LOCUS       NM_003765               1304 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens syntaxin 10 (STX10), transcript variant 1, mRNA.
ACCESSION   NM_003765
VERSION     NM_003765.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1304)
  AUTHORS   Lucas,A.L., Ouellette,S.P., Kabeiseman,E.J., Cichos,K.H. and
            Rucks,E.A.
  TITLE     The trans-Golgi SNARE syntaxin 10 is required for optimal
            development of Chlamydia trachomatis
  JOURNAL   Front Cell Infect Microbiol 5, 68 (2015)
   PUBMED   26442221
  REMARK    GeneRIF: Loss of syntaxin 10 leads to defects in normal chlamydial
            maturation including: variable inclusion size with fewer chlamydial
            organisms per inclusion, fewer infectious progeny, and delayed or
            halted reticulate body-elementary body differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1304)
  AUTHORS   Abascal-Palacios,G., Schindler,C., Rojas,A.L., Bonifacino,J.S. and
            Hierro,A.
  TITLE     Structural basis for the interaction of the Golgi-Associated
            Retrograde Protein Complex with the t-SNARE Syntaxin 6
  JOURNAL   Structure 21 (9), 1698-1706 (2013)
   PUBMED   23932592
REFERENCE   4  (bases 1 to 1304)
  AUTHORS   Ganley,I.G., Espinosa,E. and Pfeffer,S.R.
  TITLE     A syntaxin 10-SNARE complex distinguishes two distinct transport
            routes from endosomes to the trans-Golgi in human cells
  JOURNAL   J Cell Biol 180 (1), 159-172 (2008)
   PUBMED   18195106
REFERENCE   5  (bases 1 to 1304)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1304)
  AUTHORS   Wang,Y., Tai,G., Lu,L., Johannes,L., Hong,W. and Tang,B.L.
  TITLE     Trans-Golgi network syntaxin 10 functions distinctly from syntaxins
            6 and 16
  JOURNAL   Mol Membr Biol 22 (4), 313-325 (2005)
   PUBMED   16154903
  REMARK    GeneRIF: May have a hitherto unrecognized function in the
            trans-Golgi network-endosome boundary.
            Erratum:[Mol Membr Biol. 2005 Sep-Oct;22(5):453]
REFERENCE   7  (bases 1 to 1304)
  AUTHORS   Liewen,H., Meinhold-Heerlein,I., Oliveira,V., Schwarzenbacher,R.,
            Luo,G., Wadle,A., Jung,M., Pfreundschuh,M. and Stenner-Liewen,F.
  TITLE     Characterization of the human GARP (Golgi associated retrograde
            protein) complex
  JOURNAL   Exp Cell Res 306 (1), 24-34 (2005)
   PUBMED   15878329
REFERENCE   8  (bases 1 to 1304)
  AUTHORS   Martin-Martin,B., Nabokina,S.M., Lazo,P.A. and Mollinedo,F.
  TITLE     Co-expression of several human syntaxin genes in neutrophils and
            differentiating HL-60 cells: variant isoforms and detection of
            syntaxin 1
  JOURNAL   J Leukoc Biol 65 (3), 397-406 (1999)
   PUBMED   10080545
REFERENCE   9  (bases 1 to 1304)
  AUTHORS   Tang,B.L., Low,D.Y., Tan,A.E. and Hong,W.
  TITLE     Syntaxin 10: a member of the syntaxin family localized to the
            trans-Golgi network
  JOURNAL   Biochem Biophys Res Commun 242 (2), 345-350 (1998)
   PUBMED   9446797
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011446.6, BM847745.1,
            BM830816.1, AF035531.1 and CD364936.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003765.2.
