LOCUS       NM_152713               4501 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens STT3 oligosaccharyltransferase complex catalytic
            subunit A (STT3A), transcript variant 2, mRNA.
ACCESSION   NM_152713 NM_002219
VERSION     NM_152713.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Ma,M., Dubey,R., Jen,A., Pusapati,G.V., Singal,B., Shishkova,E.,
            Overmyer,K.A., Cormier-Daire,V., Fedry,J., Aravind,L., Coon,J.J.
            and Rohatgi,R.
  TITLE     Regulated N-glycosylation controls chaperone function and receptor
            trafficking
  JOURNAL   Science 386 (6722), 667-672 (2024)
   PUBMED   39509507
REFERENCE   2  (bases 1 to 4501)
  AUTHORS   Lampson,B.L., Ramiotarez,A.S., Baro,M., He,L., Hegde,M., Koduri,V.,
            Pfaff,J.L., Hanna,R.E., Kowal,J., Shirole,N.H., He,Y., Doench,J.G.,
            Contessa,J.N., Locher,K.P. and Kaelin,W.G. Jr.
  TITLE     Positive selection CRISPR screens reveal a druggable pocket in an
            oligosaccharyltransferase required for inflammatory signaling to
            NF-kappaB
  JOURNAL   Cell 187 (9), 2209-2223 (2024)
   PUBMED   38670073
REFERENCE   3  (bases 1 to 4501)
  AUTHORS   Song,D., Jia,X., Gao,Y., Xiao,T., Dan,J., Shen,R., Cai,J.,
            Liang,J., Zhu,W., Hu,J., Yan,G., Zhang,Q. and Lin,Y.
  TITLE     STT3A-mediated viral N-glycosylation underlies the tumor
            selectivity of oncolytic virus M1
  JOURNAL   Oncogene 42 (48), 3575-3588 (2023)
   PUBMED   37864032
  REMARK    GeneRIF: STT3A-mediated viral N-glycosylation underlies the tumor
            selectivity of oncolytic virus M1.
REFERENCE   4  (bases 1 to 4501)
  AUTHORS   Gemmer,M., Chaillet,M.L., van Loenhout,J., Cuevas Arenas,R.,
            Vismpas,D., Grollers-Mulderij,M., Koh,F.A., Albanese,P.,
            Scheltema,R.A., Howes,S.C., Kotecha,A., Fedry,J. and Forster,F.
  TITLE     Visualization of translation and protein biogenesis at the ER
            membrane
  JOURNAL   Nature 614 (7946), 160-167 (2023)
   PUBMED   36697828
REFERENCE   5  (bases 1 to 4501)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   6  (bases 1 to 4501)
  AUTHORS   Yoshida,S., Matsuura,A., Merregaert,J. and Anraku,Y.
  TITLE     Schizosaccharomyces pombe stt3+ is a functional homologue of
            Saccharomyces cerevisiae STT3 which regulates
            oligosaccharyltransferase activity
  JOURNAL   Yeast 15 (6), 497-505 (1999)
   PUBMED   10234787
REFERENCE   7  (bases 1 to 4501)
  AUTHORS   Lissy,N.A., Bellacosa,A., Sonoda,G., Miller,P.D., Jhanwar,S.C. and
            Testa,J.R.
  TITLE     Isolation, characterization, and mapping to human chromosome
            11q24-25 of a cDNA encoding a highly conserved putative
            transmembrane protein, TMC
  JOURNAL   Biochim Biophys Acta 1306 (2-3), 137-141 (1996)
   PUBMED   8634329
REFERENCE   8  (bases 1 to 4501)
  AUTHORS   Hong,G., Deleersnijder,W., Kozak,C.A., Van Marck,E., Tylzanowski,P.
            and Merregaert,J.
  TITLE     Molecular cloning of a highly conserved mouse and human integral
            membrane protein (Itm1) and genetic mapping to mouse chromosome 9
  JOURNAL   Genomics 31 (3), 295-300 (1996)
   PUBMED   8838310
REFERENCE   9  (bases 1 to 4501)
  AUTHORS   Van Hul,W., Hong,G., Wauters,J., Van Hul,E., Nowak,N., Shows,T.B.,
            Willems,P.J. and Merregaert,J.
