            Heterozygous STX11 and Homozygous UNC13D Mutations Diagnosed in the
            Neonatal Period.
REFERENCE   5  (bases 1 to 5504)
  AUTHORS   zur Stadt,U., Schmidt,S., Kasper,B., Beutel,K., Diler,A.S.,
            Henter,J.I., Kabisch,H., Schneppenheim,R., Nurnberg,P., Janka,G.
            and Hennies,H.C.
  TITLE     Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4
            to chromosome 6q24 and identification of mutations in syntaxin 11
  JOURNAL   Hum Mol Genet 14 (6), 827-834 (2005)
   PUBMED   15703195
REFERENCE   6  (bases 1 to 5504)
  AUTHORS   Martin-Martin,B., Nabokina,S.M., Lazo,P.A. and Mollinedo,F.
  TITLE     Co-expression of several human syntaxin genes in neutrophils and
            differentiating HL-60 cells: variant isoforms and detection of
            syntaxin 1
  JOURNAL   J Leukoc Biol 65 (3), 397-406 (1999)
   PUBMED   10080545
REFERENCE   7  (bases 1 to 5504)
  AUTHORS   Valdez,A.C., Cabaniols,J.P., Brown,M.J. and Roche,P.A.
  TITLE     Syntaxin 11 is associated with SNAP-23 on late endosomes and the
            trans-Golgi network
  JOURNAL   J Cell Sci 112 (Pt 6), 845-854 (1999)
   PUBMED   10036234
REFERENCE   8  (bases 1 to 5504)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   9  (bases 1 to 5504)
  AUTHORS   Tang,B.L., Low,D.Y. and Hong,W.
  TITLE     Syntaxin 11: a member of the syntaxin family without a carboxyl
            terminal transmembrane domain
  JOURNAL   Biochem Biophys Res Commun 245 (2), 627-632 (1998)
   PUBMED   9571206
REFERENCE   10 (bases 1 to 5504)
  AUTHORS   Zhang,K., Astigarraga,I., Bryceson,Y., Lehmberg,K., Machowicz,R.,
            Marsh,R., Sieni,E., Wang,Z. and Nichols,K.E.
  TITLE     Familial Hemophagocytic Lymphohistiocytosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM150302.1, BC033519.1,
            BQ030324.1, AL135917.15, CR739089.1, AI791689.1 and BF941242.1.
            
            On May 17, 2019 this sequence version replaced NM_003764.3.
            
            Summary: This gene encodes a member of the syntaxin family.
            Syntaxins have been implicated in the targeting and fusion of
            intracellular transport vesicles. This family member may regulate
            protein transport among late endosomes and the trans-Golgi network.
            Mutations in this gene have been associated with familial
            hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.380161.1,
                                           SRR1660809.237270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367568.5/ ENSP00000356540.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BM150302.1         2-16
            16-1931             BC033519.1         1-1916
            1932-2227           BQ030324.1         23-318              c
            2228-3662           AL135917.15        37335-38769
            3663-4128           CR739089.1         1-466
            4129-4379           AL135917.15        39236-39486
            4380-4916           AI791689.1         1-537
            4917-5257           AL135917.15        40024-40364
            5258-5504           BF941242.1         6-252               c
FEATURES             Location/Qualifiers
     source          1..5504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..5504
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="syntaxin 11"
                     /db_xref="GeneID:8676"
                     /db_xref="HGNC:HGNC:11429"
                     /db_xref="MIM:605014"
     exon            1..187
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /inference="alignment:Splign:2.1.0"
     exon            188..5504
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1056
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /codon_start=1
                     /product="syntaxin-11"
                     /protein_id="NP_003755.2"
                     /db_xref="CCDS:CCDS5205.1"
                     /db_xref="GeneID:8676"
                     /db_xref="HGNC:HGNC:11429"
                     /db_xref="MIM:605014"
