LOCUS       NM_001003665            7757 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens stum, mechanosensory transduction mediator homolog
            (STUM), transcript variant 1, mRNA.
ACCESSION   NM_001003665 XM_375849
VERSION     NM_001003665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7757)
  AUTHORS   Desai,B.S., Chadha,A. and Cook,B.
  TITLE     The stum gene is essential for mechanical sensing in proprioceptive
            neurons
  JOURNAL   Science 343 (6176), 1256-1259 (2014)
   PUBMED   24626929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359704.9, AL137507.1, AL357122.13, AL365444.11 and AL134612.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001003665.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL137507.1, DY655815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366788.8/ ENSP00000355752.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL359704.9         5880-5915           c
            37-2650             AL137507.1         1-2614
            2651-6862           AL357122.13        51446-55657
            6863-7682           AL365444.11        178325-179144       c
            7683-7741           AL134612.1         25-83               c
            7742-7757           AL365444.11        178250-178265       c
FEATURES             Location/Qualifiers
     source          1..7757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..7757
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /note="stum, mechanosensory transduction mediator homolog"
                     /db_xref="GeneID:375057"
                     /db_xref="HGNC:HGNC:30491"
     exon            1..343
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..567
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein stum homolog; stumble homolog"
                     /codon_start=1
                     /product="protein stum homolog isoform 1"
                     /protein_id="NP_001003665.1"
                     /db_xref="CCDS:CCDS31044.1"
                     /db_xref="GeneID:375057"
                     /db_xref="HGNC:HGNC:30491"
                     /translation="MEPSHKDAETAAAAAAVAAADPRGASSSSGVVVQVREKKGPLRA
                     AIPYMPFPVAVICLFLNTFVPGLGTFVSAFTVLCGARTDLPDRHVCCVFWLNIAAALI
                     QILTAIVMVGWIMSIFWGMDMVILAISQGYKEQGIPQQL"
     exon            344..523
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            524..532
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            533..7757
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7611..7616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /note="hexamer: AATATA"
     polyA_site      7632
                     /gene="STUM"
                     /gene_synonym="C1orf95"
     regulatory      7720..7725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /note="hexamer: AATAAA"
     polyA_site      7757
                     /gene="STUM"
                     /gene_synonym="C1orf95"
                     /note="major polyA site"
ORIGIN      
        1 gcgagccgcg cggcgcacgg agcacggcgg ccgcctgagc tcggcgcgga gcccggagcc
       61 cgcagccgac agtctcctgc tcccgtacgc tgggcgccag ctccggccgt gctgcccggc
      121 tgcctgagag cgcgcccggc catggagccc tcgcacaaag acgccgagac ggcggcggcg