  TITLE     Assignment of the human integral transmembrane protein 1 gene
            (ITM1) to human chromosome band 11q23.3 by in situ hybridization
            and YAC mapping
  JOURNAL   Cytogenet Cell Genet 74 (3), 218-219 (1996)
   PUBMED   8941377
REFERENCE   10 (bases 1 to 4501)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA577274.1, BC020965.2,
            BE503634.1, AP001132.4 and BM667548.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_152713.4.
            
            Summary: The protein encoded by this gene is a catalytic subunit of
            the N-oligosaccharyltransferase (OST) complex, which functions in
            the endoplasmic reticulum to transfer glycan chains to asparagine
            residues of target proteins. A separate complex containing a
            similar catalytic subunit with an overlapping function also exists.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.186860.1,
                                           SRR1803617.262118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392708.9/ ENSP00000376472.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA577274.1         58-67
            11-2301             BC020965.2         1-2291
            2302-2795           BE503634.1         3-496
            2796-4167           AP001132.4         14718-16089
            4168-4169           BM667548.1         19-20               c
            4170-4501           AP001132.4         16092-16423
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..4501
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="STT3 oligosaccharyltransferase complex catalytic
                     subunit A"
                     /db_xref="GeneID:3703"
                     /db_xref="HGNC:HGNC:6172"
                     /db_xref="MIM:601134"
     exon            1..67
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            68..190
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2220
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /EC_number="2.4.99.18"
                     /note="isoform a is encoded by transcript variant 2;
                     integral transmembrane protein 1; integral membrane
                     protein 1; STT3A, subunit of the oligosaccharyltransferase
                     complex (catalytic);
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit STT3A; transmembrane
                     conserved; B5; transmembrane protein TMC; oligosaccharyl
                     transferase subunit STT3A; STT3, subunit of the
                     oligosaccharyltransferase complex, homolog A;
                     dolichyl-diphosphooligosaccharide protein
                     glycotransferase; STT3A, catalytic subunit of the
                     oligosaccharyltransferase complex"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit STT3A isoform a"
                     /protein_id="NP_689926.1"
                     /db_xref="CCDS:CCDS8458.1"
                     /db_xref="GeneID:3703"
                     /db_xref="HGNC:HGNC:6172"
                     /db_xref="MIM:601134"
                     /translation="MTKFGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESV
                     IHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHV
                     LHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISR
                     SVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSICWAAKCALAYFYMVSSWGGYVFLINL
                     IPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGL
                     CQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLTGKISPWTGRFYSLL
                     DPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMY
                     GVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKSKKQQDSTY
                     PIKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREA
                     YYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKA
                     YEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTGKHIKENDYYTPTGEF
                     RVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGFDRVRNAEIGNKDFELDVLEEAY
                     TTEHWLVRIYKVKDLDNRGLSRT"
     exon            191..251
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            252..373
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            374..519
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            520..610
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            611..717
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            718..882
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1063
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1219
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1311
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1467
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1656
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1773
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1876
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2065
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2181
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..4501
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="hexamer: ATTAAA"
     polyA_site      2473
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="major polyA site"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="hexamer: AATAAA"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="hexamer: AATAAA"
     polyA_site      2735
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
     polyA_site      2752
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="hexamer: TATAAA"
     polyA_site      3789
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
                     /note="hexamer: ATTAAA"
     polyA_site      4169
                     /gene="STT3A"
                     /gene_synonym="CDG1WAD; CDG1WAR; ITM1; STT3-A; TMC"
ORIGIN      
        1 agggttgggt gcgccgctga acggatggct gagggagccc cgcggatcgt ttaggaaagc
       61 cggccagctg atcgtcgtgt gttgccaccc attcatgtca agatgactaa gtttggattt
      121 ttgcgattgt cctatgagaa gcaggacaca cttttgaagc ttctcattct gtcaatggct
      181 gctgtattat ccttctccac tcgtctgttt gctgtcctga gatttgaaag tgttatccat
      241 gagtttgatc cgtactttaa ttatcggact accaggttcc tggctgagga ggggttttat
      301 aaattccata actggtttga tgaccgagcc tggtaccctt tgggacgaat cattggagga
      361 acaatttacc caggtttaat gatcacctct gctgcaatct accatgtact ccattttttc
      421 cacatcacca tcgacattcg gaatgtctgt gtgttcctgg cccctctctt ctcctccttc
      481 accaccatcg tcacgtacca ccttaccaaa gagctcaagg atgcaggggc tgggcttctt
      541 gctgctgcca tgattgctgt agttcctgga tatatctccc gatctgtggc tggctcctat
      601 gataatgaag ggattgccat cttttgcatg ctactcacct actacatgtg gatcaaggca
      661 gtaaagactg gttccatctg ttgggcagct aagtgtgccc ttgcttattt ctacatggtc
      721 tcgtcatggg gaggttatgt gttcctgatc aacttaattc ctctccacgt cctcgtgctg
      781 atgctcacag gccgtttctc tcaccggatc tatgtggcct actgtactgt ttactgcctg
      841 ggcactatac tttctatgca gatctccttt gtgggtttcc agcctgtcct ttcatcagag
      901 cacatggcag cctttggggt ctttggtctc tgccagatcc atgcctttgt ggattacctg
      961 cgcagcaagt tgaatccaca acaatttgaa gttcttttcc ggagcgtcat ctctctggta
     1021 ggctttgtcc ttctcaccgt gggagctctc ctcatgctga caggaaaaat atctccctgg
     1081 acggggcgtt tctactcgct gctggatccc tcttatgcta agaacaacat ccccatcatt
     1141 gcttctgtgt ctgagcatca gcccacaacc tggtcctcat actattttga cctgcagctc
     1201 ctcgtcttca tgtttccagt tggcctctat tactgcttta gcaacctgtc tgatgcccgg
     1261 atttttatca tcatgtatgg tgtgaccagc atgtactttt cagctgtaat ggtgcgtcta
     1321 atgctagtgt tggcacctgt tatgtgcatt ctctctggca ttggagtctc ccaggtgctg
     1381 tccacataca tgaagaatct ggacataagt cgtccagaca agaagagcaa gaagcaacag