                     /translation="MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESL
                     YRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHC
                     KLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIR
                     IQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLE
                     SRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCR
                     TLCCFCCPCLK"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="hexamer: TATAAA"
     polyA_site      1933
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="major polyA site"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="hexamer: AATAAA"
     regulatory      4112..4117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="hexamer: AAGAAA"
     polyA_site      4121
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
     polyA_site      4128
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
                     /note="hexamer: AATAAA"
     polyA_site      5504
                     /gene="STX11"
                     /gene_synonym="FHL4; HLH4; HPLH4"
ORIGIN      
        1 agatgcggcc gcggcggcgc ggagctcggg cggccgtgga ggaactcagc ctcggccgca
       61 ggaggcgccg ggagcggagc cgccgggagt cgcgcaacag gtttccttct ccatcgctgc
      121 gcccacaggg gacgcgcgcc ctgccgggag aggggcttct cggttcgcac tctcgctccc
      181 agtccaggca aaatgaaaga ccggctagca gaacttctgg acttgtccaa gcaatatgac
      241 cagcagttcc cagacgggga cgatgagttt gactcgcccc acgaggacat cgtgttcgag
      301 acggaccaca tcctggagtc cctgtaccga gacatccggg acattcagga tgaaaaccag
      361 ctgctggtgg ccgacgtgaa gcggctggga aagcagaacg cccgcttcct cacgtccatg
      421 cggcgcctca gcagcatcaa gcgcgacacc aactccatcg ccaaggccat caaggcccgg
      481 ggcgaggtca tccactgcaa gctgcgcgcc atgaaggagc tgagcgaggc ggctgaggcc
      541 cagcacggcc cgcactcggc agtggcgcgc atttcgcggg cgcagtacaa cgcgctcacc
      601 ctcaccttcc agcgcgccat gcacgactac aaccaggccg agatgaagca gcgcgacaac
      661 tgcaagatcc gcatccagcg ccagctggag atcatgggca aggaagtctc gggcgaccag
      721 atcgaggaca tgttcgagca gggtaagtgg gacgtgtttt ccgagaactt gctggccgac
      781 gtgaagggcg cgcgggccgc cctcaacgag atcgagagcc gccaccgcga actgctgcgc
      841 ctggagagcc gcatccgcga cgtacacgag ctcttcttgc agatggcggt gctggtggag
      901 aagcaggccg acaccctgaa cgtcatcgag ctcaacgtac aaaagacggt cgactacacc
      961 ggccaggcca aggcgcaggt gcggaaggcc gtgcagtacg aggagaagaa cccctgccgg
     1021 accctctgct gcttctgctg tccctgcctc aagtagcagg ccggcccggg ccgccaccgc
     1081 ccatcccaga ccatggagcg cgctgggaag gacgcaccaa agccgggagc tctgccctgc
     1141 agggagttgc cccaaccctt tccggaactc agtctttaga aaagaaacgc caggttcaag
     1201 aattgcaaac cagcctgtgc ttggaaagat ggttagttga taccgtccga tgattcttca
     1261 gtaaagatag attcccacaa agttgtgcaa tgtcattata tgacaccttg cactcttacc
     1321 gtcttgacag aagccaagta aggaactgaa gttgtatctg actgtagggt gaatgtctga
     1381 ggcctgcctc ctaataaaga ctcaaggagg aagtcaattg ggcatctgct aatagaatga
     1441 actcatgatg gaaacttcag ttcatttact ttgtcctgaa aattccctgg ttctgttcca
     1501 ttttgagcga aattggcctt gggaaaaacc acgttcttcc tttccgattc ttcatccggt
     1561 ctacgctatg caattcctcc ccaaatatag atcttatttc tgctcatttc ccctacttat
     1621 taaaatcaca ccaaacactt actattttct tatctctttc actttttaaa tatctttcac
     1681 caggttatat tttggtatta tttttccaaa catttttaag cactgaatat cgaacaagca
     1741 ctcaaattga agtatcagtc atgttttgtg tatttttcgc tgataaaaat tatttaacat
     1801 ttatattttt acttgattac atatgcacat gtatgtaaat gtaaaatact aatattcact
     1861 aatatatgta cataatgatc aattggttta acttctttta tgtaagtatg gtatataaat
     1921 ttcaagacga acacttttct ggctcttggt attggtttgc ttgttttgag tttgtttcac
     1981 tccagtttgc cccttcctag tccagtttgg gtcaaacttc atgttaaaca actctgcatt
     2041 ggttatggcg gtagacatat ggcggtagaa aatgtatacg gagctagaga caactaacat
     2101 tcttggaaat actgcttttg ttttactgtg gaccattcct tccatgcatt gaaatggaga
     2161 aattcaaagt aaaagaattc tgtttttcaa gcaagcttaa taaacattac attatacaca
     2221 tatttttata catttctggc ttgaccattt agtttacttt ctcaattatt gttaaaattt
     2281 ttctttttcc tttttttttt tttttttttg agatggagtc tcactgtgtt gcccaggctg