      181 gcggcggcgg tggcggcggc ggacccccgg ggggcgtcct cgtccagcgg ggtggtggtg
      241 caggtccgcg agaagaaggg ccccctgcgc gccgccatcc cctacatgcc cttccccgtg
      301 gccgtcatct gcctcttcct caacactttc gtgccgggac tggggacatt cgtctcggcc
      361 ttcactgtgc tgtgcggggc ccgcaccgac ctcccggaca ggcatgtgtg ctgcgtcttc
      421 tggctgaaca ttgcagcagc cctcatccaa atcctcactg ccatcgtcat ggtgggctgg
      481 atcatgagca tcttctgggg catggacatg gtcatccttg ccatttccca aggctacaag
      541 gagcagggca tcccacagca gctgtgagcc cacgggagcc gctggggaga tccagggggg
      601 ccctgtgagg gctgcaccag gcagctttgg gcacaaggac ctttacatgt tcttttctgc
      661 cattttctgg actgggggtg gaaagggggt atttttaaaa atattattta ttttgaaaac
      721 gcatctgctt ttctcagcag gttgtgaggg ctgccagccc ctcctgctct ggaaagcact
      781 gtgggcgcag gcaccagagc atcagagagt ggggtggaga tgagaacgcc cacagagagg
      841 ctgggatgct ccggcaggct ccaactggcc ttgctgtacc cactgcccac cgcaaaggca
      901 cgccacgtct gctgggccgg gccacaccgg gccctgtctg ggtgagcagg ggctcaccaa
      961 ggggacagga ctgtggtaga cccgtcctgt gggaccccac ctgcctcaaa atctggtgcc
     1021 ccgagtgttt actgtgtggt ctcctggggg cagcaccagg gtgtgggtga ggatggccag
     1081 gctccaccct agcgtggaaa ggcccactgt gcccacagct ggcctgaggc ctcggggaga
     1141 agaccagtcc cacaggcgtc tcctgggcct gcctccctga ccgcaccccc cgcctcctcg
     1201 cagctgaaat ctgagggctg ggtgtgtcgt gacctgtgtt ttcctgggaa ggagaggagt
     1261 agctccttcc ctggggtgaa actgccagat gtttatacac aaagttatta gactgaagca
     1321 ggagtgggca gactagcagg ctttcaccca atacttaaca gcatttctgg cccacattcc
     1381 tttttctgaa gtcattgggg ccagatgtgt ctccgaattg agaaatttta gatttgagaa
     1441 agacaatgcg atccatttat cgtacacttt ctaacttccc ggcagagtgt ggaacatctc
     1501 gcctaccatc aggcacgtga atatttctgc agagaaacat gtgactagtc ccattaactg
     1561 ggagctatac aaactgtaaa tagcctcacc tcagttcagt ctaattttgc cactaagtaa
     1621 cttagggaaa aacttaccat ttgagagctt ttagggtttc agaattgcaa gaacaattgt
     1681 atggggttgt ggaccttgat ctgaaaatcc tgcttgcaaa cagatgtgtt agagggtgaa
     1741 attgtcggca ttacacaagg actccttcag ttgccaaaag accatgggcc tctttaagga
     1801 gcccctctgt aagtgattgg gacagggcta gatccctaat gggggctagg ggtggggaga
     1861 atctagcaga agttgtccag gatactgtgg atcaagtatc aatctgaaat taagagaaat
     1921 tagatactaa gaggatggac atttacatgt ctgtttcctt tcctttcatt ttcattctaa
     1981 cataggaaat gctaacagat ggggctggcc caaagtcaag cttctgactc cacttgacac
     2041 agtgccattg ggcatgtccc tctctgaagg gcttgtttgt ctatcagaga ctgtcagaac
     2101 tccatgaggg caggagaagg gattttgcag gatgaaagtg cttgggaagt agtggccacc
     2161 gttctggggg tttcagccca cctaccccat ccaccgggct ttctaatcac agtcctgcct
     2221 gagaagcggg ccctgctgcc caccccttat catggatccc ttagctactg tccgtcttcc
     2281 attgctgcct ggggctgggc tgccgttttt gaacacctgg cagtgtcttt gtcgcgtcct
     2341 gtcctctctt cttacagacc ccaacccagg cctttgcctt cttctctcct gtttggaagc
     2401 ctctgtatct tcaaggtgtg ggaacagatt tggttttctc taaaaagcta gaaccttctg
     2461 ctgtgtgcag caggcatcct ccaggctggt gctggctgct ctcgaggaag ctgcgtcaga
     2521 gtggagctgc ccctctactc agataaaata gcttcagctg caggaagccg ccccctccca
     2581 tgcccaccag cccacagccc ttcaccccac acagccccca gagtttgccc gacaccccct
     2641 gagtgatgac aggtctcagg agggggccgc ccccacaaat gggaggcgga agcttatttt