            
            Summary: This gene belongs to the syntaxin family and encodes a
            soluble N-ethylmaleimide sensitive factor attachment protein
            receptor (SNARE). The encoded protein is involved in docking and
            fusion events at the Golgi apparatus. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.117378.1,
                                           SRR3476690.373590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587230.6/ ENSP00000466298.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC011446.6         21332-21332         c
            2-6                 BM847745.1         1-5
            7-202               BM830816.1         1-196
            203-952             AF035531.1         1-750
            953-1304            CD364936.1         18-369              c
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1304
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /note="syntaxin 10"
                     /db_xref="GeneID:8677"
                     /db_xref="HGNC:HGNC:11428"
                     /db_xref="MIM:603765"
     exon            1..237
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..952
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaxin-10 isoform 1"
                     /protein_id="NP_003756.1"
                     /db_xref="CCDS:CCDS32922.1"
                     /db_xref="GeneID:8677"
                     /db_xref="HGNC:HGNC:11428"
                     /db_xref="MIM:603765"
                     /translation="MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELD
                     WTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEM
                     KDHMVSPTAVAFLERNNREILAGKPAAQKSPSDLLDASAVSATSRYIEEQQATQQLIM
                     DEQDQQLEMVSGSIQVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAK
                     VSHMTSDRRQWCAIAVLVGVLLLVLILLFSL"
     exon            238..407
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            408..502
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            503..565
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            566..673
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            674..780
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            781..875
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1304
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /note="hexamer: AATAAA"
     polyA_site      1304
                     /gene="STX10"
                     /gene_synonym="hsyn10; SYN10"
                     /note="major polyA site"
ORIGIN      
        1 gcccacaacc aagatggctg aggagagggc ggaagtgtcc gcacgtcggg cctccgaggc
       61 ttctctttct cccctggcgg tccggctctc gatggtggcg tgacgggggc gggggtggcg
      121 gcgcgttctc ctcggttggg agggaaccag cccgcgaacc caggccggga ggggggttcg
      181 gcctgggggg gaagggactg acatgtctct cgaagacccc ttttttgtag tccgaggcga
      241 ggtgcagaag gcggtgaaca cggcccgcgg gctgtaccag cgctggtgcg agctcctgca
      301 ggaaagcgcg gcggtcggac gcgaggagct ggactggacg accaatgagc tgcggaatgg
      361 cctgcgcagc atcgagtggg acctcgagga cctggaagag accatcggta tagtggaagc
      421 caacccaggc aagttcaagc tcccagccgg ggacctgcag gagagaaagg tgttcgtgga
      481 gcggatgcga gaggcagtcc aggaaatgaa ggaccatatg gtcagcccaa cagccgtagc
      541 atttttggag aggaataaca gagagatact cgcaggcaag ccagctgccc agaagtcacc
      601 cagcgacctg ctggatgcca gcgcagtctc ggccacatct cgctacatcg aggagcagca
      661 ggccacacag cagctgatca tggatgaaca ggatcaacag ctggagatgg tgtctgggag
      721 catccaggtt ctgaagcaca tgtccggccg cgttggagaa gagctggacg agcagggcat
      781 catgctggat gccttcgccc aagagatgga ccacacccag tcccgcatgg acggggtcct
      841 caggaagttg gccaaagtat cccacatgac gagtgaccgc cgacagtggt gtgccatcgc
      901 cgtgctagtg ggggtgcttc tcctcgttct catcttacta ttctctctct gaccccagcc
      961 ctccctggca ggctggtccc ttaagcctgg ggagccacca agcactttgg agctggcctc
     1021 gccccctagg aggagagggt ccctcctggg tagctggaga gtagagggtc ccgcctgggg
     1081 agctgtcccc atggctctcc cctagagcca gtgggaccct tcaggaccct gggctggaac
     1141 caccaccact ggtcctgtct caagtgcact tagggggtgg tggaggcagg gacacctgag
     1201 acacacctgt ctccatttcc agttccagga ccccaaagcc atttgcccct gtgccttata
     1261 cacgtgccaa cctggaaata aaatgtcagc cttttttata cgta
//