     2341 gagtgcagtg gcaggatctt ggctcattgc aacctctgtc tcccaggttc gagcgattct
     2401 cctgactcag cctcctgaga agttgggact ctgggcgcgt gccacaatgt ctggctaatt
     2461 ttttatgttt ttagtaaaga cggtgtttca ccgtgttagc caggatggtc ttgatctcct
     2521 gacctcgtga tccgcccgcc tcagcctccc atagtgctgg gattacaggt gtgagccacc
     2581 atgcctggcc ttttttcccc ccttttgaga cagggtctcc ctttgtcacc caggctgaag
     2641 tgcagtggca taatcatggc ttactgcagc cttaaactcc caggctcaag tgatcctccc
     2701 acctcagcct acaaatagct gagactacag atatgtgcca ccatgcccgg ctaatttttg
     2761 tattttctgt agagacaggg tttgccatgt ggcccaggct ggtctcaaac ttgtgagctt
     2821 gagcaatccg cccaccttgg cctcccaaag tgctgagatt acaggcctga gccactgacc
     2881 ctggccaaat tttttttcta ctagctactg aggctgccac atctggatgg aactgagtgg
     2941 agggggaaaa gaatgaaaaa ctcaaaagaa ttcccatgag ggtgtcttgc tttctctcct
     3001 gagttacaat actttagcaa aatcatgagg ctttagagat atggtgtagt ctgcaaactt
     3061 cttaatgccc ttacccacat ttaccatgtt tcctggcctt cctctgtgtc aactcttagc
     3121 tcttcctaat cattatttaa tacatgagtg agtttagtag tgatcatatt tctcaggtcc
     3181 tttagaagct ggaattttaa aagaattaga aggaggagta tgtgaattct ttggagctca
     3241 ctgcctgact tgcttatgac caggaaaatc tatcccctgt atctaatttt aatttcatgg
     3301 ttaaatttga gaattgtgga aaccaagttc cacaaggcta ttctcatatt tctcccaatt
     3361 tctttttcag ccaactccaa ggatatgtat cacctttgac ttaatttgct ttctctaagg
     3421 gaaaggggaa aaaatgttca catagctcca ctgcaatgtt ttttataata gaggagagat
     3481 attgtaaata gagactgcca gccagtttcc acaaaaaaac gaagagttca taaatttgac
     3541 atgtttgaac ccataaagca ttttctttgc ttggaaccat tataaaagta agtgagtttt
     3601 caggctctat atacatttta attcctcacg ttttatattg gagagttcgg tacagactgt
     3661 ccattactgc accaaaagaa tgagtgaact gttacctata gggaaagaac acttcttctt
     3721 cctgctgttt gggaaccatc tcagtgtggc gtaatggtta ggagtacaga ttccagatcc
     3781 tgtttcttag atttaaatct tgactctgcc acatactagc tgtctgactg aaccttggtt
     3841 tttctgtgct tcagtttcct catctgtaaa acggagataa cagtacttac ctcatagagc
     3901 tgttgtgaaa agtgatgact gaatatgtaa aagcacctag aacagtgcct ggcacatgct
     3961 aagtgctttg ttcattattg ttgttattat gtaattttct ctcagactga gagcactgtt
     4021 agtgacccaa gtaaatttat agtttttaag tacagaggaa aaataaagcc tattttttgt
     4081 taacagtctt aataaataat aaaatggaat aaagaaacca agaccccatc ttctgtgaat
     4141 attagggctt tttttttttt gacagtcata aagatgtttt cactatggca tttctatccc
     4201 tgtgtatatc caaacatgtc ctgaagaaga aatgagatgt tccaccaaaa acacgtaagc
     4261 aggaagcagc tgttctgctc agcttggcag gtgttctttc ctaattcttc ccaagctgtg
     4321 agtcagaaag tcctggaagg agttgtagga agttgtagag gctgggtcac tgacctaaga
     4381 gaaggcatca tttggcccac tgcacgtcct ggcctattca ccaaagccct tcctggctct
     4441 gactgccaca ccaggcagtg ggtgaaatgc tggctttttc cttaagaaat tgtgttctag
     4501 tgccaccaag agatgctgta gagctggctt taccaatctc atgatgcttg cttggcaact
     4561 ctgaaaggtg actttggcca agaagacctt gtggcaattc tgcaaatttt atacactcat
     4621 atcttttagg gtacaaaatg aaagaacaaa tcacaaagaa caatagatcc ttcaggagct
     4681 gaaggtaaga atcttttata gctattttaa catatacagt gactactttc tactagccaa
     4741 atatcaaatt ttacaactac caccaagcca cagattatag gtggtaacaa ctccagaaat
     4801 gtcctaacta ggaaaggtgc tcatctagta tgcatcggta tccaggataa tatgagttag
     4861 aattttaaaa atgtcagtca ttcaaaaata tttgaactgt gacatcacag aagtaatttt
     4921 atggcctttt aaggtaacaa cttaaaaaga gaacagtact ctttttatat caatgccttt
     4981 acatttattt aaaaacagtc ctaatgcttt atagttaaat gtcatatgca gatatgttca
     5041 ggctctaaca tataaagttc ctaacttgac aggaaactac tgaagattgt gtacagctta
     5101 aaaaaaaaaa tagggtaact atagtcttga tttttatgta taaattctat cattctatat
     5161 tttaccatca gacatatttc tactcctttc tttgaagtat gcgaagtatc tccaactgca
     5221 gcatgcaact cattcatttg taatcaagac gatagtttga aacacccaat tgtaatcaga
     5281 gcaacagttg acttcctttt gatagcggag ttgaaaatca ttgcaattaa taaaatgggg
     5341 ctattagaaa tggaaaacga ataggatcta gaatgtaact tcatcatata aatgatgagt
     5401 gtctttgtta tcaacacgtt attaagaatg ggcaagatgt ccttatatac tagaagcttt
     5461 tgtaaagtca tgtgtctatt gataataaag attttcggaa ctga
//