     2701 ccccgcttgg gctgggggcg gctgctgagg gggtgaagaa gagatagcaa tttatgtcgc
     2761 atgtttagtg acacaatcca gatgcaggtg ggactttctt gagtggcagg tgtcaccctg
     2821 ggtcccgtgt gggatggttt aatacagggg tttgtgtgtt tgtgtgtgtg gagggccact
     2881 gcgcccccag atcctcctct cccccgaggg ctgcgtctct aaacctggga aaacatcagc
     2941 ctcaggagga ggcccctttc cgggtaactg atgtgtggga gaagccaaga ggcccctgcc
     3001 tgtctcctga atgaggctgt gagggttgcc atgtgggcgg gaccggttca aaatagcgcc
     3061 cccgcccctc taaattagac cgtggtctca gcatgatcat cttcagtaga taagggacag
     3121 tggctgattt actccaaata gttccagctg gccactcaga ccagggccag agttaacttc
     3181 tcaaacacca gccagctgaa aattagggtt ctcgtgcagg caagtgcatg gttgacacac
     3241 agccctttgg tgacaaagct gggctttgcc tgcatagtgc agacaaggct gttggttcag
     3301 aggctgcagg gcacattcca ggttggggcc ttttgtcggt cggaattcaa taggacattc
     3361 cctggctgtg ggtgtttagg gcaggaatta caggcttgca gagaaagtca gaggcaatga
     3421 gatgctccca gtaccaaact gtgacactgg gatcagggtg gtcattccct tgggtcagag
     3481 tgggacccta gagccagagt gagctgtggg tggcctgggt gtgtcctgtg gacggcggag
     3541 actgttgatt tggatgttga gctctgagtc agtttcagaa ccaaggatct caggctgaga
     3601 aggccaggtc cccatgggag cggcaggagt ctgatggctc tgctgccaga gcctacccca
     3661 gcctgccacg ccgctgacct tcccatggta aggaaggggc aggcagcatg gttcccaccc
     3721 tcagctgccc cagacccaca catccagccc caagagcagc ctcacccagg cacagtgcag
     3781 ggcattttag ctcctgggag gggagatgcc tttgtgagtt tcagatgtca gaggagaagc
     3841 tccgagagag taagtcatgt gcccccaaac actcagctcc taagtggcag gacaggcaag
     3901 tggccaggtt gggccgcccc cacagcctgt gccgtccaca cactcactac agcactccca
     3961 gaagaaggag cagaatcgca tgcagcccag agcaggtcct gtggaggggt cctcacccct
     4021 caggagtaat agggtgatta tgtcacatgt ttagtgatac aatcccacct gtgtctggat
     4081 tgtgtcacta aacatgcaac ataaattacc atctcttctc catcccctca gcagccgccc
     4141 ccaccccaag ctgggaaaat aagcttctcc ctcccatatg tgggggcggc cccctcctga
     4201 gacctgtcat cacttagggg gagttgggca aaacctccta ggaaggtcct ggacgcctcc
     4261 accctgcccc acaaggctcc gtactcccac ctgcctgggc agccctcaca cccatgctcc
     4321 ctcctttagg caggcccaga aaggtgcccc ttcctgaggg tgttggggga tggcggcaga
     4381 gagacagctg gtattaggag cttccccatc ctaatgtgca ggaccaagtt gcccgctctg
     4441 ccagccaggg gctccagcca tgctggcaca ggcatctcag aggtgtgaga tgaactccgc
     4501 ctcatgcagg atgcccaggg ctcggaagca gtaaggagga tgctacagaa aggaactgca
     4561 gaaagaaaaa aagccacatg gttaactttt cccctggagg gcaaaggggt ccggctctca
     4621 aaaagaaaag ccaggcacag atcccaacac caagtgtaag gcagcacaaa gtgggtctga
     4681 aaccccagga ccgggtcaaa ggccttccga aggcccgagg ttcttgagga ggggaagctg
     4741 atagggccct ggtctttctg caccagcgtg gctctttaaa atacaaaaca cccacaaagc
     4801 caaaaaccct gaaacatgtt ctttagctaa ccccttccct gcccagatgc ctgcaattct
     4861 gagaattcac ttcagttttg ccagatccaa cccctaggct tgagggtgga gagccaggcc
     4921 tcctcagggt cccttctagg ctcccaggcc caccttaggc tttaattgca ttggctgttt
     4981 cttatggtgt tagtgaattt tgcaaagaaa gccctgagca ttgcataaat gcttgggggc
     5041 gtgtcattta aatggaagtt ctccaatagt ggctgaaggc agagtttact gttatccctc
     5101 cctcttgctg gctttgctgg agggctttta tcagagagat tggaggtggg agagcacttt
     5161 taaagcacac cccaccccct gcacccgagc ggcacctaag cttcccagag accatgacct