     1441 gattccacct accctattaa gaatgaagtg gcaagtggga tgatactggt catggctttc
     1501 tttctcatca cctacacctt tcattcaacc tgggtgacca gtgaggccta ctcttctccg
     1561 tccattgtac tatctgcccg tggtggggat ggcagtagga tcatatttga tgacttccga
     1621 gaagcatatt attggcttcg tcataatact ccagaggatg cgaaggtcat gtcctggtgg
     1681 gattatggct atcagattac agctatggca aaccgaacaa ttttagtgga caataacaca
     1741 tggaataata cccatatttc tcgagtaggg caggcaatgg cgtccacaga ggaaaaagcc
     1801 tatgagatca tgagggagct cgatgtcagc tatgtgctgg tcatttttgg aggcctcact
     1861 gggtattcct ctgatgatat caacaagttt ctttggatgg tccggattgg agggagcaca
     1921 gatacaggca aacatatcaa ggagaatgac tattatactc caactgggga gttccgtgtg
     1981 gaccgtgaag gttctccagt gctgctcaac tgcctcatgt acaagatgtg ttactatcgc
     2041 tttggacagg tttacacaga agccaagcgt cctccaggct ttgaccgtgt ccgaaatgct
     2101 gagattggga ataaagactt tgagcttgat gtcctggagg aagcatatac cacagaacat
     2161 tggctggtca ggatatacaa ggtaaaggac ctggataatc gaggcttgtc aaggacataa
     2221 atgtcacgtc cagctctgat atgcttcgca ctgagcacat cacatttagg acgttgaaga
     2281 tttttttttt tttttttttt taatatgcag tttgtaagaa caaaactgga tggcatcaga
     2341 attgtctgga agttttgtct tgggcagtat gggctgggcc aaatgaaatg atttttataa
     2401 ttctaaacag gttaccaaat gaaatgtcat ggctttactt tggtcaatta aaggggggaa
     2461 tttttttaaa aaatgtgcct tatttgtttt gacttataac tgatttgagg gaggcaaaag
     2521 ctatgctagg ctgccagaag gacataagca gaccttgtcc attctcttag ctccctaaat
     2581 tagccaaata gagacttctt tctcaaatca ggaaaactat caaagaccaa ttcagatcct
     2641 acatttacag acagttttgt cataaccctt tgcattgcag cacctagtac aattccttgg
     2701 aaacagcgtg gctcaataaa tttttattga atgaataaat gtgggaccag aagagtgcta
     2761 gaagagtgcc tttctgggct actatgtctc tgttctcaat gtcttttatc cttagacgct
     2821 ctttgacttt ataaatcagc agttttgaag actcaagaca aacagtgaaa ttattggttt
     2881 atcaatggag aggaagaaac tcttccagca ttacatatag agcttgatgg tcagtaggtg
     2941 tttttgaatc agcttaaata taatcataca tatcaatttg aaatggagct tttcagtact
     3001 ctcacttatt catgacacag gaatgaccct ttactcaaaa ctcttgtggt tgttcaaagg
     3061 tgagcttctt tttcccttag tcttagccta tgtgttgctg ttgtatattg ttaccaagtt
     3121 caactaccta attttgaagc tctttccaaa taagatacaa attaaaaggg gaagcattgc
     3181 cagtaacagg tccctagaga gcagtgccag cctgcctgca agaaaagagg agaaacttct
     3241 taaaaagttt taagcctggg caacataagg agattgtttc tatgaaaaat aaaaattagc
     3301 caggtatggt ggtgtacacc tgtagtccca gctactcggg aagatgagat tggaggatca
     3361 cttgggcctg ggaggttgag gctacagtga actgtgattg tgccactgta ctccagtctg
     3421 ggcgacagtg aaatcttgtc taaacaaaaa caatttaact gggaagcaca gtggtccttg
     3481 aggacattta atatcaggac aaagagccta tgaatatatc actgatgtat ataaacccta
     3541 aggcgttaat aaaagctaac tgtttagtgt tatccattta agggaacagg aggaattgca
     3601 taacttttag attagtcata gtggtgctcc taagggatat gctgttgtat atttgtatag
     3661 ccagggcact tagccttcca aaccaattta tataccatgt tcttcaactg tgggtgagat
     3721 ttagcctcaa gatttgattt actatatgta agtacattac ttgatttcta taaagaatct
     3781 ttagtggaag aggttattct gaattattta tcaatatgat taataccagt tagaaattat
     3841 taatgatctt cctttatact atacatagga taacttttaa cttgtcgcta cagttgttgc
     3901 tctgaggatc ttaattttgt tactttctag gctacatgaa gctatctttt taaaaagtgt
     3961 actcttcatt ttcactgtta ttgtgtactt agcataaaaa actcaaatct aggccaggtg
     4021 cagtggctca tgcctgtaat cccagcactt tgggaggctg aagcatgcgg atcacttgag
     4081 cccaggagtt caagaccagc ctgggcaaca tggctaatga acactaagca tagttttgat
     4141 gtctttcata ttaaagactt tctcaaattc ttgctagtct gctcctcttt aagagtggga
     4201 ccctaggcag ggcgcagtgg atcatgcctg taatcccagc actttgggag gccgaggcag
     4261 gcagatcact tgaggccagg agtttgagac cggcctggca acgtgggaaa actctgtctc
     4321 tactaaaaat acaaaaatta gctgggtgtg gggtacacac cctgtaatct cagctactgg
     4381 ggaggctgag gcatgagaat tgcccaggag gtggaggttg cagtgagcag acatcatgcc
     4441 actgcactcc aacctgggag acagagcaag actgtctcaa aaaaaaaaaa aaaaaaaaaa
     4501 a
//