     5221 tgtatgtggc tggaggcctc aggcttaggg agcagcctga agcctttgct gtcaaccctc
     5281 ccaggaaaga agccgggcct caggctgagg aaaaacagag tttcctctcc agagggctca
     5341 atgagcagcc aggtagtggc ctcgggcagt cctcaccagg gggacacctc cctgctttgc
     5401 attaactcat cagcaagctc atcgagagct aacgtgggcc cagcagtcct gtgcttggaa
     5461 atgatgccgt cacctccaca ctcctgctgt tccagcctct gcaggtgaag ctgcaaggtg
     5521 agcagaggca ggcgtgggga cacactcttc aaggactgca ctgccccttc tccctcctga
     5581 gagctctgtg cactgggttt ggggatgagg cgccagcctg gtcaggggag gtgactgtgg
     5641 tccttctgac cagcttggat ctttaaaata atcacaaaaa agctcagcct gagcaggtgg
     5701 gtgcaaggct caggggcctg tgtttttcat caatcagttt tcttcctgca agattcttag
     5761 agctggatgt tcacgggatc atggggcatg gaggtggtca cgctcagaca gtcatgcacc
     5821 accctcaatc ccaggccctg cagagatagg aagaatccca accagaggga ttcttcccca
     5881 aacgttccct tgtggcccaa gagtgagttc cggcctgagt gctgttatga ctgccggcgt
     5941 ctctccgact gcctctcgcc tcagtttaac catctatagg ttaggaacaa agaagggctt
     6001 aggcagccat cgtttcccca tttctgtcag agccaagggc ttggaggccc agccccatcc
     6061 gggcaagggc tgtccgctcc tgcccaggcc tcacctcctc gctgcagctg gcaagattct
     6121 ttctagcaga acagaaacac tggcccccaa ttccactctc ccctcctgat gctaccgcag
     6181 agggcagaaa ggtgccctgt agcgtccacc atgtgtgtgt cctgagtttc cagtgcaagt
     6241 catctggatt tgcatttagc tagggaaact cggccctcaa accctctccc tctctgcctg
     6301 aatttgccaa aatgccaacc atccgggcag gtgtggatgc cacagtccat ccccattgca
     6361 tttcaccccc acatggacag aggcacacac tcgcacacat tcccagcacc tttgactgct
     6421 gggggatgca ggccagggtc tgcctggagc ctcagggttg ggacttatct ccaaaggagc
     6481 ccacaccccc tcttccagga tgggcactgg ctggcagcac ttttttccct catcacatcc
     6541 ctgacccctg cccagcccac atgcacatgc tgtttcctgt ctccagggcc ctagcctgtg
     6601 gatctcttcc tcccatgcac tcctagggtg aatgggctca gcaccaaacc tggctgtgcc
     6661 cattccccac aaccccagct tggcctcctg tgggaaggag aaggcagacc tgcccagagg
     6721 agaggggcag tgttcccacc cacctgctcc agcacaggaa ccagggagga aagaagggag
     6781 agggaggttc cattcaccgt tttctgggtt agcgcttgat tggatgtttc aagcaaggga
     6841 caaggtgatg gtggctgtaa taggctcctc gtgggcaccg tcaccccaga aggcctgggc
     6901 acccatgaga acctgtggcc agcccttttc attggctgag ttccctgctg ttgtgcgtgg
     6961 tgccattttt tttttaaaca acatatataa aaacaaaaca actggttctg tgtgtatcaa
     7021 cttaatttgc atatgaatga gtgttgtgtt gtgatttgca gtgttttgac accgtgattg
     7081 gctttgtttg ggtctctctt ctttctgtga aattaactgc tgtgcgtttt cactgttctt
     7141 agagaagacc ctgagctcct ggggttttct tgtctcactt ctaccctgac ctgctgggag
     7201 cccaccccac cccagtccag ccatgagggt atttccagcc tattccaatg actgaaaccc
     7261 ttcttggaag aaaacgtcta atgtcgggga cgtagggacg cttccagact tgccctggcc
     7321 ggaaccctgc agcctggggc cccagcccgc ctgcagctca gctttcccca acaccctcag
     7381 gacccagccc cagccccggc agaccttccc tgggagctgc ttaggtggtc tccacagcgc
     7441 cctctagggg ccaagcaggg ttccagattc tccagccttc tgccagcttt aaaacccttc
     7501 actcaagcag cattactgta catgcaatga aaaatactat atatgacagt caaaacctgt
     7561 gtacatattt ccatgtacat atttatacat acacacacct tcctattata aatatataaa
     7621 gcatgacatc tctttggcat tccaagtttg tgttttttta aatccttgga aatacggctt
     7681 tggaaacctt tttcttcctt tccctctttt ctatgttgta ataaacattc atgtgacctt
     7741 tctggtagtt tctcaaa
//
